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Quantifying Protein Unfolding Kinetics with a High-Throughput Microfluidic Platform

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Natural Selection for Kinetic Stability Is a Likely Origin of Correlations between Mutational Effects on Protein Energetics and Frequencies of Amino Acid Occurrences in Sequence Alignments
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Point Mutations in Protein Globular Domains: Contributions from Function, Stability and Misfolding
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Microsecond Hydrophobic Collapse in the Folding of Escherichia coli Dihydrofolate Reductase, an α/β-Type Protein
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Mapping Transient Partial Unfolding by Protein Engineering and Native-State Proteolysis
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Microsecond Subdomain Folding in Dihydrofolate Reductase
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Protein Quality Control Acts on Folding Intermediates to Shape the Effects of Mutations on Organismal Fitness
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An open-source, programmable pneumatic setup for operation and automated control of single- and multi-layer microfluidic devices
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Disease-linked mutations cause exposure of a protein quality control degron
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Theoretical analysis of Lumry-Eyring models in differential scanning calorimetry
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Principles of Protein Misfolding
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Core Structure of gp41 from the HIV Envelope Glycoprotein
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The consensus concept for thermostability engineering of proteins
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Folding dynamics of single GCN-4 peptides by fluorescence resonant energy transfer confocal microscopy
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Kinetic role of early intermediates in protein folding
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Methods for exploring early events in protein folding
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High-Performance Binary Protein Interaction Screening in a Microfluidic Format
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Exploring the Evolutionary History of Kinetic Stability in the α-Lytic Protease Family
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Biological Roles of Protein Kinetic Stability
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A reexamination of the folding mechanism of dihydrofolate reductase from Escherichia coli: Verification and refinement of a four-channel model
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Folding of dihydrofolate reductase from Escherichia coli
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Effects of multiple replacements at a single position on the folding and stability of dihydrofolate reductase from Escherichia coli
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Implications of the three-dimensional structure of .alpha.1-antitrypsin for structure and function of serpins
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Loop and Subdomain Movements in the Mechanism of Escherichia coli Dihydrofolate Reductase: Crystallographic Evidence,
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A Fluorogenic TMP-Tag for High Signal-to-Background Intracellular Live Cell Imaging
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Conformation Changes of Proteins
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Evolutionary paths to antibiotic resistance under dynamically sustained drug selection
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Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation
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Detection of rare partially folded molecules in equilibrium with the native conformation of RNaseH
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Site-specific ubiquitination affects protein energetics and proteasomal degradation
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Comprehensive, high-resolution binding energy landscapes reveal context dependencies of transcription factor binding
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Global analysis of methionine oxidation provides a census of folding stabilities for the human proteome
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High-Order Epistasis in Catalytic Power of Dihydrofolate Reductase Gives Rise to a Rugged Fitness Landscape in the Presence of Trimethoprim Selection
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A Strategy for Testing the Suitability of Cysteine Replacements in Dihydrofolate Reductase from Escherichia coli1
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Directed evolution of trimethoprim resistance in Escherichia coli
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Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells
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A Systems Approach to Measuring the Binding Energy Landscapes of Transcription Factors
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Tracking cancer drugs in living cells by thermal profiling of the proteome
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A Thermodynamic Scale for the Helix-Forming Tendencies of the Commonly Occurring Amino Acids
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Protein Folding Intermediates: Native-State Hydrogen Exchange
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Regulation of Drosophila Heat Shock Factor Trimerization: Global Sequence Requirements and Independence of Nuclear Localization
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Specific Intermediates in the Folding Reactions of Small Proteins and the Mechanism of Protein Folding
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PATHWAYS OF PROTEIN FOLDING
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Structure, Dynamics, and Catalytic Function of Dihydrofolate Reductase
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A Stability Pattern of Protein Hydrophobic Mutations that Reflects Evolutionary Structural Optimization
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Altered expression of a quality control protease in E. coli reshapes the in vivo mutational landscape of a model enzyme
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