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Pharmacokinetics,Tissue Distribution, Metabolism, and Excretion Studies of the Active Component R,S-Goitrin in Radix Isatidis by Lc-Ms/Ms Determination

https://doi.org/10.2139/ssrn.5123166
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Outgoing claims: the papers this work cites, builds on, or argues with.

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Metabolic profiles and pharmacokinetics of goitrin in rats through liquid chromatography combined with electrospray ionization–tandem mass spectrometry
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Optimization of ultrasound-assisted extraction of indigo and indirubin from Isatis indigotica Fort. and their antioxidant capacities
inferredcites →https://doi.org/10.1007/s10753-009-9164-9openalex-snapshot
The Anti-Inflammatory Effects of a Methanolic Extract from Radix Isatidis in Murine Macrophages and Mice
inferredcites →https://doi.org/10.1007/s13318-015-0296-zopenalex-snapshot
Pharmacokinetic Herb-Drug Interactions: Insight into Mechanisms and Consequences
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Study on pharmacokinetics and tissue distribution of single dose oral tryptanthrin in Kunming mice by validated reversed-phase high-performance liquid chromatography with ultraviolet detection
inferredcites →https://doi.org/10.1016/j.jep.2014.09.005openalex-snapshot
In vitro antioxidant and anti-inflammatory activities of Radix Isatidis extract and bioaccessibility of six bioactive compounds after simulated gastro-intestinal digestion
inferredcites →https://doi.org/10.1016/j.jep.2016.05.016openalex-snapshot
Antiviral activity of hydroalcoholic extract from Eupatorium perfoliatum L. against the attachment of influenza A virus
inferredcites →https://doi.org/10.1016/j.jep.2017.06.007openalex-snapshot
Recent pharmaceutical evidence on the compatibility rationality of traditional Chinese medicine
inferredcites →https://doi.org/10.1016/j.jep.2020.112550openalex-snapshot
Antiviral activity of Isatidis Radix derived glucosinolate isomers and their breakdown products against influenza A in vitro/ovo and mechanism of action
inferredcites →https://doi.org/10.1016/j.jep.2021.114648openalex-snapshot
Isatidis Radix and Isatidis Folium: A systematic review on ethnopharmacology, phytochemistry and pharmacology
inferredcites →https://doi.org/10.1016/j.jpba.2020.113356openalex-snapshot
Stereoselective pharmacokinetic study of epiprogoitrin and progoitrin in rats with UHPLC–MS/MS method
inferredcites →https://doi.org/10.1016/j.phymed.2009.11.003openalex-snapshot
The plant extract Isatis tinctoria L. extract (ITE) inhibits allergen-induced airway inflammation and hyperreactivity in mice
inferredcites →https://doi.org/10.1016/j.psj.2023.102534openalex-snapshot
Radix Isatidis polysaccharide (RIP) resists the infection of QX-type infectious bronchitis virus via the MDA5/TLR3/IRF7 signaling pathway
inferredcites →https://doi.org/10.1016/s0254-6272(16)30051-6openalex-snapshot
Antiviral activities against influenza virus (FM1) of bioactive fractions and representative compounds extracted from Banlangen (Radix Isatidis)
inferredcites →https://doi.org/10.1021/jf203321uopenalex-snapshot
Biotransformation of Glucosinolates Epiprogoitrin and Progoitrin to (R)- and (S)-Goitrin in Radix isatidis
inferredcites →https://doi.org/10.1021/ol302660topenalex-snapshot
Enantiomers of an Indole Alkaloid Containing Unusual Dihydrothiopyran and 1,2,4-Thiadiazole Rings from the Root of Isatis indigotica
inferredcites →https://doi.org/10.1023/a:1026095608691openalex-snapshot
Isatis tinctoria – From the rediscovery of an ancient medicinal plant towards a novel anti-inflammatory phytopharmaceutical
inferredcites →https://doi.org/10.1055/s-2006-931562openalex-snapshot
Anti-Inflammatory and Antiallergic Activityin vivoof LipophilicIsatis tinctoriaExtracts and Tryptanthrin
inferredcites →https://doi.org/10.1055/s-2006-946679openalex-snapshot
The Leaf Volatile Constituents of Isatis tinctoria by Solid-Phase Microextraction and Gas Chromatography/Mass Spectrometry
inferredcites →https://doi.org/10.1055/s-2008-1074554openalex-snapshot
Glucosinolate Pattern inIsatis tinctoriaandI. indigoticaSeeds
inferredcites →https://doi.org/10.1080/14786419.2020.1779716openalex-snapshot
Four new indole alkaloids from the roots of Isatis tinctoria
inferredcites →https://doi.org/10.1080/17460441.2021.1961741openalex-snapshot
An update on the importance of plasma protein binding in drug discovery and development
inferredcites →https://doi.org/10.1177/009127000004001211openalex-snapshot
Pharmacokinetic/Pharmacodynamic Modeling in Drug Research and Development
inferredcites →https://doi.org/10.1186/s12906-020-2838-4openalex-snapshot
Antiviral activities of Radix isatidis polysaccharide against pseudorabies virus in swine testicle cells
inferredcites →https://doi.org/10.1186/s13020-018-0183-zopenalex-snapshot
Pharmacokinetics of Chinese medicines: strategies and perspectives
inferredcites →https://doi.org/10.1186/s13020-022-00624-5openalex-snapshot
Inhibitory effect of Isatis tinctoria L. water extract on DNCB-induced atopic dermatitis in BALB/c mice and HaCaT cells
inferredcites →https://doi.org/10.1186/s43897-021-00021-wopenalex-snapshot
Isatis indigotica: from (ethno) botany, biochemistry to synthetic biology
inferredcites →https://doi.org/10.1590/1678-457x.19317openalex-snapshot
Antiviral activities of Radix Isatidis polysaccharide against type II herpes simplex virus in vitro
inferredcites →https://doi.org/10.19540/j.cnki.cjcmm.2017.0016openalex-snapshot
[Multi-compound pharmacokinetic research on Chinese herbal medicines: approach and methodology].
inferredcites →https://doi.org/10.2174/138161205774580679openalex-snapshot
Drug Tissue Distribution: Study Methods and Therapeutic Implications
inferredcites →https://doi.org/10.2174/138161211795164194openalex-snapshot
ADME Properties of Herbal Medicines in Humans: Evidence, Challenges and Strategies
inferredcites →https://doi.org/10.3109/03602532.2015.1124888openalex-snapshot
Pharmacokinetic herb–drug interactions with traditional Chinese medicine: progress, causes of conflicting results and suggestions for future research
inferredcites →https://doi.org/10.3389/fphar.2021.664022openalex-snapshot
A Comprehensive Review of the Chemistry, Pharmacokinetics, Pharmacology, Clinical Applications, Adverse Events, and Quality Control of Indigo Naturalis
inferredcites →https://doi.org/10.3390/ijms19010305openalex-snapshot
Compatibility with Panax notoginseng and Rehmannia glutinosa Alleviates the Hepatotoxicity and Nephrotoxicity of Tripterygium wilfordii via Modulating the Pharmacokinetics of Triptolide
inferredcites →https://doi.org/10.3390/molecules191220906openalex-snapshot
Total Synthesis and Anti-Viral Activities of an Extract of Radix isatidis
inferredcites →https://doi.org/10.3390/molecules22010116openalex-snapshot
Radix isatidis Polysaccharides Inhibit Influenza a Virus and Influenza A Virus-Induced Inflammation via Suppression of Host TLR3 Signaling In Vitro
inferredcites →https://doi.org/10.3390/molecules23061305openalex-snapshot
Separation and Quantification of Four Main Chiral Glucosinolates in Radix Isatidis and Its Granules Using High-Performance Liquid Chromatography/Diode Array Detector Coupled with Circular Dichroism Detection
inferredcites →https://doi.org/10.3390/plants13202897openalex-snapshot
Cyclic Isothiocyanate Goitrin Impairs Lotus japonicus Nodulation, Affects the Proteomes of Nodules and Free Mesorhizobium loti, and Induces the Formation of Caffeic Acid Derivatives in Bacterial Cultures
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