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A Bioprinting Approach for High-Throughput Production of Micropatterned Neuroepithelial Tissues And Modeling TSC2-Deficient Brain Malformations

https://doi.org/10.2139/ssrn.5227917
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Rapamycin and rapalogs for tuberous sclerosis complex
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A Micropatterned Human‐Specific Neuroepithelial Tissue for Modeling Gene and Drug‐Induced Neurodevelopmental Defects
inferredcites →https://doi.org/10.1002/advs.202101786openalex-snapshot
A Micropatterned Human‐Specific Neuroepithelial Tissue for Modeling Gene and Drug‐Induced Neurodevelopmental Defects
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Towards a cellular and molecular understanding of neurulation
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Developmental atlas of the early first trimester human embryo
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Neural tube defects: a review of global prevalence, causes, and primary prevention
inferredcites →https://doi.org/10.1016/j.cell.2008.07.017openalex-snapshot
Regulation of Neurogenesis by Interkinetic Nuclear Migration through an Apical-Basal Notch Gradient
inferredcites →https://doi.org/10.1016/j.celrep.2016.02.090openalex-snapshot
mTORC1 Inhibition Corrects Neurodevelopmental and Synaptic Alterations in a Human Stem Cell Model of Tuberous Sclerosis
inferredcites →https://doi.org/10.1016/j.celrep.2018.06.110openalex-snapshot
Ki67 is a Graded Rather than a Binary Marker of Proliferation versus Quiescence
inferredcites →https://doi.org/10.1016/j.celrep.2022.111048openalex-snapshot
Renal organoid modeling of tuberous sclerosis complex reveals lesion features arise from diverse developmental processes
inferredcites →https://doi.org/10.1016/j.devcel.2023.11.004openalex-snapshot
Shaping the brain: The emergence of cortical structure and folding
inferredcites →https://doi.org/10.1016/j.ejmg.2018.06.002openalex-snapshot
Polymicrogyria in association with hypoglycemia points to mutation in the mTOR pathway
inferredcites →https://doi.org/10.1016/j.expneurol.2020.113432openalex-snapshot
Dynamic analysis of 4E-BP1 phosphorylation in neurons with Tsc2 or Depdc5 knockout
inferredcites →https://doi.org/10.1016/j.ohx.2021.e00186openalex-snapshot
Design and implementation of a low cost bio-printer modification, allowing for switching between plastic and gel extrusion
inferredcites →https://doi.org/10.1016/j.ohx.2021.e00230openalex-snapshot
Open-source hybrid 3D-bioprinter for simultaneous printing of thermoplastics and hydrogels
inferredcites →https://doi.org/10.1016/j.pediatrneurol.2024.09.012openalex-snapshot
Cortical Gyrification Is Associated With the Clinical Phenotype in Tuberous Sclerosis Complex
inferredcites →https://doi.org/10.1016/j.seizure.2008.11.005openalex-snapshot
Tuberous sclerosis complex with unilateral perisylvian polymicrogyria and contralateral hippocampal sclerosis—A case report
inferredcites →https://doi.org/10.1016/j.seizure.2022.03.003openalex-snapshot
Sirolimus treatment for tuberous sclerosis complex prior to epilepsy: Evidence from a registry-based real-world study
inferredcites →https://doi.org/10.1016/j.semcdb.2017.11.033openalex-snapshot
Nuclear migration in mammalian brain development
inferredcites →https://doi.org/10.1016/j.stem.2011.09.008openalex-snapshot
Sustained Activation of mTOR Pathway in Embryonic Neural Stem Cells Leads to Development of Tuberous Sclerosis Complex-Associated Lesions
inferredcites →https://doi.org/10.1016/j.stem.2013.02.001openalex-snapshot
Opposing Regulation of Sox2 by Cell-Cycle Effectors E2f3a and E2f3b in Neural Stem Cells
inferredcites →https://doi.org/10.1016/j.stem.2016.11.017openalex-snapshot
Induction of Expansion and Folding in Human Cerebral Organoids
inferredcites →https://doi.org/10.1016/j.tcb.2012.11.001openalex-snapshot
Mechanisms controlling arrangements and movements of nuclei in pseudostratified epithelia
inferredcites →https://doi.org/10.1038/nbt.1529openalex-snapshot
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
inferredcites →https://doi.org/10.1038/nbt1310openalex-snapshot
A ROCK inhibitor permits survival of dissociated human embryonic stem cells
inferredcites →https://doi.org/10.1038/ncomms14167openalex-snapshot
Dynamic behaviour of human neuroepithelial cells in the developing forebrain
inferredcites →https://doi.org/10.1038/nn1726openalex-snapshot
The first neurons of the human cerebral cortex
inferredcites →https://doi.org/10.1038/s41379-020-00659-9openalex-snapshot
Subependymal giant cell astrocytomas are characterized by mTORC1 hyperactivation, a very low somatic mutation rate, and a unique gene expression profile
inferredcites →https://doi.org/10.1038/s41567-018-0046-7openalex-snapshot
Human brain organoids on a chip reveal the physics of folding
inferredcites →https://doi.org/10.1038/s41586-021-04026-9openalex-snapshot
Human neural tube morphogenesis in vitro by geometric constraints
inferredcites →https://doi.org/10.1038/s41586-024-07204-7openalex-snapshot
A patterned human neural tube model using microfluidic gradients
inferredcites →https://doi.org/10.1038/s41587-019-0237-5openalex-snapshot
Self-organizing neuruloids model developmental aspects of Huntington’s disease in the ectodermal compartment
inferredcites →https://doi.org/10.1038/s41598-022-26809-4openalex-snapshot
Development of a high-performance open-source 3D bioprinter
inferredcites →https://doi.org/10.1042/bst0370217openalex-snapshot
A complex interplay between Akt, TSC2 and the two mTOR complexes
inferredcites →https://doi.org/10.1073/pnas.0308600100openalex-snapshot
Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: A major site of neurogenesis
inferredcites →https://doi.org/10.1073/pnas.1106454108openalex-snapshot
Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex
inferredcites →https://doi.org/10.1074/jbc.ra118.003908openalex-snapshot
The scaffolding protein ZO-1 coordinates actomyosin and epithelial apical specializations in vitro and in vivo
inferredcites →https://doi.org/10.1093/brain/awaa174openalex-snapshot
Definitions and classification of malformations of cortical development: practical guidelines
inferredcites →https://doi.org/10.1093/brain/awaa268openalex-snapshot
Recent progress in translational engineered in vitro models of the central nervous system
inferredcites →https://doi.org/10.1093/hmg/ddae199openalex-snapshot
Human TSC2 mutant cells exhibit aberrations in early neurodevelopment accompanied by changes in the DNA Methylome
inferredcites →https://doi.org/10.1093/hmg/ddp025openalex-snapshot
Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse
inferredcites →https://doi.org/10.1093/neuonc/nou164openalex-snapshot
The mTOR signaling pathway as a treatment target for intracranial neoplasms
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Genome-wide functional genomics screens identify therapeutic vulnerabilities for lymphangioleiomyomatosis
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Cell Division Modes and Cleavage Planes of Neural Progenitors during Mammalian Cortical Development
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Reprogramming progeria fibroblasts re‐establishes a normal epigenetic landscape
inferredcites →https://doi.org/10.1172/jci7319openalex-snapshot
Tsc2+/– mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background
inferredcites →https://doi.org/10.1186/s13023-022-02266-0openalex-snapshot
Perfect match: mTOR inhibitors and tuberous sclerosis complex
inferredcites →https://doi.org/10.1242/dev.186387openalex-snapshot
Quantitative developmental biology in vitro using micropatterning
inferredcites →https://doi.org/10.1242/jcs.230300openalex-snapshot
Rho kinase-dependent apical constriction counteracts M-phase apical expansion to enable mouse neural tube closure
inferredcites →https://doi.org/10.1371/journal.pone.0106952openalex-snapshot
Dual Small-Molecule Targeting of SMAD Signaling Stimulates Human Induced Pluripotent Stem Cells toward Neural Lineages
inferredcites →https://doi.org/10.3389/fnana.2020.00039openalex-snapshot
The Neurodevelopmental Pathogenesis of Tuberous Sclerosis Complex (TSC)
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