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Alfalfa Saponins Alleviate High-Fat Diet-Induced Hyperlipidemia Via Targeted Modulation of Gut Microbiota and Bile Acid Metabolism in Rats

https://doi.org/10.2139/ssrn.5251663
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Outgoing claims: the papers this work cites, builds on, or argues with.

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Dietary lipids, gut microbiota and lipid metabolism
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Intestinal microbiota in human health and disease: the impact of probiotics
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The nutritional & biological significance of saponins
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Bile Acid Metabolism and Signaling in Cholestasis, Inflammation, and Cancer
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Type 1 diabetes induces cognitive dysfunction in rats associated with alterations of the gut microbiome and metabolomes in serum and hippocampus
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Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist
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Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling
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Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism
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The global burden of metabolic disease: Data from 2000 to 2019
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Modulating bile acid pathways and TGR5 receptors for treating liver and GI diseases
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Study of soy-fortified green tea curd formulated using potential hypocholesterolemic and hypotensive probiotics isolated from locally made curd
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Effect of lotus seed resistant starch on small intestinal flora and bile acids in hyperlipidemic rats
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Probiotic-fermented rice buckwheat alleviates high-fat diet-induced hyperlipidemia in mice by suppressing lipid accumulation and modulating gut microbiota
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Changes of intestinal microflora diversity in diarrhea model of KM mice and effects of Psidium guajava L. as the treatment agent for diarrhea
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Quantitative profiling of 19 bile acids in rat plasma, liver, bile and different intestinal section contents to investigate bile acid homeostasis and the application of temporal variation of endogenous bile acids
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Effects of alfalfa saponin extract on growth performance and some antioxidant indices of weaned piglets
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Tissue-specific function of farnesoid X receptor in liver and intestine
inferredcites →https://doi.org/10.1016/j.phrs.2020.105088openalex-snapshot
A review of saponin intervention in metabolic syndrome suggests further study on intestinal microbiota
inferredcites →https://doi.org/10.1021/acs.jafc.1c01813openalex-snapshot
Flavonoids from Whole-Grain Oat Alleviated High-Fat Diet-Induced Hyperlipidemia via Regulating Bile Acid Metabolism and Gut Microbiota in Mice
inferredcites →https://doi.org/10.1021/acs.jafc.2c04817openalex-snapshot
Nuciferine Protects Against High-Fat Diet-Induced Hepatic Steatosis via Modulation of Gut Microbiota and Bile Acid Metabolism in Rats
inferredcites →https://doi.org/10.1038/ncomms10166openalex-snapshot
Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction
inferredcites →https://doi.org/10.1038/ncomms3384openalex-snapshot
Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity
inferredcites →https://doi.org/10.1038/nrgastro.2012.14openalex-snapshot
IBD—what role do Proteobacteria play?
inferredcites →https://doi.org/10.1038/nrgastro.2017.119openalex-snapshot
Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis
inferredcites →https://doi.org/10.1038/s41385-019-0162-4openalex-snapshot
Emerging roles of bile acids in mucosal immunity and inflammation
inferredcites →https://doi.org/10.1038/s41467-019-11460-xopenalex-snapshot
Genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome
inferredcites →https://doi.org/10.1038/s41467-019-12896-xopenalex-snapshot
Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism
inferredcites →https://doi.org/10.1038/s41574-018-0143-9openalex-snapshot
Microbiota and metabolites in metabolic diseases
inferredcites →https://doi.org/10.1038/s41598-019-49462-wopenalex-snapshot
Discrepant gut microbiota markers for the classification of obesity-related metabolic abnormalities
inferredcites →https://doi.org/10.1039/d1fo04004aopenalex-snapshot
Konjac oligosaccharides attenuate DSS-induced ulcerative colitis in mice: mechanistic insights
inferredcites →https://doi.org/10.1039/d1fo04387kopenalex-snapshot
Lactobacillus reuteri J1 prevents obesity by altering the gut microbiota and regulating bile acid metabolism in obese mice
inferredcites →https://doi.org/10.1039/d2fo01828dopenalex-snapshot
Gougunao tea polysaccharides ameliorate high-fat diet-induced hyperlipidemia and modulate gut microbiota
inferredcites →https://doi.org/10.1053/j.gastro.2011.10.028openalex-snapshot
Selective Activation of Nuclear Bile Acid Receptor FXR in the Intestine Protects Mice Against Cholestasis
inferredcites →https://doi.org/10.1073/pnas.1323599111openalex-snapshot
Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut
inferredcites →https://doi.org/10.1080/09712119.2018.1454323openalex-snapshot
Effects of dietary alfalfa saponins on laying performance, egg cholesterol concentration, and ATP-binding cassette transporters G5 and G8 expression in laying hens
inferredcites →https://doi.org/10.1096/fj.201700741rropenalex-snapshot
Ophiopogonin D alleviates high‐fat diet‐induced metabolic syndrome and changes the structure of gut microbiota in mice
inferredcites →https://doi.org/10.1097/pat.0b013e328351bcc8openalex-snapshot
The liver sieve and atherosclerosis
inferredcites →https://doi.org/10.1111/imm.12760openalex-snapshot
The immune response to Prevotella bacteria in chronic inflammatory disease
inferredcites →https://doi.org/10.1126/science.284.5418.1362openalex-snapshot
Identification of a Nuclear Receptor for Bile Acids
inferredcites →https://doi.org/10.1152/physrev.00010.2008openalex-snapshot
Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation
inferredcites →https://doi.org/10.1172/jci129194openalex-snapshot
The gut microbiome and metabolic syndrome
inferredcites →https://doi.org/10.1172/jci25604openalex-snapshot
Farnesoid X receptor is essential for normal glucose homeostasis
inferredcites →https://doi.org/10.1194/jlr.m005546openalex-snapshot
Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms
inferredcites →https://doi.org/10.1194/jlr.r054114openalex-snapshot
Intestinal transport and metabolism of bile acids
inferredcites →https://doi.org/10.1194/jlr.r088989openalex-snapshot
Microbial impact on cholesterol and bile acid metabolism: current status and future prospects
inferredcites →https://doi.org/10.1194/jlr.r500013-jlr200openalex-snapshot
Bile salt biotransformations by human intestinal bacteria
inferredcites →https://doi.org/10.1371/journal.pone.0088282openalex-snapshot
The Regulation of Alfalfa Saponin Extract on Key Genes Involved in Hepatic Cholesterol Metabolism in Hyperlipidemic Rats
inferredcites →https://doi.org/10.1371/journal.pone.0098578openalex-snapshot
Digital Gene-Expression Profiling Analysis of the Cholesterol-Lowering Effects of Alfalfa Saponin Extract on Laying Hens
inferredcites →https://doi.org/10.1515/dmdi.2000.17.1-4.211openalex-snapshot
The Bioactivity of Saponins: Triterpenoid and Steroidal Glycosides
inferredcites →https://doi.org/10.3389/fimmu.2018.01853openalex-snapshot
Bile Acids Activated Receptors Regulate Innate Immunity
inferredcites →https://doi.org/10.3389/fmicb.2016.00185openalex-snapshot
Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health
inferredcites →https://doi.org/10.3389/fphar.2021.627920openalex-snapshot
Linderae Radix Ethanol Extract Alleviates Diet-Induced Hyperlipidemia by Regulating Bile Acid Metabolism Through gut Microbiota
inferredcites →https://doi.org/10.3390/nu14234945openalex-snapshot
Lactobacillus gasseri RW2014 Ameliorates Hyperlipidemia by Modulating Bile Acid Metabolism and Gut Microbiota Composition in Rats
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