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Dihydromyricetin Improved Systemic Inflammation-Induced Depression Through Bdnf/Trkb/Pgc-1α/Fndc5 Pathway

https://doi.org/10.2139/ssrn.5334206
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1 of the 64 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-28): 10.1155/2021/6664591 (notice 2024-03-20).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/978-3-319-72790-5_8openalex-snapshot
The Role of FNDC5/Irisin in the Nervous System and as a Mediator for Beneficial Effects of Exercise on the Brain
inferredcites →https://doi.org/10.1007/s00213-017-4761-zopenalex-snapshot
Dihydromyricetin exerts a rapid antidepressant-like effect in association with enhancement of BDNF expression and inhibition of neuroinflammation
inferredcites →https://doi.org/10.1007/s00726-018-2631-6openalex-snapshot
Taurine regulates mucosal barrier function to alleviate lipopolysaccharide-induced duodenal inflammation in chicken
inferredcites →https://doi.org/10.1007/s10495-008-0309-3openalex-snapshot
Cell death pathways in Parkinson’s disease: proximal triggers, distal effectors, and final steps
inferredcites →https://doi.org/10.1007/s10495-015-1143-zopenalex-snapshot
Multifaceted role of prohibitin in cell survival and apoptosis
inferredcites →https://doi.org/10.1007/s10571-011-9794-yopenalex-snapshot
Increased Expression of the Anti-Apoptotic Protein Bcl-xL in the Brain is Associated with Resilience to Stress-Induced Depression-Like Behavior
inferredcites →https://doi.org/10.1007/s10753-017-0573-xopenalex-snapshot
Salidroside Inhibits Inflammation Through PI3K/Akt/HIF Signaling After Focal Cerebral Ischemia in Rats
inferredcites →https://doi.org/10.1007/s11064-008-9865-8openalex-snapshot
Mitochondrial Dysfunction and Psychiatric Disorders
inferredcites →https://doi.org/10.1007/s11064-013-1231-9openalex-snapshot
1,8-Cineole (Eucalyptol) Mitigates Inflammation in Amyloid Beta Toxicated PC12 Cells: Relevance to Alzheimer’s Disease
inferredcites →https://doi.org/10.1007/s12264-016-0048-3openalex-snapshot
The Immune System and the Role of Inflammation in Perinatal Depression
inferredcites →https://doi.org/10.1016/j.bbi.2008.04.001openalex-snapshot
Inoculation of Bacillus Calmette-Guerin to mice induces an acute episode of sickness behavior followed by chronic depressive-like behavior
inferredcites →https://doi.org/10.1016/j.bbi.2020.11.008openalex-snapshot
Ibrutinib alleviates LPS-induced neuroinflammation and synaptic defects in a mouse model of depression
inferredcites →https://doi.org/10.1016/j.bbr.2017.05.064openalex-snapshot
Behavioral, inflammatory and neurochemical disturbances in LPS and UCMS-induced mouse models of depression
inferredcites →https://doi.org/10.1016/j.bbr.2022.113775openalex-snapshot
Dihydromyricetin improves LPS-induced sickness and depressive-like behaviors in mice by inhibiting the TLR4/Akt/HIF1a/NLRP3 pathway
inferredcites →https://doi.org/10.1016/j.bbr.2022.114006openalex-snapshot
Rosmarinic acid relieves LPS-induced sickness and depressive-like behaviors in mice by activating the BDNF/Nrf2 signaling and autophagy pathway
inferredcites →https://doi.org/10.1016/j.biocel.2004.05.010openalex-snapshot
Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for β-amyloid peptide over-production and localization in Alzheimer’s disease
inferredcites →https://doi.org/10.1016/j.brainresbull.2008.03.005openalex-snapshot
Antidepressive-like effects of rapamycin in animal models: Implications for mTOR inhibition as a new target for treatment of affective disorders
inferredcites →https://doi.org/10.1016/j.cmet.2013.09.008openalex-snapshot
Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway
inferredcites →https://doi.org/10.1016/j.mehy.2020.110094openalex-snapshot
Neuroprotective and neuro-survival properties of safinamide against methamphetamine-induced neurodegeneration: Hypothetic possible role of BDNF/TrkB/PGC-1α signaling pathway and mitochondrial uncoupling protein −2(UCP-2)
inferredcites →https://doi.org/10.1016/j.neulet.2021.135963openalex-snapshot
Dihydromyricetin attenuates D-galactose-induced brain aging of mice via inhibiting oxidative stress and neuroinflammation
inferredcites →https://doi.org/10.1016/j.neuron.2020.06.002openalex-snapshot
The Bidirectional Relationship of Depression and Inflammation: Double Trouble
inferredcites →https://doi.org/10.1016/j.neuropharm.2015.10.034openalex-snapshot
BDNF – a key transducer of antidepressant effects
inferredcites →https://doi.org/10.1016/j.pnpbp.2020.110151openalex-snapshot
Brain-derived neurotrophic factor (BDNF) and inflammatory markers: Perspectives for the management of depression
inferredcites →https://doi.org/10.1016/j.psyneuen.2007.03.005openalex-snapshot
Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior
inferredcites →https://doi.org/10.1016/j.tcb.2017.01.001openalex-snapshot
Autophagy Receptors and Neurodegenerative Diseases
inferredcites →https://doi.org/10.1016/s0006-3223(00)00971-9openalex-snapshot
The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death
inferredcites →https://doi.org/10.1021/acs.jafc.8b02433openalex-snapshot
Dihydromyricetin Inhibits Lead-Induced Cognitive Impairments and Inflammation by the Adenosine 5′-Monophosphate-Activated Protein Kinase Pathway in Mice
inferredcites →https://doi.org/10.1023/b:appt.0000018793.10779.dcopenalex-snapshot
The kinder side of killer proteases: Caspase activation contributes to neuroprotection and CNS remodeling
inferredcites →https://doi.org/10.1038/515180aopenalex-snapshot
Mental health: A world of depression
inferredcites →https://doi.org/10.1038/mp.2013.105openalex-snapshot
Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N=9484)
inferredcites →https://doi.org/10.1038/nri.2015.5openalex-snapshot
The role of inflammation in depression: from evolutionary imperative to modern treatment target
inferredcites →https://doi.org/10.1038/s41386-018-0090-0openalex-snapshot
Multivariate meta-analyses of mitochondrial complex I and IV in major depressive disorder, bipolar disorder, schizophrenia, Alzheimer disease, and Parkinson disease
inferredcites →https://doi.org/10.1038/s41419-019-1813-9openalex-snapshot
The effect of fluoxetine on astrocyte autophagy flux and injured mitochondria clearance in a mouse model of depression
inferredcites →https://doi.org/10.1038/s41467-021-24810-5openalex-snapshot
Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion
inferredcites →https://doi.org/10.1038/sj.npp.1301527openalex-snapshot
Repeated Unpredictable Stress and Antidepressants Differentially Regulate Expression of the Bcl-2 Family of Apoptotic Genes in Rat Cortical, Hippocampal, and Limbic Brain Structures
inferredcites →https://doi.org/10.1038/tp.2011.33openalex-snapshot
Enriched environment treatment reverses depression-like behavior and restores reduced hippocampal neurogenesis and protein levels of brain-derived neurotrophic factor in mice lacking its expression through promoter IV
inferredcites →https://doi.org/10.1080/1028415x.2020.1807711openalex-snapshot
Sex-biased transgenerational transmission of betaine-induced epigenetic modifications in glucocorticoid receptor gene and its down-stream BDNF/ERK pathway in rat hippocampus
inferredcites →https://doi.org/10.1093/abbs/gmy003openalex-snapshot
Dihydromyricetin improves type 2 diabetes-induced cognitive impairment via suppressing oxidative stress and enhancing brain-derived neurotrophic factor-mediated neuroprotection in mice
inferredcites →https://doi.org/10.1093/ijnp/pyu077openalex-snapshot
Antidepressant Effects of TrkB Ligands on Depression-Like Behavior and Dendritic Changes in Mice After Inflammation
inferredcites →https://doi.org/10.1111/cns.12983openalex-snapshot
Dihydromyricetin inhibits microglial activation and neuroinflammation by suppressing NLRP 3 inflammasome activation in APP / PS 1 transgenic mice
inferredcites →https://doi.org/10.1111/ejn.14720openalex-snapshot
Neuroinflammation and depression: A review
inferredcites →https://doi.org/10.1111/j.1527-3458.2008.00040.xopenalex-snapshot
Therapeutic Potential of Fluoxetine in Neurological Disorders
inferredcites →https://doi.org/10.1128/mcb.25.3.1025-1040.2005openalex-snapshot
Inhibition of Macroautophagy Triggers Apoptosis
inferredcites →https://doi.org/10.1155/2017/6871089openalex-snapshot
The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex
inferredcites →https://doi.org/10.1155/2021/6664591openalex-snapshot
[Retracted] Agomelatine Softens Depressive‐Like Behavior through the Regulation of Autophagy and Apoptosis
inferredcites →https://doi.org/10.1158/0008-5472.can-05-4412openalex-snapshot
Bcl-2 Inhibition of Autophagy: A New Route to Cancer?
inferredcites →https://doi.org/10.1176/appi.ajp.161.11.1957openalex-snapshot
Hippocampal Volume and Depression: A Meta-Analysis of MRI Studies
inferredcites →https://doi.org/10.1177/1073858410371379openalex-snapshot
Inflammation in Neurological Disorders: A Help or a Hindrance?
inferredcites →https://doi.org/10.1186/2047-9158-1-7openalex-snapshot
Erythropoietin prevents PC12 cells from beta-amyloid-induced apoptosis via PI3K⁄Akt pathway
inferredcites →https://doi.org/10.1186/s12974-019-1475-7openalex-snapshot
Role of inflammation in depression relapse
inferredcites →https://doi.org/10.12047/j.cjap.5852.2019.108openalex-snapshot
[Dihydromyricetin ameliorates chronic social defeat stress induced cognitive and affective disorder in mice].
inferredcites →https://doi.org/10.2174/1567205017666201006162538openalex-snapshot
Alterations in Mitochondrial Dynamic-related Genes in the Peripheral Blood of Alzheimer’s Disease Patients
inferredcites →https://doi.org/10.2174/1570159x14666160229114755openalex-snapshot
Mitochondrial Dysfunction in Depression
inferredcites →https://doi.org/10.24869/psyd.2018.129openalex-snapshot
DOES PHYSICAL EXERCISE INCREASE BRAIN-DERIVED NEUROTROPHIC FACTOR IN MAJOR DEPRESSIVE DISORDER? A META-ANALYSIS
inferredcites →https://doi.org/10.24869/psyd.2018.273openalex-snapshot
CHALLENGES OF TREATMENT-RESISTANT DEPRESSION
inferredcites →https://doi.org/10.3389/fphar.2018.01204openalex-snapshot
Recent Update on the Pharmacological Effects and Mechanisms of Dihydromyricetin
inferredcites →https://doi.org/10.3389/fphar.2019.01334openalex-snapshot
Preclinical Research of Dihydromyricetin for Brain Aging and Neurodegenerative Diseases
inferredcites →https://doi.org/10.3390/ijms18030545openalex-snapshot
More Insight into BDNF against Neurodegeneration: Anti-Apoptosis, Anti-Oxidation, and Suppression of Autophagy
inferredcites →https://doi.org/10.3390/ijms21051769openalex-snapshot
EPA is More Effective than DHA to Improve Depression-Like Behavior, Glia Cell Dysfunction and Hippcampal Apoptosis Signaling in a Chronic Stress-Induced Rat Model of Depression
inferredcites →https://doi.org/10.3390/molecules24112035openalex-snapshot
Antidepressant-Like Effect and Mechanism of Action of Honokiol on the Mouse Lipopolysaccharide (LPS) Depression Model
inferredcites →https://doi.org/10.4088/jcp.14m09298openalex-snapshot
The Economic Burden of Adults With Major Depressive Disorder in the United States (2005 and 2010)
inferredcites →https://doi.org/10.4103/psychiatry.indianjpsychiatry_858_20openalex-snapshot
Transcriptomics and sequencing analysis of gene expression profiling for major depressive disorder
inferredcites →https://doi.org/10.7150/thno.37119openalex-snapshot
Upregulation of neuronal PGC-1α ameliorates cognitive impairment induced by chronic cerebral hypoperfusion
inferredcites →https://doi.org/10.7326/aitc202105180openalex-snapshot
Depression
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