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The Landscape of Gain and Loss of Function Mutations in Melanoma

https://doi.org/10.2139/ssrn.5372911
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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jamadermatol.2022.0160openalex-snapshot
Global Burden of Cutaneous Melanoma in 2020 and Projections to 2040
inferredcites →https://doi.org/10.1001/jamanetworkopen.2022.25459openalex-snapshot
Use of First-Line Immune Checkpoint Inhibitors and Association With Overall Survival Among Patients With Metastatic Melanoma in the Anti–PD-1 Era
inferredcites →https://doi.org/10.1002/cam4.628openalex-snapshot
Targeted next‐generation sequencing of 22 mismatch repair genes identifies Lynch syndrome families
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Induced expression of PD‐1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.
inferredcites →https://doi.org/10.1007/978-981-32-9755-5_7openalex-snapshot
Analytical Platforms 3: Processing Samples via the RPPA Pipeline to Generate Large-Scale Data for Clinical Studies
inferredcites →https://doi.org/10.1016/j.bcp.2010.04.029openalex-snapshot
Targeting the MAPK pathway in melanoma: Why some approaches succeed and other fail
inferredcites →https://doi.org/10.1016/j.ccell.2021.06.001openalex-snapshot
Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity
inferredcites →https://doi.org/10.1016/j.ccr.2010.11.023openalex-snapshot
Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K
inferredcites →https://doi.org/10.1016/j.cell.2012.06.024openalex-snapshot
A Landscape of Driver Mutations in Melanoma
inferredcites →https://doi.org/10.1016/j.cell.2015.05.044openalex-snapshot
Genomic Classification of Cutaneous Melanoma
inferredcites →https://doi.org/10.1016/j.cell.2018.03.039openalex-snapshot
Pathogenic Germline Variants in 10,389 Adult Cancers
inferredcites →https://doi.org/10.1016/j.celrep.2017.10.021openalex-snapshot
A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma
inferredcites →https://doi.org/10.1016/j.jid.2016.01.035openalex-snapshot
The Growing Burden of Invasive Melanoma: Projections of Incidence Rates and Numbers of New Cases in Six Susceptible Populations through 2031
inferredcites →https://doi.org/10.1016/j.tranon.2017.09.007openalex-snapshot
Intratumor and Intertumor Heterogeneity in Melanoma
inferredcites →https://doi.org/10.1016/s0140-6736(14)60958-2openalex-snapshot
Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial
inferredcites →https://doi.org/10.1016/s0959-8049(03)00313-7openalex-snapshot
Genetic epidemiology of melanoma
inferredcites →https://doi.org/10.1016/s1074-7613(00)80406-9openalex-snapshot
Lymphoproliferation in CTLA-4–Deficient Mice Is Mediated by Costimulation-Dependent Activation of CD4 + T Cells
inferredcites →https://doi.org/10.1038/ejhg.2015.178openalex-snapshot
The Koolen-de Vries syndrome: a phenotypic comparison of patients with a 17q21.31 microdeletion versus a KANSL1 sequence variant
inferredcites →https://doi.org/10.1038/nature12213openalex-snapshot
Mutational heterogeneity in cancer and the search for new cancer-associated genes
inferredcites →https://doi.org/10.1038/nature12477openalex-snapshot
Signatures of mutational processes in human cancer
inferredcites →https://doi.org/10.1038/ncomms4887openalex-snapshot
A pan-cancer proteomic perspective on The Cancer Genome Atlas
inferredcites →https://doi.org/10.1038/nmeth.1923openalex-snapshot
Fast gapped-read alignment with Bowtie 2
inferredcites →https://doi.org/10.1038/oncsis.2014.23openalex-snapshot
ERBB3 is required for metastasis formation of melanoma cells
inferredcites →https://doi.org/10.1038/s41419-024-06563-3openalex-snapshot
KEAP1 promotes anti-tumor immunity by inhibiting PD-L1 expression in NSCLC
inferredcites →https://doi.org/10.1038/s41467-022-31686-6openalex-snapshot
Loss-of-function, gain-of-function and dominant-negative mutations have profoundly different effects on protein structure
inferredcites →https://doi.org/10.1038/s41577-019-0185-9openalex-snapshot
Photoimmunology: how ultraviolet radiation affects the immune system
inferredcites →https://doi.org/10.1038/s41586-021-03819-2openalex-snapshot
Highly accurate protein structure prediction with AlphaFold
inferredcites →https://doi.org/10.1038/s41586-022-04738-6openalex-snapshot
Signatures of copy number alterations in human cancer
inferredcites →https://doi.org/10.1038/s41587-020-0546-8openalex-snapshot
Visualizing and interpreting cancer genomics data via the Xena platform
inferredcites →https://doi.org/10.1038/s41598-020-72664-6openalex-snapshot
How to do quantile normalization correctly for gene expression data analyses
inferredcites →https://doi.org/10.1039/c7pp00312aopenalex-snapshot
Ultraviolet radiation-induced immunosuppression and its relevance for skin carcinogenesis
inferredcites →https://doi.org/10.1053/j.seminoncol.2007.09.009openalex-snapshot
Angiogenesis in Melanoma
inferredcites →https://doi.org/10.1056/nejmoa1103782openalex-snapshot
Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
inferredcites →https://doi.org/10.1056/nejmoa1104621openalex-snapshot
Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma
inferredcites →https://doi.org/10.1056/nejmoa1412690openalex-snapshot
Improved Overall Survival in Melanoma with Combined Dabrafenib and Trametinib
inferredcites →https://doi.org/10.1056/nejmoa1904059openalex-snapshot
Five-Year Outcomes with Dabrafenib plus Trametinib in Metastatic Melanoma
inferredcites →https://doi.org/10.1073/pnas.0711741105openalex-snapshot
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
inferredcites →https://doi.org/10.1093/bioinformatics/btac665openalex-snapshot
RPPA SPACE: an R package for normalization and quantitation of Reverse-Phase Protein Array data
inferredcites →https://doi.org/10.1093/bioinformatics/btp324openalex-snapshot
Fast and accurate short read alignment with Burrows–Wheeler transform
inferredcites →https://doi.org/10.1093/bioinformatics/btv098openalex-snapshot
Sambamba: fast processing of NGS alignment formats
inferredcites →https://doi.org/10.1093/biostatistics/kxx028openalex-snapshot
Smooth quantile normalization
inferredcites →https://doi.org/10.1093/nar/gkab1061openalex-snapshot
AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models
inferredcites →https://doi.org/10.1101/gr.129684.111openalex-snapshot
VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing
inferredcites →https://doi.org/10.1126/science.adg7492openalex-snapshot
Accurate proteome-wide missense variant effect prediction with AlphaMissense
inferredcites →https://doi.org/10.1136/gutjnl-2012-304121openalex-snapshot
Genetic variants associated with colorectal cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence
inferredcites →https://doi.org/10.1146/annurev-pathol-012513-104658openalex-snapshot
The Molecular Pathology of Melanoma: An Integrated Taxonomy of Melanocytic Neoplasia
inferredcites →https://doi.org/10.1186/gb-2009-10-3-r25openalex-snapshot
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
inferredcites →https://doi.org/10.1200/jco.21.02229openalex-snapshot
Long-Term Outcomes With Nivolumab Plus Ipilimumab or Nivolumab Alone Versus Ipilimumab in Patients With Advanced Melanoma
inferredcites →https://doi.org/10.1200/op.21.00686openalex-snapshot
Managing Metastatic Melanoma in 2022: A Clinical Review
inferredcites →https://doi.org/10.1210/jc.2003-031898openalex-snapshot
RET Exon 11 (G691S) Polymorphism Is Significantly More Frequent in Sporadic Medullary Thyroid Carcinoma Than in the General Population
inferredcites →https://doi.org/10.1371/journal.pcbi.1004873openalex-snapshot
CNVkit: Genome-Wide Copy Number Detection and Visualization from Targeted DNA Sequencing
inferredcites →https://doi.org/10.1371/journal.pone.0200996openalex-snapshot
Germline single nucleotide polymorphisms in ERBB3 and BARD1 genes result in a worse relapse free survival response for HER2-positive breast cancer patients treated with adjuvant based docetaxel, carboplatin and trastuzumab (TCH)
inferredcites →https://doi.org/10.15252/msb.20178124openalex-snapshot
Multi‐Omics Factor Analysis—a framework for unsupervised integration of multi‐omics data sets
inferredcites →https://doi.org/10.18632/oncotarget.1892openalex-snapshot
Pathways and therapeutic targets in melanoma
inferredcites →https://doi.org/10.3389/fcell.2016.00033openalex-snapshot
The Complexity of the ERK/MAP-Kinase Pathway and the Treatment of Melanoma Skin Cancer
inferredcites →https://doi.org/10.3791/59508-vopenalex-snapshot
A Melanoma Patient-Derived Xenograft Model
inferredcites →https://doi.org/10.3978/j.issn.2305-5839.2015.08.11openalex-snapshot
Update in genetic susceptibility in melanoma.
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