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Injectable Microgels Carrying Engineered Biomimetic Nanoparticles as a Treatment for Osteoarthritis by Dual Targeting of Senescent Chondrocytes

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Engineered Nanoplatelets for Targeted Delivery of Plasminogen Activators to Reverse Thrombus in Multiple Mouse Thrombosis Models
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Cancer‐Cell‐Biomimetic Nanoparticles for Targeted Therapy of Multiple Myeloma Based on Bone Marrow Homing
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Immunostimulatory DNA Hydrogel Enhances Protective Efficacy of Nanotoxoids against Bacterial Infection
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Genetically Engineering Cell Membrane‐Coated BTO Nanoparticles for MMP2‐Activated Piezocatalysis‐Immunotherapy
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Injectable Microgels with Hybrid Exosomes of Chondrocyte‐Targeted FGF18 Gene‐Editing and Self‐Renewable Lubrication for Osteoarthritis Therapy
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In Situ Remodeling of Efferocytosis via Lesion‐Localized Microspheres to Reverse Cartilage Senescence
inferredcites →https://doi.org/10.1002/advs.202410795openalex-snapshot
Targeting p21‐Positive Senescent Chondrocytes via IL‐6R/JAK2 Inhibition to Alleviate Osteoarthritis
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Engineered MSC‐sEVs as a Versatile Nanoplatform for Enhanced Osteoarthritis Treatment via Targeted Elimination of Senescent Chondrocytes and Maintenance of Cartilage Matrix Metabolic Homeostasis
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Rejuvenating Hyaline Cartilage with Senescence‐Targeting Si‐ADAM19 Delivery for Osteoarthritis Therapy
inferredcites →https://doi.org/10.1007/s40820-021-00670-yopenalex-snapshot
Nanoparticle–Cartilage Interaction: Pathology-Based Intra-articular Drug Delivery for Osteoarthritis Therapy
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Nanofibrous hyaluronic acid scaffolds delivering TGF-β3 and SDF-1α for articular cartilage repair in a large animal model
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Cellular senescence in knee osteoarthritis: molecular mechanisms and therapeutic implications
inferredcites →https://doi.org/10.1016/j.arr.2024.102275openalex-snapshot
Senolytic therapeutics: An emerging treatment modality for osteoarthritis
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Microcarriers in application for cartilage tissue engineering: Recent progress and challenges
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Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis
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The role of stromal cell-derived factor 1 on cartilage development and disease
inferredcites →https://doi.org/10.1016/j.jot.2024.11.004openalex-snapshot
Harnessing the potential of hyaluronic acid methacrylate (HAMA) hydrogel for clinical applications in orthopaedic diseases
inferredcites →https://doi.org/10.1016/j.tips.2021.12.004openalex-snapshot
Overcoming barriers for intra-articular delivery of disease-modifying osteoarthritis drugs
inferredcites →https://doi.org/10.1016/s0140-6736(14)60802-3openalex-snapshot
Osteoarthritis
inferredcites →https://doi.org/10.1021/acsnano.2c06393openalex-snapshot
Injectable Drug Delivery Systems for Osteoarthritis and Rheumatoid Arthritis
inferredcites →https://doi.org/10.1021/acsnano.3c08097openalex-snapshot
An Engineered Bionic Nanoparticle Sponge as a Cytokine Trap and Reactive Oxygen Species Scavenger to Relieve Disc Degeneration and Discogenic Pain
inferredcites →https://doi.org/10.1038/cdd.2017.179openalex-snapshot
MOMP, cell suicide as a BCL-2 family business
inferredcites →https://doi.org/10.1038/nm.3074openalex-snapshot
WNT signaling in bone homeostasis and disease: from human mutations to treatments
inferredcites →https://doi.org/10.1038/nm.4010openalex-snapshot
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
inferredcites →https://doi.org/10.1038/nm.4324openalex-snapshot
Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
inferredcites →https://doi.org/10.1038/nnano.2013.54openalex-snapshot
A biomimetic nanosponge that absorbs pore-forming toxins
inferredcites →https://doi.org/10.1038/nrd.2017.116openalex-snapshot
Senescent cells: an emerging target for diseases of ageing
inferredcites →https://doi.org/10.1038/s41392-021-00631-2openalex-snapshot
Recent progress in targeted delivery vectors based on biomimetic nanoparticles
inferredcites →https://doi.org/10.1038/s41413-024-00375-zopenalex-snapshot
Cross-talk of inflammation and cellular senescence: a new insight into the occurrence and progression of osteoarthritis
inferredcites →https://doi.org/10.1038/s41419-021-03765-xopenalex-snapshot
Kartogenin prevents cartilage degradation and alleviates osteoarthritis progression in mice via the miR-146a/NRF2 axis
inferredcites →https://doi.org/10.1038/s41420-024-01976-7openalex-snapshot
Targeting senescent cells with NKG2D-CAR T cells
inferredcites →https://doi.org/10.1038/s41467-020-16439-7openalex-snapshot
Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines
inferredcites →https://doi.org/10.1038/s41565-021-00972-7openalex-snapshot
T lymphocyte membrane-decorated epigenetic nanoinducer of interferons for cancer immunotherapy
inferredcites →https://doi.org/10.1038/s41584-020-00533-7openalex-snapshot
Mechanisms and therapeutic implications of cellular senescence in osteoarthritis
inferredcites →https://doi.org/10.1038/s41586-022-05499-yopenalex-snapshot
A plant-derived natural photosynthetic system for improving cell anabolism
inferredcites →https://doi.org/10.1038/s41586-022-05535-xopenalex-snapshot
Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration
inferredcites →https://doi.org/10.1038/s41586-023-06621-4openalex-snapshot
Apoptotic stress causes mtDNA release during senescence and drives the SASP
inferredcites →https://doi.org/10.1038/s41591-019-0668-zopenalex-snapshot
A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity
inferredcites →https://doi.org/10.1097/js9.0000000000002076openalex-snapshot
Innovative hydrogel solutions for articular cartilage regeneration: a comprehensive review
inferredcites →https://doi.org/10.1111/acel.14161openalex-snapshot
Selective targeting of dipeptidyl‐peptidase 4 (DPP‐4) positive senescent chondrocyte ameliorates osteoarthritis progression
inferredcites →https://doi.org/10.1111/acel.14361openalex-snapshot
Senolytic therapy combining Dasatinib and Quercetin restores the chondrogenic phenotype of human osteoarthritic chondrocytes by the release of pro‐anabolic mediators
inferredcites →https://doi.org/10.1111/imr.12328openalex-snapshot
Genetics, genomics, and evolutionary biology of NKG 2D ligands
inferredcites →https://doi.org/10.1111/joim.13141openalex-snapshot
Senolytic drugs: from discovery to translation
inferredcites →https://doi.org/10.1126/science.adj7050openalex-snapshot
Cellular senescence in normal physiology
inferredcites →https://doi.org/10.1126/scitranslmed.add1951openalex-snapshot
NKG2D-CAR T cells eliminate senescent cells in aged mice and nonhuman primates
inferredcites →https://doi.org/10.1126/scitranslmed.adh9751openalex-snapshot
Chondrocyte membrane–coated nanoparticles promote drug retention and halt cartilage damage in rat and canine osteoarthritis
inferredcites →https://doi.org/10.1136/ard-2022-223227openalex-snapshot
Senescent cell population with ZEB1 transcription factor as its main regulator promotes osteoarthritis in cartilage and meniscus
inferredcites →https://doi.org/10.1158/0008-5472.can-07-5836openalex-snapshot
ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor
inferredcites →https://doi.org/10.1182/blood-2011-04-347849openalex-snapshot
Bcl-xL–inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets
inferredcites →https://doi.org/10.14336/ad.2024.10016openalex-snapshot
Enhanced Chondrogenic Potential and Osteoarthritis Treatment Using Cyaonoside A-Induced MSC Delivered via a Hyaluronic Acid-Based Hydrogel System
inferredcites →https://doi.org/10.15252/embj.2021107739openalex-snapshot
NKG2D discriminates diverse ligands through selectively mechano‐regulated ligand conformational changes
inferredcites →https://doi.org/10.3390/ijms22179137openalex-snapshot
Drug Delivery Systems for the Treatment of Knee Osteoarthritis: A Systematic Review of In Vivo Studies
inferredcites →https://doi.org/10.4028/b-xdtcg5openalex-snapshot
12th Annual International Conference on Material Science and Engineering (12th ICMSE)
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