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Optimized capillary liquid chromatography / inductively-coupled plasma mass spectrometry for selective detection & quantification of fluorinated drugs and their metabolites

https://doi.org/10.2139/ssrn.5436907
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Outgoing claims: the papers this work cites, builds on, or argues with.

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A Phase 1 Study to Assess Mass Balance and Absolute Bioavailability of Zimlovisertib in Healthy Male Participants Using a 14C‐Microtracer Approach
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Metabolism and Excretion of Nirmatrelvir in Humans Using Quantitative Fluorine Nuclear Magnetic Resonance Spectroscopy: A Novel Approach for Accelerating Drug Development
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Speciation analysis of bromine-containing drug metabolites in feces samples from a human in vivo study by means of HPLC/ICP-MS combined with on-line isotope dilution
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Development and validation of a novel quantification approach for gradient elution reversed phase high-performance liquid chromatography coupled to tandem ICP-mass spectrometry (RP-HPLC-ICP-MS/MS) and its application to diclofenac and its related compounds
inferredcites →https://doi.org/10.1016/j.aca.2017.07.067openalex-snapshot
High sensitivity and selectivity in quantitative analysis of drugs in biological samples using 4-column multidimensional micro-UHPLC-MS enabling enhanced sample loading capacity
inferredcites →https://doi.org/10.1016/j.aca.2018.11.037openalex-snapshot
Novel non-targeted analysis of perfluorinated compounds using fluorine-specific detection regardless of their ionisability (HPLC-ICPMS/MS-ESI-MS)
inferredcites →https://doi.org/10.1016/j.chroma.2008.09.002openalex-snapshot
Improved liquid chromatography—Online radioactivity detection for metabolite profiling
inferredcites →https://doi.org/10.1016/j.chroma.2014.10.087openalex-snapshot
High volume injections of biological samples for sensitive metabolite profiling and quantitation
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Selective drug metabolite trace analysis by very high-volume injections and heartcut two-dimensional (2D)-ultrahigh performance liquid chromatography (UHPLC)
inferredcites →https://doi.org/10.1016/j.jpba.2016.02.019openalex-snapshot
Determination of the total drug-related chlorine and bromine contents in human blood plasma using high performance liquid chromatography–tandem ICP-mass spectrometry (HPLC–ICP-MS/MS)
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Monitoring pharmacokinetics of anticancer drugs: non-invasive investigation using magnetic resonance spectroscopy
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A comparison of quantitative NMR and radiolabelling studies of the metabolism and excretion of Statil™ (3-(4-bromo-2-fluorobenzyl)-4-oxo-3H-phthalazin-1-ylacetic acid) in the rat
inferredcites →https://doi.org/10.1021/acs.analchem.1c00031openalex-snapshot
Fluorine-Specific Detection Using ICP-MS Helps to Identify PFAS Degradation Products in Nontargeted Analysis
inferredcites →https://doi.org/10.1021/acs.analchem.2c02359openalex-snapshot
High-Resolution Elemental Mass Spectrometry Using LC-ICP-Nanospray-Orbitrap for Simultaneous and Species-Independent Quantitation of Fluorinated and Chlorinated Compounds
inferredcites →https://doi.org/10.1038/clpt.1981.56openalex-snapshot
Determination of mean valproic acid serum level by assay of a single pooled sample
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A pilot study on the use of laser ablation-ICP-mass spectrometry for assessing/mapping the distribution of a drug and its metabolites across the body compartments of rats
inferredcites →https://doi.org/10.1039/c7ja00051kopenalex-snapshot
Novel non-target analysis of fluorine compounds using ICPMS/MS and HPLC-ICPMS/MS
inferredcites →https://doi.org/10.1039/c8ja00050fopenalex-snapshot
Plasma processes to detect fluorine with ICPMS/MS as [M–F] + : an argument for building a negative mode ICPMS/MS
inferredcites →https://doi.org/10.1080/00498254.2018.1523488openalex-snapshot
19F-NMR-based determination of the absorption, metabolism and excretion of the oral phosphatidylinositol-3-kinase (PI3K) delta inhibitor leniolisib (CDZ173) in healthy volunteers
inferredcites →https://doi.org/10.1124/dmd.114.059774openalex-snapshot
A Nonradioactive Approach to Investigate the Metabolism of Therapeutic Peptides by Tagging with 127I and Using Inductively-Coupled Plasma Mass Spectrometry Analysis
inferredcites →https://doi.org/10.1124/dmd.117.075424openalex-snapshot
Comparison of 19F NMR and 14C Measurements for the Assessment of ADME of BYL719 (Alpelisib) in Humans
inferredcites →https://doi.org/10.1124/dmd.122.001240openalex-snapshot
Mass Balance and Absorption, Distribution, Metabolism, and Excretion Properties of Balcinrenone following Oral Administration in Combination with Intravenous Microtracer in Healthy Subjects
inferredcites →https://doi.org/10.3389/fphar.2024.1369079openalex-snapshot
The application of Phase 0 and microtracer approaches in early clinical development: past, present, and future
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The Pharmaceutical Industry in 2023: An Analysis of FDA Drug Approvals from the Perspective of Molecules
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