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A green and sustainable whole-cell biotransformation system for efficient production of rare and high-value flavonoids genistein and baohuoside Ⅰ through the engineered Escherichia coli cells expressing thermophilic β-D-glucosidases

https://doi.org/10.2139/ssrn.5536725
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inferredcites →https://doi.org/10.1002/jev2.12493openalex-snapshot
Baohuoside I chemosensitises breast cancer to paclitaxel by suppressing extracellular vesicle/CXCL1 signal released from apoptotic cells
inferredcites →https://doi.org/10.1002/prot.25256openalex-snapshot
Crystal structure of β-glucosidase 1A fromThermotoga neapolitanaand comparison of active site mutants for hydrolysis of flavonoid glucosides
inferredcites →https://doi.org/10.1007/s00217-011-1491-zopenalex-snapshot
Probing the interaction between 3 flavonoids and pancreatic lipase by methods of fluorescence spectroscopy and enzymatic kinetics
inferredcites →https://doi.org/10.1007/s10295-018-2040-6openalex-snapshot
A highly glucose-tolerant GH1 β-glucosidase with greater conversion rate of soybean isoflavones in monogastric animals
inferredcites →https://doi.org/10.1007/s11274-014-1777-yopenalex-snapshot
Effective bioconversion of sophoricoside to genistein from Fructus sophorae using immobilized Aspergillus niger and Yeast
inferredcites →https://doi.org/10.1016/j.bbrc.2021.06.086openalex-snapshot
Characterization of a novel isoflavone glycoside-hydrolyzing β-glucosidase from mangrove soil metagenomic library
inferredcites →https://doi.org/10.1016/j.biopha.2016.05.023openalex-snapshot
Genistein as antioxidant and antibrowning agents in in vivo and in vitro: A review
inferredcites →https://doi.org/10.1016/j.biopha.2021.111596openalex-snapshot
Antiviral activities of flavonoids
inferredcites →https://doi.org/10.1016/j.biortech.2021.124665openalex-snapshot
Efficient single whole-cell biotransformation for L-2-aminobutyric acid production through engineering of leucine dehydrogenase combined with expression regulation
inferredcites →https://doi.org/10.1016/j.biotechadv.2010.09.001openalex-snapshot
Enzymatic and whole cell catalysis: Finding new strategies for old processes
inferredcites →https://doi.org/10.1016/j.copbio.2016.05.005openalex-snapshot
Recent advances in whole cell biocatalysis techniques bridging from investigative to industrial scale
inferredcites →https://doi.org/10.1016/j.coph.2019.04.014openalex-snapshot
Flavonoids in hypertension: a brief review of the underlying mechanisms
inferredcites →https://doi.org/10.1016/j.enzmictec.2019.109431openalex-snapshot
Eco-efficient biphasic enzymatic hydrolysis for the green production of rare baohuoside I
inferredcites →https://doi.org/10.1016/j.foodchem.2015.10.096openalex-snapshot
Phenolic content, antioxidant activity and effective compounds of kumquat extracted by different solvents
inferredcites →https://doi.org/10.1016/j.foodchem.2024.142274openalex-snapshot
Co-expression of α-L-rhamnosidase and β-glucosidase in Aspergillus niger and its application in enzymatic production of quercetin
inferredcites →https://doi.org/10.1016/j.ijbiomac.2019.10.184openalex-snapshot
Spectroscopy and molecular docking analysis reveal structural specificity of flavonoids in the inhibition of α-glucosidase activity
inferredcites →https://doi.org/10.1016/j.ijbiomac.2021.07.167openalex-snapshot
Flavonoids in Ampelopsis grossedentata as covalent inhibitors of SARS-CoV-2 3CLpro: Inhibition potentials, covalent binding sites and inhibitory mechanisms
inferredcites →https://doi.org/10.1016/j.jbiotec.2016.04.022openalex-snapshot
Improve ethanol tolerance of β-glucosidase Bgl1A by semi-rational engineering for the hydrolysis of soybean isoflavone glycosides
inferredcites →https://doi.org/10.1016/j.jclepro.2017.09.192openalex-snapshot
Construction of a novel catalysis system for clean and efficient preparation of Baohuoside I from Icariin based on biphase enzymatic hydrolysis
inferredcites →https://doi.org/10.1016/j.jff.2021.104739openalex-snapshot
Structure-activity relationship and interaction mechanism of nine structurally similar flavonoids and α-amylase
inferredcites →https://doi.org/10.1016/j.molcatb.2013.01.017openalex-snapshot
Baohuoside I production through enzyme hydrolysis and parameter optimization by using response surface and subset selection
inferredcites →https://doi.org/10.1016/j.ymben.2022.10.015openalex-snapshot
Sustainable production of genistin from glycerol by constructing and optimizing Escherichia coli
inferredcites →https://doi.org/10.1016/j.ymben.2023.10.003openalex-snapshot
De novo biosynthesis of anticarcinogenic icariin in engineered yeast
inferredcites →https://doi.org/10.1021/acs.jafc.0c04974openalex-snapshot
Effects of Different Dietary Flavonoids on Dipeptidyl Peptidase-IV Activity and Expression: Insights into Structure–Activity Relationship
inferredcites →https://doi.org/10.1021/acs.jafc.0c06695openalex-snapshot
Malvidin-3-O-Glucoside from Blueberry Ameliorates Nonalcoholic Fatty Liver Disease by Regulating Transcription Factor EB-Mediated Lysosomal Function and Activating the Nrf2/ARE Signaling Pathway
inferredcites →https://doi.org/10.1021/acs.jafc.1c02015openalex-snapshot
Anti-Inflammation Activity of Flavones and Their Structure–Activity Relationship
inferredcites →https://doi.org/10.1021/acs.jafc.8b02420openalex-snapshot
Differential Effects of Quercetin and Two of Its Derivatives, Isorhamnetin and Isorhamnetin-3-glucuronide, in Inhibiting the Proliferation of Human Breast-Cancer MCF-7 Cells
inferredcites →https://doi.org/10.1021/acs.jafc.8b04683openalex-snapshot
Synergistic Inhibitory Effects of Acacetin and 11 Other Flavonoids Isolated from Artemisia sacrorum on Lipid Accumulation in 3T3-L1 Cells
inferredcites →https://doi.org/10.1021/acs.jafc.9b02592openalex-snapshot
Complete Biotransformation of Protopanaxadiol-Type Ginsenosides into 20- O - β- Glucopyranosyl-20( S )-protopanaxadiol by Permeabilized Recombinant Escherichia coli Cells Coexpressing β-Glucosidase and Chaperone Genes
inferredcites →https://doi.org/10.1021/acs.jafc.9b04943openalex-snapshot
Comparative Study of Dietary Flavonoids with Different Structures as α-Glucosidase Inhibitors and Insulin Sensitizers
inferredcites →https://doi.org/10.1021/jf1046915openalex-snapshot
Comparison of Three Thermostable β-Glucosidases for Application in the Hydrolysis of Soybean Isoflavone Glycosides
inferredcites →https://doi.org/10.1021/jf204432gopenalex-snapshot
Hydrolysis of Isoflavone Glycosides by a Thermostable β-Glucosidase from Pyrococcus furiosus
inferredcites →https://doi.org/10.1021/jf502850zopenalex-snapshot
Characterization of a Novel β-Glucosidase from Gongronella sp. W5 and Its Application in the Hydrolysis of Soybean Isoflavone Glycosides
inferredcites →https://doi.org/10.1038/nchembio.1865openalex-snapshot
The amylase inhibitor montbretin A reveals a new glycosidase inhibition motif
inferredcites →https://doi.org/10.1038/s42255-021-00491-8openalex-snapshot
The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice
inferredcites →https://doi.org/10.1039/b920195popenalex-snapshot
Exploring the possibility of using a thermostable mutant of β-glucosidase for rapid hydrolysis of quercetin glucosides in hot water
inferredcites →https://doi.org/10.1039/c004698copenalex-snapshot
The biological potential of flavones
inferredcites →https://doi.org/10.1039/c7fo00220copenalex-snapshot
Differential α-amylase/α-glucosidase inhibitory activities of plant-derived phenolic compounds: a virtual screening perspective for the treatment of obesity and diabetes
inferredcites →https://doi.org/10.1039/c7fo01094jopenalex-snapshot
Anti-obesity molecular mechanism of soy isoflavones: weaving the way to new therapeutic routes
inferredcites →https://doi.org/10.1039/c8gc03661fopenalex-snapshot
Selective synthesis of citrus flavonoids prunin and naringenin using heterogeneized biocatalyst on graphene oxide
inferredcites →https://doi.org/10.1039/d0gc00669fopenalex-snapshot
Highly efficient bioconversion of flavonoid glycosides from citrus-processing wastes in solvent-buffer systems
inferredcites →https://doi.org/10.1080/073911012010525028openalex-snapshot
An Integrated Study of Tyrosinase Inhibition by Rutin: Progress using a Computational Simulation
inferredcites →https://doi.org/10.1080/10826068.2025.2471892openalex-snapshot
One-pot green and sustainable process for the biotransformation of sophoricoside to genistein from Fructus Sophorae with magnetic cellulose spheres immobilized Aspergillus oryzae on cellulose using deep eutectic solvent assisted
inferredcites →https://doi.org/10.1080/13880209.2017.1418391openalex-snapshot
Baohuoside-I suppresses cell proliferation and migration by up-regulating miR-144 in melanoma
inferredcites →https://doi.org/10.1093/nar/gki376openalex-snapshot
JCat: a novel tool to adapt codon usage of a target gene to its potential expression host
inferredcites →https://doi.org/10.1111/1751-7915.12363openalex-snapshot
Whole cell biocatalysts: essential workers from Nature to the industry
inferredcites →https://doi.org/10.1186/s13068-023-02348-6openalex-snapshot
Efficient production of icariin and baohuoside I from Epimedium Folium flavonoids by fungal α-l-rhamnosidase hydrolysing regioselectively the terminal rhamnose of epimedin C
inferredcites →https://doi.org/10.2147/cmar.s228926openalex-snapshot
Baohuoside I Inhibits the Proliferation of Pancreatic Cancer Cells via mTOR/S6K1-Caspases/Bcl2/Bax Apoptotic Signaling
inferredcites →https://doi.org/10.2147/cmar.s265803openalex-snapshot
Baohuoside I via mTOR Apoptotic Signaling to Inhibit Glioma Cell Growth
inferredcites →https://doi.org/10.3390/cimb43030106openalex-snapshot
Genistein: A Potent Anti-Breast Cancer Agent
inferredcites →https://doi.org/10.3390/ijms25105556openalex-snapshot
Molecular Pathways of Genistein Activity in Breast Cancer Cells
inferredcites →https://doi.org/10.3390/molecules28207173openalex-snapshot
Advancements in the Biotransformation and Biosynthesis of the Primary Active Flavonoids Derived from Epimedium
inferredcites →https://doi.org/10.3390/molecules29225280openalex-snapshot
Efficient Biotransformation of Icariin to Baohuoside I Using Two Novel GH1 β-Glucosidases
inferredcites →https://doi.org/10.3390/nu9060622openalex-snapshot
Dietary Management of Skin Health: The Role of Genistein
inferredcites →https://doi.org/10.3945/an.114.008052openalex-snapshot
Genistein and Cancer: Current Status, Challenges, and Future Directions
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