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Protein•DNA Mesh Assembly Drives dsDNA-Specific and Duplex Length-Dependent Activation of cGAS

https://doi.org/10.2139/ssrn.6978764
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Outgoing claims: the papers this work cites, builds on, or argues with.

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Expression of Cyclic GMP‐AMP Synthase in Patients With Systemic Lupus Erythematosus
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Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase
inferredcites →https://doi.org/10.1016/j.cell.2024.01.015openalex-snapshot
PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction of broken DNA ends
inferredcites →https://doi.org/10.1016/j.celrep.2014.01.003openalex-snapshot
The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop
inferredcites →https://doi.org/10.1016/j.celrep.2025.116920openalex-snapshot
Dimerization-dependent gel-like condensation with dsDNA underpins the activation of human cGAS
inferredcites →https://doi.org/10.1016/j.immuni.2005.12.003openalex-snapshot
Recognition of Cytosolic DNA Activates an IRF3-Dependent Innate Immune Response
inferredcites →https://doi.org/10.1016/j.immuni.2013.10.019openalex-snapshot
Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization
inferredcites →https://doi.org/10.1016/j.immuni.2024.02.019openalex-snapshot
New frontiers in the cGAS-STING intracellular DNA-sensing pathway
inferredcites →https://doi.org/10.1016/j.molcel.2024.12.021openalex-snapshot
Molecular determinants of condensate composition
inferredcites →https://doi.org/10.1016/s0006-3495(97)78780-0openalex-snapshot
Stretching DNA with optical tweezers
inferredcites →https://doi.org/10.1021/acs.chemrev.2c00814openalex-snapshot
Phase Transitions of Associative Biomacromolecules
inferredcites →https://doi.org/10.1038/nature10879openalex-snapshot
Phase transitions in the assembly of multivalent signalling proteins
inferredcites →https://doi.org/10.1038/nature12305openalex-snapshot
Structural mechanism of cytosolic DNA sensing by cGAS
inferredcites →https://doi.org/10.1038/nature23890openalex-snapshot
cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders
inferredcites →https://doi.org/10.1038/nri3719openalex-snapshot
OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids
inferredcites →https://doi.org/10.1038/nrm.2017.7openalex-snapshot
Biomolecular condensates: organizers of cellular biochemistry
inferredcites →https://doi.org/10.1038/s41467-022-34858-6openalex-snapshot
DNA mechanical flexibility controls DNA potential to activate cGAS-mediated immune surveillance
inferredcites →https://doi.org/10.1038/s41467-024-48365-3openalex-snapshot
The structural basis for 2′−5′/3′−5′-cGAMP synthesis by cGAS
inferredcites →https://doi.org/10.1038/s41467-025-62055-8openalex-snapshot
Current practices in the study of biomolecular condensates: a community comment
inferredcites →https://doi.org/10.1038/s41577-024-01112-7openalex-snapshot
Regulation of cGAS–STING signalling and its diversity of cellular outcomes
inferredcites →https://doi.org/10.1038/s41580-020-0244-xopenalex-snapshot
Molecular mechanisms and cellular functions of cGAS–STING signalling
inferredcites →https://doi.org/10.1038/s41586-018-0629-6openalex-snapshot
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis
inferredcites →https://doi.org/10.1038/s41586-020-2749-zopenalex-snapshot
The molecular basis of tight nuclear tethering and inactivation of cGAS
inferredcites →https://doi.org/10.1038/s41586-020-2750-6openalex-snapshot
Structural mechanism of cGAS inhibition by the nucleosome
inferredcites →https://doi.org/10.1073/pnas.1218528110openalex-snapshot
Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1
inferredcites →https://doi.org/10.1073/pnas.1516465112openalex-snapshot
Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases
inferredcites →https://doi.org/10.1073/pnas.1905013116openalex-snapshot
Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation
inferredcites →https://doi.org/10.1073/pnas.2118819119openalex-snapshot
STING mediates neurodegeneration and neuroinflammation in nigrostriatal α-synucleinopathy
inferredcites →https://doi.org/10.1073/pnas.2202222119openalex-snapshot
Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions
inferredcites →https://doi.org/10.1073/pnas.2411659122openalex-snapshot
Crucial role of the cGAS N terminus in mediating flowable and functional cGAS–DNA condensate formation via DNA interactions
inferredcites →https://doi.org/10.1073/pnas.2523058123openalex-snapshot
Measuring bridging forces in protein–DNA condensates
inferredcites →https://doi.org/10.1084/jem.20180139openalex-snapshot
The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer
inferredcites →https://doi.org/10.1093/nar/gkaa084openalex-snapshot
Allosteric coupling between Mn2+ and dsDNA controls the catalytic efficiency and fidelity of cGAS
inferredcites →https://doi.org/10.1126/sciadv.aay6804openalex-snapshot
A conserved ATP- and Scc2/4-dependent activity for cohesin in tethering DNA molecules
inferredcites →https://doi.org/10.1126/sciadv.abb8941openalex-snapshot
cGAS suppresses genomic instability as a decelerator of replication forks
inferredcites →https://doi.org/10.1126/science.1232458openalex-snapshot
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
inferredcites →https://doi.org/10.1126/science.1240933openalex-snapshot
Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses
inferredcites →https://doi.org/10.1126/science.1244040openalex-snapshot
Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects
inferredcites →https://doi.org/10.1126/science.aab3291openalex-snapshot
DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway
inferredcites →https://doi.org/10.1126/science.aaf4382openalex-snapshot
Liquid phase condensation in cell physiology and disease
inferredcites →https://doi.org/10.1126/science.aat1022openalex-snapshot
DNA-induced liquid phase condensation of cGAS activates innate immune signaling
inferredcites →https://doi.org/10.1126/science.abd0237openalex-snapshot
Structural basis for the inhibition of cGAS by nucleosomes
inferredcites →https://doi.org/10.1126/science.abd0609openalex-snapshot
Structural basis of nucleosome-dependent cGAS inhibition
inferredcites →https://doi.org/10.1146/annurev-genet-112618-043527openalex-snapshot
Liquid–Liquid Phase Separation in Disease
inferredcites →https://doi.org/10.15252/embj.201488029openalex-snapshot
Listeria monocytogenes induces IFNβ expression through an IFI16‐, cGAS‐ and STING‐dependent pathway
inferredcites →https://doi.org/10.15252/embj.2019102718openalex-snapshot
Chromatin‐bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death
inferredcites →https://doi.org/10.15252/embr.201744017openalex-snapshot
cGAS is activated by DNA in a length‐dependent manner
inferredcites →https://doi.org/10.3390/v16060872openalex-snapshot
Cationic Residues of the HIV-1 Nucleocapsid Protein Enable DNA Condensation to Maintain Viral Core Particle Stability during Reverse Transcription
inferredcites →https://doi.org/10.4049/jimmunol.1500969openalex-snapshot
Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi–Goutières Syndrome
inferredcites →https://doi.org/10.4049/jimmunol.1601909openalex-snapshot
Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation
inferredcites →https://doi.org/10.7554/elife.22582openalex-snapshot
Single-molecule observation of DNA compaction by meiotic protein SYCP3
inferredcites →https://doi.org/10.7554/elife.39984openalex-snapshot
The allosteric activation of cGAS underpins its dynamic signaling landscape
inferredcites →https://doi.org/10.7554/elife.81907openalex-snapshot
Biological condensates form percolated networks with molecular motion properties distinctly different from dilute solutions
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