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Mechanism-informed computational toxicology identifies screening-level health-risk priorities for short-chain chlorinated paraffins

https://doi.org/10.2139/ssrn.7512131
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Building and Applying Quantitative Adverse Outcome Pathway Models for Chemical Hazard and Risk Assessment
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In vitro human cell-based TTR-TRβ CALUX assay indicates thyroid hormone transport disruption of short-chain, medium-chain, and long-chain chlorinated paraffins
inferredcites →https://doi.org/10.1016/j.chemosphere.2023.139131openalex-snapshot
Concentrations and homologue patterns of SCCPs and MCCPs in the serum of the general population of adults in Hangzhou, China
inferredcites →https://doi.org/10.1016/j.comtox.2021.100195openalex-snapshot
Towards a qAOP framework for predictive toxicology - Linking data to decisions
inferredcites →https://doi.org/10.1016/j.ecoenv.2025.119307openalex-snapshot
Longitudinal multi-omics decipher chlorinated paraffin 52 disruption of gut-brain axis homeostasis in HFD-fed mice
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Environmentally relevant concentrations of short chain chlorinated paraffins induce transgenerational reproductive toxicity associated with mitochondrial homeostasis disruption in Caenorhabditis elegans
inferredcites →https://doi.org/10.1016/j.envpol.2024.125323openalex-snapshot
Short-chain chlorinated paraffins induce liver injury in mice through mitochondrial disorders and disruption of cholesterol-bile acid pathway
inferredcites →https://doi.org/10.1016/j.envres.2025.121179openalex-snapshot
A critical review of human internal exposure to short-chain chlorinated paraffins and its concerning health risks
inferredcites →https://doi.org/10.1016/j.scitotenv.2023.163953openalex-snapshot
Effects of exposure to chlorinated paraffins on human health: A scoping review
inferredcites →https://doi.org/10.1016/j.scitotenv.2023.168192openalex-snapshot
Short-chain chlorinated paraffin (SCCP) exposure and type 2 diabetes risk: A population-based case-control study in East China
inferredcites →https://doi.org/10.1016/j.scitotenv.2024.171372openalex-snapshot
Metabolic disturbance of short- and medium-chain chlorinated paraffins to zebrafish larva
inferredcites →https://doi.org/10.1016/j.taap.2022.116141openalex-snapshot
Advances in computational methods along the exposure to toxicological response paradigm
inferredcites →https://doi.org/10.1016/j.yrtph.2015.03.015openalex-snapshot
Building scientific confidence in the development and evaluation of read-across
inferredcites →https://doi.org/10.1021/acs.chemrestox.5b00388openalex-snapshot
Current and Future Perspectives on the Development, Evaluation, and Application of in Silico Approaches for Predicting Toxicity
inferredcites →https://doi.org/10.1021/acs.est.1c00975openalex-snapshot
Cross-Model Comparison of Transcriptomic Dose–Response of Short-Chain Chlorinated Paraffins
inferredcites →https://doi.org/10.1021/acs.est.3c08064openalex-snapshot
Exposure to Short- and Medium-Chain Chlorinated Paraffins and the Risk of Gestational Diabetes Mellitus: A Nested Case–Control Study in Eastern China
inferredcites →https://doi.org/10.1021/acs.est.4c05895openalex-snapshot
Short Chain Chlorinated Paraffins Impaired Spermatogenesis Process in Mice via Inhibiting α-KG/TET Enzyme Activity
inferredcites →https://doi.org/10.1021/acs.est.4c08622openalex-snapshot
Short-Chain Chlorinated Paraffins May Induce Ovarian Damage in Mice via AIM2- and NLRP12-PANoptosome
inferredcites →https://doi.org/10.1021/acs.est.6c01647openalex-snapshot
Salinity Modulates Hormetic Responses of the Estuarine Diatom Chaetoceros muelleri to Short-Chain Chlorinated Paraffins: Insights from Physiology and Transcriptomics
inferredcites →https://doi.org/10.1021/acs.jafc.0c03491openalex-snapshot
Short- and Medium-Chain Chlorinated Paraffins in Foods from the Sixth Chinese Total Diet Study: Occurrences and Estimates of Dietary Intakes in South China
inferredcites →https://doi.org/10.1038/s41598-024-69157-1openalex-snapshot
Assessment of performance of the profilers provided in the OECD QSAR toolbox for category formation of chemicals
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