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New Isatin–Indole Conjugates: Synthesis, Characterization, and a Plausible Mechanism of Their in vitro Antiproliferative Activity

https://doi.org/10.2147/dddt.s227862
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Synthesis and biological evaluation of indole-based, anti-cancer agents inspired by the vascular disrupting agent 2-(3′-hydroxy-4′-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole (OXi8006)
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Synthesis and pharmacological evaluation of novel bisindolylalkanes analogues
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Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors
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Synthesis and structure–activity relationships of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide hydrazone derivatives as potential agents against A549 lung cancer cells
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Synthesis and cytotoxic activity of novel 3-(1H-indol-3-yl)-1H-pyrazole-5-carbohydrazide derivatives
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Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides
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Current developments of coumarin-based anti-cancer agents in medicinal chemistry
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Hybrid molecules: The privileged scaffolds for various pharmaceuticals
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Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view
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Recent advances (2015–2016) in anticancer hybrids
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Indoles — A promising scaffold for drug development
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Nucleophilic Reactivities of Indoles
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Receptor tyrosine kinase signalling as a target for cancer intervention strategies.
inferredcites →https://doi.org/10.2147/dddtopenalex-snapshot
Drug Design, Development and Therapy
inferredcites →https://doi.org/10.2147/dddt.s140164openalex-snapshot
Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling
inferredcites →https://doi.org/10.2147/dddt.s208241openalex-snapshot
Antiproliferative activity and possible mechanism of action of certain 5-methoxyindole tethered C-5 functionalized isatins
inferredcites →https://doi.org/10.2174/138945010791170923openalex-snapshot
Anticancer Properties of Indole Compounds: Mechanism of Apoptosis Induction and Role in Chemotherapy
inferredcites →https://doi.org/10.2174/138955706778560184openalex-snapshot
Small Molecule Inhibitors of Protein Kinases in Cancer- How to Overcome Resistance
inferredcites →https://doi.org/10.2174/138955709788452649openalex-snapshot
From Nature to Drug Discovery: The Indole Scaffold as a ‘Privileged Structure’
inferredcites →https://doi.org/10.2174/1568026616666160530154812openalex-snapshot
Indole-based, Antiproliferative Agents Targeting Tubulin Polymerization
inferredcites →https://doi.org/10.2174/1871520610909040397openalex-snapshot
Cytotoxic and Anticancer Activities of Isatin and Its Derivatives: A Comprehensive Review from 2000-2008
inferredcites →https://doi.org/10.2174/1871520615666150520144217openalex-snapshot
Indole Derivatives as Anticancer Agents for Breast Cancer Therapy: A Review
inferredcites →https://doi.org/10.3109/14756366.2016.1151015openalex-snapshot
Synthesis and anti-inflammatory activity evaluation of novel triazolyl-isatin hybrids
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Global cancer statistics
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Ethanolic Extract of Propolis (EEP) Enhances the Apoptosis- Inducing Potential of TRAIL in Cancer Cells
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Design, synthesis, and biological evaluation of indole-based 1,4-disubstituted piperazines as cytotoxic agents

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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The anti‐breast cancer potential of indole/isatin hybrids
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Advances of antitumor drug discovery in traditional Chinese medicine and natural active products by using multi‐active components combination
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Steroid‐Hymecromone Conjugates with Improved Antiproliferative and Antimicrobial Potential: Synthesis, Biological Evaluation, and in silico ADME Prediction
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Discovering a New N ‐acylhydrazone Tethered Isatin/Benzofuran Scaffold for Colorectal Cancer: Design, Synthesis, Biological Activity, and ADME‐ Tox Modelling
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Isatin Derivatives as Emerging Frontiers in Cancer Treatment: Recent Updates in Synthesis, Anticancer Effect, and SAR Studies
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A Review on Isatin–Acenaphthoquinone Hybrids: Emerging Multitarget Scaffolds for Antimicrobial and Anticancer Therapy
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Synthesis of α-indolylacrylates as potential anticancer agents using a Brønsted acid ionic liquid catalyst and the butyl acetate solvent
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Isatin-based benzyloxybenzene derivatives as monoamine oxidase inhibitors with neuroprotective effect targeting neurogenerative disease treatment
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Effect of Structure of 1-Substituted Isatins on Direction of Their Reactions with Some Acetohydrazide Ammonium Derivatives
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Small Heterocyclic Molecules as Anticancer Agents: Design, Synthesis, and Evaluation Against MCF-7 Cell Lines
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Small Heterocyclic Molecules as Anticancer Agents: Design, Syntheses and Evaluation Against MCF-7 Cell Lines
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Thiazole, Isatin and Phthalimide Derivatives Tested in vivo against Cancer Models: A Literature Review of the Last Six Years
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An Overview of Recent Advances in Isatin-Based Multicomponent Reactions
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A Review of the Therapeutic Importance of Indole Scaffold in Drug Discovery
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A Mini-Review on the Synthesis of Substituted Isatins: From Early Approaches to Recent Advances with a Specific Focus on Sulfamoyl and Amino Derivatives
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Selective Cytotoxic Effects of 5-Trifluoromethoxy-1H-indole-2,3-dione 3-Thiosemicarbazone Derivatives on Lymphoid-originated Cells
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In-vitro Evaluation of Isatin Derivatives as Potent Anti-Breast Cancer Agents against MCF-7, MDA MB 231, MDA-MB 435 and MDA-MB 468 Breast Cancers Cell Lines: A Review
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A Facile Synthesis and Molecular Characterization of Certain New Anti-Proliferative Indole-Based Chemical Entities
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Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole–Indole Conjugates as Anticancer CDK Inhibitors
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Therapeutic Outcomes of Isatin and Its Derivatives against Multiple Diseases: Recent Developments in Drug Discovery
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Additional file 1 of Synthesis, biological activity of newly designed sulfonamide based indole derivative as anti-microbial agent
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