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Investigating the effect of Crocus sativus L. petal hydroalcoholic extract on inflammatory and enzymatic indices resulting from alcohol use in kidney and liver of male rats

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jamapsychiatry.2015.0584openalex-snapshot

Epidemiology of DSM-5 Alcohol Use Disorder

inferredcites →https://doi.org/10.1001/jamapsychiatry.2017.2161openalex-snapshot

Prevalence of 12-Month Alcohol Use, High-Risk Drinking, and DSM-IV Alcohol Use Disorder in the United States, 2001-2002 to 2012-2013

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Naturally occurring antinociceptive substances from plants

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Interleukin-22 Treatment Ameliorates Alcoholic Liver Injury in a Murine Model of Chronic-Binge Ethanol Feeding: Role of Signal Transducer and Activator of Transcription 3

inferredcites →https://doi.org/10.1002/hep.27778openalex-snapshot

Novel role for carbohydrate responsive element binding protein in the control of ethanol metabolism and susceptibility to binge drinking

inferredcites →https://doi.org/10.1002/hep.510280521openalex-snapshot

Acute and Chronic Ethanol Increases Reactive Oxygen Species Generation and Decreases Viability in Fresh, Isolated Rat Hepatocytes

inferredcites →https://doi.org/10.1002/hep.510280624openalex-snapshot

Sodium Taurocholate Cotransporting Polypeptide Is A Serine, Threonine Phosphoprotein and Is Dephosphorylated by Cyclic Adenosine Monophosphate

inferredcites →https://doi.org/10.1002/ptr.5622openalex-snapshot

Antiinflammatory, Antioxidant, and Immunomodulatory Effects ofCrocus sativusL. and its Main Constituents

inferredcites →https://doi.org/10.1007/s00204-011-0763-5openalex-snapshot

A preliminary investigation into the venom proteome of Macrovipera lebetina obtusa (Dwigubsky, 1832) from Southeastern Anatolia by MALDI-TOF mass spectrometry and comparison of venom protein profiles with Macrovipera lebetina lebetina (Linnaeus, 1758) from Cyprus by 2D-PAGE

inferredcites →https://doi.org/10.1007/s00204-012-0814-6openalex-snapshot

Cytokines in alcoholic liver disease

inferredcites →https://doi.org/10.1007/s10522-012-9409-0openalex-snapshot

Safranal ameliorates antioxidant enzymes and suppresses lipid peroxidation and nitric oxide formation in aged male rat liver

inferredcites →https://doi.org/10.1007/s12010-009-8740-7openalex-snapshot

Potential of Crocus sativus (saffron) and its Constituent, Crocin, as Hypolipidemic and Antioxidant in Rats

inferredcites →https://doi.org/10.1016/0014-5793(85)80532-9openalex-snapshot

4‐Hydroxyalk‐2‐enals are substrates for glutathione transferase

inferredcites →https://doi.org/10.1016/0167-4838(94)90086-8openalex-snapshot

Structure and function of glutathione S-transferases

inferredcites →https://doi.org/10.1016/j.ajpath.2011.11.017openalex-snapshot

Chronic Alcohol Exposure Stimulates Adipose Tissue Lipolysis in Mice

inferredcites →https://doi.org/10.1016/j.alcohol.2014.10.002openalex-snapshot

Acute immunomodulatory effects of binge alcohol ingestion

inferredcites →https://doi.org/10.1016/j.biocel.2017.06.009openalex-snapshot

Etiology of alcoholic cardiomyopathy: Mitochondria, oxidative stress and apoptosis

inferredcites →https://doi.org/10.1016/j.cbi.2015.01.015openalex-snapshot

Gastroprotective effect of crocin in ethanol-induced gastric injury in rats

inferredcites →https://doi.org/10.1016/j.disamonth.2017.02.001openalex-snapshot

Cardio-Renal Syndrome: A double edged sword

inferredcites →https://doi.org/10.1016/j.ecoenv.2012.06.003openalex-snapshot

Crocin “saffron” protects against beryllium chloride toxicity in rats through diminution of oxidative stress and enhancing gene expression of antioxidant enzymes

inferredcites →https://doi.org/10.1016/j.fct.2010.07.010openalex-snapshot

Sub-acute effects of diazinon on biochemical indices and specific biomarkers in rats: Protective effects of crocin and safranal

inferredcites →https://doi.org/10.1016/j.fitote.2010.08.017openalex-snapshot

The effect of safranal on histamine (H1) receptors of guinea pig tracheal chains

inferredcites →https://doi.org/10.1016/j.fitote.2015.05.014openalex-snapshot

Petals of Crocus sativus L. as a potential source of the antioxidants crocin and kaempferol

inferredcites →https://doi.org/10.1016/j.freeradbiomed.2007.12.029openalex-snapshot

Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases

inferredcites →https://doi.org/10.1016/j.freeradbiomed.2007.12.032openalex-snapshot

Copper dependence of the biotin switch assay: Modified assay for measuring cellular and blood nitrosated proteins

inferredcites →https://doi.org/10.1016/j.jhep.2011.05.015openalex-snapshot

Pathways of liver injury in alcoholic liver disease

inferredcites →https://doi.org/10.1016/j.jhep.2015.11.006openalex-snapshot

Alcohol and liver disease in Europe – Simple measures have the potential to prevent tens of thousands of premature deaths

inferredcites →https://doi.org/10.1016/j.jscs.2010.10.012openalex-snapshot

Evaluation of the safety and antioxidant activities of Crocus sativus and Propolis ethanolic extracts

inferredcites →https://doi.org/10.1016/j.pnpbp.2006.11.010openalex-snapshot

Comparison of petal of Crocus sativus L. and fluoxetine in the treatment of depressed outpatients: A pilot double-blind randomized trial

inferredcites →https://doi.org/10.1016/j.redox.2017.04.020openalex-snapshot

Mitochondrial ROS induced by chronic ethanol exposure promote hyper-activation of the NLRP3 inflammasome

inferredcites →https://doi.org/10.1016/j.tice.2015.03.007openalex-snapshot

Neuroprotective effects of safranal in a rat model of traumatic injury to the spinal cord by anti-apoptotic, anti-inflammatory and edema-attenuating

inferredcites →https://doi.org/10.1016/s0027-5107(01)00183-xopenalex-snapshot

Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-κB activation

inferredcites →https://doi.org/10.1016/s0140-6736(12)61766-8openalex-snapshot

A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

inferredcites →https://doi.org/10.1016/s0378-8741(02)00299-4openalex-snapshot

Effects of Crocus sativus petals’ extract on rat blood pressure and on responses induced by electrical field stimulation in the rat isolated vas deferens and guinea-pig ileum

inferredcites →https://doi.org/10.1016/s0378-8741(98)00048-8openalex-snapshot

Antinociceptive and anti-inflammatory activity of a flavonoid isolated from Caralluma attenuata

inferredcites →https://doi.org/10.1016/s0733-8627(20)30236-4openalex-snapshot

Electrolyte Abnormalities in the Alcoholic Patient

inferredcites →https://doi.org/10.1021/jf901752fopenalex-snapshot

Preventive Effect of Crocin in Inflamed Animals and in LPS-Challenged RAW 264.7 Cells

inferredcites →https://doi.org/10.1038/jhh.2013.55openalex-snapshot

Hypertension and kidneys: unraveling complex molecular mechanisms underlying hypertensive renal damage

inferredcites →https://doi.org/10.1038/nrgastro.2015.35openalex-snapshot

Alcoholic liver disease: mechanisms of injury and targeted treatment

inferredcites →https://doi.org/10.1038/nrneph.2016.113openalex-snapshot

Heart failure and kidney dysfunction: epidemiology, mechanisms and management

inferredcites →https://doi.org/10.1042/cs20160243openalex-snapshot

Angiotensin II type 2 receptor (AT2R) in renal and cardiovascular disease

inferredcites →https://doi.org/10.1053/jopenalex-snapshot

Rome III functional constipation and irritable bowel syndrome with constipation are similar disorders within a spectrum of sensitization, regulated by serotonin.

inferredcites →https://doi.org/10.1053/j.gastro.2004.09.049openalex-snapshot

The role of AMP-activated protein kinase in the action of ethanol in the liver

inferredcites →https://doi.org/10.1053/j.gastro.2016.01.025openalex-snapshot

Inflammation in Alcoholic and Nonalcoholic Fatty Liver Disease: Friend or Foe?

inferredcites →https://doi.org/10.1055/s-0028-1088319openalex-snapshot

Purification and Biochemical Characterization of a Novel Allergenic Protein from Tatary Buckwheat Seeds

inferredcites →https://doi.org/10.1055/s-0033-1357196openalex-snapshot

Crocin Improves Lipid Dysregulation in Subacute Diazinon Exposure through ERK1/2 Pathway in Rat Liver

inferredcites →https://doi.org/10.1055/s-2008-1074498openalex-snapshot

LC-DAD-MS (ESI+) Analysis and Antioxidant Capacity of Crocus sativus Petal Extracts

inferredcites →https://doi.org/10.1079/pns2006496openalex-snapshot

Alcohol, oxidative stress and free radical damage

inferredcites →https://doi.org/10.1089/cbr.1993.8.339openalex-snapshot

Protective Effects of Crocetin on the Bladder Toxicity Induced by Cyclophosphamide

inferredcites →https://doi.org/10.1093/alcalc/35.6.612openalex-snapshot

MECHANISMS OF HYPONATRAEMIA IN ALCOHOL PATIENTS

inferredcites →https://doi.org/10.1093/alcalc/agt040openalex-snapshot

Time-Course of Neuroendocrine Changes and Its Correlation with Hypertension Induced by Ethanol Consumption

inferredcites →https://doi.org/10.1093/carcin/12.3.459openalex-snapshot

Effects of crocetin on the hepatotoxicity and hepatic DNA binding of aflatoxin B1 in rats

inferredcites →https://doi.org/10.1093/carcin/7.4.595openalex-snapshot

Protection of crocin dyes on the acute hepatic damage induced by aflatoxin B1 and dimethylnitrosamine in rats

inferredcites →https://doi.org/10.1093/oxfordjournals.alcalc.a045580openalex-snapshot

ALCOHOL AND ANTIOXIDANT SYSTEMS *

inferredcites →https://doi.org/10.1095/biolreprod67.2.668openalex-snapshot

Nuclear Factor Kappa B Regulation of Proinflammatory Cytokines in Human Gestational Tissues In Vitro1

inferredcites →https://doi.org/10.1111/acer.13346openalex-snapshot

Liver Injury and Endotoxemia in Male and Female Alcohol‐Dependent Individuals Admitted to an Alcohol Treatment Program

inferredcites →https://doi.org/10.1111/hepr.12594openalex-snapshot

Molecular basis of alcoholic fatty liver disease: From incidence to treatment

inferredcites →https://doi.org/10.1111/j.1465-3362.2009.00153.xopenalex-snapshot

Alcohol as a risk factor for liver cirrhosis: A systematic review and meta‐analysis

inferredcites →https://doi.org/10.1111/j.1939-165x.2003.tb00330.xopenalex-snapshot

Fundamentals of Veterinary Clinical Pathology

inferredcites →https://doi.org/10.1111/jgh.12709openalex-snapshot

Acute kidney injury and hepatorenal syndrome in cirrhosis

inferredcites →https://doi.org/10.1111/jphp.12016openalex-snapshot

Crocin, a dietary colorant mitigates cyclophosphamide-induced organ toxicity by modulating antioxidant status and inflammatory cytokines

inferredcites →https://doi.org/10.1111/jphp.12456openalex-snapshot

Saffron: a natural product with potential pharmaceutical applications

inferredcites →https://doi.org/10.1134/s0006350910060114openalex-snapshot

Role of mitochondria in hepatotoxicity of ethanol

inferredcites →https://doi.org/10.1136/bmj.d671openalex-snapshot

Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis

inferredcites →https://doi.org/10.1152/ajpendo.00011.2008openalex-snapshot

Alcohol and lipid metabolism

inferredcites →https://doi.org/10.1152/ajpendo.00270.2016openalex-snapshot

Physiological processes underlying organ injury in alcohol abuse

inferredcites →https://doi.org/10.1152/physiol.00055.2013openalex-snapshot

Alcohol Abuse: Critical Pathophysiological Processes and Contribution to Disease Burden

inferredcites →https://doi.org/10.1155/2013/495156openalex-snapshot

The Effect of Inflammatory Cytokines in Alcoholic Liver Disease

inferredcites →https://doi.org/10.1155/2013/781050openalex-snapshot

Increased Nitroxidative Stress Promotes Mitochondrial Dysfunction in Alcoholic and Nonalcoholic Fatty Liver Disease

inferredcites →https://doi.org/10.1155/2014/728709openalex-snapshot

Crocin Suppresses LPS-Stimulated Expression of Inducible Nitric Oxide Synthase by Upregulation of Heme Oxygenase-1 via Calcium/Calmodulin-Dependent Protein Kinase 4

inferredcites →https://doi.org/10.1155/2016/3529149openalex-snapshot

Is Liver Enzyme Release Really Associated with Cell Necrosis Induced by Oxidant Stress?

inferredcites →https://doi.org/10.1177/0748233713475519openalex-snapshot

Evaluation of diazinon-induced hepatotoxicity and protective effects of crocin

inferredcites →https://doi.org/10.1186/1471-2210-2-7openalex-snapshot

Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice

inferredcites →https://doi.org/10.1371/journal.pone.0091308openalex-snapshot

Acute Ethanol Causes Hepatic Mitochondrial Depolarization in Mice: Role of Ethanol Metabolism

inferredcites →https://doi.org/10.15537/1658-3175.5142openalex-snapshot

Role of saffron (Crocus sativus L.) and honey syrup on aluminum-induced hepatotoxicity

inferredcites →https://doi.org/10.1590/0001-3765201420140067openalex-snapshot

Attenuation of oxidative stress, inflammation and apoptosis by ethanolic and aqueous extracts of Crocus sativus L. stigma after chronic constriction injury of rats

inferredcites →https://doi.org/10.2011/jcpsp.642643openalex-snapshot

Ethanol induced hepatotoxicity in albino rats.

inferredcites →https://doi.org/10.2147/jir.s165172openalex-snapshot

The effect of hydroalcoholic extract of Teucrium polium L. on the inflammatory markers and lipid profile in hypercholesterolemic rats

inferredcites →https://doi.org/10.2174/1574887111666160810101202openalex-snapshot

Epidemiology and Natural History of Alcoholic Liver Disease

inferredcites →https://doi.org/10.22038/ijbms.2018.31243.7529openalex-snapshot

Saffron (Crocus sativus) petal as a new pharmacological target: a review.

inferredcites →https://doi.org/10.23736/s0026-4806.17.05431-3openalex-snapshot

Acute alcoholic hepatitis: a literature review and proposal of treatment

inferredcites →https://doi.org/10.3109/10715762.2013.819428openalex-snapshot

Role of oxidative stress in the pathogenesis of alcohol-induced liver disease

inferredcites →https://doi.org/10.3109/10715762.2013.828836openalex-snapshot

The antioxidant enzyme peroxiredoxin-2 is depleted in lymphocytes seven days after ultra-endurance exercise

inferredcites →https://doi.org/10.3181/0902-mr-61openalex-snapshot

Adiponectin: A Key Adipokine in Alcoholic Fatty Liver

inferredcites →https://doi.org/10.3389/fcell.2015.00040openalex-snapshot

Dysfunctional mitochondrial bioenergetics and the pathogenesis of hepatic disorders

inferredcites →https://doi.org/10.3389/fimmu.2016.00538openalex-snapshot

Critical Roles of Kupffer Cells in the Pathogenesis of Alcoholic Liver Disease: From Basic Science to Clinical Trials

inferredcites →https://doi.org/10.3390/ijerph7124281openalex-snapshot

Cellular and Mitochondrial Effects of Alcohol Consumption

inferredcites →https://doi.org/10.3390/molecules23081851openalex-snapshot

UHPLC Analysis of Saffron (Crocus sativus L.): Optimization of Separation Using Chemometrics and Detection of Minor Crocetin Esters

inferredcites →https://doi.org/10.35946/arcr.v38.2.10openalex-snapshot

Alcohol Misuse and Kidney Injury: Epidemiological Evidence and Potential Mechanisms

inferredcites →https://doi.org/10.3748/wjg.v13.i37.4974openalex-snapshot

Alcohol-induced steatosis in liver cells

inferredcites →https://doi.org/10.3923/javaa.2012.1985.1994openalex-snapshot

Protective Effect of Ethanolic Extract of Saffron (Dried Stigmas of Crocus sativus L.) on Hepatic Tissue Injury in Streptozotocin-Induced Diabetic Rats

inferredcites →https://doi.org/10.4172/pharmaceutical-sciences.1000254openalex-snapshot

In vitro Antimicrobial and Free Radical Scavenging Activities of the Total Flavonoid in Petal and Stamen of Crocus sativus

inferredcites →https://doi.org/10.4330/wjc.v6.i5.245openalex-snapshot

Alcohol-induced hypertension: Mechanism and prevention

inferredcites →https://doi.org/10.5009/gnl16477openalex-snapshot

Pathophysiology and Management of Alcoholic Liver Disease: Update 2016

inferredcites →https://doi.org/10.5681/apb.2014.073openalex-snapshot

Protective Effects of Crocus Sativus L. Extract and Crocin against Chronic-Stress Induced Oxidative Damage of Brain, Liver and Kidneys in Rats

inferredcites →https://doi.org/10.5812/ircmj.36226openalex-snapshot

Anti-Dyslipidemic Properties of Saffron: Reduction in the Associated Risks of Atherosclerosis and Insulin Resistance

inferredcites →https://doi.org/10.5897/ajbr.9000131openalex-snapshot

Hepatoprotective potential of crocin and curcumin against iron overload-induced biochemical alterations in rat.

inferredcites →https://doi.org/10.7324/japs.2015.510.s5openalex-snapshot

Evaluation of acute and chronic toxic effects of Algerian germander in Swiss albino mice

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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“Plant Golden” C. Sativus: Qualitative and Quantitative Analysis of Uplc-Q-Orbitrap Hrms & Uplc-Qqq-Ms/Ms to Compare Flavonoids in Stigmas and Petals and Their Biological Activity in Vitro

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L‐Theanine Alleviates Alcohol‐Induced Kidney Injury by Inhibiting the Sphingolipid Metabolism‐S1PR2‐JNK Pathway and Activating the PPARα‐Steroid Synthesis Pathway

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A histomorphological analysis of the effects of Ghanaian alcoholic bitters and natural cocoa powder on the liver and kidney tissues in Sprague Dawley rats

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Alteration of Glycerophospholipid Metabolism in Hippocampus of Post-stroke Depression Rats

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Use of saffron as a functional food and saffron nutraceuticals

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Stigma and petals of Crocus sativus L.: Review and comparison of phytochemistry and pharmacology

inferred← citeshttps://doi.org/10.1016/j.jep.2021.114594openalex-snapshot

Crocus sativus (saffron) petals extract and its active ingredient, anthocyanin improves ovarian dysfunction, regulation of inflammatory genes and antioxidant factors in testosterone-induced PCOS mice

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Ethnobotanical, pharmacological, phytochemical, and clinical investigations on Moroccan medicinal plants traditionally used for the management of renal dysfunctions

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“Plant Golden” C. sativus: Qualitative and quantitative analysis of major components in stigmas and petals and their biological activity in vitro

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Oxidative stress marker changes and cognitive decline prevention in Pb contaminated mice by Crocus sativus L. Supplementation and interval training

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HNF4α promotes urate excretion by activating ABCG2 and mediates the anti-hyperuricemic effect of saffron floral bio-residue

inferred← citeshttps://doi.org/10.1016/j.sajb.2025.04.038openalex-snapshot

A comprehensive review on Ayurvedic medicinal plants in the management of chronic kidney disease

inferred← citeshttps://doi.org/10.1021/acs.jafc.3c04494openalex-snapshot

Bioactive Components and Biological Activities of Crocus sativus L. Byproducts: A Comprehensive Review

inferred← citeshttps://doi.org/10.1080/09553002.2026.2692106openalex-snapshot

Saffron – stigma extract alleviates brain and liver injury in γ-irradiated aged albino rats

inferred← citeshttps://doi.org/10.1080/10408398.2023.2199434openalex-snapshot

Bioactivity and applications of saffron floral bio-residues (tepals): a natural by-product for the food, pharmaceutical, and cosmetic industries

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Analysis of the biological mechanism of Gurigumu-13 in the treatment of non-alcoholic fatty liver disease based on network pharmacology

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A review of therapeutic impacts of saffron (Crocus sativusL.) and its constituents

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Saffron nephroprotective effects against medications and toxins: A review of preclinical data.

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Identification of phenolamine in rape bee pollen and its protective effect and mechanism on alcoholic liver injury

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Ethnobotanical survey and scientific validation of liver-healing plants in northeastern Morocco

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Protective Mechanism of Edible Food Plants against Alcoholic Liver Disease with Special Mention to Polyphenolic Compounds

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Saffron (Crocus sativus L.) Flower Water Extract Disrupts the Cecal Microbiome, Brush Border Membrane Functionality, and Morphology In Vivo (Gallus gallus)

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Crocus sativus L. Petal Extract Inhibits Inflammation and Osteoclastogenesis in RAW 264.7 Cell Model

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Inventory of Medicinal Plants Used Traditionally to Manage Kidney Diseases in North-Eastern Morocco: Ethnobotanical Fieldwork and Pharmacological Evidence

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Comprehensive Phytochemical Profiling of Native Cannabis sativa L. from Dehloran Using HS-SPME, GC–MS, and FT-IR Techniques

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