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The Anti-Breast Cancer Effect and Mechanism of Glimepiride-Metformin Adduct

https://doi.org/10.2147/ott.s240252
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/978-3-319-43589-3_9openalex-snapshot
AMPK and Cancer
inferredcites →https://doi.org/10.1007/s13402-018-0398-0openalex-snapshot
Metformin inhibits human breast cancer cell growth by promoting apoptosis via a ROS-independent pathway involving mitochondrial dysfunction: pivotal role of superoxide dismutase (SOD)
inferredcites →https://doi.org/10.1016/j.ejps.2017.03.042openalex-snapshot
Fast dissolving drug-drug eutectics with improved compressibility and synergistic effects
inferredcites →https://doi.org/10.1016/j.ijpharm.2011.07.037openalex-snapshot
Pharmaceutical cocrystals: An overview
inferredcites →https://doi.org/10.1016/j.molcel.2005.03.027openalex-snapshot
AMP-Activated Protein Kinase Induces a p53-Dependent Metabolic Checkpoint
inferredcites →https://doi.org/10.1016/j.molmed.2017.02.001openalex-snapshot
p21: A Two-Faced Genome Guardian
inferredcites →https://doi.org/10.1016/j.xphs.2019.02.014openalex-snapshot
A Novel Drug-Drug Cocrystal of Levofloxacin and Metacetamol: Reduced Hygroscopicity and Improved Photostability of Levofloxacin
inferredcites →https://doi.org/10.1016/s0140-6736(16)31891-8openalex-snapshot
Breast cancer
inferredcites →https://doi.org/10.1038/cddis.2017.1openalex-snapshot
Loss of BRG1 induces CRC cell senescence by regulating p53/p21 pathway
inferredcites →https://doi.org/10.1038/ncb2329openalex-snapshot
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
inferredcites →https://doi.org/10.1038/nrc.2017.109openalex-snapshot
Targeting mutant p53 for efficient cancer therapy
inferredcites →https://doi.org/10.1038/nrc2657openalex-snapshot
p21 in cancer: intricate networks and multiple activities
inferredcites →https://doi.org/10.1038/nrc2723openalex-snapshot
The first 30 years of p53: growing ever more complex
inferredcites →https://doi.org/10.1042/cs20110386openalex-snapshot
Cellular and molecular mechanisms of metformin: an overview
inferredcites →https://doi.org/10.1074/jbc.m114.622571openalex-snapshot
Reciprocal Regulation of AMP-activated Protein Kinase and Phospholipase D
inferredcites →https://doi.org/10.1080/15384101.2015.1087623openalex-snapshot
5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR) enhances the efficacy of rapamycin in human cancer cells
inferredcites →https://doi.org/10.1111/jdi.12328openalex-snapshot
New mechanisms of metformin action: Focusing on mitochondria and the gut
inferredcites →https://doi.org/10.1158/1078-0432.ccr-06-3045openalex-snapshot
Triple-Negative Breast Cancer: Clinical Features and Patterns of Recurrence
inferredcites →https://doi.org/10.1158/1078-0432.ccr-13-0203openalex-snapshot
Prognostic Significance of AMPK Activation and Therapeutic Effects of Metformin in Hepatocellular Carcinoma
inferredcites →https://doi.org/10.1159/000373980openalex-snapshot
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
inferredcites →https://doi.org/10.1172/jci13505openalex-snapshot
Role of AMP-activated protein kinase in mechanism of metformin action
inferredcites →https://doi.org/10.1186/s12935-019-0732-2openalex-snapshot
Rosiglitazone metformin adduct inhibits hepatocellular carcinoma proliferation via activation of AMPK/p21 pathway
inferredcites →https://doi.org/10.1186/s13045-017-0424-0openalex-snapshot
Metformin potentiates the effect of arsenic trioxide suppressing intrahepatic cholangiocarcinoma: roles of p38 MAPK, ERK3, and mTORC1
inferredcites →https://doi.org/10.1208/s12249-016-0701-1openalex-snapshot
Drug-Drug Multicomponent Solid Forms: Cocrystal, Coamorphous and Eutectic of Three Poorly Soluble Antihypertensive Drugs Using Mechanochemical Approach
inferredcites →https://doi.org/10.1371/journal.pone.0074157openalex-snapshot
Amino Acids and mTOR Mediate Distinct Metabolic Checkpoints in Mammalian G1 Cell Cycle
inferredcites →https://doi.org/10.1586/14779072.2016.1128827openalex-snapshot
Sacubitril/valsartan (LCZ696) for the treatment of heart failure
inferredcites →https://doi.org/10.18632/oncoscience.253openalex-snapshot
Synthetic lethality in KRas-driven cancer cells created by glutamine deprivation
inferredcites →https://doi.org/10.2337/dc09-1380openalex-snapshot
Metformin Associated With Lower Cancer Mortality in Type 2 Diabetes
inferredcites →https://doi.org/10.3322/caac.21551openalex-snapshot
Cancer statistics, 2019
inferredcites →https://doi.org/10.3892/ijo.2013.2077openalex-snapshot
Low concentration of metformin induces a p53-dependent senescence in hepatoma cells via activation of the AMPK pathway
inferredcites →https://doi.org/10.3892/ijo.2016.3372openalex-snapshot
Piperlongumine exerts cytotoxic effects against cancer cells with mutant p53 proteins at least in part by restoring the biological functions of the tumor suppressor
inferredcites →https://doi.org/10.3892/ol.2019.10119openalex-snapshot
Combination of metformin and paclitaxel suppresses proliferation and induces apoptosis of human prostate cancer cells via oxidative stress and targeting the mitochondria‑dependent pathway
inferredcites →https://doi.org/10.7326/m15-2650openalex-snapshot
Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4765193openalex-extracted
Synergistic Effects of Sulfonylureas with Chemotherapeutics: In Vitro Screening Reveals Enhanced Cytotoxicity of Doxorubicin in Combination with Sulfonylureas
inferred← citeshttps://doi.org/10.1007/s40495-023-00336-wopenalex-snapshot
Anti-cancer Efficacy of Metformin: Recent Updates on Breast and Other Cancers
inferred← citeshttps://doi.org/10.1007/s44411-024-00015-2openalex-snapshot
Sulfonylureas Glimepiride and Gliclazide Prevent Pancreatic Cancer Progression by Modulating Capn2 and Strengthening Tumor Immunotherapy
inferred← citeshttps://doi.org/10.1016/j.ejmech.2026.119009openalex-snapshot
Sulfonylureas beyond diabetes: A comprehensive review on anticancer and off-target effects (1956–2025)
inferred← citeshttps://doi.org/10.21037/gs-22-629openalex-snapshot
Breast carcinoma with spontaneous regression after needle biopsy: a case report and literature review
inferred← citeshttps://doi.org/10.3389/fcell.2021.770811openalex-snapshot
CAMSAP1 Mutation Correlates With Improved Prognosis in Small Cell Lung Cancer Patients Treated With Platinum-Based Chemotherapy
inferred← citeshttps://doi.org/10.3390/cancers17071244openalex-snapshot
Can the Tumor Microenvironment Alter Ion Channels? Unraveling Their Role in Cancer
inferred← citeshttps://doi.org/10.3390/ijms25042129openalex-snapshot
Exploring the Role of Surface and Mitochondrial ATP-Sensitive Potassium Channels in Cancer: From Cellular Functions to Therapeutic Potentials
inferred← citeshttps://doi.org/10.3390/ijms26041429openalex-snapshot
Combining Sulfonylureas with Anticancer Drugs: Evidence of Synergistic Efficacy with Doxorubicin In Vitro and In Vivo
inferred← citeshttps://doi.org/10.3390/ijms26062720openalex-snapshot
Prolonged Low-Dose Administration of FDA-Approved Drugs for Non-Cancer Conditions: A Review of Potential Targets in Cancer Cells
inferred← citeshttps://doi.org/10.3390/molecules27113472openalex-snapshot
A Drug–Drug Multicomponent Crystal of Metformin and Dobesilate: Crystal Structure Analysis and Hygroscopicity Property
inferred← citeshttps://doi.org/10.3892/ol.2019.10119openalex-snapshot
Combination of metformin and paclitaxel suppresses proliferation and induces apoptosis of human prostate cancer cells via oxidative stress and targeting the mitochondria‑dependent pathway
inferred← citeshttps://doi.org/10.5306/wjco.v16.i8.108112openalex-snapshot
Glucose and antidiabetic therapy in temozolomide resistance in glioblastoma
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