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Preclinical Profile of Bacopasides From Bacopa monnieri (BM) As An Emerging Class of Therapeutics for Management of Chronic Pains

https://doi.org/10.2174/0929867311320080006

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Depression and Pain Comorbidity

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Antioxidant activity ofBacopa monniera in rat frontal cortex, striatum and hippocampus

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The relationship between depression, clinical pain, and experimental pain in a chronic pain cohort

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Quantitative determination of the major saponin mixture bacoside A in Bacopa monnieri by HPLC

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Protective role of Bacopa monniera on morphine induced hepatotoxicity in rats

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Antistress effects of bacosides of Bacopa monnieri: modulation of Hsp70 expression, superoxide dismutase and cytochrome P450 activity in rat brain

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Free radical scavenging capacity and protective effect of Bacopa monniera L. on DNA damage

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Bacopa monniera (L.) wettst inhibits type ii collagen‐induced arthritis in rats

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A Bacoside ContainingBacopa monnieriExtract Reduces Both Morphine Hyperactivity Plus the Elevated Striatal Dopamine and Serotonin Turnover

inferredcites →https://doi.org/10.1002/ptr.4685openalex-snapshot

Bacopa monnieri Increases Cerebral Blood Flow in Rat Independent of Blood Pressure

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Regulation of Pituitary ACTH Secretion during Chronic Stress

inferredcites →https://doi.org/10.1007/978-1-59745-476-6_16openalex-snapshot

Complementary and Alternative Approaches for Chronic Pain

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Chronic Neuropathic Pain

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Alteration of regional cerebral blood flow in patients with chronic pain —Evaluation before and after epidural spinal cord stimulation—

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Central mechanisms of experimental and chronic neuropathic pain: Findings from functional imaging studies

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Inhibition of pro-inflammatory mediators: role of Bacopa monniera (L.) Wettst

inferredcites →https://doi.org/10.1016/0031-9422(73)80697-1openalex-snapshot

Bacogenin-A1: A novel dammarane triterpene sapogenin from Bacopa monniera

inferredcites →https://doi.org/10.1016/0031-9422(77)83039-2openalex-snapshot

Bacogenin-A3: A new sapogenin from Bacopa monniera

inferredcites →https://doi.org/10.1016/0031-9422(93)85537-2openalex-snapshot

Bacoside A1, A minor saponin from Bacopa monniera

inferredcites →https://doi.org/10.1016/j.cclet.2009.01.004openalex-snapshot

A new triterpenoid saponin from Bacopa monniera

inferredcites →https://doi.org/10.1016/j.chemosphere.2005.07.030openalex-snapshot

Effect of iron on lipid peroxidation, and enzymatic and non-enzymatic antioxidants and bacoside-A content in medicinal plant Bacopa monnieri L.

inferredcites →https://doi.org/10.1016/j.fitote.2008.03.010openalex-snapshot

Ethnobotany of plants used by the Thari people of Nara Desert, Pakistan

inferredcites →https://doi.org/10.1016/j.fitote.2011.06.003openalex-snapshot

Anti-inflammatory activities of Taxusabietane A isolated from Taxus wallichiana Zucc.

inferredcites →https://doi.org/10.1016/j.intimp.2008.11.016openalex-snapshot

Efficacy and mechanism of action of KHBJ-9B, a new herbal medicine, and its major compound triterpenoids in human cartilage culture and in a rabbit model of collagenase-induced osteoarthritis

inferredcites →https://doi.org/10.1016/j.intimp.2010.04.013openalex-snapshot

Betulinic acid isolated from Bacopa monniera (L.) Wettst suppresses lipopolysaccharide stimulated interleukin-6 production through modulation of nuclear factor-κB in peripheral blood mononuclear cells

inferredcites →https://doi.org/10.1016/j.jep.2005.10.009openalex-snapshot

Anti-inflammatory activity of Bacopa monniera in rodents

inferredcites →https://doi.org/10.1016/j.jep.2007.01.025openalex-snapshot

Effect of Bacopa monniera on stress induced changes in plasma corticosterone and brain monoamines in rats

inferredcites →https://doi.org/10.1016/j.jep.2008.04.017openalex-snapshot

Inhibition of lipoxygenases and cyclooxygenase-2 enzymes by extracts isolated from Bacopa monniera (L.) Wettst

inferredcites →https://doi.org/10.1016/j.jpain.2008.10.008openalex-snapshot

Clinical Guidelines for the Use of Chronic Opioid Therapy in Chronic Noncancer Pain

inferredcites →https://doi.org/10.1016/j.neuro.2005.12.007openalex-snapshot

Neuroprotective role of Bacopa monniera extract against aluminium-induced oxidative stress in the hippocampus of rat brain

inferredcites →https://doi.org/10.1016/j.niox.2009.03.001openalex-snapshot

Neuronal nitric oxide synthase: Structure, subcellular localization, regulation, and clinical implications

inferredcites →https://doi.org/10.1016/j.pain.2005.09.028openalex-snapshot

The economic impact of chronic pain in adolescence: Methodological considerations and a preliminary costs-of-illness study

inferredcites →https://doi.org/10.1016/j.pain.2008.03.002openalex-snapshot

Incidence rates and treatment of neuropathic pain conditions in the general population ☆

inferredcites →https://doi.org/10.1016/j.phymed.2003.12.008openalex-snapshot

Bacopa monniera, a reputed nootropic plant: an overview

inferredcites →https://doi.org/10.1016/j.phymed.2007.11.020openalex-snapshot

Hepatoprotective effect of Bacoside-A, a major constituent of Bacopa monniera Linn

inferredcites →https://doi.org/10.1016/j.phymed.2009.03.005openalex-snapshot

Effect of Bacopa monniera on liver and kidney toxicity in chronic use of opioids

inferredcites →https://doi.org/10.1016/j.phymed.2011.01.023openalex-snapshot

Effect of Bacopasides on acquisition and expression of morphine tolerance

inferredcites →https://doi.org/10.1016/j.phytochem.2005.09.016openalex-snapshot

Triterpenoid glycosides from Bacopa monnieri

inferredcites →https://doi.org/10.1016/s0024-3205(03)00476-4openalex-snapshot

Nitric oxide-related toxicity in cultured astrocytes: effect of Bacopa monniera

inferredcites →https://doi.org/10.1016/s0031-9422(00)94166-9openalex-snapshot

Pseudojujubogenin, a new sapogenin from Bacopa monniera

inferredcites →https://doi.org/10.1016/s0031-9422(01)00275-8openalex-snapshot

Bacopaside I and II: two pseudojujubogenin glycosides from Bacopa monniera

inferredcites →https://doi.org/10.1016/s0031-9422(99)00384-2openalex-snapshot

Bacopasaponins E and F: two jujubogenin bisdesmosides from Bacopa monniera

inferredcites →https://doi.org/10.1016/s0091-3057(03)00112-6openalex-snapshot

Plants and the central nervous system

inferredcites →https://doi.org/10.1016/s0091-3057(03)00156-4openalex-snapshot

Adaptogenic effect of Bacopa monniera (Brahmi)

inferredcites →https://doi.org/10.1016/s0140-6736(99)01307-0openalex-snapshot

Neuropathic pain: aetiology, symptoms, mechanisms, and management

inferredcites →https://doi.org/10.1016/s0367-326x(02)00114-4openalex-snapshot

Protective role of Bacopa monniera on morphine-induced brain mitochondrial enzyme activity in rats

inferredcites →https://doi.org/10.1016/s0378-8741(02)00139-3openalex-snapshot

Alcoholic extract of ‘Bacopa monniera’ reduces the in vitro effects of morphine withdrawal in guinea-pig ileum

inferredcites →https://doi.org/10.1016/s0378-8741(98)00240-2openalex-snapshot

Calcium antagonistic activity of Bacopa monniera on vascular and intestinal smooth muscles of rabbit and guinea-pig

inferredcites →https://doi.org/10.1016/s0893-133x(01)00358-xopenalex-snapshot

Regulation of Adult Neurogenesis by Antidepressant Treatment

inferredcites →https://doi.org/10.1016/s1090-3801(02)00143-xopenalex-snapshot

Recommendations for using opioids in chronic non‐cancer pain

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Discovery of Novel PPAR Ligands by a Virtual Screening Approach Based on Pharmacophore Modeling, 3D Shape, and Electrostatic Similarity Screening

inferredcites →https://doi.org/10.1021/np020238wopenalex-snapshot

Bacopaside III, Bacopasaponin G, and Bacopasides A, B, and C from Bacopa monniera

inferredcites →https://doi.org/10.1021/np060470sopenalex-snapshot

Triterpene Saponins from Bacopa monnieri and Their Antidepressant Effects in Two Mice Models

inferredcites →https://doi.org/10.1023/a:1010652006417openalex-snapshot

Comparative studies of cytokinins on in vitro propagation of Bacopa monniera

inferredcites →https://doi.org/10.1038/nri2094openalex-snapshot

Cytokines in the pathogenesis of rheumatoid arthritis

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Chronic Pain, Chronic Stress and Depression: Coincidence or Consequence?

inferredcites →https://doi.org/10.1073/pnas.120552597openalex-snapshot

Opiates inhibit neurogenesis in the adult rat hippocampus

inferredcites →https://doi.org/10.1078/0944-7113-00116openalex-snapshot

Antidepressant activity of standardized extract of Bacopa monniera in experimental models of depression in rats

inferredcites →https://doi.org/10.1078/s0944-7113(04)70060-4openalex-snapshot

Prophylactic and curative effects of in gastric ulcer models

inferredcites →https://doi.org/10.1084/jem.162.6.2163openalex-snapshot

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

inferredcites →https://doi.org/10.1097/00002508-199106000-00004openalex-snapshot

Clinical Aspects of Depression in Chronic Pain Patients

inferredcites →https://doi.org/10.1097/00002508-199706000-00009openalex-snapshot

Prescription Opiate Abuse in Chronic Pain Patients: Clinical Criteria, Incidence, and Predictors

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Neuronal nitric oxide synthase contributes to chronic stress‐induced depression by suppressing hippocampal neurogenesis

inferredcites →https://doi.org/10.1111/j.1476-5381.2010.01112.xopenalex-snapshot

Betulinic acid inhibits endotoxin‐stimulated phosphorylation cascade and pro‐inflammatory prostaglandin E2 production in human peripheral blood mononuclear cells

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A Review of the Epidemiology of Painful Diabetic Peripheral Neuropathy, Postherpetic Neuralgia, and Less Commonly Studied Neuropathic Pain Conditions

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Tricyclic antidepressant overdose: a review

inferredcites →https://doi.org/10.1139/v09-111openalex-snapshot

Dammarane triterpenoid saponins from Bacopa monnieri

inferredcites →https://doi.org/10.1146/annurev.med.60.042307.110802openalex-snapshot

The Expanded Biology of Serotonin

inferredcites →https://doi.org/10.1159/000097332openalex-snapshot

Chronic Pain and Fatigue Syndromes: Overlapping Clinical and Neuroendocrine Features and Potential Pathogenic Mechanisms

inferredcites →https://doi.org/10.1186/ar748openalex-snapshot

Efficacy of treatment with glycosaminoglycans on experimental collagen-induced arthritis in rats

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Neuroendocrine Mechanisms and the Precipitation of Depression by Life Events

inferredcites →https://doi.org/10.1210/en.139.5.2407openalex-snapshot

Pituitary-Adrenocortical Responses to Persistent Noxious Stimuli in the Awake Rat: Endogenous Corticosterone Does Not Reduce Nociception in the Formalin Test

inferredcites →https://doi.org/10.1213/01.ane.0000268145.52345.55openalex-snapshot

Pain Management: A Fundamental Human Right

inferredcites →https://doi.org/10.1248/cpb.51.215openalex-snapshot

Bacopasides III-V: Three New Triterpenoid Glycosides from Bacopa monniera.

inferredcites →https://doi.org/10.1248/cpb.54.907openalex-snapshot

Estimation of Twelve Bacopa Saponins in Bacopa monnieri Extracts and Formulations by High-Performance Liquid Chromatography

inferredcites →https://doi.org/10.1345/aph.1g217openalex-snapshot

Cannabinoid Analgesia as a Potential New Therapeutic Option in the Treatment of Chronic Pain

inferredcites →https://doi.org/10.1523/jneurosci.0004-11.2011openalex-snapshot

Hippocampal Neuronal Nitric Oxide Synthase Mediates the Stress-Related Depressive Behaviors of Glucocorticoids by Downregulating Glucocorticoid Receptor

inferredcites →https://doi.org/10.1523/jneurosci.20-24-09104.2000openalex-snapshot

Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus

inferredcites →https://doi.org/10.1590/s1807-59322011000400023openalex-snapshot

Enhancement of basolateral amygdaloid neuronal dendritic arborization following Bacopa monniera extract treatment in adult rats

inferredcites →https://doi.org/10.1615/jenvpathtoxoncol.v24.i3.80openalex-snapshot

Protective Effect of Bacoside A on Cigarette Smoking-Induced Brain Mitochondrial Dysfunction in Rats

inferredcites →https://doi.org/10.22377/ijgp.v4i1.111openalex-snapshot

A review on Bacopa monniera: Current research and future prospects

inferredcites →https://doi.org/10.3109/15360288.2011.650359openalex-snapshot

The Consequences of Chronic Pain

inferredcites →https://doi.org/10.5897/ajb09.878openalex-snapshot

In vitro rapid and mass multiplication of highly valuable medicinal plant Bacopa monnieri (L.) Wettst.

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The involvement of opioidergic mechanisms in the activity of Bacopa monnieriextract and its toxicological studies

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Characterized Profiles of Gut Microbiota in Morphine Abstinence-Induced Depressive-Like Behavior

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Diabetes Mellitus Type 2 Induces Brain Aging and Memory Impairment in Mice: Neuroprotective Effects of Bacopa monnieri Extract

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Protective Effect of Bacopasides on 7-Ketocholesterol Induced Damage in Human Brain Endothelial Cells

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Bacopa monnieri and Alzheimer’s disease: mechanistic convergence, cognitive outcomes and translational perspectives

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Neuroprotection with Bacopa monnieri–A review of experimental evidence

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inferred← citeshttps://doi.org/10.1016/j.biopha.2022.113469openalex-snapshot

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inferred← citeshttps://doi.org/10.1016/j.fitote.2025.106788openalex-snapshot

Exploring the therapeutic potential of Bacopa monnieri in autism spectrum disorder: A comprehensive review

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inferred← citeshttps://doi.org/10.1016/j.indcrop.2023.117241openalex-snapshot

A metabolic reprogramming in Bacopa monnieri plants induced by methyl-jasmonate and enhanced biosynthesis of triterpene saponins

inferred← citeshttps://doi.org/10.1016/j.jarmap.2022.100423openalex-snapshot

Unveiling the interaction of divergent abiotic stresses and their consequences in terms of bacosides in Bacopa monnieri (L.) Wettst.

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Antinociceptive activity of standardized extract of Bacopa monnieri in different pain models of zebrafish

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Effects of a Bacopa monnieri extract (Bacognize®) on stress, fatigue, quality of life and sleep in adults with self-reported poor sleep: A randomised, double-blind, placebo-controlled study

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Characterized profiles of gut microbiota in morphine abstinence-induced depressive-like behavior

inferred← citeshttps://doi.org/10.1016/j.sajb.2024.03.017openalex-snapshot

Participation of Brahmi (Bacopa monnieri L.) plant in regulation of cancer

inferred← citeshttps://doi.org/10.1039/c3fo60467eopenalex-snapshot

Bacopamonnieri (L.) exerts anti-inflammatory effects on cells of the innate immune system in vitro

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Study of neurodifferentiation potential of different extracts of Bacopa monnieri

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The Evolving Roles of Bacopa monnieri as Potential Anti-Cancer Agent: A Review

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Sodium chloride-induced metabolic shifts and morpho-physiological responses in Bacopa monnieri (L.) Wettst. for enhanced bacoside-A production

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Bacopa monnieri , a Neuroprotective Lead in Alzheimer Disease: A Review on Its Properties, Mechanisms of Action, and Preclinical and Clinical Studies

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A bacosides containing Bacopa monnieri extract alleviates allodynia and hyperalgesia in the chronic constriction injury model of neuropathic pain in rats

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Bacoside A Induced Sub-G0 Arrest and Early Apoptosis in Human Glioblastoma Cell Line U-87 MG through Notch Signaling Pathway

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Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation

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Neuroprotective compounds from three common medicinal plants of West Bengal, India: a mini review

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