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Optimization of an In Silico Cardiac Cell Model for Proarrhythmia Risk Assessment
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1016/j.ahj.2013.11.004openalex-snapshot
Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium
inferredcites →https://doi.org/10.1016/j.pharmthera.2008.04.010openalex-snapshot
Preclinical Torsades-de-Pointes Screens: Advantages and limitations of surrogate and direct approaches in evaluating proarrhythmic risk
inferredcites →https://doi.org/10.1016/j.vascn.2010.02.007openalex-snapshot
Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 °C: Cisapride versus dofetilide
inferredcites →https://doi.org/10.1016/j.vascn.2014.07.002openalex-snapshot
Prediction of Thorough QT study results using action potential simulations based on ion channel screens
inferredcites →https://doi.org/10.1016/j.vascn.2016.03.009openalex-snapshot
An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel
inferredcites →https://doi.org/10.1016/j.vascn.2016.05.005openalex-snapshot
A temperature-dependent in silico model of the human ether-à-go-go-related (hERG) gene channel
inferredcites →https://doi.org/10.1016/s0022-3565(25)29845-7openalex-snapshot
EFFECTS OF VERAPAMIL ON ELECTROPHYSIOLOGIC PROPERTIES OF CANINE CARDIAC PURKINJE FIBERS
inferredcites →https://doi.org/10.1038/psp.2014.32openalex-snapshot
A Critical Role for Immune System Response in Mediating Anti‐influenza Drug Synergies Assessed by Mechanistic Modeling
inferredcites →https://doi.org/10.1111/jce.12289openalex-snapshot
hERG Inhibitors with Similar Potency But Different Binding Kinetics Do Not Pose the Same Proarrhythmic Risk: Implications for Drug Safety Assessment
inferredcites →https://doi.org/10.1161/01.cir.0000139333.83620.5dopenalex-snapshot
Electrophysiological Effects of Ranolazine, a Novel Antianginal Agent With Antiarrhythmic Properties
inferredcites →https://doi.org/10.1161/01.cir.96.6.2038openalex-snapshot
Sodium Channel Block With Mexiletine Is Effective in Reducing Dispersion of Repolarization and Preventing Torsade de Pointes in LQT2 and LQT3 Models of the Long-QT Syndrome
inferredcites →https://doi.org/10.1371/journal.pcbi.1002061openalex-snapshot
Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4065593openalex-extracted
Translating the Measurement of Herg Kinetics and Drug Block for Cipa to a High Throughput Platform
inferred← citeshttps://doi.org/10.1002/jcph.1129openalex-snapshot
Drug‐induced Proarrhythmia and Torsade de Pointes: A Primer for Students and Practitioners of Medicine and Pharmacy
inferred← citeshttps://doi.org/10.1016/j.bpj.2020.01.012openalex-snapshot
Classifying Drugs by their Arrhythmogenic Risk Using Machine Learning
inferred← citeshttps://doi.org/10.1016/j.cmpb.2022.106934openalex-snapshot
Considering population variability of electrophysiological models improves the in silico assessment of drug-induced torsadogenic risk
inferred← citeshttps://doi.org/10.1016/j.vascn.2018.06.005openalex-snapshot
CiPA challenges and opportunities from a non-clinical, clinical and regulatory perspectives. An overview of the safety pharmacology scientific discussion
inferred← citeshttps://doi.org/10.1016/j.vascn.2018.12.004openalex-snapshot
Impact of disease state on arrhythmic event detection by action potential modelling in cardiac safety pharmacology
inferred← citeshttps://doi.org/10.1021/acs.jcim.0c00201openalex-snapshot
In Silico Classifiers for the Assessment of Drug Proarrhythmicity
inferred← citeshttps://doi.org/10.1101/2020.06.11.144238openalex-snapshot
Cardiac toxicity predictions: Safety pharmacologists correlate with the CiPA model
inferred← citeshttps://doi.org/10.1111/bph.14357openalex-snapshot
Arrhythmic hazard map for a 3D whole‐ventricle model under multiple ion channel block
inferred← citeshttps://doi.org/10.1111/bph.16250openalex-snapshot
The impact of uncertainty in hERG binding mechanism on in silico predictions of drug‐induced proarrhythmic risk
inferred← citeshttps://doi.org/10.1111/cts.12976openalex-snapshot
Chloroquine and hydroxychloroquine provoke arrhythmias at concentrations higher than those clinically used to treat COVID‐19: A simulation study
inferred← citeshttps://doi.org/10.1111/jcpt.13762openalex-snapshot
Utilization of mechanistic modelling and simulation to analyse fenspiride proarrhythmic potency – Role of physiological and other non‐drug related parameters
inferred← citeshttps://doi.org/10.1113/jp285162openalex-snapshot
Human sodium current voltage‐dependence at physiological temperature measured by coupling a patch‐clamp experiment to a mathematical model
inferred← citeshttps://doi.org/10.1113/jp288197openalex-snapshot
Electrophysiological characterization of pre‐adolescents born with intrauterine growth restriction: insights from clinical and computational data
inferred← citeshttps://doi.org/10.1371/journal.pone.0231695openalex-snapshot
Genetic algorithm-based personalized models of human cardiac action potential
inferred← citeshttps://doi.org/10.22489/cinc.2018.333openalex-snapshot
Optimization of the O’Hara-Rudy Model of Human Ventricular Action Potential With Respect to Electrolyte Concentrations and Rate Dependence
inferred← citeshttps://doi.org/10.3389/fphar.2017.00816openalex-snapshot
Novel Two-Step Classifier for Torsades de Pointes Risk Stratification from Direct Features
inferred← citeshttps://doi.org/10.3389/fphys.2017.00616openalex-snapshot
Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment
inferred← citeshttps://doi.org/10.3389/fphys.2017.00934openalex-snapshot
In Vitro and In Silico Risk Assessment in Acquired Long QT Syndrome: The Devil Is in the Details
inferred← citeshttps://doi.org/10.3389/fphys.2021.761691openalex-snapshot
Assessment of Drug Proarrhythmicity Using Artificial Neural Networks With in silico Deterministic Model Outputs
inferred← citeshttps://doi.org/10.5281/zenodo.167842openalex-snapshot
A Comparison Between The Variational Iteration Method And The Homotopy Perturbation Method For The Burgers - Huxley Equation
inferred← citeshttps://doi.org/10.7554/elife.91911.1openalex-snapshot
Neural network emulation of the human ventricular cardiomyocyte action potential: a tool for more efficient computation in pharmacological studies
inferred← citeshttps://doi.org/10.7554/elife.91911.2openalex-snapshot
Neural network emulation of the human ventricular cardiomyocyte action potential: a tool for more efficient computation in pharmacological studies
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