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Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/dmrr.1185openalex-snapshot

Effects of insulin and oral anti‐diabetic agents on glucose metabolism, vascular dysfunction and skeletal muscle inflammation in type 2 diabetic subjects

inferredcites →https://doi.org/10.1007/s00125-011-2126-4openalex-snapshot

AMP-activated protein kinase is activated in adipose tissue of individuals with type 2 diabetes treated with metformin: a randomised glycaemia-controlled crossover study

inferredcites →https://doi.org/10.1016/j.chom.2009.08.004openalex-snapshot

Vitamin D3 Induces Autophagy in Human Monocytes/Macrophages via Cathelicidin

inferredcites →https://doi.org/10.1016/j.cmet.2010.11.011openalex-snapshot

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

inferredcites →https://doi.org/10.1016/j.coi.2009.01.006openalex-snapshot

Sensing pathogens and danger signals by the inflammasome

inferredcites →https://doi.org/10.1016/j.freeradbiomed.2010.12.006openalex-snapshot

Oxidative stress, insulin signaling, and diabetes

inferredcites →https://doi.org/10.1016/j.it.2011.05.004openalex-snapshot

NLRP3 inflammasomes link inflammation and metabolic disease

inferredcites →https://doi.org/10.1016/j.molmed.2010.11.001openalex-snapshot

Inflammasomes and autoimmunity

inferredcites →https://doi.org/10.1016/s0065-2776(06)91004-9openalex-snapshot

Endogenous TLR Ligands and Autoimmunity

inferredcites →https://doi.org/10.1023/b:mcbi.0000009862.17396.8dopenalex-snapshot

VDAC: The channel at the interface between mitochondria and the cytosol

inferredcites →https://doi.org/10.1038/icb.2011.72openalex-snapshot

Mycobacterium abscessus activates the NLRP3 inflammasome via Dectin‐1–Syk and p62/SQSTM1

inferredcites →https://doi.org/10.1038/nature09663openalex-snapshot

A role for mitochondria in NLRP3 inflammasome activation

inferredcites →https://doi.org/10.1038/ng756openalex-snapshot

Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome

inferredcites →https://doi.org/10.1038/ni.1831openalex-snapshot

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

inferredcites →https://doi.org/10.1038/ni.1980openalex-snapshot

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

inferredcites →https://doi.org/10.1038/ni.2022openalex-snapshot

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

inferredcites →https://doi.org/10.1038/nm.2279openalex-snapshot

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

inferredcites →https://doi.org/10.1038/nrd3403openalex-snapshot

Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

inferredcites →https://doi.org/10.1038/nrendo.2009.271openalex-snapshot

Blockade of interleukin 1 in type 1 diabetes mellitus

inferredcites →https://doi.org/10.1038/nri2925openalex-snapshot

Type 2 diabetes as an inflammatory disease

inferredcites →https://doi.org/10.1042/cs20110386openalex-snapshot

Cellular and molecular mechanisms of metformin: an overview

inferredcites →https://doi.org/10.1056/nejmoa065213openalex-snapshot

Interleukin-1–Receptor Antagonist in Type 2 Diabetes Mellitus

inferredcites →https://doi.org/10.1073/pnas.1100255108openalex-snapshot

Inflammasome is a central player in the induction of obesity and insulin resistance

inferredcites →https://doi.org/10.1084/jem.20102049openalex-snapshot

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

inferredcites →https://doi.org/10.1084/jem.20110367openalex-snapshot

Mitochondrial reactive oxygen species drive proinflammatory cytokine production

inferredcites →https://doi.org/10.1126/scitranslmed.3001902openalex-snapshot

The Inflammasome in Atherosclerosis and Type 2 Diabetes

inferredcites →https://doi.org/10.1152/ajpendo.00363.2011openalex-snapshot

Mitochondrial dysfunction and insulin resistance from the outside in: extracellular matrix, the cytoskeleton, and mitochondria

inferredcites →https://doi.org/10.1161/01.atv.0000122852.22604.78openalex-snapshot

Is Oxidative Stress the Pathogenic Mechanism Underlying Insulin Resistance, Diabetes, and Cardiovascular Disease? The Common Soil Hypothesis Revisited

inferredcites →https://doi.org/10.1164/rccm.200710-1602ocopenalex-snapshot

Mitochondrial Respiratory Complex I Regulates Neutrophil Activation and Severity of Lung Injury

inferredcites →https://doi.org/10.1172/jci29069openalex-snapshot

Inflammation and insulin resistance

inferredcites →https://doi.org/10.1172/jci40599openalex-snapshot

Inflammasomes: too big to miss

inferredcites →https://doi.org/10.1182/blood-2008-03-146720openalex-snapshot

Differential requirement for the activation of the inflammasome for processing and release of IL-1β in monocytes and macrophages

inferredcites →https://doi.org/10.1200/jco.2009.25.4110openalex-snapshot

Metformin As an Addition to Conventional Chemotherapy in Breast Cancer

inferredcites →https://doi.org/10.1200/jco.2009.25.4292openalex-snapshot

Reply to T. Grenader et al

inferredcites →https://doi.org/10.1210/en.2006-0692openalex-snapshot

Interleukin-1β-Induced Insulin Resistance in Adipocytes through Down-Regulation of Insulin Receptor Substrate-1 Expression

inferredcites →https://doi.org/10.1210/en.2008-0404openalex-snapshot

Superoxide and Respiratory Coupling in Mitochondria of Insulin-Deficient Diabetic Rats

inferredcites →https://doi.org/10.2337/db08-0127openalex-snapshot

Metformin Decreases the Adipokine Vaspin in Overweight Women With Polycystic Ovary Syndrome Concomitant With Improvement in Insulin Sensitivity and a Decrease in Insulin Resistance

inferredcites →https://doi.org/10.2337/db11-0416openalex-snapshot

Sirtuin 1–Mediated Cellular Metabolic Memory of High Glucose Via the LKB1/AMPK/ROS Pathway and Therapeutic Effects of Metformin

inferredcites →https://doi.org/10.2337/dc09-1799openalex-snapshot

Increased Toll-Like Receptor (TLR) Activation and TLR Ligands in Recently Diagnosed Type 2 Diabetic Subjects

inferredcites →https://doi.org/10.2337/dc11-s221openalex-snapshot

Type 2 Diabetes Can Be Prevented With Early Pharmacological Intervention

inferredcites →https://doi.org/10.2337/diabetes.51.7.2074openalex-snapshot

Metformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects With Type 2 Diabetes

inferredcites →https://doi.org/10.2337/diabetes.52.3.812openalex-snapshot

Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes

inferredcites →https://doi.org/10.4110/in.2011.11.2.95openalex-snapshot

Role of Innate Immunity in Diabetes and Metabolism: Recent Progress in the Study of Inflammasomes

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Design, Synthesis and Evaluation of Oxazaborine Inhibitors of the NLRP3 Inflammasome

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The complex interplay between endoplasmic reticulum stress and the NLRP3 inflammasome: a potential therapeutic target for inflammatory disorders

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Increased inflammasome activity in subcutaneous adipose tissue of patients with metabolic syndrome

inferred← citeshttps://doi.org/10.1002/dmrr.3841openalex-snapshot

Progress in the Pathogenesis of Diabetic Encephalopathy: The Key Role of Neuroinflammation

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NLRP3‐Caspase‐1 Axis in Human Adipose Tissue Crown‐Like Structures: A Potential Mediator of Inflammation and the Effects of Bariatric Surgery

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NLRP3 expression and urinary HSP72 in relation to biomarkers of inflammation and oxidative stress in diabetic nephropathy patients

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Downregulation of IL‐22 can be considered as a risk factor for onset of type 2 diabetes

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NLRP3 inﬂammasome mediates chronic intermittent hypoxia‐induced renal injury implication of the microRNA‐155/FOXO3a signaling pathway

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Double‐negative T cells mediate M1 polarization of microglial cells via TNF‐α‐NLRP3 to aggravate neuroinflammation and cognitive impairment in Alzheimer's disease mice

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FOXO3a acetylation regulates PINK1, mitophagy, inflammasome activation in murine palmitate-conditioned and diabetic macrophages

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Kakonein restores hyperglycemia-induced macrophage digestion dysfunction through regulation of cathepsin B-dependent NLRP3 inflammasome activation

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Metformin ameliorates experimental diabetic periodontitis independently of mammalian target of rapamycin (mTOR) inhibition by reducing NIMA‐related kinase 7 (Nek7) expression

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Lavender essential oil accelerates lipopolysaccharide‐induced chronic wound healing by inhibiting caspase‐11‐mediated macrophage pyroptosis

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Solubilization of Saturated Fatty Acids and Its Lysophosphatidylcholine by Complexation With Bovine Serum Albumin

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Exercise‐Induced Exerkines: Multi‐Nodal Suppression of the NLRP3 Inflammasome and Translational Potential

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Potential Interplay between Dietary Saturated Fats and Genetic Variants of the NLRP3 Inflammasome to Modulate Insulin Resistance and Diabetes Risk: Insights from a Meta‐Analysis of 19 005 Individuals

inferred← citeshttps://doi.org/10.1002/oby.21003openalex-snapshot

Adipose tissue as an immunological organ

inferred← citeshttps://doi.org/10.1002/oby.22734openalex-snapshot

Differential Impact of Weight Loss and Glycemic Control on Inflammasome Signaling

inferred← citeshttps://doi.org/10.1002/ptr.6088openalex-snapshot

Protective effects of sarsasapogenin against early stage of diabetic nephropathy in rats

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Piperazine Derivatives Attenuate Scopolamine‐Induced Memory Deficits by Modulating Neuroinflammation and Oxidative Stress via the NF‐κB/TNF‐α/COX‐2 Pathway

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Ex Vivo Molecular Rejuvenation Improves the Therapeutic Activity of Senescent Human Cardiac Stem Cells in a Mouse Model of Myocardial Infarction

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Role of Innate Immune Receptors in Cardiac Damage Linked to Metabolic Disorders

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Endothelial Dysfunction in Vascular Inflammation: The Role of NLRP3, NLRP10, AIM2, TLR9, and PANoptosis

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Pyroptosis Markers in Human Primary Specimens: Quantification of Intracellular ASC Specks by Imaging Flow Cytometry and Extracellular Oxidized Mitochondrial by ELISA

inferred← citeshttps://doi.org/10.1007/978-3-030-47336-5_5openalex-snapshot

Role of NLRP3 Inflammasomes in Obesity-Induced Cardiovascular Diseases

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Chronic Systemic Inflammation Measured by Bioimpedance Technology Before and After Sleeve Gastrectomy: A Feasibility Study

inferred← citeshttps://doi.org/10.1007/978-3-031-40116-9_29openalex-snapshot

Linking Inflammation, Obesity, and Diabetes

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Autoimmune Connective Tissue Disorders in Diabetic Patients

inferred← citeshttps://doi.org/10.1007/978-3-0348-0620-6_77-1openalex-snapshot

Inflammasomes

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Endogenous DAMPs, Category I: Constitutively Expressed, Native Molecules (Cat. I DAMPs)

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Inflammasomes

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Activation of the TXNIP/NLRP3 inflammasome pathway contributes to inflammation in diabetic retinopathy: a novel inhibitory effect of minocycline

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Selective inhibition of PKR by C16 accelerates diabetic wound healing by inhibiting NALP3 expression in mice

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Lactate acts as a metabolic brake on inflammation by repressing NLRP3 transcription via NF-κB inhibition

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Macrophage polarization in pathology

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Diabetes propels the risk for cardiovascular disease: sweet monocytes becoming aggressive?

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The role of caloric load and mitochondrial homeostasis in the regulation of the NLRP3 inflammasome

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Targeting the pathways of regulated necrosis: a potential strategy for alleviation of cardio-cerebrovascular injury

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Obesity phenotype is related to NLRP3 inflammasome activity and immunological profile of visceral adipose tissue

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TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6

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Targeting 12-lipoxygenase as a novel strategy to combat the effects of inflammation on beta cells in diabetes

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Combined SGLT2 and DPP4 Inhibition Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Nephropathy in Mice with Type 2 Diabetes

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Gut Barrier Dysfunction and Bacterial Lipopolysaccharides in Colorectal Cancer

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Blockade of Notch signaling promotes acetaminophen-induced liver injury

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Lysosomal destabilization activates the NLRP3 inflammasome in human umbilical vein endothelial cells (HUVECs)

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Mitochondria and the NLRP3 inflammasome: physiological and pathological relevance

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Inflammatory Consequences of Maternal Diabetes on the Offspring Brain: a Hippocampal Organotypic Culture Study

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Brain inflammaging in the pathogenesis of late-life depression

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Eplerenone alleviates diabetic cardiomyopathy by modulating ER stress, oxidative stress, and NLRP3 inflammasome activation

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Neuroinflammation, Type 2 Diabetes, and Dementia

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Inflammasomes Action as an Important Mechanism in Experimental and Clinical Depression

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Inflammatory Abnormalities in Major Depressive Disorder

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Pathogenesis of diabetic atherosclerotic cardiovascular disease

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Inflammasome implications in metabolic disorders

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Inflammasomes in the pathobiology of degenerative retinopathies

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Integrating immunogenetics in T2DM research and practices

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Immune-targeted therapies: Management of diabetes and fostering healthy aging

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Development of covalent NLRP3 inflammasome inhibitors: Chemistry and biological activity

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Nickel-refining fumes induce NLRP3 activation dependent on mitochondrial damage and ROS production in Beas-2B cells

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Effects of tunable, 3D-bioprinted hydrogels on human brown adipocyte behavior and metabolic function

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Computational screening of benzophenone integrated derivatives (BIDs) targeting the NACHT domain of the potential target NLRP3 inflammasome

inferred← citeshttps://doi.org/10.1016/j.aquatox.2024.106839openalex-snapshot

Perfluorooctane sulfonate causes pyroptosis and lipid metabolism disorders through ROS-mediated NLRP3 inflammasome activation in grass carp hepatocyte

inferred← citeshttps://doi.org/10.1016/j.archoralbio.2020.104692openalex-snapshot

The anti-periodontitis action of metformin via targeting NLRP3 inflammasome

inferred← citeshttps://doi.org/10.1016/j.arr.2015.06.004openalex-snapshot

Damage-associated molecular patterns and their pathological relevance in diabetes mellitus

inferred← citeshttps://doi.org/10.1016/j.arr.2023.101958openalex-snapshot

RNA binding proteins in senescence: A potential common linker for age-related diseases?

inferred← citeshttps://doi.org/10.1016/j.arr.2024.102505openalex-snapshot

Exploring cytokines dynamics: Uncovering therapeutic concepts for metabolic disorders in postmenopausal women- diabetes, metabolic bone diseases, and non-alcohol fatty liver disease

inferred← citeshttps://doi.org/10.1016/j.autrev.2021.102867openalex-snapshot

Dysfunctional mitochondria as critical players in the inflammation of autoimmune diseases: Potential role in Sjögren’s syndrome

inferred← citeshttps://doi.org/10.1016/j.bbadis.2016.04.017openalex-snapshot

Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease

inferred← citeshttps://doi.org/10.1016/j.bbalip.2015.08.009openalex-snapshot

Electronegative LDL induces priming and inflammasome activation leading to IL-1β release in human monocytes and macrophages

inferred← citeshttps://doi.org/10.1016/j.bbalip.2016.09.002openalex-snapshot

Macrophage fatty acid oxidation and its roles in macrophage polarization and fatty acid-induced inflammation

inferred← citeshttps://doi.org/10.1016/j.bbih.2024.100862openalex-snapshot

Circulating Interleukin-17A is associated with executive function in middle aged adults with and without type 2 diabetes

inferred← citeshttps://doi.org/10.1016/j.bbrc.2015.06.060openalex-snapshot

Inhibition of autophagy induces IL-1β release from ARPE-19 cells via ROS mediated NLRP3 inflammasome activation under high glucose stress

inferred← citeshttps://doi.org/10.1016/j.bbrc.2017.02.021openalex-snapshot

Triptolide attenuates pressure overload-induced myocardial remodeling in mice via the inhibition of NLRP3 inflammasome expression

inferred← citeshttps://doi.org/10.1016/j.bbrc.2018.09.134openalex-snapshot

Liraglutide protects non-alcoholic fatty liver disease via inhibiting NLRP3 inflammasome activation in a mouse model induced by high-fat diet

inferred← citeshttps://doi.org/10.1016/j.bbrc.2022.04.131openalex-snapshot

Kindlin-2 protects pancreatic β cells through inhibiting NLRP3 inflammasome activation in diabetic mice

inferred← citeshttps://doi.org/10.1016/j.bbrc.2023.149409openalex-snapshot

The transcriptomic landscape of canonical activation of NLRP3 inflammasome from bone marrow-derived macrophages

inferred← citeshttps://doi.org/10.1016/j.bcp.2014.08.013openalex-snapshot

Free fatty acids as modulators of the NLRP3 inflammasome in obesity/type 2 diabetes

inferred← citeshttps://doi.org/10.1016/j.bcp.2014.10.001openalex-snapshot

Procyanidin B2 inhibits NLRP3 inflammasome activation in human vascular endothelial cells

inferred← citeshttps://doi.org/10.1016/j.bcp.2023.115911openalex-snapshot

Strategies targeting IL-33/ST2 axis in the treatment of allergic diseases

inferred← citeshttps://doi.org/10.1016/j.bcp.2023.115959openalex-snapshot

Purinergic P2X7 receptor as a potential therapeutic target in depression

inferred← citeshttps://doi.org/10.1016/j.bcp.2026.117860openalex-snapshot

YTHDF2 alleviates diabetic cardiomyopathy by targeting m6A-mediated degradation of lncRNA RMRP and inhibiting NLRP3-dependent pyroptosis

inferred← citeshttps://doi.org/10.1016/j.biocel.2017.01.001openalex-snapshot

Vascular endothelial cells senescence is associated with NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation via reactive oxygen species (ROS)/thioredoxin-interacting protein (TXNIP) pathway

inferred← citeshttps://doi.org/10.1016/j.biopha.2017.03.003openalex-snapshot

Berberine inhibits palmitate-induced NLRP3 inflammasome activation by triggering autophagy in macrophages: A new mechanism linking berberine to insulin resistance improvement

inferred← citeshttps://doi.org/10.1016/j.biopha.2018.04.140openalex-snapshot

Peperomin E (PepE) protects against high fat diet-induced atherosclerosis in Apolipoprotein E deficient (ApoE−/−) mice through reducing inflammation via the suppression of NLRP3 signaling pathway

inferred← citeshttps://doi.org/10.1016/j.biopha.2019.109410openalex-snapshot

Metformin inhibited Nod-like receptor protein 3 inflammasomes activation and suppressed diabetes-accelerated atherosclerosis in apoE−/− mice

inferred← citeshttps://doi.org/10.1016/j.biopha.2021.111325openalex-snapshot

Puerarin suppresses the hepatic gluconeogenesis via activation of PI3K/Akt signaling pathway in diabetic rats and HepG2 cells

inferred← citeshttps://doi.org/10.1016/j.biopha.2021.112219openalex-snapshot

Regulation and functions of NLRP3 inflammasome in cardiac fibrosis: Current knowledge and clinical significance

inferred← citeshttps://doi.org/10.1016/j.biopha.2022.112933openalex-snapshot

HMGB1 signaling pathway in diabetes-related dementia: Blood-brain barrier breakdown, brain insulin resistance, and Aβ accumulation

inferred← citeshttps://doi.org/10.1016/j.biopha.2024.116863openalex-snapshot

The role of pyroptosis in metabolism and metabolic disease

inferred← citeshttps://doi.org/10.1016/j.bmcl.2016.10.025openalex-snapshot

Variation of the aryl substituent on the piperazine ring within the 4-(piperazin-1-yl)-2,6-di(pyrrolidin-1-yl)pyrimidine scaffold unveils potent, non-competitive inhibitors of the inflammatory caspases

inferred← citeshttps://doi.org/10.1016/j.cbi.2018.05.004openalex-snapshot

Improvement of hyperglycemia in a murine model of insulin resistance and high glucose- and inflammasome-mediated IL-1β expressions in macrophages by silymarin

inferred← citeshttps://doi.org/10.1016/j.cca.2022.04.011openalex-snapshot

Pyroptosis in diabetes and diabetic nephropathy

inferred← citeshttps://doi.org/10.1016/j.cej.2024.149014openalex-snapshot

Anti-inflammasome bio-heterojunction (AI-bioHJ): Revolutionizing diabetic wound healing with in situ self-transformation and programmed gas therapy

inferred← citeshttps://doi.org/10.1016/j.celrep.2018.03.097openalex-snapshot

The NLRP3 Inflammasome Suppresses Protective Immunity to Gastrointestinal Helminth Infection

inferred← citeshttps://doi.org/10.1016/j.chembiol.2024.04.006openalex-snapshot

Metabolism-inflammasome crosstalk shapes innate and adaptive immunity

inferred← citeshttps://doi.org/10.1016/j.cjca.2025.04.017openalex-snapshot

The Evolving Role of Macrophage Metabolic Reprogramming in Obesity

inferred← citeshttps://doi.org/10.1016/j.clinre.2021.101843openalex-snapshot

Upregulated NLRP3 inflammasome activation is attenuated by anthocyanins in patients with nonalcoholic fatty liver disease: A case-control and an intervention study

inferred← citeshttps://doi.org/10.1016/j.cmet.2019.07.004openalex-snapshot

Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes

inferred← citeshttps://doi.org/10.1016/j.cmet.2020.04.015openalex-snapshot

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

inferred← citeshttps://doi.org/10.1016/j.cmet.2020.06.013openalex-snapshot

The World Goes Bats: Living Longer and Tolerating Viruses

inferred← citeshttps://doi.org/10.1016/j.coi.2014.03.007openalex-snapshot

Inflammation, ageing and chronic disease

inferred← citeshttps://doi.org/10.1016/j.compbiolchem.2026.109454openalex-snapshot

Network pharmacology and molecular docking-based investigation of flavonoids against diabetes-associated inflammation: Mechanistic insights into a multi-target therapeutic approach

inferred← citeshttps://doi.org/10.1016/j.cstres.2024.01.002openalex-snapshot

Heat shock response during the resolution of inflammation and its progressive suppression in chronic-degenerative inflammatory diseases

inferred← citeshttps://doi.org/10.1016/j.cyto.2013.08.003openalex-snapshot

Convergence of innate immunity and insulin resistance as evidenced by increased nucleotide oligomerization domain (NOD) expression and signaling in monocytes from patients with type 2 diabetes

inferred← citeshttps://doi.org/10.1016/j.cyto.2016.11.009openalex-snapshot

Defective production of interleukin-1 beta in patients with type 2 diabetes mellitus: Restoration by proper glycemic control

inferred← citeshttps://doi.org/10.1016/j.cyto.2018.07.020openalex-snapshot

Hyperglycemia induces inflammatory mediators in the human chorionic villous

inferred← citeshttps://doi.org/10.1016/j.cyto.2020.155101openalex-snapshot

Effects of oral butyrate and inulin supplementation on inflammation-induced pyroptosis pathway in type 2 diabetes: A randomized, double-blind, placebo-controlled trial

inferred← citeshttps://doi.org/10.1016/j.cyto.2025.156999openalex-snapshot

Relative mRNA expression signature of PBMC-derived NLRP3 inflammasomes in progression of type 2 diabetic kidney disease

inferred← citeshttps://doi.org/10.1016/j.cytogfr.2014.07.020openalex-snapshot

Inflammasome activation and metabolic disease progression

inferred← citeshttps://doi.org/10.1016/j.cytogfr.2023.09.007openalex-snapshot

Mechanisms of NLRP3 inflammasome activation and the development of peptide inhibitors

inferred← citeshttps://doi.org/10.1016/j.det.2013.04.006openalex-snapshot

Type 2 Diabetes Mellitus

inferred← citeshttps://doi.org/10.1016/j.devcel.2020.07.015openalex-snapshot

Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production

inferred← citeshttps://doi.org/10.1016/j.diabres.2013.04.005openalex-snapshot

Effect of laparoscopic Roux-en-Y gastric bypass surgery on type 2 diabetes mellitus with hypertension: A randomized controlled trial

inferred← citeshttps://doi.org/10.1016/j.drudis.2018.08.005openalex-snapshot

Effects of antidiabetic drugs on NLRP3 inflammasome activity, with a focus on diabetic kidneys

inferred← citeshttps://doi.org/10.1016/j.drudis.2021.02.018openalex-snapshot

Specific NLRP3 inflammasome inhibitors: promising therapeutic agents for inflammatory diseases

inferred← citeshttps://doi.org/10.1016/j.drudis.2025.104456openalex-snapshot

Adipose tissue NLRP3 inflammasome: a therapeutic target in obesity and type 2 diabetes mellitus

inferred← citeshttps://doi.org/10.1016/j.dsx.2017.03.006openalex-snapshot

Signaling pathways linking inflammation to insulin resistance

inferred← citeshttps://doi.org/10.1016/j.ecoenv.2024.117504openalex-snapshot

NLRP3 inflammasome activation and disruption of IRS-1/PI3K/AKT signaling: Potential mechanisms of arsenic-induced pancreatic beta cells dysfunction in rats

inferred← citeshttps://doi.org/10.1016/j.ejmech.2023.115336openalex-snapshot

Inhibition of the pyroptosis-associated inflammasome pathway: The important potential mechanism of ginsenosides in ameliorating diabetes and its complications

inferred← citeshttps://doi.org/10.1016/j.ejmech.2025.118023openalex-snapshot

Discovery of novel 8-hydroxyquinoline derivatives as NLRP3 inflammasome inhibitors with therapeutic potential for inflammatory bowel disease

inferred← citeshttps://doi.org/10.1016/j.ejphar.2017.05.032openalex-snapshot

Magnesium isoglycyrrhizinate blocks fructose-induced hepatic NF-κB/NLRP3 inflammasome activation and lipid metabolism disorder

inferred← citeshttps://doi.org/10.1016/j.ejphar.2019.03.006openalex-snapshot

Metformin reduced NLRP3 inflammasome activity in Ox-LDL stimulated macrophages through adenosine monophosphate activated protein kinase and protein phosphatase 2A

inferred← citeshttps://doi.org/10.1016/j.ejphar.2020.173503openalex-snapshot

Targeting NLRP3 inflammasome as a promising approach for treatment of diabetic nephropathy: Preclinical evidences with therapeutic approaches

inferred← citeshttps://doi.org/10.1016/j.ejphar.2022.175091openalex-snapshot

Therapeutic potential of MCC950, a specific inhibitor of NLRP3 inflammasome

inferred← citeshttps://doi.org/10.1016/j.ejphar.2023.175901openalex-snapshot

NLR family pyrin domain containing 3 (NLRP3) inflammasomes and peripheral neuropathic pain - Emphasis on microRNAs (miRNAs) as important regulators

inferred← citeshttps://doi.org/10.1016/j.eplepsyres.2026.107783openalex-snapshot

Causal relationship between hypertension and epilepsy mediated by diabetic retinopathy

inferred← citeshttps://doi.org/10.1016/j.expneurol.2013.11.001openalex-snapshot

Metabolic inflammation exacerbates dopaminergic neuronal degeneration in response to acute MPTP challenge in type 2 diabetes mice

inferred← citeshttps://doi.org/10.1016/j.foodres.2017.01.017openalex-snapshot

Lycopene rich extract from red guava (Psidium guajava L.) displays anti-inflammatory and antioxidant profile by reducing suggestive hallmarks of acute inflammatory response in mice

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2017.02.027openalex-snapshot

Contribution of guanine nucleotide exchange factor Vav2 to NLRP3 inflammasome activation in mouse podocytes during hyperhomocysteinemia

inferred← citeshttps://doi.org/10.1016/j.gene.2013.07.082openalex-snapshot

Variants of NLRP3 gene are associated with insulin resistance in Chinese Han population with type-2 diabetes

inferred← citeshttps://doi.org/10.1016/j.heliyon.2022.e12304openalex-snapshot

Increased mitochondrial proton leak and glycolysis in peripheral blood mononuclear cells in type-1-diabetes

inferred← citeshttps://doi.org/10.1016/j.humgen.2022.201057openalex-snapshot

Role of the NLRP3-Q705K polymorphism in the pathogenesis of inflammatory-mediated diseases: A brief look at impacts of the Q705 polymorphism and NLRP3 activation on cancer immunotherapy

inferred← citeshttps://doi.org/10.1016/j.humimm.2024.111164openalex-snapshot

Investigating the influence of inflammasome complex genes on Turner syndrome

inferred← citeshttps://doi.org/10.1016/j.humimm.2025.111337openalex-snapshot

Precision medicine and machine learning to predict critical disease and death due to Coronavirus disease 2019 (COVID-19)

inferred← citeshttps://doi.org/10.1016/j.imlet.2017.10.010openalex-snapshot

Inflammasomes and type 2 diabetes: An updated systematic review

inferred← citeshttps://doi.org/10.1016/j.immuni.2021.05.004openalex-snapshot

Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation

inferred← citeshttps://doi.org/10.1016/j.immuni.2025.09.011openalex-snapshot

Obesity, diabetes, and inflammation: Pathophysiology and clinical implications

inferred← citeshttps://doi.org/10.1016/j.immuni.2025.09.012openalex-snapshot

Inflammation in atherosclerosis: Lessons and therapeutic implications

inferred← citeshttps://doi.org/10.1016/j.intimp.2020.106653openalex-snapshot

Betulin alleviates on myocardial inflammation in diabetes mice via regulating Siti1/NLRP3/NF-κB pathway

inferred← citeshttps://doi.org/10.1016/j.intimp.2020.106987openalex-snapshot

Inhibition of HMGB1 involved in the protective of salidroside on liver injury in diabetes mice

inferred← citeshttps://doi.org/10.1016/j.intimp.2022.108595openalex-snapshot

MCC950 in the treatment of NLRP3-mediated inflammatory diseases: Latest evidence and therapeutic outcomes

inferred← citeshttps://doi.org/10.1016/j.intimp.2023.110024openalex-snapshot

Leukadherin-1 inhibits NLRP3 inflammasome by blocking inflammasome assembly

inferred← citeshttps://doi.org/10.1016/j.intimp.2023.110292openalex-snapshot

Ergolide covalently binds NLRP3 and inhibits NLRP3 inflammasome-mediated pyroptosis

inferred← citeshttps://doi.org/10.1016/j.isci.2024.111544openalex-snapshot

ZFAND6 promotes TRAF2-dependent mitophagy to restrain cGAS-STING signaling

inferred← citeshttps://doi.org/10.1016/j.it.2019.05.001openalex-snapshot

The Healing Power of Neutrophils

inferred← citeshttps://doi.org/10.1016/j.it.2024.02.004openalex-snapshot

Inflammasome diversity: exploring novel frontiers in the innate immune response

inferred← citeshttps://doi.org/10.1016/j.jacbts.2020.03.015openalex-snapshot

Innate Immune Receptors, Key Actors in Cardiovascular Diseases

inferred← citeshttps://doi.org/10.1016/j.jacc.2019.05.045openalex-snapshot

Clonal Hematopoiesis of Indeterminate Potential Reshapes Age-Related CVD

inferred← citeshttps://doi.org/10.1016/j.jaci.2013.06.022openalex-snapshot

Innate sensors of pathogen and stress: Linking inflammation to obesity

inferred← citeshttps://doi.org/10.1016/j.jad.2026.121830openalex-snapshot

Peripheral inflammation mediates the association between triglyceride-glucose index and cognitive impairment in comorbid major depressive disorder and type 2 diabetes: Translational implications for Alzheimer's disease risk via neuroinflammatory pathways

inferred← citeshttps://doi.org/10.1016/j.jaut.2017.02.006openalex-snapshot

Mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye

inferred← citeshttps://doi.org/10.1016/j.jcjd.2020.11.003openalex-snapshot

Effect of Empagliflozin and Liraglutide on the Nucleotide-Binding and Oligomerization Domain-Like Receptor Family Pyrin Domain-Containing 3 Inflammasome in a Rodent Model of Type 2 Diabetes Mellitus

inferred← citeshttps://doi.org/10.1016/j.jep.2026.121903openalex-snapshot

Melampodium divaricatum (Rich.) DC. extracts exert anti-inflammatory effects via inhibition of the NLRP3 inflammasome

inferred← citeshttps://doi.org/10.1016/j.jff.2022.105348openalex-snapshot

α-Linolenic acid regulates macrophages via GPR120-NLRP3 inflammasome pathway to ameliorate diabetic rats

inferred← citeshttps://doi.org/10.1016/j.jgr.2026.101022openalex-snapshot

Red ginseng-mediated modulation of the NLRP3 Inflammasome in neuroinflammatory-related cognitive impairments

inferred← citeshttps://doi.org/10.1016/j.jhep.2021.11.026openalex-snapshot

Myeloid Ikaros–SIRT1 signaling axis regulates hepatic inflammation and pyroptosis in ischemia-stressed mouse and human liver

inferred← citeshttps://doi.org/10.1016/j.jnutbio.2015.04.012openalex-snapshot

Purple sweet potato color inhibits endothelial premature senescence by blocking the NLRP3 inflammasome

inferred← citeshttps://doi.org/10.1016/j.jnutbio.2016.04.004openalex-snapshot

Fish-oil-derived n-3 polyunsaturated fatty acids reduce NLRP3 inflammasome activity and obesity-related inflammatory cross-talk between adipocytes and CD11b+ macrophages

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