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Distribution and biosynthesis of caffeine in plants
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/jsfa.2740220512openalex-snapshot
Theobromine and caffeine content of the cocoa bean during its growth
inferredcites →https://doi.org/10.1006/anbo.1993.1034openalex-snapshot
Biosynthesis of Caffeine in Flower Buds of Camellia sinensis
inferredcites →https://doi.org/10.1007/978-3-642-73026-9_14openalex-snapshot
Caffeine: Production by Plant (Coffea spp.) Cell Cultures
inferredcites →https://doi.org/10.1007/978-3-642-83343-4_11openalex-snapshot
Metabolism and Analysis of Caffeine and Other Methylxanthines in Coffee, Tea, Cola, Guarana and Cacao
inferredcites →https://doi.org/10.1007/bf00025361openalex-snapshot
Breeding for low seed caffeine content of coffee (Coffea L.) by interspecific hybridization
inferredcites →https://doi.org/10.1007/bf00269231openalex-snapshot
N-methyltransferase activities in suspension cultures of Coffea arabica L.
inferredcites →https://doi.org/10.1007/bf00389311openalex-snapshot
Kaffeinsynthese in Fr�chten und Gewebekulturen von Coffea arabica
inferredcites →https://doi.org/10.1007/bf02381733openalex-snapshot
Allelopathy due to purine alkaloids in tea seeds during germination
inferredcites →https://doi.org/10.1007/bf02507798openalex-snapshot
Biosynthesis and metabolism of purine alkaloids in leaves of cocoa tea (Camellia ptilophylla)
inferredcites →https://doi.org/10.1007/bf02876217openalex-snapshot
Biochemical frontiers of allelopathy
inferredcites →https://doi.org/10.1016/0031-9422(75)83027-5openalex-snapshot
O(2),1,9-trimethyluric acid and 1,3,7,9-tetramethyluric acid in leaves of different Coffea species
inferredcites →https://doi.org/10.1016/0031-9422(86)88009-8openalex-snapshot
Purine alkaloid formation in buds and developing leaflets of Coffea arabica: Expression of an optimal defence strategy?
inferredcites →https://doi.org/10.1016/0031-9422(90)85266-iopenalex-snapshot
Adenine metabolism and the synthesis of purine alkaloids in flowers of Camellia
inferredcites →https://doi.org/10.1016/0031-9422(91)83622-ropenalex-snapshot
Seasonal variations in biosynthetic capacity for the synthesis of caffeine in tea leaves
inferredcites →https://doi.org/10.1016/0031-9422(92)83590-uopenalex-snapshot
Purine and purine alkaloid metabolism in Camellia and Coffea plants
inferredcites →https://doi.org/10.1016/0031-9422(93)85103-xopenalex-snapshot
Purine metabolism and the biosynthesis of caffeine in maté leaves
inferredcites →https://doi.org/10.1016/0031-9422(94)00141-fopenalex-snapshot
Guaraná (Paullinia cupana) rewards seed dispersers without intoxicating them by caffeine
inferredcites →https://doi.org/10.1016/0031-9422(94)00812-8openalex-snapshot
Stimulation of caffeine biosynthesis in suspension-cultured coffee cells and the in situ existence of 7-methylxanthosine
inferredcites →https://doi.org/10.1016/0031-9422(95)00586-2openalex-snapshot
Caffeine biosynthesis starts with the metabolically channelled formation of 7-methyl-XMP—A new hypothesis
inferredcites →https://doi.org/10.1016/0031-9422(96)00072-6openalex-snapshot
Compartmentation of caffeine and related purine alkaloids depends exclusively on the physical chemistry of their vacuolar complex formation with chlorogenic acids
inferredcites →https://doi.org/10.1016/c2009-0-03518-1openalex-snapshot
Introduction to Ecological Biochemistry
inferredcites →https://doi.org/10.1016/j.plantsci.2003.11.024openalex-snapshot
Distribution, biosynthesis and function of purine and pyridine alkaloids in Coffea arabica seedlings
inferredcites →https://doi.org/10.1016/j.plaphy.2003.07.002openalex-snapshot
Metabolism of purine bases, nucleosides and alkaloids in theobromine-forming Theobroma cacao leaves
inferredcites →https://doi.org/10.1016/s0014-5793(01)02512-1openalex-snapshot
A new caffeine biosynthetic pathway in tea leaves: utilisation of adenosine released from the S‐adenosyl‐ L ‐methionine cycle
inferredcites →https://doi.org/10.1016/s0014-5793(03)00670-7openalex-snapshot
The first committed step reaction of caffeine biosynthesis: 7‐methylxanthosine synthase is closely homologous to caffeine synthases in coffee (Coffea arabica L.)1
inferredcites →https://doi.org/10.1016/s0014-5793(03)01213-4openalex-snapshot
Inhibition of caffeine biosynthesis in tea (Camellia sinensis) and coffee (Coffea arabica) plants by ribavirin
inferredcites →https://doi.org/10.1016/s0021-9258(19)73963-5openalex-snapshot
The Biosynthesis of Caffeine in the Coffee Plant
inferredcites →https://doi.org/10.1016/s0031-9422(00)00324-1openalex-snapshot
Caffeine and theobromine in epicuticular wax of Ilex paraguariensis A. St.-Hil.
inferredcites →https://doi.org/10.1016/s0031-9422(00)81886-5openalex-snapshot
N-methyltransferases and 7-methyl-N9-nucleoside hydrolase activity in Coffea arabica and the biosynthesis of caffeine
inferredcites →https://doi.org/10.1016/s0031-9422(00)83024-1openalex-snapshot
Purine base pattern of camellia irrawadiensis
inferredcites →https://doi.org/10.1016/s0031-9422(00)86929-0openalex-snapshot
The biosynthesis of caffeine in the coffee plant
inferredcites →https://doi.org/10.1016/s0031-9422(00)89570-9openalex-snapshot
S-adenosyl-l-methionine:Theobromine 1-N-methyltransferase an enzyme catalysing the synthesis of caffeine in coffee
inferredcites →https://doi.org/10.1016/s0031-9422(00)89724-1openalex-snapshot
Biosynthesis of theobromine and caffeine in developing leaves of Coffea arabica
inferredcites →https://doi.org/10.1016/s0031-9422(00)98064-6openalex-snapshot
Formation and intracellular accumulation of caffeine and chlorogenic acid in suspension cultures of Coffea arabica
inferredcites →https://doi.org/10.1016/s0031-9422(02)00086-9openalex-snapshot
Theacrine (1,3,7,9-tetramethyluric acid) synthesis in leaves of a Chinese tea, kucha (Camellia assamica var. kucha)
inferredcites →https://doi.org/10.1016/s0031-9422(03)00372-8openalex-snapshot
Purine alkaloids in Paullinia
inferredcites →https://doi.org/10.1016/s0031-9422(96)00662-0openalex-snapshot
N-methyltransferase activities in caffeine biosynthesis: Biochemical characterization and time course during leaf development of Coffea arabica
inferredcites →https://doi.org/10.1016/s0031-9422(97)00187-8openalex-snapshot
Separation of the N-7 methyltransferase, the key enzyme in caffeine biosynthesis
inferredcites →https://doi.org/10.1016/s0031-9422(97)00975-8openalex-snapshot
Subcellular localization of the N-3 methyltransferase involved in caffeine biosynthes in tea
inferredcites →https://doi.org/10.1016/s0031-9422(98)00610-4openalex-snapshot
Effect of caffeine on shot-hole borer beetle (Xyleborusfornicatus) of tea (Camellia sinensis)
inferredcites →https://doi.org/10.1016/s0031-9422(99)00119-3openalex-snapshot
Caffeine in Citrus flowers
inferredcites →https://doi.org/10.1016/s0065-2296(08)60151-2openalex-snapshot
Compartmentation of Secondary Metabolites and Xenobiotics in Plant Vacuoles
inferredcites →https://doi.org/10.1016/s0065-2296(08)60228-1openalex-snapshot
Biosynthesis and Metabolism of Caffeine and Related Purine Alkaloids in Plants
inferredcites →https://doi.org/10.1016/s0176-1617(99)80202-8openalex-snapshot
Contribution Purine Nucleotide Biosynthesis de novo to the Formation of Caffeine in Young Tea (Camellia sinensis) Leaves
inferredcites →https://doi.org/10.1021/ja01286a030openalex-snapshot
Purines in the Plant Kingdom: The Discovery of a New Purine in Tea1
inferredcites →https://doi.org/10.1021/jf0104679openalex-snapshot
Profiles of Purine and Pyrimidine Nucleotides in Fresh and Manufactured Tea Leaves
inferredcites →https://doi.org/10.1034/j.1399-3054.1996.980325.xopenalex-snapshot
Caffeine biosynthesis in young leaves of Camellia sinensis: In vitro studies on N-methyltransferase activity involved in the conversion of xanthosine to caffeine
inferredcites →https://doi.org/10.1034/j.1399-3054.1997.1000417.xopenalex-snapshot
Metabolic fate of guanosine in higher plants
inferredcites →https://doi.org/10.1038/417915aopenalex-snapshot
Caffeine as a repellent for slugs and snails
inferredcites →https://doi.org/10.1038/423823aopenalex-snapshot
Producing decaffeinated coffee plants
inferredcites →https://doi.org/10.1042/bj1170715openalex-snapshot
Biosynthesis of caffeine in tea callus tissue
inferredcites →https://doi.org/10.1042/bj1460079openalex-snapshot
Metabolism of xanthine and hypoxanthine in the tea plant (Thea sinensis L.)
inferredcites →https://doi.org/10.1042/bj1460087openalex-snapshot
Biosynthesis of caffeine by tea-leaf extracts. Enzymic formation of theobromine from 7-methylxanthine and of caffeine from theobromine
inferredcites →https://doi.org/10.1074/jbc.m009480200openalex-snapshot
7-Methylxanthine Methyltransferase of Coffee Plants
inferredcites →https://doi.org/10.1078/0176-1617-01253openalex-snapshot
Biosynthesis, accumulation and degradation of theobromine in developing Theobroma cacao fruits
inferredcites →https://doi.org/10.1080/00021369.1985.10866823openalex-snapshot
Methylation of Xanthosine by Tea-leaf Extracts and Caffeine Biosynthesis
inferredcites →https://doi.org/10.1093/oxfordjournals.pcp.a077325openalex-snapshot
Biosynthesis of Purine Alkaloids in Camellia Plants
inferredcites →https://doi.org/10.1104/pp.111.3.747openalex-snapshot
Biosynthesis of Caffeine in Leaves of Coffee
inferredcites →https://doi.org/10.1104/pp.120.2.579openalex-snapshot
Purification and Characterization of Caffeine Synthase from Tea Leaves1
inferredcites →https://doi.org/10.1104/pp.73.4.961openalex-snapshot
Metabolic Relations between Methylxanthines and Methyluric Acids in Coffea L.
inferredcites →https://doi.org/10.1111/j.1399-3054.1986.tb01926.xopenalex-snapshot
Patterns of adenine metabolism and caffeine biosynthesis in different parts of tea seedlings
inferredcites →https://doi.org/10.1111/j.1399-3054.1996.tb05720.xopenalex-snapshot
Caffeine biosynthesis in young leaves of Camellia sinensis: In vitro studies on N‐methyltransferase activity involved in the conversion of xanthosine to caffeine
inferredcites →https://doi.org/10.1126/science.6207592openalex-snapshot
Caffeine and Related Methylxanthines: Possible Naturally Occurring Pesticides
inferredcites →https://doi.org/10.1201/9780429126789-1openalex-snapshot
Introduction to the Chemistry, Isolation, and Biosynthesis of Methylxanthines
inferredcites →https://doi.org/10.1201/9781420050134.ch1openalex-snapshot
Introduction to the Chemistry, Isolation, and Biosynthesis of Methylxanthines
inferredcites →https://doi.org/10.1271/bbb.58.1277openalex-snapshot
Guanosine Deaminase and Guanine Deaminase from Tea Leaves
inferredcites →https://doi.org/10.1271/bbb1961.52.169openalex-snapshot
N-methyl nucleosidase from tea leaves.
inferredcites →https://doi.org/10.3109/03602537708997480openalex-snapshot
Biosynthesis of Purine Nucleotides and Methylated Purines in Higher Plants
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Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Binding of caffeine with caffeic acid and chlorogenic acid using fluorescence quenching, UV/vis and FTIR spectroscopic techniques
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Purine Alkaloids, Cytokinins, and Purine-Like Neurotoxin Alkaloids
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Caffeic acid and caffeine attenuate toxicity associated with malonic or methylmalonic acid exposure in Drosophila melanogaster
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Differential regulation of caffeine metabolism in Coffea arabica (Arabica) and Coffea canephora (Robusta)
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Matcha Green Tea (Camellia sinensis) Inhibits Gamma Radiation-Induced Genotoxic Damage and Oxidative Stress Via Modulating P38 MAPK Pathway and ROS Generation in Murine Bone Marrow
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SNP in the Coffea arabica genome associated with coffee quality
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inferred← citeshttps://doi.org/10.1093/molbev/msab059openalex-snapshot
Convergent Biochemical Pathways for Xanthine Alkaloid Production in Plants Evolved from Ancestral Enzymes with Different Catalytic Properties
inferred← citeshttps://doi.org/10.1104/pp.106.094854openalex-snapshot
The Structure of Two N-Methyltransferases from the Caffeine Biosynthetic Pathway
inferred← citeshttps://doi.org/10.1107/s1744309107009268openalex-snapshot
Cloning, expression, crystallization and preliminary X-ray analysis of the XMT and DXMTN-methyltransferases fromCoffea canephora(robusta)
inferred← citeshttps://doi.org/10.1111/1755-0998.70053openalex-snapshot
A Near Telomere‐To‐Telomere Genome Assembly of Coffea arabica (Mundo Novo) Provides Insights Into Its Secondary Metabolism
inferred← citeshttps://doi.org/10.1111/j.1365-2621.2006.tb12404.xopenalex-snapshot
Rose Petal Tea as an Antioxidant‐rich Beverage: Cultivar Effects
inferred← citeshttps://doi.org/10.1111/j.1570-7458.2011.01113.xopenalex-snapshot
Induced responses of Coffea arabica to attack of Coccus viridis stimulate locomotion of the herbivore
inferred← citeshttps://doi.org/10.1111/nph.70415openalex-snapshot
A critical reassessment of the novel weapons hypothesis and allelopathy as an adaptive strategy that facilitates plant invasion
inferred← citeshttps://doi.org/10.1111/pbi.12912openalex-snapshot
Use of a draft genome of coffee (Coffea arabica) to identify SNP s associated with caffeine content
inferred← citeshttps://doi.org/10.1111/tpj.16249openalex-snapshot
The role of long‐distance mobile metabolites in the plant stress response and signaling
inferred← citeshttps://doi.org/10.1146/annurev.arplant.57.032905.105421openalex-snapshot
PYRIMIDINE AND PURINE BIOSYNTHESIS AND DEGRADATION IN PLANTS
inferred← citeshttps://doi.org/10.1177/1934578x0800300907openalex-snapshot
Biosynthesis and Catabolism of Purine Alkaloids in Camellia Plants
inferred← citeshttps://doi.org/10.1177/1934578x1501000502openalex-snapshot
Occurrence and De novo Biosynthesis of Caffeine and Theanine in Seedlings of Tea ( Camellia sinensis )
inferred← citeshttps://doi.org/10.1177/1934578x1501000503openalex-snapshot
Metabolism of Purine Alkaloids and Xanthine in Leaves of Maté ( Ilex paraguariensis )
inferred← citeshttps://doi.org/10.1177/1934578x1501000506openalex-snapshot
Unraveling the Biosynthesis of Pilocarpine in Pilocarpus microphyllus
inferred← citeshttps://doi.org/10.1177/1934578x1501000510openalex-snapshot
Short Term Effect of Caffeine on Purine, Pyrimidine and Pyridine Metabolism in Rice ( Oryza sativa ) Seedlings
inferred← citeshttps://doi.org/10.1186/1550-2783-7-5openalex-snapshot
International society of sports nutrition position stand: caffeine and performance
inferred← citeshttps://doi.org/10.1186/s12970-020-00383-4openalex-snapshot
International society of sports nutrition position stand: caffeine and exercise performance
inferred← citeshttps://doi.org/10.1186/s42269-024-01204-3openalex-snapshot
Metabolomic responses of tea [Camellia sinensis (L.) O. Kuntze] leaves to red spider mite [Oligonychus coffeae (Nietner)] and tea mosquito bug [Helopeltis theivora Waterhouse] infestation: a GC–MS-based study
inferred← citeshttps://doi.org/10.1371/journal.pone.0117328openalex-snapshot
Cytochrome P450-Dependent Metabolism of Caffeine in Drosophila melanogaster
inferred← citeshttps://doi.org/10.14214/df.308openalex-snapshot
Recovery of antifungal compounds from wood and coffee industry side-streams and residues for wood preservative formulations
inferred← citeshttps://doi.org/10.14233/ajchem.2021.23142openalex-snapshot
Brønsted Acid Catalysis in the Oxidation of Purine Based Alkaloids by Mn(VII) in Aqueous Acetonitrile and Sodium Fluoride Medium: A Kinetic Approach
inferred← citeshttps://doi.org/10.14264/uql.2019.194openalex-snapshot
Canopy position influences on gene expression and coffee quality
inferred← citeshttps://doi.org/10.1515/pac-2016-0102openalex-snapshot
Synthesis of glucopyranos-6′-yl purine and pyrimidine isonucleosides as potential cholinesterase inhibitors. Access to pyrimidine-linked pseudodisaccharides through Mitsunobu reaction
inferred← citeshttps://doi.org/10.1590/s1677-04202006000100001openalex-snapshot
Metabolism of alkaloids in coffee plants
inferred← citeshttps://doi.org/10.1590/s1677-04202006000100017openalex-snapshot
Some thoughts on the physiology of caffeine in coffee: and a glimpse of metabolite profiling
inferred← citeshttps://doi.org/10.17077/etd.qto8ggr4openalex-snapshot
Metabolism, enzymology, and genetic characterization of caffeine degradation by pseudomonas putida CBB5
inferred← citeshttps://doi.org/10.18388/abp.2004_3587openalex-snapshot
Xanthine, xanthosine and its nucleotides: solution structures of neutral and ionic forms, and relevance to substrate properties in various enzyme systems and metabolic pathways.
inferred← citeshttps://doi.org/10.20964/2018.07.66openalex-snapshot
One-pot Synthesis of Fe2O3/PEDOT/rGO Nanocomposite for Sensitive Determination of Caffeine
inferred← citeshttps://doi.org/10.2139/ssrn.5363360openalex-snapshot
Novel Metabolites Detected During Solid-State Fermentation of Colombian Specialty Coffee Using a Multiplatform Untargeted Metabolomics Approach
inferred← citeshttps://doi.org/10.26599/jfb.2026.95035451openalex-snapshot
Matcha (Japanese ground green tea) and cognitive function
inferred← citeshttps://doi.org/10.2741/1975openalex-snapshot
Metabolism and Ecology of Purine Alkaloids
inferred← citeshttps://doi.org/10.30799/jacs.s03.26120105openalex-snapshot
Spectrophotometric Assessment of Caffeine Content in Commercially Available Tea and Coffee
inferred← citeshttps://doi.org/10.3389/fnut.2023.1142971openalex-snapshot
Chemical composition and anti-cholesterol activity of tea (Camellia sinensis) flowers from albino cultivars
inferred← citeshttps://doi.org/10.3389/fphar.2022.1025591openalex-snapshot
No ambiguity: Chemosensory-based ayurvedic classification of medicinal plants can be fingerprinted using E-tongue coupled with multivariate statistical analysis
inferred← citeshttps://doi.org/10.3389/fpls.2022.1033316openalex-snapshot
Functional identification of purine permeases reveals their roles in caffeine transport in tea plants (Camellia sinensis)
inferred← citeshttps://doi.org/10.3389/fvets.2021.650531openalex-snapshot
Hepatosplenic Protective Actions of Spirulina platensis and Matcha Green Tea Against Schistosoma mansoni Infection in Mice via Antioxidative and Anti-inflammatory Mechanisms
inferred← citeshttps://doi.org/10.3390/biology12010063openalex-snapshot
Caffeine Delays Ethanol-Induced Sedation in Drosophila
inferred← citeshttps://doi.org/10.3390/ijms26041510openalex-snapshot
Progress in Methylxanthine Biosynthesis: Insights into Pathways and Engineering Strategies
inferred← citeshttps://doi.org/10.3390/molecules21080974openalex-snapshot
Structure-Bioactivity Relationships of Methylxanthines: Trying to Make Sense of All the Promises and the Drawbacks
inferred← citeshttps://doi.org/10.3390/molecules22010160openalex-snapshot
Ultrafast Electronic Deactivation Dynamics of Xanthosine Monophosphate
inferred← citeshttps://doi.org/10.3390/nano12244494openalex-snapshot
Nanoparticles in Drug Delivery: From History to Therapeutic Applications
inferred← citeshttps://doi.org/10.3390/nu10101468openalex-snapshot
Stress-Reducing Function of Matcha Green Tea in Animal Experiments and Clinical Trials
inferred← citeshttps://doi.org/10.3390/nu15102369openalex-snapshot
Testing the Anticancer Effect of Matcha Using Zebrafish as an Animal Model
inferred← citeshttps://doi.org/10.3390/ph16081067openalex-snapshot
Overview of Caffeine Effects on Human Health and Emerging Delivery Strategies
inferred← citeshttps://doi.org/10.3390/plants14071127openalex-snapshot
Low Caffeine Concentrations Induce Callus and Direct Organogenesis in Tissue Cultures of Ornithogalum dubium
inferred← citeshttps://doi.org/10.3390/textiles5020019openalex-snapshot
Biotextiles for Biomedical Applications: A Review
inferred← citeshttps://doi.org/10.3390/w17060881openalex-snapshot
Ball-Milled Spent Coffee Ground Biochar Effectively Removes Caffeine from Water
inferred← citeshttps://doi.org/10.35537/10915/52399openalex-snapshot
Extracción y bioconversión del ácido clorogénico de la yerba mate en químicos finos
inferred← citeshttps://doi.org/10.36995/j.recyt.2023.40.002openalex-snapshot
First report of pseudogenes of SABATH enzymes from xanthinesmetabolic pathway in Ilex paraguariensis
inferred← citeshttps://doi.org/10.37896/ymer21.08/41openalex-snapshot
Herbal Moieties and its effect on Parkinsonism: A New Prospective
inferred← citeshttps://doi.org/10.4141/p06-034openalex-snapshot
Neurotransmitters, neuroregulators and neurotoxins in the life of plants
inferred← citeshttps://doi.org/10.4236/ajps.2023.148057openalex-snapshot
Cellular Growth Dynamics Affects Allelopathic Activity in Coffee Cell Culture
inferred← citeshttps://doi.org/10.47749/t/unicamp.2013.917547openalex-snapshot
Teores de metilxantinas e metabolismo de cafeína em frutos de guaraná (Paullinia cupanavar. sorbilisKunth.)
inferred← citeshttps://doi.org/10.51847/md2j5bmnqfopenalex-snapshot
Comparative Antiplasmodial and Cytotoxic Activities of Coffea arabica and Coffea canephora alkaloids extracts
inferred← citeshttps://doi.org/10.51847/nutu3o3vu6openalex-snapshot
Comparative Evaluation of Antiplasmodial and Cytotoxic Activities of Alkaloid Extracts from Coffea arabica and Coffea canephora
inferred← citeshttps://doi.org/10.5216/ref.v8i3.15966openalex-snapshot
ERVA-MATE, MUITO MAIS QUE UMA TRADIÇÃO, UM VERDADEIRO POTENCIAL TERAPÊUTICO
inferred← citeshttps://doi.org/10.5539/jfr.v10n2p32openalex-snapshot
Identification of Methylxanthines and Phenolic Compounds by UPLC-DAD-ESI-MS OTOF and Antioxidant Capacities of Beans and Dark Chocolate Bars from Three Trinitario×Forastero Cocoa (Theobroma cacao L.) Hybrids
inferred← citeshttps://doi.org/10.55905/cuadv17n9-089openalex-snapshot
Ocorrência de cafeína em plantas de áreas urbanas no Noroeste Paulista
inferred← citeshttps://doi.org/10.5902/1980509830217openalex-snapshot
INFLUÊNCIA DA LUMINOSIDADE E FERTILIZANTES NOS TEORES DE METILXANTINAS E COMPOSTOS FENÓLICOS EM FOLHAS DE ERVA-MATE
Editorial review for independent work. ICSAC — the Institute for Complexity
Science and Advanced Computing — runs a structured editorial panel for researchers
publishing outside journals, and publishes on CiteStamp rails. Submission is free
and goes through ORCID: icsacinstitute.org/submit.