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Loss of mechanosensitive sclerostin may accelerate cranial bone growth and regeneration

https://doi.org/10.3171/2017.5.jns17219

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/jbmr.1807openalex-snapshot

Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading

inferredcites →https://doi.org/10.1002/jbmr.1984openalex-snapshot

Sclerostin antibody stimulates bone regeneration after experimental periodontitis

inferredcites →https://doi.org/10.1002/jbmr.2278openalex-snapshot

Mechanical Load Increases in Bone Formation via a Sclerostin-Independent Pathway

inferredcites →https://doi.org/10.1002/jbmr.2351openalex-snapshot

A Randomized, Double-Blind Phase 2 Clinical Trial of Blosozumab, a Sclerostin Antibody, in Postmenopausal Women with Low Bone Mineral Density

inferredcites →https://doi.org/10.1002/jbmr.2460openalex-snapshot

Spatiotemporal Analyses of Osteogenesis and Angiogenesis via Intravital Imaging in Cranial Bone Defect Repair

inferredcites →https://doi.org/10.1007/s00223-010-9372-1openalex-snapshot

Sclerostin: Current Knowledge and Future Perspectives

inferredcites →https://doi.org/10.1007/s00256-009-0849-9openalex-snapshot

The periosteum: what is it, where is it, and what mimics it in its absence?

inferredcites →https://doi.org/10.1007/s10856-016-5746-xopenalex-snapshot

Functional synergy of anti-mir221 and nanohydroxyapatite scaffold in bone tissue engineering of rat skull

inferredcites →https://doi.org/10.1016/j.abb.2008.02.028openalex-snapshot

The response of bone to mechanical loading and disuse: Fundamental principles and influences on osteoblast/osteocyte homeostasis

inferredcites →https://doi.org/10.1016/j.addr.2012.03.005openalex-snapshot

Bone repair cells for craniofacial regeneration

inferredcites →https://doi.org/10.1016/j.biomaterials.2010.09.035openalex-snapshot

Bone regeneration using a microstereolithography-produced customized poly(propylene fumarate)/diethyl fumarate photopolymer 3D scaffold incorporating BMP-2 loaded PLGA microspheres

inferredcites →https://doi.org/10.1016/j.biomaterials.2011.03.053openalex-snapshot

Critical-size calvarial bone defects healing in a mouse model with silk scaffolds and SATB2-modified iPSCs

inferredcites →https://doi.org/10.1016/j.bone.2005.03.018openalex-snapshot

SOST is a target gene for PTH in bone

inferredcites →https://doi.org/10.1016/j.bone.2011.07.034openalex-snapshot

High-bone-mass-producing mutations in the Wnt signaling pathway result in distinct skeletal phenotypes

inferredcites →https://doi.org/10.1016/j.bone.2014.07.033openalex-snapshot

Bone fracture healing: Cell therapy in delayed unions and nonunions

inferredcites →https://doi.org/10.1016/j.bone.2015.04.048openalex-snapshot

Sclerostin antibody treatment improves fracture outcomes in a Type I diabetic mouse model

inferredcites →https://doi.org/10.1016/j.jot.2015.08.004openalex-snapshot

Sclerostin, an emerging therapeutic target for treating osteoporosis and osteoporotic fracture: A general review

inferredcites →https://doi.org/10.1016/s0030-5898(20)30386-2openalex-snapshot

Immunologic Aspects of Bone Transplantation A Rationale for Future Studies

inferredcites →https://doi.org/10.1034/j.1399-0004.2003.00036.xopenalex-snapshot

The natural history of sclerosteosis

inferredcites →https://doi.org/10.1038/nbt958openalex-snapshot

Adipose-derived adult stromal cells heal critical-size mouse calvarial defects

inferredcites →https://doi.org/10.1038/ncb3139openalex-snapshot

The suture provides a niche for mesenchymal stem cells of craniofacial bones

inferredcites →https://doi.org/10.1038/nprot.2012.113openalex-snapshot

Evaluation of bone regeneration using the rat critical size calvarial defect

inferredcites →https://doi.org/10.1055/s-0029-1215875openalex-snapshot

Bone Grafts in Craniofacial Surgery

inferredcites →https://doi.org/10.1055/s-0029-1224777openalex-snapshot

Review of Bone Substitutes

inferredcites →https://doi.org/10.1073/pnas.1218052109openalex-snapshot

In vivo directed differentiation of pluripotent stem cells for skeletal regeneration

inferredcites →https://doi.org/10.1074/jbc.m110.153890openalex-snapshot

Distinct Modes of Inhibition by Sclerostin on Bone Morphogenetic Protein and Wnt Signaling Pathways

inferredcites →https://doi.org/10.1074/jbc.m504308200openalex-snapshot

SOST Is a Ligand for LRP5/LRP6 and a Wnt Signaling Inhibitor

inferredcites →https://doi.org/10.1074/jbc.m705092200openalex-snapshot

Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin

inferredcites →https://doi.org/10.1096/fj.14-265496openalex-snapshot

Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse model

inferredcites →https://doi.org/10.1097/00005373-197811000-00002openalex-snapshot

Fracture Healing in Weight-bearing and Nonweight-bearing Bones

inferredcites →https://doi.org/10.1097/id.0000000000000396openalex-snapshot

Effect of Resorbable Collagen Plug on Bone Regeneration in Rat Critical-Size Defect Model

inferredcites →https://doi.org/10.1155/2016/6217286openalex-snapshot

Sclerostin Antibody Therapy for the Treatment of Osteoporosis: Clinical Prospects and Challenges

inferredcites →https://doi.org/10.1203/pdr.0b013e31816bdf36openalex-snapshot

Tissue Engineering Craniofacial Defects With Adult Stem Cells? Are We Ready Yet?

inferredcites →https://doi.org/10.1242/dev.025825openalex-snapshot

BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway

inferredcites →https://doi.org/10.1359/jbmr.061002openalex-snapshot

Wnt but Not BMP Signaling Is Involved in the Inhibitory Action of Sclerostin on BMP-Stimulated Bone Formation

inferredcites →https://doi.org/10.1371/journal.pone.0053813openalex-snapshot

Load Regulates Bone Formation and Sclerostin Expression through a TGFβ-Dependent Mechanism

inferredcites →https://doi.org/10.2106/00004623-198365020-00015openalex-snapshot

Immune responses of rats to frozen bone allografts.

inferredcites →https://doi.org/10.5312/wjo.v6.i2.269openalex-snapshot

Use of demineralized bone matrix in the extremities

inferredcites →https://doi.org/10.5966/sctm.2015-0426openalex-snapshot

A Selective Cell Population from Dermis Strengthens Bone Regeneration

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.3919746openalex-extracted

inferred← citeshttps://doi.org/10.1002/jcp.31214openalex-snapshot

Mechanical strain regulates osteogenesis via Antxr1/LncRNA H19/Wnt/β‐catenin axis

inferred← citeshttps://doi.org/10.1016/j.actbio.2021.11.046openalex-snapshot

Combining sclerostin neutralization with tissue engineering: An improved strategy for craniofacial bone repair

inferred← citeshttps://doi.org/10.1016/j.bioactmat.2023.02.001openalex-snapshot

Regulating macrophage-MSC interaction to optimize BMP-2-induced osteogenesis in the local microenvironment

inferred← citeshttps://doi.org/10.1016/j.bone.2020.115491openalex-snapshot

Wnt modulation in bone healing

inferred← citeshttps://doi.org/10.1038/s41598-022-18643-5openalex-snapshot

Localized, time-dependent responses of rat cranial bone to repeated mild traumatic brain injuries

inferred← citeshttps://doi.org/10.1155/2020/7865484openalex-snapshot

Phosphodiesterase 10A Is a Mediator of Osteogenic Differentiation and Mechanotransduction in Bone Marrow-Derived Mesenchymal Stromal Cells

inferred← citeshttps://doi.org/10.1371/journal.pone.0261660openalex-snapshot

Direct visualization by FRET-FLIM of a putative mechanosome complex involving Src, Pyk2 and MBD2 in living MLO-Y4 cells

inferred← citeshttps://doi.org/10.3389/fphys.2022.893025openalex-snapshot

Spaceflight-Associated Vascular Remodeling and Gene Expression in Mouse Calvaria

inferred← citeshttps://doi.org/10.3390/ijms20010083openalex-snapshot

Anabolic Therapies in Osteoporosis and Bone Regeneration

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