On the public citation graph

DAla2-GIP-GLU-PAL Protects Against Cognitive Deficits and Pathology in APP/PS1 Mice by Inhibiting Neuroinflammation and Upregulating cAMP/PKA/CREB Signaling Pathways

https://doi.org/10.3233/jad-201262

0 signed · 82 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.

Claim with ORCID

Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.

See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/archneurol.2012.277openalex-snapshot

Plasma Signaling Proteins in Persons at Genetic Risk for Alzheimer Disease

inferredcites →https://doi.org/10.1002/hipo.22202openalex-snapshot

The neuroprotection of Rattin against amyloid β peptide in spatial memory and synaptic plasticity of rats

inferredcites →https://doi.org/10.1002/hipo.22837openalex-snapshot

A novel GLP‐1/GIP/Gcg triagonist reduces cognitive deficits and pathology in the 3xTg mouse model of Alzheimer's disease

inferredcites →https://doi.org/10.1007/s00125-017-4447-4openalex-snapshot

GIP(3-30)NH2 is an efficacious GIP receptor antagonist in humans: a randomised, double-blinded, placebo-controlled, crossover study

inferredcites →https://doi.org/10.1007/s11011-017-0059-4openalex-snapshot

Beneficial effects of liraglutide (GLP1 analog) in the hippocampal inflammation

inferredcites →https://doi.org/10.1007/s12264-016-0041-xopenalex-snapshot

[Gly14]-Humanin Protects Against Amyloid β Peptide-Induced Impairment of Spatial Learning and Memory in Rats

inferredcites →https://doi.org/10.1007/s13311-019-00770-zopenalex-snapshot

Cyclooxygenase-2 Induced the β-Amyloid Protein Deposition and Neuronal Apoptosis Via Upregulating the Synthesis of Prostaglandin E2 and 15-Deoxy-Δ12,14-prostaglandin J2

inferredcites →https://doi.org/10.1016/j.bbagen.2013.03.011openalex-snapshot

A novel acylated form of (d-Ala2)GIP with improved antidiabetic potential, lacking effect on body fat stores

inferredcites →https://doi.org/10.1016/j.bbrc.2012.01.081openalex-snapshot

Regulation of NF-κB activity in astrocytes: effects of flavonoids at dietary-relevant concentrations

inferredcites →https://doi.org/10.1016/j.bcp.2017.02.012openalex-snapshot

GIP(3–30)NH2 is a potent competitive antagonist of the GIP receptor and effectively inhibits GIP-mediated insulin, glucagon, and somatostatin release

inferredcites →https://doi.org/10.1016/j.bcp.2018.07.021openalex-snapshot

Novel dual incretin agonist peptide with antidiabetic and neuroprotective potential

inferredcites →https://doi.org/10.1016/j.brainres.2017.10.012openalex-snapshot

Neuroprotective effects of a triple GLP-1/GIP/glucagon receptor agonist in the APP/PS1 transgenic mouse model of Alzheimer's disease

inferredcites →https://doi.org/10.1016/j.dsx.2016.01.021openalex-snapshot

Shared links between type 2 diabetes mellitus and Alzheimer's disease: A review

inferredcites →https://doi.org/10.1016/j.ejphar.2011.11.007openalex-snapshot

Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice

inferredcites →https://doi.org/10.1016/j.ejphar.2016.11.050openalex-snapshot

D-Ala2-GIP-glu-PAL is neuroprotective in a chronic Parkinson's disease mouse model and increases BNDF expression while reducing neuroinflammation and lipid peroxidation

inferredcites →https://doi.org/10.1016/j.ejphar.2017.06.029openalex-snapshot

A novel GLP-1/GIP dual agonist is more effective than liraglutide in reducing inflammation and enhancing GDNF release in the MPTP mouse model of Parkinson's disease

inferredcites →https://doi.org/10.1016/j.intimp.2019.02.053openalex-snapshot

Indirubin-3′-monoxime prevents aberrant activation of GSK-3β/NF-κB and alleviates high fat-high fructose induced Aβ-aggregation, gliosis and apoptosis in mice brain

inferredcites →https://doi.org/10.1016/j.jalz.2016.01.012openalex-snapshot

Molecular genetics of early‐onset Alzheimer's disease revisited

inferredcites →https://doi.org/10.1016/j.jchemneu.2011.05.014openalex-snapshot

Neuropsin—A possible modulator of synaptic plasticity

inferredcites →https://doi.org/10.1016/j.neurobiolaging.2008.04.002openalex-snapshot

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

inferredcites →https://doi.org/10.1016/j.neurobiolaging.2012.04.009openalex-snapshot

Liraglutide protects against amyloid-β protein-induced impairment of spatial learning and memory in rats

inferredcites →https://doi.org/10.1016/j.neuropharm.2015.10.002openalex-snapshot

Neuroprotective effects of a GIP analogue in the MPTP Parkinson's disease mouse model

inferredcites →https://doi.org/10.1016/j.neuropharm.2018.01.040openalex-snapshot

Novel dual GLP-1/GIP receptor agonists show neuroprotective effects in Alzheimer's and Parkinson's disease models

inferredcites →https://doi.org/10.1016/j.nrl.2012.12.007openalex-snapshot

Astrocitos en las enfermedades neurodegenerativas (I): función y caracterización molecular

inferredcites →https://doi.org/10.1016/j.nrleng.2014.12.005openalex-snapshot

Astrocytes in neurodegenerative diseases (I): function and molecular description

inferredcites →https://doi.org/10.1016/j.yhbeh.2015.06.013openalex-snapshot

Leptin attenuates the detrimental effects of β-amyloid on spatial memory and hippocampal later-phase long term potentiation in rats

inferredcites →https://doi.org/10.1016/s0168-8227(11)70011-0openalex-snapshot

Incretin effect: GLP-1, GIP, DPP4

inferredcites →https://doi.org/10.1017/s1461145711000149openalex-snapshot

Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease

inferredcites →https://doi.org/10.1038/nn.2785openalex-snapshot

Aβ1–42 inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β

inferredcites →https://doi.org/10.1038/nrd2896openalex-snapshot

Alzheimer's disease: strategies for disease modification

inferredcites →https://doi.org/10.1038/s41598-019-41114-3openalex-snapshot

Jujuboside A prevents sleep loss-induced disturbance of hippocampal neuronal excitability and memory impairment in young APP/PS1 mice

inferredcites →https://doi.org/10.1042/bst20140016openalex-snapshot

Insulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseases

inferredcites →https://doi.org/10.1097/fbp.0b013e32833c8544openalex-snapshot

Role of the glucose-dependent insulinotropic polypeptide and its receptor in the central nervous system: therapeutic potential in neurological diseases

inferredcites →https://doi.org/10.1111/ejn.12710openalex-snapshot

Tumor necrosis factor‐alpha mediates activation of NF ‐κB and JNK signaling cascades in retinal ganglion cells and astrocytes in opposite ways

inferredcites →https://doi.org/10.1111/jpi.12470openalex-snapshot

Melatonin ameliorates Aβ42‐induced alteration of β APP ‐processing secretases via the melatonin receptor through the Pin1/ GSK 3β/ NF ‐κB pathway in SH ‐ SY 5Y cells

inferredcites →https://doi.org/10.1126/sciadv.aav0316openalex-snapshot

Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer’s disease

inferredcites →https://doi.org/10.1152/jn.00866.2010openalex-snapshot

Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis

inferredcites →https://doi.org/10.1152/jn.01161.2007openalex-snapshot

Protease-Resistant Glucose-Dependent Insulinotropic Polypeptide Agonists Facilitate Hippocampal LTP and Reverse the Impairment of LTP Induced by Beta-Amyloid

inferredcites →https://doi.org/10.1155/2015/985845openalex-snapshot

Diabetes and Alzheimer Disease, Two Overlapping Pathologies with the Same Background: Oxidative Stress

inferredcites →https://doi.org/10.1155/2018/3128758openalex-snapshot

Immunosenescence of Natural Killer Cells, Inflammation, and Alzheimer’s Disease

inferredcites →https://doi.org/10.1172/jci59903openalex-snapshot

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

inferredcites →https://doi.org/10.1186/alzrt174openalex-snapshot

Neuroprotective effects of D-Ala2GIP on Alzheimer's disease biomarkers in an APP/PS1 mouse model

inferredcites →https://doi.org/10.1186/alzrt182openalex-snapshot

Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease

inferredcites →https://doi.org/10.1186/s12974-017-1027-yopenalex-snapshot

Inhibition of cyclin-dependent kinase 5 affects early neuroinflammatory signalling in murine model of amyloid beta toxicity

inferredcites →https://doi.org/10.1210/en.136.8.3585openalex-snapshot

Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV

inferredcites →https://doi.org/10.1523/jneurosci.4920-04.2005openalex-snapshot

Glucose-Dependent Insulinotropic Polypeptide Is Expressed in Adult Hippocampus and Induces Progenitor Cell Proliferation

inferredcites →https://doi.org/10.2174/157488910791213130openalex-snapshot

Incretin Analogues that have been Developed to Treat Type 2 Diabetes Hold Promise as a Novel Treatment Strategy for Alzheimers Disease

inferredcites →https://doi.org/10.2337/db17-0480openalex-snapshot

The Gluco- and Liporegulatory and Vasodilatory Effects of Glucose-Dependent Insulinotropic Polypeptide (GIP) Are Abolished by an Antagonist of the Human GIP Receptor

inferredcites →https://doi.org/10.3233/jad-121888openalex-snapshot

D-Ala2GIP Facilitated Synaptic Plasticity and Reduces Plaque Load in Aged Wild Type Mice and in an Alzheimer's Disease Mouse Model

inferredcites →https://doi.org/10.3233/jad-140375openalex-snapshot

Apolipoprotein E4 Impairs in vivo Hippocampal Long-Term Synaptic Plasticity by Reducing the Phosphorylation of CaMKIIα and CREB

inferredcites →https://doi.org/10.3233/jad-141791openalex-snapshot

Long-Acting Intranasal Insulin Detemir Improves Cognition for Adults with Mild Cognitive Impairment or Early-Stage Alzheimer's Disease Dementia

inferredcites →https://doi.org/10.3389/fgene.2014.00088openalex-snapshot

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

inferredcites →https://doi.org/10.3390/nu7095341openalex-snapshot

Shared Neuropathological Characteristics of Obesity, Type 2 Diabetes and Alzheimer’s Disease: Impacts on Cognitive Decline

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4610828openalex-extracted

Correlation Study of 5-Ht in Brain with Cognitive Function and Anxious Behavior in App/Ps1 Gene Mice

inferred← citeshttps://doi.org/10.1002/9781119824701.ch09openalex-snapshot

Incretins and Development of Incretin‐based Therapeutics

inferred← citeshttps://doi.org/10.1007/s00221-023-06749-9openalex-snapshot

Effects of exercise-targeted hippocampal PDE-4 methylation on synaptic plasticity and spatial learning/memory impairments in D-galactose-induced aging rats

inferred← citeshttps://doi.org/10.1007/s11481-023-10085-8openalex-snapshot

5-HT4 Receptor is Protective for MPTP-induced Parkinson’s Disease Mice Via Altering Gastrointestinal Motility or Gut Microbiota

inferred← citeshttps://doi.org/10.1007/s12020-024-04013-wopenalex-snapshot

Tirzepatide administration improves cognitive impairment in HFD mice by regulating the SIRT3-NLRP3 axis

inferred← citeshttps://doi.org/10.1007/s41105-025-00581-0openalex-snapshot

Correlation study of 5-HT in brain with cognitive function and anxious-like behavior in APP/PS1 transgene mice

inferred← citeshttps://doi.org/10.1016/j.cnd.2025.12.005openalex-snapshot

GIP. Le retour en grâce

inferred← citeshttps://doi.org/10.1016/j.cnd.2026.01.001openalex-snapshot

GIP is back

inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e27161openalex-snapshot

Scutellaria baicalensis Georgi stems and leaves flavonoids promote neuroregeneration and ameliorate memory loss in rats through cAMP-PKA-CREB signaling pathway based on network pharmacology and bioinformatics analysis

inferred← citeshttps://doi.org/10.1016/j.molmet.2025.102118openalex-snapshot

Glucose-dependent insulinotropic polypeptide (GIP)

inferred← citeshttps://doi.org/10.1016/j.neulet.2026.138680openalex-snapshot

DAla2-GIP-Glu-PAL exerts neuroprotective effect on diabetic retinopathy by attenuating microglia activation and regulating NF-κB/NLRP3 and Nrf2/HO-1 pathways

inferred← citeshttps://doi.org/10.1016/j.neuroscience.2026.01.038openalex-snapshot

Therapeutic efficacy of synthetic analogues of gut hormones in a mouse model of Alzheimer’s disease

inferred← citeshttps://doi.org/10.1038/s41574-022-00783-3openalex-snapshot

Beyond the pancreas: contrasting cardiometabolic actions of GIP and GLP1

inferred← citeshttps://doi.org/10.1039/d5fo03139gopenalex-snapshot

The intricate microbial–gut–brain axis in Alzheimer's disease: a review of microbiota-targeted strategies

inferred← citeshttps://doi.org/10.1080/13880209.2023.2291689openalex-snapshot

Potential mechanism of Qinggong Shoutao pill alleviating age-associated memory decline based on integration strategy

inferred← citeshttps://doi.org/10.1111/cns.13807openalex-snapshot

Inhibition of phosphodiesterase‐4 in the spinal dorsal horn ameliorates neuropathic pain via cAMP‐cytokine‐Cx43 signaling in mice

inferred← citeshttps://doi.org/10.1155/2022/8694462openalex-snapshot

Electroacupuncture Enhances Neuroplasticity by Regulating the Orexin A‐Mediated cAMP/PKA/CREB Signaling Pathway in Senescence‐Accelerated Mouse Prone 8 (SAMP8) Mice

inferred← citeshttps://doi.org/10.1177/13872877241304673openalex-snapshot

Association of dipeptidyl peptidase-4 with Alzheimer's disease: A new therapeutic prospect

inferred← citeshttps://doi.org/10.1186/s13195-025-01869-6openalex-snapshot

Dual PDE4/10A inhibition restores CREB1 function and enhances neuronal resilience in models of alzheimer's disease

inferred← citeshttps://doi.org/10.21203/rs.3.rs-2028233/v1openalex-snapshot

Potential Mechanism of Qinggong Shoutao Pill Alleviates Age-associated Memory Decline in D-Galactose-Injured Mice Based on Network Pharmacology, Molecular Docking, and Experimental Verification Integration Strategy

inferred← citeshttps://doi.org/10.2147/dddt.s399183openalex-snapshot

Integrating Network Pharmacology, Molecular Docking and Pharmacological Evaluation for Exploring the Polyrhachis vicina Rogers in Ameliorating Depression

inferred← citeshttps://doi.org/10.2147/dddt.s542074openalex-snapshot

Zhinao Capsule Improved Sleep and Memory Disorders in APP/PS1 Mice via cAMP/PKA/CREB Signaling Pathway Modulation

inferred← citeshttps://doi.org/10.2147/dmso.s559587openalex-snapshot

Revitalizing GIP: Therapeutic Potential in Metabolic and Neurodegenerative Disorders

inferred← citeshttps://doi.org/10.3233/jad-210256openalex-snapshot

A GLP-1/GIP Dual Receptor Agonist DA4-JC Effectively Attenuates Cognitive Impairment and Pathology in the APP/PS1/Tau Model of Alzheimer’s Disease1

inferred← citeshttps://doi.org/10.3233/jad-240069openalex-snapshot

Conquering Insulin Network Dysfunctions in Alzheimer’s Disease: Where Are We Today?

inferred← citeshttps://doi.org/10.3389/fnins.2026.1759500openalex-snapshot

Moxa-combustion byproducts improve cognitive function via olfactory-mediated modulation of the GSK-3β/CREB pathway

inferred← citeshttps://doi.org/10.3389/fphar.2024.1361651openalex-snapshot

Neuroprotective effects of dipeptidyl peptidase 4 inhibitor on Alzheimer’s disease: a narrative review

inferred← citeshttps://doi.org/10.3390/ijms26052121openalex-snapshot

Therapeutic Mechanisms of Medicine Food Homology Plants in Alzheimer’s Disease: Insights from Network Pharmacology, Machine Learning, and Molecular Docking

inferred← citeshttps://doi.org/10.3390/pharmaceutics15082052openalex-snapshot

Therapeutic Strategies Aimed at Improving Neuroplasticity in Alzheimer Disease

Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.