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Combinatorial Effect of ARTP Mutagenesis and Ribosome Engineering on an Industrial Strain of Streptomyces albus S12 for Enhanced Biosynthesis of Salinomycin

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/anie.201503561openalex-snapshot
Formation of the Δ18,19 Double Bond and Bis(spiroacetal) in Salinomycin Is Atypically Catalyzed by SlnM, a Methyltransferase‐like Enzyme
inferredcites →https://doi.org/10.1002/bab.1525openalex-snapshot
Characterization of a cold‐adapted esterase and mutants from a psychotolerant Pseudomonas sp. strain
inferredcites →https://doi.org/10.1002/cbic.201100590openalex-snapshot
A Late‐Stage Intermediate in Salinomycin Biosynthesis Is Revealed by Specific Mutation in the Biosynthetic Gene Cluster
inferredcites →https://doi.org/10.1002/cbic.201402300openalex-snapshot
Site‐Specific Modification of the Anticancer and Antituberculosis Polyether Salinomycin by Biosynthetic Engineering
inferredcites →https://doi.org/10.1002/cbic.201490049openalex-snapshot
Inside Cover: Site‐Specific Modification of the Anticancer and Antituberculosis Polyether Salinomycin by Biosynthetic Engineering (ChemBioChem 14/2014)
inferredcites →https://doi.org/10.1007/978-3-662-45657-6_14openalex-snapshot
Breeding High Producers of Enduracidin from Streptomyces fungicidicus by Combination of Various Mutation Treatments
inferredcites →https://doi.org/10.1007/s00034-004-1208-7openalex-snapshot
Stability and Performance of Single-Bit Sigma-Delta Modulators Operated in Quasi-Sliding Mode
inferredcites →https://doi.org/10.1007/s00253-011-3619-2openalex-snapshot
The ECF sigma factor SigT regulates actinorhodin production in response to nitrogen stress in Streptomyces coelicolor
inferredcites →https://doi.org/10.1007/s00253-014-5755-yopenalex-snapshot
Atmospheric and room temperature plasma (ARTP) as a new powerful mutagenesis tool
inferredcites →https://doi.org/10.1007/s00253-014-5759-7openalex-snapshot
An extracytoplasmic function sigma factor, σ25, differentially regulates avermectin and oligomycin biosynthesis in Streptomyces avermitilis
inferredcites →https://doi.org/10.1007/s00253-014-5878-1openalex-snapshot
GlnR-mediated regulation of nitrogen metabolism in the actinomycete Saccharopolyspora erythraea
inferredcites →https://doi.org/10.1007/s00253-014-5970-6openalex-snapshot
Combined application of plasma mutagenesis and gene engineering leads to 5-oxomilbemycins A3/A4 as main components from Streptomyces bingchenggensis
inferredcites →https://doi.org/10.1007/s00253-016-7918-5openalex-snapshot
SlnR is a positive pathway-specific regulator for salinomycin biosynthesis in Streptomyces albus
inferredcites →https://doi.org/10.1007/s00253-017-8658-xopenalex-snapshot
Enhanced avermectin production by Streptomyces avermitilis ATCC 31267 using high-throughput screening aided by fluorescence-activated cell sorting
inferredcites →https://doi.org/10.1007/s00438-004-0982-zopenalex-snapshot
The novel mutation K87E in ribosomal protein S12 enhances protein synthesis activity during the late growth phase in Escherichia coli
inferredcites →https://doi.org/10.1007/s11274-016-2156-7openalex-snapshot
Highly improved acarbose production of Actinomyces through the combination of ARTP and penicillin susceptible mutant screening
inferredcites →https://doi.org/10.1007/s12010-014-0765-xopenalex-snapshot
Direct Fermentation of Gelatinized Cassava Starch to Acetone, Butanol, and Ethanol Using Clostridium acetobutylicum Mutant Obtained by Atmospheric and Room Temperature Plasma
inferredcites →https://doi.org/10.1007/s13213-015-1039-8openalex-snapshot
Improved ε-poly-l-lysine production of Streptomyces sp. FEEL-1 by atmospheric and room temperature plasma mutagenesis and streptomycin resistance screening
inferredcites →https://doi.org/10.1016/0022-2836(88)90517-7openalex-snapshot
Mapping and sequencing of mutations in the Escherichia colirpoB gene that lead to rifampicin resistance
inferredcites →https://doi.org/10.1016/j.bbrc.2010.03.138openalex-snapshot
Salinomycin overcomes ABC transporter-mediated multidrug and apoptosis resistance in human leukemia stem cell-like KG-1a cells
inferredcites →https://doi.org/10.1016/j.biortech.2017.05.039openalex-snapshot
Improving of lipid productivity of the oleaginous microalgae Chlorella pyrenoidosa via atmospheric and room temperature plasma (ARTP)
inferredcites →https://doi.org/10.1016/j.ymben.2016.02.012openalex-snapshot
Enhanced salinomycin production by adjusting the supply of polyketide extender units in Streptomyces albus
inferredcites →https://doi.org/10.1016/s0065-2164(04)56005-7openalex-snapshot
Ribosome Engineering and Secondary Metabolite Production
inferredcites →https://doi.org/10.1038/s41598-018-32341-1openalex-snapshot
Multi-omics integrative analysis with genome-scale metabolic model simulation reveals global cellular adaptation of Aspergillus niger under industrial enzyme production condition
inferredcites →https://doi.org/10.1073/pnas.0501170102openalex-snapshot
DksA potentiates direct activation of amino acid promoters by ppGpp
inferredcites →https://doi.org/10.1073/pnas.1019383108openalex-snapshot
Direct regulation of Escherichia coli ribosomal protein promoters by the transcription factors ppGpp and DksA
inferredcites →https://doi.org/10.1073/pnas.1216691110openalex-snapshot
Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis
inferredcites →https://doi.org/10.1073/pnas.1522179113openalex-snapshot
ppGpp negatively impacts ribosome assembly affecting growth and antimicrobial tolerance in Gram-positive bacteria
inferredcites →https://doi.org/10.1074/jbc.m309925200openalex-snapshot
RNA Polymerase Mutation Activates the Production of a Dormant Antibiotic 3,3′-Neotrehalosadiamine via an Autoinduction Mechanism in Bacillus subtilis
inferredcites →https://doi.org/10.1099/mic.0.26811-0openalex-snapshot
Two relA/spoT homologous genes are involved in the morphological and physiological differentiation of Streptomyces clavuligerus
inferredcites →https://doi.org/10.1111/j.1365-2672.2009.04483.xopenalex-snapshot
Novel mutation breeding method forStreptomyces avermitilisusing an atmospheric pressure glow discharge plasma
inferredcites →https://doi.org/10.1111/j.1365-2958.2006.05285.xopenalex-snapshot
Increased expression of ribosome recycling factor is responsible for the enhanced protein synthesis during the late growth phase in an antibiotic‐overproducing Streptomyces coelicolor ribosomal rpsL mutant
inferredcites →https://doi.org/10.1111/j.1365-2958.2007.06072.xopenalex-snapshot
ppGpp and DksA likely regulate the activity of the extracytoplasmic stress factor σE in Escherichia coli by both direct and indirect mechanisms
inferredcites →https://doi.org/10.1111/mmi.12080openalex-snapshot
Identification of two‐component system AfsQ1/Q2 regulon and its cross‐regulation with GlnR in S treptomyces coelicolor
inferredcites →https://doi.org/10.1111/mmi.13412openalex-snapshot
The magic dance of the alarmones (p)ppGpp
inferredcites →https://doi.org/10.1128/aac.41.3.523openalex-snapshot
Characterization of the potent in vitro and in vivo antimalarial activities of ionophore compounds
inferredcites →https://doi.org/10.1128/aac.42.8.2041openalex-snapshot
Acquisition of Certain Streptomycin-Resistant (str) Mutations Enhances Antibiotic Production in Bacteria
inferredcites →https://doi.org/10.1128/aem.06701-11openalex-snapshot
Cloning and Characterization of the Polyether Salinomycin Biosynthesis Gene Cluster of Streptomyces albus XM211
inferredcites →https://doi.org/10.1128/aem.69.11.6412-6417.2003openalex-snapshot
Innovative Approach for Improvement of an Antibiotic-Overproducing Industrial Strain of Streptomyces albus
inferredcites →https://doi.org/10.1128/aem.72.1.71-77.2006openalex-snapshot
Improvement of α-Amylase Production by Modulation of Ribosomal Component Protein S12 in Bacillus subtilis 168
inferredcites →https://doi.org/10.1128/jb.01981-05openalex-snapshot
Growth Phase-Dependent Regulation of the Extracytoplasmic Stress Factor, σ E , by Guanosine 3′,5′-Bispyrophosphate (ppGpp)
inferredcites →https://doi.org/10.1128/jb.178.24.7276-7284.1996openalex-snapshot
Induction of actinorhodin production by rpsL (encoding ribosomal protein S12) mutations that confer streptomycin resistance in Streptomyces lividans and Streptomyces coelicolor A3(2)
inferredcites →https://doi.org/10.1146/annurev-biochem-062917-011942openalex-snapshot
Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design
inferredcites →https://doi.org/10.1186/1471-2407-12-556openalex-snapshot
Salinomycin induces cell death and differentiation in head and neck squamous cell carcinoma stem cells despite activation of epithelial-mesenchymal transition and Akt
inferredcites →https://doi.org/10.1371/journal.pgen.1007514openalex-snapshot
Regulation of the opposing (p)ppGpp synthetase and hydrolase activities in a bifunctional RelA/SpoT homologue from Staphylococcus aureus
inferredcites →https://doi.org/10.1371/journal.pone.0001573openalex-snapshot
The Extracytoplasmic Stress Factor, σE, Is Required to Maintain Cell Envelope Integrity in Escherichia coli
inferredcites →https://doi.org/10.1371/journal.pone.0077046openalex-snapshot
Rapid Mutation of Spirulina platensis by a New Mutagenesis System of Atmospheric and Room Temperature Plasmas (ARTP) and Generation of a Mutant Library with Diverse Phenotypes
inferredcites →https://doi.org/10.3389/fmicb.2018.00312openalex-snapshot
The SCO4117 ECF Sigma Factor Pleiotropically Controls Secondary Metabolism and Morphogenesis in Streptomyces coelicolor

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4660724openalex-extracted
inferred← citeshttps://doi.org/10.1007/s00253-022-11983-2openalex-snapshot
ARTP and NTG compound mutations improved Cry protein production and virulence of Bacillus thuringiensis X023
inferred← citeshttps://doi.org/10.1007/s00284-025-04317-8openalex-snapshot
Ribosome Engineering for Enhanced Butenyl-Spinosyn Production in Saccharopolyspora pogona
inferred← citeshttps://doi.org/10.1007/s00449-026-03327-5openalex-snapshot
Enhancing ε-poly-l-lysine production in Streptomyces albulus through tea polyphenols addition
inferred← citeshttps://doi.org/10.1007/s11274-021-03191-3openalex-snapshot
Avilamycin production enhancement by mutagenesis and fermentation optimization in Streptomyces viridochromogenes
inferred← citeshttps://doi.org/10.1007/s11274-026-04931-zopenalex-snapshot
Construction of engineered Streptomyces albulus by increasing ATP and NADH supply and efficient production of ε-poly-L-lysine from sweet potato powder
inferred← citeshttps://doi.org/10.1007/s12010-020-03357-zopenalex-snapshot
Role of a Two-Component Signal Transduction System RspA1/A2 in Regulating the Biosynthesis of Salinomycin in Streptomyces albus
inferred← citeshttps://doi.org/10.1007/s12033-020-00246-yopenalex-snapshot
Engineering the Translational Machinery for Biotechnology Applications
inferred← citeshttps://doi.org/10.1007/s12033-024-01231-5openalex-snapshot
Research Progress of ARTP Mutagenesis Technology Based on Citespace Visualization Analysis
inferred← citeshttps://doi.org/10.1007/s12035-024-04665-9openalex-snapshot
Diagnostic Value of IL-4, IL-10, and Neutrophil/Lymphocyte Ratio in Febrile Seizures During Viral Epidemic Period
inferred← citeshttps://doi.org/10.1016/j.bej.2024.109371openalex-snapshot
Improved expression of Cerrena unicolor Laccase in Aspergillus niger via combined strategies and its applications
inferred← citeshttps://doi.org/10.1016/j.biortech.2024.131123openalex-snapshot
Combinatorial strain improvement and bioprocess development for efficient production of ε-poly-L-lysine in Streptomyces albulus
inferred← citeshttps://doi.org/10.1016/j.fuel.2025.134343openalex-snapshot
Atmospheric and room temperature plasma treatment to improve methanol tolerance and catalytic activity of Mucor circinelloides for one-step biodiesel production
inferred← citeshttps://doi.org/10.1016/j.gene.2024.148837openalex-snapshot
Application and research progress of ARTP mutagenesis in actinomycetes breeding
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2025.09.017openalex-snapshot
Enhancement of natamycin production in Streptomyces gilvosporeus through heavy ion beam mutagenesis and global transcription machinery engineering
inferred← citeshttps://doi.org/10.1016/j.pestbp.2020.104732openalex-snapshot
Screening of Beauveria bassiana with high biocontrol potential based on ARTP mutagenesis and high-throughput FACS
inferred← citeshttps://doi.org/10.1016/j.procbio.2025.06.014openalex-snapshot
Effect of exogenous combinations of fatty acids on the production of monensin by Streptomyces cinnamonensis
inferred← citeshttps://doi.org/10.1016/j.synbio.2025.06.002openalex-snapshot
Improving fidaxomicin production through ARTP mutagenesis and fermentation optimization in Actinoplanes deccanensis
inferred← citeshttps://doi.org/10.1016/j.tibtech.2020.01.001openalex-snapshot
High-Throughput Screening Technology in Industrial Biotechnology
inferred← citeshttps://doi.org/10.1038/s41429-023-00636-9openalex-snapshot
Constitutive and high gene expression in the diaminopimelate pathway accelerates ε-poly-l-lysine production in Streptomyces albulus
inferred← citeshttps://doi.org/10.1038/s41598-022-14199-6openalex-snapshot
Comparative genomic analysis of Streptomyces rapamycinicus NRRL 5491 and its mutant overproducing rapamycin
inferred← citeshttps://doi.org/10.1042/ebc20250018openalex-snapshot
Translation as a regulatory hub for secondary metabolism in Streptomyces spp.
inferred← citeshttps://doi.org/10.1093/jambio/lxad230openalex-snapshot
Daptomycin production enhancement by ARTP mutagenesis and fermentation optimization in Streptomyces roseosporus
inferred← citeshttps://doi.org/10.1093/jambio/lxaf014openalex-snapshot
Unconventional approaches for the induction of microbial natural products
inferred← citeshttps://doi.org/10.1093/jimb/kuac030openalex-snapshot
Improvement of rimocidin production in Streptomyces rimosus M527 by reporter-guided mutation selection
inferred← citeshttps://doi.org/10.1111/1751-7915.13686openalex-snapshot
Reconstitution of a mini‐gene cluster combined with ribosome engineering led to effective enhancement of salinomycin production in Streptomyces albus
inferred← citeshttps://doi.org/10.1186/s12934-022-01953-8openalex-snapshot
Transcriptomic and metabolomic analyses for providing insights into the influence of polylysine synthetase on the metabolism of Streptomyces albulus
inferred← citeshttps://doi.org/10.1186/s12934-023-02215-xopenalex-snapshot
Systems biology of industrial oxytetracycline production in Streptomyces rimosus: the secrets of a mutagenized hyperproducer
inferred← citeshttps://doi.org/10.1186/s12934-024-02628-2openalex-snapshot
Metabolic engineering approaches for the biosynthesis of antibiotics
inferred← citeshttps://doi.org/10.1186/s12934-025-02873-zopenalex-snapshot
Advances in high-throughput mutation breeding systems integrating atmospheric and room-temperature plasma (ARTP) with droplet-based microfluidics
inferred← citeshttps://doi.org/10.3389/fbioe.2021.748976openalex-snapshot
Epsilon-poly-L-lysine: Recent Advances in Biomanufacturing and Applications
inferred← citeshttps://doi.org/10.3389/fbioe.2022.1066651openalex-snapshot
Engineering the glyoxylate cycle for chemical bioproduction
inferred← citeshttps://doi.org/10.3389/fbioe.2023.1329859openalex-snapshot
Mechanistic insight for improving butenyl-spinosyn production through combined ARTP/UV mutagenesis and ribosome engineering in Saccharopolyspora pogona
inferred← citeshttps://doi.org/10.3389/fmicb.2020.01658openalex-snapshot
Two-Component-System RspA1/A2-Dependent Regulation on Primary Metabolism in Streptomyces albus A30 Cultivated With Glutamate as the Sole Nitrogen Source
inferred← citeshttps://doi.org/10.3389/fmicb.2024.1328321openalex-snapshot
Metabolic perturbation of Streptomyces albulus by introducing NADP-dependent glyceraldehyde 3-phosphate dehydrogenase
inferred← citeshttps://doi.org/10.3389/fmicb.2025.1561042openalex-snapshot
Improving butenyl-spinosyn production in Saccharopolyspora pogona through combination of metabolic engineering and medium optimization
inferred← citeshttps://doi.org/10.3390/cimb45080408openalex-snapshot
Application of Atmospheric and Room-Temperature Plasma (ARTP) to Microbial Breeding
inferred← citeshttps://doi.org/10.3390/fermentation9040398openalex-snapshot
Enhanced Pentostatin Production in Actinomadura sp. by Combining ARTP Mutagenesis, Ribosome Engineering and Subsequent Fermentation Optimization
inferred← citeshttps://doi.org/10.3390/foods13223624openalex-snapshot
Efficacy and Molecular Mechanisms of Nystatin Against Botrytis cinerea on Postharvest Table Grape
inferred← citeshttps://doi.org/10.3390/foods14071260openalex-snapshot
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inferred← citeshttps://doi.org/10.4014/jmb.2210.10023openalex-snapshot
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inferred← citeshttps://doi.org/10.6084/m9.figshare.21430779openalex-snapshot
Additional file 1 of Transcriptomic and metabolomic analyses for providing insights into the influence of polylysine synthetase on the metabolism of Streptomyces albulus
inferred← citeshttps://doi.org/10.6084/m9.figshare.26633535openalex-snapshot
Additional file 1 of Systems biology of industrial oxytetracycline production in Streptomyces rimosus: the secrets of a mutagenized hyperproducer
inferred← citeshttps://doi.org/10.6084/m9.figshare.26633538openalex-snapshot
Additional file 2 of Systems biology of industrial oxytetracycline production in Streptomyces rimosus: the secrets of a mutagenized hyperproducer
inferred← citeshttps://doi.org/10.6084/m9.figshare.26633541openalex-snapshot
Additional file 3 of Systems biology of industrial oxytetracycline production in Streptomyces rimosus: the secrets of a mutagenized hyperproducer
inferred← citeshttps://doi.org/10.61187/ita.v2i2.130openalex-snapshot
Modification and Screening of Antibiotic-producing Strains
inferred← citeshttps://doi.org/10.7287/peerj.13076v0.1/reviews/1openalex-snapshot
Peer Review #1 of "Mutation breeding of Aspergillus niger by atmospheric room temperature plasma to enhance phosphorus solubilization ability (v0.1)"
inferred← citeshttps://doi.org/10.7287/peerj.13076v0.1/reviews/2openalex-snapshot
Peer Review #2 of "Mutation breeding of Aspergillus niger by atmospheric room temperature plasma to enhance phosphorus solubilization ability (v0.1)"
inferred← citeshttps://doi.org/10.7717/peerj.13076openalex-snapshot
Mutation breeding of Aspergillus niger by atmospheric room temperature plasma to enhance phosphorus solubilization ability
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