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Isorhynchophylline Ameliorates Cerebral Ischemia/Reperfusion Injury by Inhibiting CX3CR1-Mediated Microglial Activation and Neuroinflammation

https://doi.org/10.3389/fphar.2021.574793

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/glia.22474openalex-snapshot

CX3CR1 deficiency induces an early protective inflammatory environment in ischemic mice

inferredcites →https://doi.org/10.1002/jnr.20891openalex-snapshot

Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's β-amyloid proteins

inferredcites →https://doi.org/10.1007/s00467-006-0411-0openalex-snapshot

Aquaporin-4 and brain edema

inferredcites →https://doi.org/10.1007/s007010070027openalex-snapshot

Reduction of Edema and Infarction by Memantine and MK-801 After Focal Cerebral Ischaemia and Reperfusion in Rat

inferredcites →https://doi.org/10.1016/j.bbi.2019.08.194openalex-snapshot

Isorhynchophylline ameliorates cognitive impairment via modulating amyloid pathology, tau hyperphosphorylation and neuroinflammation: Studies in a transgenic mouse model of Alzheimer’s disease

inferredcites →https://doi.org/10.1016/j.brainres.2012.11.047openalex-snapshot

Both PI3K/Akt and ERK1/2 pathways participate in the protection by dexmedetomidine against transient focal cerebral ischemia/reperfusion injury in rats

inferredcites →https://doi.org/10.1016/j.carbpol.2013.07.045openalex-snapshot

Therapeutic effect of Ginkgo biloba polysaccharide in rats with focal cerebral ischemia/reperfusion (I/R) injury

inferredcites →https://doi.org/10.1016/j.fitote.2012.02.010openalex-snapshot

Isorhynchophylline: A plant alkaloid with therapeutic potential for cardiovascular and central nervous system diseases

inferredcites →https://doi.org/10.1016/j.intimp.2009.09.010openalex-snapshot

Anti-inflammatory effects of rhynchophylline and isorhynchophylline in mouse N9 microglial cells and the molecular mechanism

inferredcites →https://doi.org/10.1016/j.jneumeth.2010.08.026openalex-snapshot

An experimental model of focal ischemia using an internal carotid artery approach

inferredcites →https://doi.org/10.1016/j.jneuroim.2006.11.014openalex-snapshot

The inflammatory response in stroke

inferredcites →https://doi.org/10.1016/j.lfs.2004.08.012openalex-snapshot

Protective effect of rhynchophylline and isorhynchophylline on in vitro ischemia-induced neuronal damage in the hippocampus: putative neurotransmitter receptors involved in their action

inferredcites →https://doi.org/10.1016/j.lfs.2019.03.017openalex-snapshot

Isorhynchophylline exerts anti-inflammatory and anti-oxidative activities in LPS-stimulated murine alveolar macrophages

inferredcites →https://doi.org/10.1016/j.neuint.2016.02.015openalex-snapshot

Icariside II protects against cerebral ischemia–reperfusion injury in rats via nuclear factor-κB inhibition and peroxisome proliferator-activated receptor up-regulation

inferredcites →https://doi.org/10.1016/j.neulet.2014.10.040openalex-snapshot

Reduced brain edema and infarct volume in aquaporin-4 deficient mice after transient focal cerebral ischemia

inferredcites →https://doi.org/10.1016/j.neuroscience.2008.07.007openalex-snapshot

NF-κB signaling in cerebral ischemia

inferredcites →https://doi.org/10.1016/j.pbb.2015.09.001openalex-snapshot

Icariin, a major constituent of flavonoids from Epimedium brevicornum, protects against cognitive deficits induced by chronic brain hypoperfusion via its anti-amyloidogenic effect in rats

inferredcites →https://doi.org/10.1016/s0024-3205(02)01534-5openalex-snapshot

Neuroprotection by methanol extract of Uncaria rhynchophylla against global cerebral ischemia in rats

inferredcites →https://doi.org/10.1016/s0140-6736(18)31269-8openalex-snapshot

Prevention of stroke: a global perspective

inferredcites →https://doi.org/10.1016/s0169-328x(00)00084-xopenalex-snapshot

Induction of aquaporin-4 water channel mRNA after focal cerebral ischemia in rat

inferredcites →https://doi.org/10.1038/jcbfm.2008.64openalex-snapshot

Role of CX3CR1 (Fractalkine Receptor) in Brain Damage and Inflammation Induced by Focal Cerebral Ischemia in Mouse

inferredcites →https://doi.org/10.1038/jcbfm.2011.150openalex-snapshot

Visualizing Cell Death in Experimental Focal Cerebral Ischemia: Promises, Problems, and Perspectives

inferredcites →https://doi.org/10.1038/nrneurol.2014.207openalex-snapshot

Microglial and macrophage polarization—new prospects for brain repair

inferredcites →https://doi.org/10.1096/fj.201802743rropenalex-snapshot

Isorhynchophylline exerts antidepressant‐like effects in mice via modulating neuroinflammation and neurotrophins: involvement of the PI3K/Akt/GSK‐3β signaling pathway

inferredcites →https://doi.org/10.1097/aln.0000000000000560openalex-snapshot

Up-regulation of CX3CL1 via Nuclear Factor-κB–dependent Histone Acetylation Is Involved in Paclitaxel-induced Peripheral Neuropathy

inferredcites →https://doi.org/10.1098/rsob.130181openalex-snapshot

Neuron–glia crosstalk in health and disease: fractalkine and CX 3 CR1 take centre stage

inferredcites →https://doi.org/10.1155/2014/297241openalex-snapshot

Therapeutically Targeting Neuroinflammation and Microglia after Acute Ischemic Stroke

inferredcites →https://doi.org/10.1155/2019/4016323openalex-snapshot

Evidence on Integrating Pharmacokinetics to Find Truly Therapeutic Agent for Alzheimer’s Disease: Comparative Pharmacokinetics and Disposition Kinetics Profiles of Stereoisomers Isorhynchophylline and Rhynchophylline in Rats

inferredcites →https://doi.org/10.1161/strokeaha.107.507939openalex-snapshot

Ischemic Postconditioning Inhibits Apoptosis After Focal Cerebral Ischemia/Reperfusion Injury in the Rat

inferredcites →https://doi.org/10.1161/strokeaha.112.659656openalex-snapshot

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

inferredcites →https://doi.org/10.1161/strokeaha.114.005443openalex-snapshot

Adherence to Third European Cooperative Acute Stroke Study 3- to 4.5-Hour Exclusions and Association With Outcome

inferredcites →https://doi.org/10.1172/jci11916openalex-snapshot

NF-κB in neuronal plasticity and neurodegenerative disorders

inferredcites →https://doi.org/10.1172/jci200421655openalex-snapshot

Neutrophil protein kinase Cδ as a mediator of stroke-reperfusion injury

inferredcites →https://doi.org/10.1186/1742-2094-11-26openalex-snapshot

CX3CR1 deficiency suppresses activation and neurotoxicity of microglia/macrophage in experimental ischemic stroke

inferredcites →https://doi.org/10.1186/s12974-015-0270-3openalex-snapshot

Malibatol A regulates microglia M1/M2 polarization in experimental stroke in a PPARγ-dependent manner

inferredcites →https://doi.org/10.1189/jlb.1109766openalex-snapshot

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

inferredcites →https://doi.org/10.1212/wnl.0b013e3182697e70openalex-snapshot

Blood–brain barrier, reperfusion injury, and hemorrhagic transformation in acute ischemic stroke

inferredcites →https://doi.org/10.2174/156652409787847236openalex-snapshot

Neuroinflammation and Neuroprotective Strategies in Acute Ischaemic Stroke - from bench to bedside

inferredcites →https://doi.org/10.2174/156720211796558078openalex-snapshot

Ameliorative Effects of GW1929, a Nonthiazolidinedione PPARγ Agonist,on Inflammation and Apoptosis in Focal Cerebral Ischemic-Reperfusion Injury

inferredcites →https://doi.org/10.2174/1567205012666150713102326openalex-snapshot

Sodium Hydrosulfide Attenuates Beta-Amyloid-Induced Cognitive Deficits and Neuroinflammation via Modulation of MAPK/NF-κB Pathway in Rats

inferredcites →https://doi.org/10.3233/jad-131457openalex-snapshot

Isorhynchophylline Treatment Improves the Amyloid-β-Induced Cognitive Impairment in Rats via Inhibition of Neuronal Apoptosis and Tau Protein Hyperphosphorylation

inferredcites →https://doi.org/10.3389/fphar.2017.00039openalex-snapshot

Icariside II, a Broad-Spectrum Anti-cancer Agent, Reverses Beta-Amyloid-Induced Cognitive Impairment through Reducing Inflammation and Apoptosis in Rats

inferredcites →https://doi.org/10.3389/fphar.2018.01211openalex-snapshot

Icariside II Ameliorates Cognitive Impairments Induced by Chronic Cerebral Hypoperfusion by Inhibiting the Amyloidogenic Pathway: Involvement of BDNF/TrkB/CREB Signaling and Up-Regulation of PPARα and PPARγ in Rats

inferredcites →https://doi.org/10.3390/molecules22111944openalex-snapshot

The Blood-Brain Barrier Permeability of Six Indole Alkaloids from Uncariae Ramulus Cum Uncis in the MDCK-pHaMDR Cell Monolayer Model

inferredcites →https://doi.org/10.4161/auto.8.1.18313openalex-snapshot

Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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A Narrative Review of Protective Effects of Natural Compounds Against Lipopolysaccharide‐Induced Injuries

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Interference with long noncoding RNA SNHG3 alleviates cerebral ischemia-reperfusion injury by inhibiting microglial activation

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Silencing of HAVCR2 Attenuates Skeletal Muscle Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress

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The protective effect and mechanism of Piezo1 inhibition on blood-brain barrier injury after focal cerebral ischemia-reperfusion in rats

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Rhynchophylline ameliorates cerebral ischemia by improving the synaptic plasticity in a middle cerebral artery occlusion induced stroke model

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Targeting the neurovascular unit: Therapeutic potential of traditional Chinese medicine for the treatment of stroke

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Baicalein ameliorates Alzheimer's disease via orchestration of CX3CR1/NF-κB pathway in a triple transgenic mouse model

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Advanced researches of traditional uses, phytochemistry, pharmacology, and toxicology of medical Uncariae Ramulus Cum Uncis

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Regulatory mechanisms of natural compounds from traditional Chinese herbal medicines on the microglial response in ischemic stroke

inferred← citeshttps://doi.org/10.1038/s41392-023-01720-0openalex-snapshot

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Integrated UPLC-MS and multivariate data processing approach to explore the chemical components of Uncaria rhynchophylla and its absorbed components in rats following oral adminstration

inferred← citeshttps://doi.org/10.1097/fjc.0000000000001655openalex-snapshot

Isorhynchophylline Inhibits Platelet Activation and Thrombus Formation

inferred← citeshttps://doi.org/10.1186/s12868-022-00762-4openalex-snapshot

Sodium formononetin-3'-sulphonate alleviates cerebral ischemia–reperfusion injury in rats via suppressing endoplasmic reticulum stress-mediated apoptosis

inferred← citeshttps://doi.org/10.2147/jir.s448620openalex-snapshot

Quercetin Protects Against Global Cerebral ischemia‒reperfusion Injury by Inhibiting Microglial Activation and Polarization

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inferred← citeshttps://doi.org/10.25236/ijfm.2023.050606openalex-snapshot

Protective effect of tanshinone ⅡA, MAPK1, and RELA on ischemic injury after stroke

inferred← citeshttps://doi.org/10.32604/biocell.2023.028866openalex-snapshot

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The key role of the ferroptosis mechanism in neurological diseases and prospects for targeted therapy

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Mechanism of isorhynchophylline in lipopolysaccharide-induced acute lung injury based on proteomic technology

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Additional file 1 of Sodium formononetin-3'-sulphonate alleviates cerebral ischemia–reperfusion injury in rats via suppressing endoplasmic reticulum stress-mediated apoptosis

inferred← citeshttps://doi.org/10.6084/m9.figshare.26552083openalex-snapshot

Additional file 2 of Sodium formononetin-3'-sulphonate alleviates cerebral ischemia–reperfusion injury in rats via suppressing endoplasmic reticulum stress-mediated apoptosis

inferred← citeshttps://doi.org/10.6084/m9.figshare.26552086openalex-snapshot

Additional file 3 of Sodium formononetin-3'-sulphonate alleviates cerebral ischemia–reperfusion injury in rats via suppressing endoplasmic reticulum stress-mediated apoptosis

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