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Dendrobium Nobile Lindl. Alkaloid Suppresses NLRP3-Mediated Pyroptosis to Alleviate LPS-Induced Neurotoxicity
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/brb3.2063openalex-snapshot
Pyroptosis executive protein GSDMD as a biomarker for diagnosis and identification of Alzheimer’s disease
inferredcites →https://doi.org/10.1007/s00221-020-05916-6openalex-snapshot
Protection of MCC950 against Alzheimer's disease via inhibiting neuronal pyroptosis in SAMP8 mice
inferredcites →https://doi.org/10.1007/s00401-018-01957-yopenalex-snapshot
Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo
inferredcites →https://doi.org/10.1007/s12035-014-8918-zopenalex-snapshot
Mitochondria-Targeted Peptide Reverses Mitochondrial Dysfunction and Cognitive Deficits in Sepsis-Associated Encephalopathy
inferredcites →https://doi.org/10.1007/s12035-017-0467-9openalex-snapshot
NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer’s Disease
inferredcites →https://doi.org/10.1016/j.arr.2019.01.002openalex-snapshot
Neuroinflammation in mild cognitive impairment and Alzheimer’s disease: A meta-analysis
inferredcites →https://doi.org/10.1016/j.brainres.2020.146871openalex-snapshot
Dendrobium nobile Lindl alkaloid and metformin ameliorate cognitive dysfunction in senescence-accelerated mice via suppression of endoplasmic reticulum stress
inferredcites →https://doi.org/10.1016/j.cell.2014.04.007openalex-snapshot
Mechanisms and Functions of Inflammasomes
inferredcites →https://doi.org/10.1016/j.jalz.2016.02.010openalex-snapshot
Neuroinflammation in Alzheimer's disease: Current evidence and future directions
inferredcites →https://doi.org/10.1016/j.jep.2020.112839openalex-snapshot
Anti-aging properties of Dendrobium nobile Lindl.: From molecular mechanisms to potential treatments
inferredcites →https://doi.org/10.1016/j.neuroscience.2015.07.084openalex-snapshot
The hippocampus in aging and disease: From plasticity to vulnerability
inferredcites →https://doi.org/10.1016/j.phymed.2013.10.026openalex-snapshot
Alkaloids enriched extract from Dendrobium nobile Lindl. attenuates tau protein hyperphosphorylation and apoptosis induced by lipopolysaccharide in rat brain
inferredcites →https://doi.org/10.1016/j.trci.2019.05.008openalex-snapshot
Alzheimer's disease drug development pipeline: 2019
inferredcites →https://doi.org/10.1038/jcbfm.2015.137openalex-snapshot
Selective Neuronal Vulnerability of Human Hippocampal CA1 Neurons: Lesion Evolution, Temporal Course, and Pattern of Hippocampal Damage in Diffusion-Weighted MR Imaging
inferredcites →https://doi.org/10.1038/nature18629openalex-snapshot
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
inferredcites →https://doi.org/10.1038/nrmicro2070openalex-snapshot
Pyroptosis: host cell death and inflammation
inferredcites →https://doi.org/10.1038/s41419-019-1761-4openalex-snapshot
Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasome
inferredcites →https://doi.org/10.1038/s41582-020-00435-yopenalex-snapshot
Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
inferredcites →https://doi.org/10.1038/s41586-019-1769-zopenalex-snapshot
NLRP3 inflammasome activation drives tau pathology
inferredcites →https://doi.org/10.1055/s-0030-1250235openalex-snapshot
Inhibitory Effects ofDendrobiumAlkaloids on Memory Impairment Induced by Lipopolysaccharide in Rats
inferredcites →https://doi.org/10.1111/cns.12678openalex-snapshot
Dendrobium nobile Lindl alkaloid, a novel autophagy inducer, protects against axonal degeneration induced by Aβ25‐35 in hippocampus neurons in vitro
inferredcites →https://doi.org/10.1111/imcb.12301openalex-snapshot
The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer's disease
inferredcites →https://doi.org/10.1126/science.abb9818openalex-snapshot
Succination inactivates gasdermin D and blocks pyroptosis
inferredcites →https://doi.org/10.1136/bmj.m3684openalex-snapshot
Alzheimer’s disease beyond amyloid: strategies for future therapeutic interventions
inferredcites →https://doi.org/10.1152/ajpheart.00731.2019openalex-snapshot
PhospholipaseCγ1/calcium-dependent membranous localization of Gsdmd-N drives endothelial pyroptosis, contributing to lipopolysaccharide-induced fatal outcome
inferredcites →https://doi.org/10.1155/2018/5823823openalex-snapshot
Recent Advances in the Molecular Mechanisms Underlying Pyroptosis in Sepsis
inferredcites →https://doi.org/10.2174/1567205014666170203141717openalex-snapshot
Neuroinflammation and Alzheimer's Disease: Implications for Microglial Activation
inferredcites →https://doi.org/10.3389/fimmu.2019.00936openalex-snapshot
Naringenin Produces Neuroprotection Against LPS-Induced Dopamine Neurotoxicity via the Inhibition of Microglial NLRP3 Inflammasome Activation
inferredcites →https://doi.org/10.3389/fncel.2018.00426openalex-snapshot
Inhibiting the NLRP3 Inflammasome With MCC950 Ameliorates Isoflurane-Induced Pyroptosis and Cognitive Impairment in Aged Mice
inferredcites →https://doi.org/10.3389/fneur.2020.570711openalex-snapshot
The Role of Microglia and the Nlrp3 Inflammasome in Alzheimer's Disease
inferredcites →https://doi.org/10.3389/fphar.2018.01479openalex-snapshot
Dendrobium nobile Lindl. Alkaloids Decreases the Level of Intracellular β-Amyloid by Improving Impaired Autolysosomal Proteolysis in APP/PS1 Mice
inferredcites →https://doi.org/10.3390/cells9091982openalex-snapshot
The MAO Inhibitor Tranylcypromine Alters LPS- and Aβ-Mediated Neuroinflammatory Responses in Wild-type Mice and a Mouse Model of AD
inferredcites →https://doi.org/10.3390/ijms20030558openalex-snapshot
Drug Development for Alzheimer’s Disease: Microglia Induced Neuroinflammation as a Target?
inferredcites →https://doi.org/10.3906/biy-1909-31openalex-snapshot
The NLRP3 inflammasome: a new player in neurological diseases
inferredcites →https://doi.org/10.4049/jimmunol.0901363openalex-snapshot
Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression
inferredcites →https://doi.org/10.7717/peerj.2739openalex-snapshot
Dendrobium alkaloids prevent Aβ 25–35 -induced neuronal and synaptic loss via promoting neurotrophic factors expression in mice
inferredcites →https://doi.org/10.9758/cpn.2017.15.1.1openalex-snapshot
Mechanisms of Alzheimer’s Disease Pathogenesis and Prevention: The Brain, Neural Pathology, N-methyl-D-aspartate Receptors, Tau Protein and Other Risk Factors
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4485173openalex-extracted
Dendrobium Nobile Lindl. Alkaloids Inhibits D-Galactose-Induced Hippocampal Neuronal Senescence Through the Sirt1-Foxo1-Autophagy Axis
inferred← citeshttps://doi.org/10.1002/ddr.22152openalex-snapshot
Dendrobine regulates STAT3 to attenuate mitochondrial dysfunction and senescence in vascular endothelial cells triggered by oxidized low‐density lipoprotein
inferred← citeshttps://doi.org/10.1007/s00018-024-05395-wopenalex-snapshot
SGK3 deficiency in macrophages suppresses angiotensin II–induced cardiac remodeling via regulating Ndufa13–mediated mitochondrial oxidative stress
inferred← citeshttps://doi.org/10.1007/s11101-024-10050-0openalex-snapshot
Advancing alkaloid-based medicines: medical applications, scalable production and synthetic innovations
inferred← citeshttps://doi.org/10.1007/s12017-025-08889-3openalex-snapshot
Picroside II Alleviates the Progression of Alzheimer’s Disease via the NLRP3/Caspase-1/GSDMD Pathway
inferred← citeshttps://doi.org/10.1016/j.archger.2026.106308openalex-snapshot
Dendrobium nobile Lindl. Alkaloids promote longevity and stress resistance of Caenorhabditis elegans via DAF-16 and skn-1
inferred← citeshttps://doi.org/10.1016/j.brainresbull.2026.111746openalex-snapshot
Dendrobine attenuates postoperative cognitive dysfunction by inhibiting Runx1-mediated NF-κB signaling pathway
inferred← citeshttps://doi.org/10.1016/j.ejphar.2025.177871openalex-snapshot
Investigating the effects of dendrobine on fibrosis and inflammation in orbital fibroblasts of thyroid-associated ophthalmopathy via network pharmacology, molecular docking, and transcriptomics
inferred← citeshttps://doi.org/10.1016/j.ejphar.2026.178847openalex-snapshot
Dendrobine alleviates the T2D/AD comorbidity in 3xTg-AD mice feeding high-fat diet via the Cav-1/PERK/CHOP pathways
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e37541openalex-snapshot
Research progress on the regulatory and pharmacological mechanism of chemical components of Dendrobium
inferred← citeshttps://doi.org/10.1016/j.jep.2023.117592openalex-snapshot
Dendrobium nobile Lindl. alkaloid decreases Tau hyperphosphorylation via regulating PI3K/Akt/GSK-3β pathway in vitro and in vivo
inferred← citeshttps://doi.org/10.1016/j.jep.2025.119634openalex-snapshot
Dendrobine alleviates LPS-induced acute lung injury via activation of the PI3K/AKT/GSK3β pathway
inferred← citeshttps://doi.org/10.1016/j.jep.2026.121234openalex-snapshot
Anti-inflammatory properties of Dendrobium: A systematic review of pharmacological mechanisms
inferred← citeshttps://doi.org/10.1016/j.jphs.2026.05.007openalex-snapshot
Dendrobine alleviates lung injury in septic mice by inhibiting mitochondrial-endoplasmic reticulum crosstalk-mediated NLRP3 inflammasome activation
inferred← citeshttps://doi.org/10.1016/j.metop.2026.100444openalex-snapshot
Obesity-induced cognitive impairment: Underlying mechanisms and therapeutic prospects
inferred← citeshttps://doi.org/10.1016/j.neulet.2024.137897openalex-snapshot
Vitamin C inhibits NLRP3 inflammasome activation and delays the development of age-related hearing loss in male C57BL/6 mice
inferred← citeshttps://doi.org/10.1016/j.phymed.2024.155623openalex-snapshot
Detoxification and underlying mechanisms towards toxic alkaloids by Traditional Chinese Medicine processing: A comprehensive review
inferred← citeshttps://doi.org/10.1016/j.phymed.2025.156952openalex-snapshot
Dendrobine attenuates lipopolysaccharide-induced acute lung injury by modulating FAM134B-mediated endoplasmic reticulum autophagy and mitochondrial function
inferred← citeshttps://doi.org/10.1016/j.phymed.2026.158364openalex-snapshot
Shuxuening injection ameliorates poststroke cognitive impairment by regulating multiple cell death pathways
inferred← citeshttps://doi.org/10.1016/j.prmcm.2023.100288openalex-snapshot
Dendrobium nobile Lindl. alkaloids (DNLA) inhibits d-galactose-induced hippocampal neuronal senescence through the SIRT1-FoxO1-autophagy axis
inferred← citeshttps://doi.org/10.1016/j.prmcm.2024.100495openalex-snapshot
Dendrobium nobile alkaloids modulate calcium dysregulation and neuroinflammation in Alzheimer's disease: A bioinformatic analysis
inferred← citeshttps://doi.org/10.1016/j.redox.2024.103026openalex-snapshot
Betaine alleviates cognitive impairment induced by homocysteine through attenuating NLRP3-mediated microglial pyroptosis in an m6A-YTHDF2-dependent manner
inferred← citeshttps://doi.org/10.1079/9781800627987.0011openalex-snapshot
Dendrobium nobile in the Treatment of Renal Diseases
inferred← citeshttps://doi.org/10.1079/9781800627987.0015openalex-snapshot
Future Research Directions for Dendrobium nobile
inferred← citeshttps://doi.org/10.1080/07388551.2024.2438161openalex-snapshot
Unveiling the potential of dendrobine: insights into bioproduction, bioactivities, safety, circular economy, and future prospects
inferred← citeshttps://doi.org/10.1111/jnc.15788openalex-snapshot
Mechanistic and therapeutic role of NLRP3 inflammasome in the pathogenesis of Alzheimer's disease
inferred← citeshttps://doi.org/10.1177/1934578x261425493openalex-snapshot
Molecular Mechanisms Underlying the Anti-Inflammatory Effects of Fritillaria Alkaloids Targeting the NLRP3 Inflammasome
inferred← citeshttps://doi.org/10.18632/aging.205528openalex-snapshot
Minocycline alleviates LPS-induced cognitive dysfunction in mice by inhibiting the NLRP3/caspase-1 pathway
inferred← citeshttps://doi.org/10.31117/neuroscirn.v7i2.315openalex-snapshot
The chronic cerebral hypoperfusion model induces proinflammatory cascades in Alzheimer's disease
inferred← citeshttps://doi.org/10.3340/jkns.2024.0230openalex-snapshot
The Biomarkers and Underlying Mechanisms of Mitochondrial and Programmed Cell Death Related Genes in Epilepsy by Combining Transcriptome and Single-Cell Sequencing
inferred← citeshttps://doi.org/10.3389/fnins.2023.1206948openalex-snapshot
The role of pyroptosis in cognitive impairment
inferred← citeshttps://doi.org/10.3389/fphar.2025.1528011openalex-snapshot
Kai-Xin-San ameliorates mild cognitive impairment in SAMP8 mice by inhibiting neuroinflammation and pyroptosis via NLRP3/Caspase-1 pathway modulation
inferred← citeshttps://doi.org/10.3389/fphar.2026.1811185openalex-snapshot
Modulation of programmed cell death by botanical drugs in Alzheimer’s disease: a review from a traditional Chinese medicine perspective
inferred← citeshttps://doi.org/10.3389/fpls.2023.1220507openalex-snapshot
Transcriptome and metabolome analysis reveals the effect of flavonoids on flower color variation in Dendrobium nobile Lindl.
inferred← citeshttps://doi.org/10.3389/fpls.2024.1326998openalex-snapshot
Effects of the epiphytic patterns on endophytes and metabolites of Dendrobium nobile Lindl
inferred← citeshttps://doi.org/10.3390/biom12091310openalex-snapshot
Ginsenoside and Its Therapeutic Potential for Cognitive Impairment
inferred← citeshttps://doi.org/10.3390/cimb48060570openalex-snapshot
Research Progress on the Alkaloids of Dendrobium nobile: Substantiation, Key Components, Pharmacological Activity, and Biosynthetic Pathways
inferred← citeshttps://doi.org/10.3390/nu18050840openalex-snapshot
The Protective Effects of Dendrobine on LPS-Induced Neuroinflammation and Related Mechanisms Based on Microglial M1/M2 Polarization
inferred← citeshttps://doi.org/10.3892/etm.2025.12796openalex-snapshot
Dendrobium nobile Lindl. alkaloids improve lipid metabolism by increasing LDL uptake through regulation of the LXRα/IDOL/LDLR pathway and inhibition of PCSK9 expression in HepG2 cells
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