On the public citation graph

Computational Modeling of Electrophysiology and Pharmacotherapy of Atrial Fibrillation: Recent Advances and Future Challenges

https://doi.org/10.3389/fphys.2018.01221

0 signed · 348 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.

Claim with ORCID

Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.

See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/cbic.201100236openalex-snapshot

Ion‐Channel Modulators: More Diversity Than Previously Thought

inferredcites →https://doi.org/10.1002/jps.23594openalex-snapshot

Application of permeability-limited physiologically-based pharmacokinetic models: Part I–digoxin pharmacokinetics incorporating P-glycoprotein-mediated efflux

inferredcites →https://doi.org/10.1002/psp4.18openalex-snapshot

Modeling and Simulation Approaches for Cardiovascular Function and Their Role in Safety Assessment

inferredcites →https://doi.org/10.1006/jmcc.2001.1355openalex-snapshot

Late Sodium Current is a Novel Target for Amiodarone: Studies in Failing Human Myocardium

inferredcites →https://doi.org/10.1007/bf02344625openalex-snapshot

Quantitative modelling of interaction of propafenone with sodium channels in cardiac cells

inferredcites →https://doi.org/10.1007/s00210-009-0454-4openalex-snapshot

The human cardiac K2P3.1 (TASK-1) potassium leak channel is a molecular target for the class III antiarrhythmic drug amiodarone

inferredcites →https://doi.org/10.1007/s00232-007-0027-8openalex-snapshot

Contribution of BKCa-Channel Activity in Human Cardiac Fibroblasts to Electrical Coupling of Cardiomyocytes-Fibroblasts

inferredcites →https://doi.org/10.1007/s00399-010-0088-8openalex-snapshot

Atrial-selective drugs for treatment of atrial fibrillation

inferredcites →https://doi.org/10.1007/s10439-016-1563-0openalex-snapshot

Multiscale Modeling in the Clinic: Drug Design and Development

inferredcites →https://doi.org/10.1007/s10840-018-0318-2openalex-snapshot

A double-blind, randomised, placebo-controlled, cross-over study assessing the use of XEN-D0103 in patients with paroxysmal atrial fibrillation and implanted pacemakers allowing continuous beat-to-beat monitoring of drug efficacy

inferredcites →https://doi.org/10.1007/s11095-010-0065-2openalex-snapshot

In-Silico Approaches to Multi-target Drug Discovery

inferredcites →https://doi.org/10.1007/s11517-012-0924-6openalex-snapshot

Computational modeling of the human atrial anatomy and electrophysiology

inferredcites →https://doi.org/10.1007/s11517-013-1090-1openalex-snapshot

In-silico modeling of atrial repolarization in normal and atrial fibrillation remodeled state

inferredcites →https://doi.org/10.1007/s11517-014-1232-0openalex-snapshot

Application of the RIMARC algorithm to a large data set of action potentials and clinical parameters for risk prediction of atrial fibrillation

inferredcites →https://doi.org/10.1007/s12195-015-0384-9openalex-snapshot

Increased Cell Membrane Capacitance is the Dominant Mechanism of Stretch-Dependent Conduction Slowing in the Rabbit Heart: A Computational Study

inferredcites →https://doi.org/10.1016/0002-9149(93)90959-gopenalex-snapshot

Comparative mechanisms of action of antiarrhythmic drugs

inferredcites →https://doi.org/10.1016/0006-2952(79)90457-xopenalex-snapshot

Some aspects of the pharmacology of sodium channels in nerve membrane. Process of inactivation

inferredcites →https://doi.org/10.1016/0008-6363(95)00224-3openalex-snapshot

Mechanosensitive connective tissue: potential influence on heart rhythm

inferredcites →https://doi.org/10.1016/0304-4157(77)90003-xopenalex-snapshot

Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels

inferredcites →https://doi.org/10.1016/j.bbrc.2011.05.113openalex-snapshot

Decreased sarcolipin protein expression and enhanced sarco(endo)plasmic reticulum Ca2+ uptake in human atrial fibrillation

inferredcites →https://doi.org/10.1016/j.bcp.2016.05.013openalex-snapshot

Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking

inferredcites →https://doi.org/10.1016/j.bpj.2008.09.057openalex-snapshot

Mechanisms of Transition from Normal to Reentrant Electrical Activity in a Model of Rabbit Atrial Tissue: Interaction of Tissue Heterogeneity and Anisotropy

inferredcites →https://doi.org/10.1016/j.bpj.2008.10.056openalex-snapshot

Parameter Sensitivity Analysis in Electrophysiological Models Using Multivariable Regression

inferredcites →https://doi.org/10.1016/j.bpj.2009.07.054openalex-snapshot

Electrotonic Coupling between Human Atrial Myocytes and Fibroblasts Alters Myocyte Excitability and Repolarization

inferredcites →https://doi.org/10.1016/j.bpj.2012.01.032openalex-snapshot

In Silico Optimization of Atrial Fibrillation-Selective Sodium Channel Blocker Pharmacodynamics

inferredcites →https://doi.org/10.1016/j.bpj.2012.03.007openalex-snapshot

Mechanisms by which Cytoplasmic Calcium Wave Propagation and Alternans Are Generated in Cardiac Atrial Myocytes Lacking T-Tubules—Insights from a Simulation Study

inferredcites →https://doi.org/10.1016/j.bpj.2013.05.025openalex-snapshot

Mechanistic Inquiry into the Role of Tissue Remodeling in Fibrotic Lesions in Human Atrial Fibrillation

inferredcites →https://doi.org/10.1016/j.cardiores.2003.12.026openalex-snapshot

Pharmacology of cardiac potassium channels

inferredcites →https://doi.org/10.1016/j.cardiores.2004.01.027openalex-snapshot

Spatially and temporally distinct expression of fibroblast connexins after sheep ventricular infarction

inferredcites →https://doi.org/10.1016/j.cardiores.2004.07.001openalex-snapshot

in left human atrium: a potential contributor to atrial ectopy

inferredcites →https://doi.org/10.1016/j.cardiores.2006.11.024openalex-snapshot

Blockade of atrial-specific K+-currents increases atrial but not ventricular contractility by enhancing reverse mode Na+/Ca2+-exchange

inferredcites →https://doi.org/10.1016/j.cardiores.2007.02.009openalex-snapshot

Differential phosphorylation-dependent regulation of constitutively active and muscarinic receptor-activated IK,ACh channels in patients with chronic atrial fibrillation

inferredcites →https://doi.org/10.1016/j.ccep.2016.02.007openalex-snapshot

Sotalol

inferredcites →https://doi.org/10.1016/j.cjca.2010.12.002openalex-snapshot

Arrhythmogenic Consequences of Action Potential Duration Gradients in the Atria

inferredcites →https://doi.org/10.1016/j.ddmod.2014.04.001openalex-snapshot

Computational models for predictive cardiac ion channel pharmacology

inferredcites →https://doi.org/10.1016/j.ejphar.2013.09.029openalex-snapshot

Class I antiarrhythmic drugs inhibit human cardiac two-pore-domain K+ (K2P) channels

inferredcites →https://doi.org/10.1016/j.ejphar.2013.12.030openalex-snapshot

Inhibition of cardiac two-pore-domain K+ (K2P) channels by the antiarrhythmic drug vernakalant – Comparison with flecainide

inferredcites →https://doi.org/10.1016/j.ejphar.2016.06.050openalex-snapshot

Block of Na + /Ca 2+ exchanger by SEA0400 in human right atrial preparations from patients in sinus rhythm and in atrial fibrillation

inferredcites →https://doi.org/10.1016/j.ejps.2006.11.012openalex-snapshot

Mechanistic modeling of digoxin distribution kinetics incorporating slow tissue binding

inferredcites →https://doi.org/10.1016/j.ejps.2016.04.027openalex-snapshot

Systems pharmacology – Towards the modeling of network interactions

inferredcites →https://doi.org/10.1016/j.eupc.2005.05.011openalex-snapshot

Of circles and spirals: Bridging the gap between the leading circle and spiral wave concepts of cardiac reentry

inferredcites →https://doi.org/10.1016/j.hlc.2017.05.119openalex-snapshot

Pathophysiology of Paroxysmal and Persistent Atrial Fibrillation: Rotors, Foci and Fibrosis

inferredcites →https://doi.org/10.1016/j.hrthm.2013.01.033openalex-snapshot

Proarrhythmic effect of blocking the small conductance calcium activated potassium channel in isolated canine left atrium

inferredcites →https://doi.org/10.1016/j.hrthm.2014.12.028openalex-snapshot

Pharmacologic inhibition of small-conductance calcium-activated potassium (SK) channels by NS8593 reveals atrial antiarrhythmic potential in horses

inferredcites →https://doi.org/10.1016/j.hrthm.2015.12.009openalex-snapshot

Antiarrhythmic effect of vernakalant in electrically remodeled goat atria is caused by slowing of conduction and prolongation of postrepolarization refractoriness

inferredcites →https://doi.org/10.1016/j.hrthm.2016.08.028openalex-snapshot

Balance between sodium and calcium currents underlying chronic atrial fibrillation termination: An in silico intersubject variability study

inferredcites →https://doi.org/10.1016/j.jacc.2005.12.023openalex-snapshot

Sodium-Calcium Exchange Initiated by the Ca2+Transient

inferredcites →https://doi.org/10.1016/j.jacc.2007.08.067openalex-snapshot

Atrial-Selective Approaches for the Treatment of Atrial Fibrillation

inferredcites →https://doi.org/10.1016/j.jacc.2010.09.049openalex-snapshot

Association of Left Atrial Fibrosis Detected by Delayed-Enhancement Magnetic Resonance Imaging and the Risk of Stroke in Patients With Atrial Fibrillation

inferredcites →https://doi.org/10.1016/j.jacc.2011.05.061openalex-snapshot

Structural Abnormalities in Atrial Walls Are Associated With Presence and Persistency of Atrial Fibrillation But Not With Age

inferredcites →https://doi.org/10.1016/j.jacc.2011.10.879openalex-snapshot

Atrial Conduction Slows Immediately Before the Onset of Human Atrial Fibrillation

inferredcites →https://doi.org/10.1016/j.jacc.2014.02.555openalex-snapshot

Atrial Remodeling and Atrial Fibrillation

inferredcites →https://doi.org/10.1016/j.jacep.2017.07.019openalex-snapshot

Relationship Between Fibrosis Detected on Late Gadolinium-Enhanced Cardiac Magnetic Resonance and Re-Entrant Activity Assessed With Electrocardiographic Imaging in Human Persistent Atrial Fibrillation

inferredcites →https://doi.org/10.1016/j.jelectrocard.2005.06.096openalex-snapshot

Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation

inferredcites →https://doi.org/10.1016/j.jmgm.2009.07.005openalex-snapshot

Modeling of high-affinity binding of the novel atrial anti-arrhythmic agent, vernakalant, to Kv1.5 channels

inferredcites →https://doi.org/10.1016/j.jprot.2011.05.011openalex-snapshot

From in silico target prediction to multi-target drug design: Current databases, methods and applications

inferredcites →https://doi.org/10.1016/j.jtbi.2010.06.041openalex-snapshot

Feedback-control induced pattern formation in cardiac myocytes: A mathematical modeling study

inferredcites →https://doi.org/10.1016/j.jtcvs.2004.08.031openalex-snapshot

Comparing the global mRNA expression profile of human atrial and ventricular myocardium with high-density oligonucleotide arrays

inferredcites →https://doi.org/10.1016/j.pbiomolbio.2011.06.011openalex-snapshot

3D virtual human atria: A computational platform for studying clinical atrial fibrillation

inferredcites →https://doi.org/10.1016/j.pbiomolbio.2015.01.008openalex-snapshot

Uncertainty quantification of fast sodium current steady-state inactivation for multi-scale models of cardiac electrophysiology

inferredcites →https://doi.org/10.1016/j.pbiomolbio.2015.12.002openalex-snapshot

Variability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm

inferredcites →https://doi.org/10.1016/j.phrs.2006.03.021openalex-snapshot

Tertiapin, a selective IKACh blocker, terminates atrial fibrillation with selective atrial effective refractory period prolongation

inferredcites →https://doi.org/10.1016/j.pneurobio.2010.03.002openalex-snapshot

Small conductance calcium-activated potassium channels: From structure to function

inferredcites →https://doi.org/10.1016/j.vascn.2016.05.005openalex-snapshot

A temperature-dependent in silico model of the human ether-à-go-go-related (hERG) gene channel

inferredcites →https://doi.org/10.1016/j.vascn.2016.06.002openalex-snapshot

The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progress

inferredcites →https://doi.org/10.1016/j.vascn.2017.04.011openalex-snapshot

Computational modeling for cardiac safety pharmacology analysis: Contribution of fibroblasts

inferredcites →https://doi.org/10.1016/j.yjmcc.2009.09.019openalex-snapshot

A novel computational model of the human ventricular action potential and Ca transient

inferredcites →https://doi.org/10.1016/j.yjmcc.2011.07.002openalex-snapshot

Efficacy and potency of class I antiarrhythmic drugs for suppression of Ca2+ waves in permeabilized myocytes lacking calsequestrin

inferredcites →https://doi.org/10.1016/j.yjmcc.2012.11.001openalex-snapshot

A functional role for transverse (t-) tubules in the atria

inferredcites →https://doi.org/10.1016/j.yjmcc.2013.03.011openalex-snapshot

Impaired Na+-dependent regulation of acetylcholine-activated inward-rectifier K+ current modulates action potential rate dependence in patients with chronic atrial fibrillation

inferredcites →https://doi.org/10.1016/j.yjmcc.2013.12.014openalex-snapshot

Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis

inferredcites →https://doi.org/10.1016/j.yjmcc.2014.02.010openalex-snapshot

If blocking potency of ivabradine is preserved under elevated endotoxin levels in human atrial myocytes

inferredcites →https://doi.org/10.1016/j.yjmcc.2014.02.018openalex-snapshot

In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome

inferredcites →https://doi.org/10.1016/j.yjmcc.2014.05.013openalex-snapshot

Ranolazine inhibition of hERG potassium channels: Drug–pore interactions and reduced potency against inactivation mutants

inferredcites →https://doi.org/10.1016/j.yjmcc.2015.06.021openalex-snapshot

Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide

inferredcites →https://doi.org/10.1016/j.yjmcc.2015.07.030openalex-snapshot

Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes

inferredcites →https://doi.org/10.1016/j.yjmcc.2015.11.018openalex-snapshot

Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models?

inferredcites →https://doi.org/10.1016/j.yjmcc.2016.10.009openalex-snapshot

Refractoriness in human atria: Time and voltage dependence of sodium channel availability

inferredcites →https://doi.org/10.1016/s0008-6363(02)00258-4openalex-snapshot

Electrical, contractile and structural remodeling during atrial fibrillation

inferredcites →https://doi.org/10.1016/s0008-6363(02)00727-7openalex-snapshot

What happens when cardiac Na channel function is compromised? 2. Numerical studies of the vulnerable period in tissue altered by drugs

inferredcites →https://doi.org/10.1016/s0022-3565(25)10121-3openalex-snapshot

Potassium channel blocking properties of propafenone in rabbit atrial myocytes.

inferredcites →https://doi.org/10.1016/s0022-3565(25)20919-3openalex-snapshot

Electrophysiologic and voltage clamp analysis of the effects of sotalol on isolated cardiac muscle and Purkinje fibers.

inferredcites →https://doi.org/10.1016/s0079-6107(03)00012-9openalex-snapshot

The role of atrial dilatation in the domestication of atrial fibrillation

inferredcites →https://doi.org/10.1016/s0165-6147(02)02104-1openalex-snapshot

β-Subunits: fine tuning of Ca2+ channel block

inferredcites →https://doi.org/10.1016/s0167-5273(97)00327-6openalex-snapshot

Dispersion of repolarization in paroxysmal atrial fibrillation

inferredcites →https://doi.org/10.1016/s0735-1097(01)01144-5openalex-snapshot

Up-regulation of inositol 1,4,5 trisphosphate receptor expression in atrial tissue in patients with chronic atrial fibrillation

inferredcites →https://doi.org/10.1016/s0735-1097(99)00169-2openalex-snapshot

Alterations in cardiac sarcoplasmic reticulum Ca2+regulatory proteins in the atrial tissue of patients with chronic atrial fibrillation

inferredcites →https://doi.org/10.1016/s0959-440x(96)80061-3openalex-snapshot

Computational methods for biomolecular docking

inferredcites →https://doi.org/10.1016/s0960-9822(00)00624-2openalex-snapshot

Functional InsP3 receptors that may modulate excitation–contraction coupling in the heart

inferredcites →https://doi.org/10.1016/s1367-5931(02)00339-3openalex-snapshot

Lead discovery using molecular docking

inferredcites →https://doi.org/10.1017/s0958067099017947openalex-snapshot

Mechanically Induced Potentials in Fibroblasts from Human Right Atrium

inferredcites →https://doi.org/10.1021/acs.biochem.7b01012openalex-snapshot

Drug–Drug Interactions between Atorvastatin and Dronedarone Mediated by Monomeric CYP3A4

inferredcites →https://doi.org/10.1021/acs.jcim.6b00029openalex-snapshot

Anti-arrhythmic Medication Propafenone a Potential Drug for Alzheimer’s Disease Inhibiting Aggregation of Aβ: In Silico and in Vitro Studies

inferredcites →https://doi.org/10.1021/jm970571aopenalex-snapshot

Bis-Quinolinium Cyclophanes: 6,10-Diaza-3(1,3),8(1,4)-dibenzena-1,5(1,4)- diquinolinacyclodecaphane (UCL 1684), the First Nanomolar, Non-Peptidic Blocker of the Apamin-Sensitive Ca 2+ -Activated K + Channel

inferredcites →https://doi.org/10.1038/ng.537openalex-snapshot

Common variants in KCNN3 are associated with lone atrial fibrillation

inferredcites →https://doi.org/10.1038/nm.1942openalex-snapshot

Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans

inferredcites →https://doi.org/10.1038/nrd2112openalex-snapshot

Innovative approaches to anti-arrhythmic drug therapy

inferredcites →https://doi.org/10.1038/nrendo.2009.225openalex-snapshot

Effects of amiodarone therapy on thyroid function

inferredcites →https://doi.org/10.1038/s41540-018-0047-2openalex-snapshot

Population-based mechanistic modeling allows for quantitative predictions of drug responses across cell types

inferredcites →https://doi.org/10.1038/s41598-018-22843-3openalex-snapshot

Coupling of SK channels, L-type Ca2+ channels, and ryanodine receptors in cardiomyocytes

inferredcites →https://doi.org/10.1042/bj3060445openalex-snapshot

Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+

inferredcites →https://doi.org/10.1046/j.1540-8167.2001.00196.xopenalex-snapshot

Mechanisms for Discordant Alternans

inferredcites →https://doi.org/10.1046/j.1540-8167.2001.01046.xopenalex-snapshot

Reentry in a Morphologically Realistic Atrial Model

inferredcites →https://doi.org/10.1056/nejm198607033150106openalex-snapshot

Flecainide

inferredcites →https://doi.org/10.1056/nejm199809033391003openalex-snapshot

Spontaneous Initiation of Atrial Fibrillation by Ectopic Beats Originating in the Pulmonary Veins

inferredcites →https://doi.org/10.1063/1.1483935openalex-snapshot

Study of atrial arrhythmias in a computer model based on magnetic resonance images of human atria

inferredcites →https://doi.org/10.1063/1.4999476openalex-snapshot

A computational framework for testing arrhythmia marker sensitivities to model parameters in functionally calibrated populations of atrial cells

inferredcites →https://doi.org/10.1063/1.5000226openalex-snapshot

Revealing kinetics and state-dependent binding properties of IKur-targeting drugs that maximize atrial fibrillation selectivity

inferredcites →https://doi.org/10.1063/1.5003340openalex-snapshot

Sensitivity of reentrant driver localization to electrophysiological parameter variability in image-based computational models of persistent atrial fibrillation sustained by a fibrotic substrate

inferredcites →https://doi.org/10.1073/pnas.0511061103openalex-snapshot

Turing instability mediated by voltage and calcium diffusion in paced cardiac cells

inferredcites →https://doi.org/10.1073/pnas.1110724108openalex-snapshot

Crucial role of a shared extracellular loop in apamin sensitivity and maintenance of pore shape of small-conductance calcium-activated potassium (SK) channels

inferredcites →https://doi.org/10.1073/pnas.1324132111openalex-snapshot

Arrhythmias, elicited by catecholamines and serotonin, vanish in human chronic atrial fibrillation

inferredcites →https://doi.org/10.1074/jbc.m113.453522openalex-snapshot

Mitochondrial Small Conductance SK2 Channels Prevent Glutamate-induced Oxytosis and Mitochondrial Dysfunction

inferredcites →https://doi.org/10.1074/jbc.m307508200openalex-snapshot

Molecular Identification and Functional Roles of a Ca2+-activated K+ Channel in Human and Mouse Hearts

inferredcites →https://doi.org/10.1074/jbc.m513125200openalex-snapshot

Regulation of Surface Localization of the Small Conductance Ca2+-activated Potassium Channel, Sk2, through Direct Phosphorylation by cAMP-dependent Protein Kinase

inferredcites →https://doi.org/10.1080/10255842.2018.1439479openalex-snapshot

Predicting the cardiac toxicity of drugs using a novel multiscale exposure–response simulator

inferredcites →https://doi.org/10.1085/jgp.111.4.565openalex-snapshot

Gating of Recombinant Small-Conductance Ca-activated K+ Channels by Calcium

inferredcites →https://doi.org/10.1085/jgp.69.4.497openalex-snapshot

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

inferredcites →https://doi.org/10.1085/jgp.78.4.383openalex-snapshot

Tetrodotoxin block of sodium channels in rabbit Purkinje fibers. Interactions between toxin binding and channel gating.

inferredcites →https://doi.org/10.1085/jgp.81.5.613openalex-snapshot

Lidocaine block of cardiac sodium channels.

inferredcites →https://doi.org/10.1093/cvr/cvq329openalex-snapshot

Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation

inferredcites →https://doi.org/10.1093/cvr/cvq398openalex-snapshot

Ultra-rapid delayed rectifier channels: molecular basis and therapeutic implications

inferredcites →https://doi.org/10.1093/cvr/cvu121openalex-snapshot

Small-conductance calcium-activated potassium (SK) channels contribute to action potential repolarization in human atria

inferredcites →https://doi.org/10.1093/cvr/cvu203openalex-snapshot

Structural basis of drugs that increase cardiac inward rectifier Kir2.1 currents

inferredcites →https://doi.org/10.1093/cvr/cvv231openalex-snapshot

Ryanodine receptor cluster fragmentation and redistribution in persistent atrial fibrillation enhance calcium release

inferredcites →https://doi.org/10.1093/cvr/cvv275openalex-snapshot

The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis

inferredcites →https://doi.org/10.1093/cvr/cvw011openalex-snapshot

Presence and stability of rotors in atrial fibrillation: evidence and therapeutic implications

inferredcites →https://doi.org/10.1093/cvr/cvx020openalex-snapshot

Functional local crosstalk of inositol 1,4,5-trisphosphate receptor- and ryanodine receptor-dependent Ca2+ release in atrial cardiomyocytes

inferredcites →https://doi.org/10.1093/eurheartj/ehi825openalex-snapshot

Prevalence, incidence and lifetime risk of atrial fibrillation: the Rotterdam study

inferredcites →https://doi.org/10.1093/eurheartj/ehv233openalex-snapshot

Atrial fibrillation driven by micro-anatomic intramural re-entry revealed by simultaneous sub-epicardial and sub-endocardial optical mapping in explanted human hearts

inferredcites →https://doi.org/10.1093/eurheartj/ehw559openalex-snapshot

Inverse remodelling of K2P3.1 K+channel expression and action potential duration in left ventricular dysfunction and atrial fibrillation: implications for patient-specific antiarrhythmic drug therapy

inferredcites →https://doi.org/10.1093/europace/eup328openalex-snapshot

Animal models for atrial fibrillation: clinical insights and scientific opportunities

inferredcites →https://doi.org/10.1093/europace/eur007openalex-snapshot

Screening of KCNN3 in patients with early-onset lone atrial fibrillation

inferredcites →https://doi.org/10.1093/europace/eus281openalex-snapshot

Impact of amiodarone and cisapride on simulated human ventricular electrophysiology and electrocardiograms

inferredcites →https://doi.org/10.1093/europace/eut349openalex-snapshot

Evolution and pharmacological modulation of the arrhythmogenic wave dynamics in canine pulmonary vein model

inferredcites →https://doi.org/10.1093/europace/euu192openalex-snapshot

Is the acetylcholine-regulated inwardly rectifying potassium current a viable antiarrhythmic target? Translational discrepancies of AZD2927 and A7071 in dogs and humans

inferredcites →https://doi.org/10.1093/europace/euu230openalex-snapshot

In-silico assessment of the dynamic effects of amiodarone and dronedarone on human atrial patho-electrophysiology

inferredcites →https://doi.org/10.1093/europace/euu274openalex-snapshot

Drug-induced post-repolarization refractoriness as an antiarrhythmic principle and its underlying mechanism

inferredcites →https://doi.org/10.1093/europace/euv263openalex-snapshot

First clinical trial of specific IKAChblocker shows no reduction in atrial fibrillation burden in patients with paroxysmal atrial fibrillation: pacemaker assessment of BMS 914392 in patients with paroxysmal atrial fibrillation

inferredcites →https://doi.org/10.1093/europace/euv445openalex-snapshot

How disruption of endo-epicardial electrical connections enhances endo-epicardial conduction during atrial fibrillation

inferredcites →https://doi.org/10.1093/europace/euw358openalex-snapshot

Towards personalized computational modelling of the fibrotic substrate for atrial arrhythmia

inferredcites →https://doi.org/10.1093/icvts/ivu095openalex-snapshot

Atrial apoptosis and fibrosis adversely affect atrial conduit, reservoir and contractile functions

inferredcites →https://doi.org/10.1097/00005344-200302000-00007openalex-snapshot

Electrophysiologic Characterization of Dronedarone in Guinea Pig Ventricular Cells

inferredcites →https://doi.org/10.1097/fjc.0b013e3181bfaddcopenalex-snapshot

Concept of the Vulnerable Parameter: The Sicilian Gambit Revisited

inferredcites →https://doi.org/10.1097/fjc.0b013e318217943dopenalex-snapshot

The Duration of Pacing-induced Atrial Fibrillation Is Reduced in Vivo by Inhibition of Small Conductance Ca2+-activated K+ Channels

inferredcites →https://doi.org/10.1097/ftd.0000000000000023openalex-snapshot

A Two-Compartment Population Pharmacokinetic–Pharmacodynamic Model of Digoxin in Adults, With Implications for Dosage

inferredcites →https://doi.org/10.1097/maj.0b013e318176b94dopenalex-snapshot

Digoxin: Current Use and Approach to Toxicity

inferredcites →https://doi.org/10.1098/rsfs.2012.0067openalex-snapshot

A novel computational sheep atria model for the study of atrial fibrillation

inferredcites →https://doi.org/10.1098/rsta.2006.1781openalex-snapshot

Heterogeneous three-dimensional anatomical and electrophysiological model of human atria

inferredcites →https://doi.org/10.1109/10.959315openalex-snapshot

A computer model of human atria with reasonable computation load and realistic anatomical properties

inferredcites →https://doi.org/10.1109/cic.2015.7408683openalex-snapshot

Influence of right and left atrial tissue heterogeneity on atrial fibrillation perpetuation

inferredcites →https://doi.org/10.1109/iembs.2006.260522openalex-snapshot

Action Potential Duration Gradient Protects the Right Atrium from Fibrillating

inferredcites →https://doi.org/10.1109/iembs.2009.5333573openalex-snapshot

Electrophysiological substrate for a dominant reentrant source during atrial fibrillation

inferredcites →https://doi.org/10.1109/iembs.2010.5626864openalex-snapshot

A new ECG biomarker for drug toxicity: A combined signal processing and computational modeling study

inferredcites →https://doi.org/10.1109/iembs.2010.5627415openalex-snapshot

Sex and age related differences in drug induced QT prolongation by dofetilide under reduced repolarization reserve in simulated ventricular cells

inferredcites →https://doi.org/10.1109/tbme.2010.2077292openalex-snapshot

Effects of the Antiarrhythmic Drug Dofetilide on Transmural Dispersion of Repolarization in Ventriculum. A Computer Modeling Study

inferredcites →https://doi.org/10.1109/tbme.2011.2165213openalex-snapshot

Interaction of Specialized Cardiac Conduction System With Antiarrhythmic Drugs: A Simulation Study

inferredcites →https://doi.org/10.1111/bcp.12151openalex-snapshot

Not‐in‐trial simulation I: Bridging cardiovascular risk from clinical trials to real‐life conditions

inferredcites →https://doi.org/10.1111/bph.12208openalex-snapshot

Structure‐activity relationships of pentamidine‐affected ion channel trafficking and dofetilide mediated rescue

inferredcites →https://doi.org/10.1111/cpf.12342openalex-snapshot

Atrial average conduction velocity in patients with and without paroxysmal atrial fibrillation

inferredcites →https://doi.org/10.1111/j.1540-8159.2006.00336.xopenalex-snapshot

Late‐Phase 3 EAD. A Unique Mechanism Contributing to Initiation of Atrial Fibrillation

inferredcites →https://doi.org/10.1111/j.1540-8167.1992.tb00972.xopenalex-snapshot

Amiodarone: Pharmacology, Clinical Actions, and Relationships Between Them

inferredcites →https://doi.org/10.1111/j.1540-8167.1994.tb01169.xopenalex-snapshot

Role of L‐Type Calcium Channel Window Current in Generating Current‐Induced Early Afterdepolarizations

inferredcites →https://doi.org/10.1111/j.1540-8167.1997.tb01030.xopenalex-snapshot

Conduction Velocity in the Tricuspid Valve‐Inferior Vena Cava Isthmus is Slower in Patients With Type I Atrial Flutter Compared to Those Without a History of Atrial Flutter

inferredcites →https://doi.org/10.1111/j.1540-8167.2011.02187.xopenalex-snapshot

Differential Structural Remodeling of the Left‐Atrial Posterior Wall in Patients Affected by Mitral Regurgitation with or Without Persistent Atrial Fibrillation: A Morphological and Molecular Study

inferredcites →https://doi.org/10.1111/jce.12212openalex-snapshot

Chronic Atrial Fibrillation Alters the Functional Properties of If in the Human Atrium

inferredcites →https://doi.org/10.1111/joim.12492openalex-snapshot

Current controversies in determining the main mechanisms of atrial fibrillation

inferredcites →https://doi.org/10.1113/jphysiol.1962.sp006849openalex-snapshot

A modification of the Hodgkin—Huxley equations applicable to Purkinje fibre action and pacemaker potentials

inferredcites →https://doi.org/10.1113/jphysiol.2003.058529openalex-snapshot

Inositol‐1,4,5‐trisphosphate‐dependent Ca2+ signalling in cat atrial excitation–contraction coupling and arrhythmias

inferredcites →https://doi.org/10.1113/jphysiol.2004.061119openalex-snapshot

Characterization of a hyperpolarization‐activated time‐dependent potassium current in canine cardiomyocytes from pulmonary vein myocardial sleeves and left atrium

inferredcites →https://doi.org/10.1113/jphysiol.2006.126714openalex-snapshot

Regional and tissue specific transcript signatures of ion channel genes in the non‐diseased human heart

inferredcites →https://doi.org/10.1113/jphysiol.2013.254987openalex-snapshot

Pro‐arrhythmogenic effects of atrial fibrillation‐induced electrical remodelling: insights from the three‐dimensional virtual human atria

inferredcites →https://doi.org/10.1113/jphysiol.2013.266676openalex-snapshot

A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na + loading and CaMKII

inferredcites →https://doi.org/10.1124/dmd.114.059311openalex-snapshot

Physiologically Based Pharmacokinetic Modeling to Predict Drug-Drug Interactions Involving Inhibitory Metabolite: A Case Study of Amiodarone

inferredcites →https://doi.org/10.1124/jpet.118.247692openalex-snapshot

New Targets for Old Drugs: Cardiac Glycosides Inhibit Atrial-Specific K2P3.1 (TASK-1) Channels

inferredcites →https://doi.org/10.1126/scitranslmed.3002588openalex-snapshot

A Computational Model to Predict the Effects of Class I Anti-Arrhythmic Drugs on Ventricular Rhythms

inferredcites →https://doi.org/10.1126/scitranslmed.aac4296openalex-snapshot

Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase

inferredcites →https://doi.org/10.1152/ajpheart.00295.2014openalex-snapshot

Variable t-tubule organization and Ca2+ homeostasis across the atria

inferredcites →https://doi.org/10.1152/ajpheart.00341.2009openalex-snapshot

Cardiac alternans induced by fibroblast-myocyte coupling: mechanistic insights from computational models

inferredcites →https://doi.org/10.1152/ajpheart.00407.2015openalex-snapshot

Phase synchrony reveals organization in human atrial fibrillation

inferredcites →https://doi.org/10.1152/ajpheart.00411.2009openalex-snapshot

K+current changes account for the rate dependence of the action potential in the human atrial myocyte

inferredcites →https://doi.org/10.1152/ajpheart.00511.2012openalex-snapshot

High-throughput screening of drug-binding dynamics to HERG improves early drug safety assessment

inferredcites →https://doi.org/10.1152/ajpheart.00534.2005openalex-snapshot

Differential expression of small-conductance Ca2+-activated K+channels SK1, SK2, and SK3 in mouse atrial and ventricular myocytes

inferredcites →https://doi.org/10.1152/ajpheart.00614.2014openalex-snapshot

TASK-1 current is inhibited by phosphorylation during human and canine chronic atrial fibrillation

inferredcites →https://doi.org/10.1152/ajpheart.00668.2011openalex-snapshot

The Na+/K+pump is an important modulator of refractoriness and rotor dynamics in human atrial tissue

inferredcites →https://doi.org/10.1152/ajpheart.00777.2005openalex-snapshot

Specific serine proteases selectively damage KCNH2 (hERG1) potassium channels and IKr

inferredcites →https://doi.org/10.1152/ajpheart.01054.2007openalex-snapshot

Mechanisms of atrial fibrillation termination by rapidly unbinding Na+ channel blockers: insights from mathematical models and experimental correlates

inferredcites →https://doi.org/10.1152/ajpheart.01083.2006openalex-snapshot

Frequency-dependent effects of variousIKrblockers on cardiac action potential duration in a human atrial model

inferredcites →https://doi.org/10.1152/ajpheart.01229.2007openalex-snapshot

In silico study on the effects ofIKurblock kinetics on prolongation of human action potential after atrial fibrillation-induced electrical remodeling

inferredcites →https://doi.org/10.1152/ajpheart.01298.2007openalex-snapshot

Loading effect of fibroblast-myocyte coupling on resting potential, impulse propagation, and repolarization: insights from a microstructure model

inferredcites →https://doi.org/10.1152/ajpheart.1998.275.1.h301openalex-snapshot

Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model

inferredcites →https://doi.org/10.1152/jn.00641.2003openalex-snapshot

Alternative to Hand-Tuning Conductance-Based Models: Construction and Analysis of Databases of Model Neurons

inferredcites →https://doi.org/10.1152/physrev.00031.2009openalex-snapshot

Pathophysiological Mechanisms of Atrial Fibrillation: A Translational Appraisal

inferredcites →https://doi.org/10.1159/000335757openalex-snapshot

TASK-1 Channels May Modulate Action Potential Duration of Human Atrial Cardiomyocytes

inferredcites →https://doi.org/10.1161/01.cir.0000065578.00869.7copenalex-snapshot

Reinduction of Atrial Fibrillation Immediately After Termination of the Arrhythmia Is Mediated by Late Phase 3 Early Afterdepolarization–Induced Triggered Activity

inferredcites →https://doi.org/10.1161/01.cir.0000139333.83620.5dopenalex-snapshot

Electrophysiological Effects of Ranolazine, a Novel Antianginal Agent With Antiarrhythmic Properties

inferredcites →https://doi.org/10.1161/01.cir.0000141296.59876.87openalex-snapshot

Atrial Fibrillation Is Associated With Increased Spontaneous Calcium Release From the Sarcoplasmic Reticulum in Human Atrial Myocytes

inferredcites →https://doi.org/10.1161/01.cir.0000162461.67140.4copenalex-snapshot

Defective Cardiac Ryanodine Receptor Regulation During Atrial Fibrillation

inferredcites →https://doi.org/10.1161/01.cir.102.14.1664openalex-snapshot

Mechanisms of Discordant Alternans and Induction of Reentry in Simulated Cardiac Tissue

inferredcites →https://doi.org/10.1161/01.cir.102.21.2665openalex-snapshot

Dofetilide

showing the first 200 of 295

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4521567openalex-extracted

Exergy Destruction in Atrial Fibrillation; a New Exergy Age Index

inferred← citeshttps://doi.org/10.1002/wsbm.1477openalex-snapshot

How personalized heart modeling can help treatment of lethal arrhythmias: A focus on ventricular tachycardia ablation strategies in post‐infarction patients

inferred← citeshttps://doi.org/10.1007/s10439-020-02448-6openalex-snapshot

Numerical Study of Atrial Fibrillation Effects on Flow Distribution in Aortic Circulation

inferred← citeshttps://doi.org/10.1007/s10439-021-02744-9openalex-snapshot

Effects of Ageing on Aortic Circulation During Atrial Fibrillation; a Numerical Study on Different Aortic Morphologies

inferred← citeshttps://doi.org/10.1016/b978-0-323-95488-4.00198-4openalex-snapshot

Measuring Cardiovascular Function in Intact Experimental Models

inferred← citeshttps://doi.org/10.1016/j.compbiomed.2024.108899openalex-snapshot

A novel ionic model for matured and paced atrial-like human iPSC-CMs integrating I K u r and I K C a currents

inferred← citeshttps://doi.org/10.1016/j.jcct.2023.03.002openalex-snapshot

State of the art paper: Cardiac computed tomography of the left atrium in atrial fibrillation

inferred← citeshttps://doi.org/10.1016/j.jtbi.2023.111623openalex-snapshot

Exergy destruction in atrial fibrillation and a new ‘Exergy Age Index’

inferred← citeshttps://doi.org/10.1016/j.lfs.2020.117797openalex-snapshot

Role of ion channels in chronic intermittent hypoxia-induced atrial remodeling in rats

inferred← citeshttps://doi.org/10.1016/j.mbs.2021.108567openalex-snapshot

Evolution of mathematical models of cardiomyocyte electrophysiology

inferred← citeshttps://doi.org/10.1016/j.mric.2019.04.006openalex-snapshot

Applications of Cardiac MR Imaging in Electrophysiology

inferred← citeshttps://doi.org/10.1016/j.pbiomolbio.2020.02.008openalex-snapshot

Cardiomyocyte calcium handling in health and disease: Insights from in vitro and in silico studies

inferred← citeshttps://doi.org/10.1016/j.phrs.2019.104444openalex-snapshot

Maastricht antiarrhythmic drug evaluator (MANTA): A computational tool for better understanding of antiarrhythmic drugs

inferred← citeshttps://doi.org/10.1016/j.premed.2026.100036openalex-snapshot

Towards mechanisms-driven strategy for persistent atrial fibrillation ablation: Leveraging digital twins

inferred← citeshttps://doi.org/10.1016/j.ymeth.2020.02.011openalex-snapshot

Multi-scale approaches for the simulation of cardiac electrophysiology: I – Sub-cellular and stochastic calcium dynamics from cell to organ

inferred← citeshttps://doi.org/10.1038/s41598-023-38256-wopenalex-snapshot

Recurrence quantification analysis for fine-scale characterisation of arrhythmic patterns in cardiac tissue

inferred← citeshttps://doi.org/10.1038/s44161-024-00489-xopenalex-snapshot

Assessing the arrhythmogenic propensity of fibrotic substrate using digital twins to inform a mechanisms-based atrial fibrillation ablation strategy

inferred← citeshttps://doi.org/10.1080/00015385.2025.2500888openalex-snapshot

Beneficial effects of doxycycline on atrial electrical remodelling in a rat model of atrial fibrillation

inferred← citeshttps://doi.org/10.1080/14779072.2023.2273896openalex-snapshot

Personalized biomechanical insights in atrial fibrillation: opportunities & challenges

inferred← citeshttps://doi.org/10.1080/24725579.2021.1879322openalex-snapshot

Spatiotemporal modeling and optimization for personalized cardiac simulation

inferred← citeshttps://doi.org/10.1090/conm/787/15793openalex-snapshot

Atrial fibrillation through strange attractor dynamics

inferred← citeshttps://doi.org/10.1093/cvr/cvab138openalex-snapshot

Computational models of atrial fibrillation: achievements, challenges, and perspectives for improving clinical care

inferred← citeshttps://doi.org/10.1098/rstb.2021.0317openalex-snapshot

Increased SERCA2a sub-cellular heterogeneity in right-ventricular heart failure inhibits excitation-contraction coupling and modulates arrhythmogenic dynamics

inferred← citeshttps://doi.org/10.1101/2024.01.12.574782openalex-snapshot

A novel ionic model for matured and paced atrial–like hiPSC–CMs integrating I Kur and I KCa currents

inferred← citeshttps://doi.org/10.1109/bibm62325.2024.10822380openalex-snapshot

Assessment of Proarrhythmic Risk for Class III Antiarrhythmic Drug in Atrium

inferred← citeshttps://doi.org/10.1109/indicon63790.2024.10958412openalex-snapshot

Influence of Glucose on Cardiac Pacemaking Electrophysiology through Potassium Ion Channel Biophysics: A Computational Study

inferred← citeshttps://doi.org/10.1111/apha.13865openalex-snapshot

Computational cardiac physiology for new modelers: Origins, foundations, and future

inferred← citeshttps://doi.org/10.1113/jp283974openalex-snapshot

A detailed mathematical model of the human atrial cardiomyocyte: integration of electrophysiology and cardiomechanics

inferred← citeshttps://doi.org/10.1113/jp285740openalex-snapshot

Interactions between calcium‐induced arrhythmia triggers and the electrophysiological–anatomical substrate underlying the induction of atrial fibrillation

inferred← citeshttps://doi.org/10.1126/sciadv.abg0927openalex-snapshot

Quantitative cross-species translators of cardiac myocyte electrophysiology: Model training, experimental validation, and applications

inferred← citeshttps://doi.org/10.1152/physrev.00024.2019openalex-snapshot

Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior

inferred← citeshttps://doi.org/10.1161/jaha.120.018572openalex-snapshot

Short P‐Wave Duration is a Marker of Higher Rate of Atrial Fibrillation Recurrences after Pulmonary Vein Isolation: New Insights into the Pathophysiological Mechanisms Through Computer Simulations

inferred← citeshttps://doi.org/10.1177/00368504251344145openalex-snapshot

The computational model lifecycle: Opportunities and challenges for computational medicine in the healthcare ecosystem

inferred← citeshttps://doi.org/10.12659/msm.918883openalex-snapshot

Doxycycline Improves Fibrosis-Induced Abnormalities in Atrial Conduction and Vulnerability to Atrial Fibrillation in Chronic Intermittent Hypoxia Rats

inferred← citeshttps://doi.org/10.1365/s13291-020-00218-wopenalex-snapshot

Modelling and Simulation for Preclinical Cardiac Safety Assessment of Drugs with Human iPSC-Derived Cardiomyocytes

inferred← citeshttps://doi.org/10.1371/journal.pcbi.1007260openalex-snapshot

Arrhythmia mechanisms and spontaneous calcium release: Bi-directional coupling between re-entrant and focal excitation

inferred← citeshttps://doi.org/10.21037/atm.2020.01.90openalex-snapshot

PITX2 upregulation increases the risk of chronic atrial fibrillation in a dose-dependent manner by modulating IKs and ICaL—insights from human atrial modelling

inferred← citeshttps://doi.org/10.21203/rs.3.rs-3098373/v1openalex-snapshot

Effects of doxycycline on atrial electrical remodeling in a rat model of atrial fibrillation

inferred← citeshttps://doi.org/10.2478/bipmf-2021-0001openalex-snapshot

A New Theoretical Model for Evaluating Atrial Fibrillations

inferred← citeshttps://doi.org/10.26481/dis.20210115hsopenalex-snapshot

Integrative computational modeling of calcium handling and cardiac arrhythmias

inferred← citeshttps://doi.org/10.3389/fphar.2018.00026openalex-snapshot

Digging into Lipid Membrane Permeation for Cardiac Ion Channel Blocker d-Sotalol with All-Atom Simulations

inferred← citeshttps://doi.org/10.3389/fphys.2020.556156openalex-snapshot

A Novel Computational Model of the Rabbit Atrial Cardiomyocyte With Spatial Calcium Dynamics

inferred← citeshttps://doi.org/10.3389/fphys.2021.651162openalex-snapshot

Immediate and Delayed Response of Simulated Human Atrial Myocytes to Clinically-Relevant Hypokalemia

inferred← citeshttps://doi.org/10.3389/fphys.2021.651428openalex-snapshot

A Computational Study of the Effects of Tachycardia-Induced Remodeling on Calcium Wave Propagation in Rabbit Atrial Myocytes

inferred← citeshttps://doi.org/10.3389/fphys.2022.836622openalex-snapshot

Multi-Scale Computational Modeling of Spatial Calcium Handling From Nanodomain to Whole-Heart: Overview and Perspectives

inferred← citeshttps://doi.org/10.3389/fpsyt.2019.00534openalex-snapshot

Biophysical Psychiatry—How Computational Neuroscience Can Help to Understand the Complex Mechanisms of Mental Disorders

inferred← citeshttps://doi.org/10.3390/antiox13101172openalex-snapshot

Modulatory Impact of Oxidative Stress on Action Potentials in Pathophysiological States: A Comprehensive Review

inferred← citeshttps://doi.org/10.3390/cells10092456openalex-snapshot

Electrophysiological Remodeling: Cardiac T-Tubules and ß-Adrenoceptors

inferred← citeshttps://doi.org/10.3390/diagnostics11030449openalex-snapshot

Latest Insights into Mechanisms behind Atrial Cardiomyopathy: It Is Not always about Ventricular Function

inferred← citeshttps://doi.org/10.3390/ijms22147681openalex-snapshot

Understanding PITX2-Dependent Atrial Fibrillation Mechanisms through Computational Models

inferred← citeshttps://doi.org/10.3390/math12081149openalex-snapshot

A Mathematical Model of Spontaneous Action Potential Based on Stochastics Synaptic Noise Dynamics in Non-Neural Cells

inferred← citeshttps://doi.org/10.3390/ph16060844openalex-snapshot

Overview of Cardiac Arrhythmias and Treatment Strategies

inferred← citeshttps://doi.org/10.4149/gpb_2021016openalex-snapshot

Evaluating atrial fibrillations through strange attractors dynamics

Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.