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A Novel Single-Site Mutation in the Catalytic Domain of Protoporphyrinogen Oxidase IX (PPO) Confers Resistance to PPO-Inhibiting Herbicides

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/ps.1518openalex-snapshot
Glyphosate: a once‐in‐a‐century herbicide
inferredcites →https://doi.org/10.1002/ps.3728openalex-snapshot
Evolution of resistance to phytoene desaturase and protoporphyrinogen oxidase inhibitors – state of knowledge
inferredcites →https://doi.org/10.1002/ps.4241openalex-snapshot
Resistance to PPO ‐inhibiting herbicide in Palmer amaranth from Arkansas
inferredcites →https://doi.org/10.1002/ps.4581openalex-snapshot
Two new PPX2 mutations associated with resistance to PPO ‐inhibiting herbicides in Amaranthus palmeri
inferredcites →https://doi.org/10.1002/ps.4744openalex-snapshot
Origins and structure of chloroplastic and mitochondrial plant protoporphyrinogen oxidases: implications for the evolution of herbicide resistance
inferredcites →https://doi.org/10.1016/b978-012077700-6/50001-8openalex-snapshot
Introduction to Protein Structure
inferredcites →https://doi.org/10.1016/j.bbapap.2010.04.004openalex-snapshot
Biochemical and structural consequences of a glycine deletion in the α-8 helix of protoporphyrinogen oxidase
inferredcites →https://doi.org/10.1016/j.tig.2013.06.001openalex-snapshot
Deciphering the evolution of herbicide resistance in weeds
inferredcites →https://doi.org/10.1017/wsc.2017.41openalex-snapshot
Frequency of Gly-210 Deletion Mutation among Protoporphyrinogen Oxidase Inhibitor–Resistant Palmer Amaranth (Amaranthus palmeri) Populations
inferredcites →https://doi.org/10.1017/wsc.2017.68openalex-snapshot
A Statewide Survey of PPO-Inhibitor Resistance and the Prevalent Target-Site Mechanisms in Palmer amaranth ( Amaranthus palmeri ) Accessions from Arkansas
inferredcites →https://doi.org/10.1021/jf00047a044openalex-snapshot
Protoporphyrinogen IX-oxidizing activities involved in the mode of action of peroxidizing Herbicides
inferredcites →https://doi.org/10.1021/jf5018115openalex-snapshot
Understanding Resistance Mechanism of Protoporphyrinogen Oxidase-Inhibiting Herbicides: Insights from Computational Mutation Scanning and Site-Directed Mutagenesis
inferredcites →https://doi.org/10.1038/sj.emboj.7600189openalex-snapshot
Crystal structure of protoporphyrinogen IX oxidase: a key enzyme in haem and chlorophyll biosynthesis
inferredcites →https://doi.org/10.1042/bj20061321openalex-snapshot
Functional definition of the tobacco protoporphyrinogen IX oxidase substrate-binding site
inferredcites →https://doi.org/10.1073/pnas.0603137103openalex-snapshot
A codon deletion confers resistance to herbicides inhibiting protoporphyrinogen oxidase
inferredcites →https://doi.org/10.1073/pnas.94.16.8895openalex-snapshot
Cloning and characterization of a plastidal and a mitochondrial isoform of tobacco protoporphyrinogen IX oxidase
inferredcites →https://doi.org/10.1073/pnas.96.26.14825openalex-snapshot
Acylation stabilizes a protease-resistant conformation of protoporphyrinogen oxidase, the molecular target of diphenyl ether-type herbicides
inferredcites →https://doi.org/10.1074/jbc.m101140200openalex-snapshot
Dual Targeting of Spinach Protoporphyrinogen Oxidase II to Mitochondria and Chloroplasts by Alternative Use of Two In-frame Initiation Codons
inferredcites →https://doi.org/10.1104/pp.101.4.1181openalex-snapshot
Porphyrin Accumulation and Export by Isolated Barley (Hordeum vulgare) Plastids (Effect of Diphenyl Ether Herbicides)
inferredcites →https://doi.org/10.1104/pp.86.2.619openalex-snapshot
Studies on the Mode of Action of Acifluorfen-Methyl in Nonchlorophyllous Soybean Cells
inferredcites →https://doi.org/10.1104/pp.90.3.1175openalex-snapshot
Protoporphyrin IX Content Correlates with Activity of Photobleaching Herbicides
inferredcites →https://doi.org/10.1104/pp.97.1.197openalex-snapshot
Effect of Diphenyl Ether Herbicides on Oxidation of Protoporphyrinogen to Protoporphyrin in Organellar and Plasma Membrane Enriched Fractions of Barley
inferredcites →https://doi.org/10.1111/j.1432-1033.1985.tb08943.xopenalex-snapshot
The mitochondrial location of protoporphyrinogen oxidase
inferredcites →https://doi.org/10.1139/cjps-2016-0029openalex-snapshot
Triallate-resistant wild oat (Avena fatua L.): Unexpected resistance to pyroxasulfone and sulfentrazone
inferredcites →https://doi.org/10.1146/annurev-arplant-042809-112119openalex-snapshot
Evolution in Action: Plants Resistant to Herbicides
inferredcites →https://doi.org/10.1371/journal.pone.0069198openalex-snapshot
Computational and Experimental Insights into the Mechanism of Substrate Recognition and Feedback Inhibition of Protoporphyrinogen Oxidase
inferredcites →https://doi.org/10.1371/journal.pone.0146021openalex-snapshot
Dose-Response Analysis Using R
inferredcites →https://doi.org/10.1511/2011.90.236openalex-snapshot
Porphyrins: One Ring in the Colors of Life
inferredcites →https://doi.org/10.1515/znc-1990-0536openalex-snapshot
Typical Peroxidative Parameters Verified with Mung-Bean Seedlings, Soybean Cells and Duckweed
inferredcites →https://doi.org/10.1590/s0100-83582009000100018openalex-snapshot
Local de absorção de fomesafen como mecanismo de resistência em biótipo de Euphorbia heterophylla resistente aos inibidores da PROTOX
inferredcites →https://doi.org/10.1614/ws-d-11-00092.1openalex-snapshot
Changes in the Prevalence of Weed Species in the Major Agronomic Crops of the Southern United States: 1994/1995 to 2008/2009
inferredcites →https://doi.org/10.1614/ws-d-11-00152.1openalex-snapshot
Characterization of a Common Ragweed ( Ambrosia artemisiifolia ) Population Resistant to ALS- and PPO-Inhibiting Herbicides
inferredcites →https://doi.org/10.1614/ws-d-13-00145.1openalex-snapshot
In-Field Movement of Glyphosate-Resistant Palmer Amaranth (Amaranthus palmeri) and Its Impact on Cotton Lint Yield: Evidence Supporting a Zero-Threshold Strategy
inferredcites →https://doi.org/10.1614/ws-d-15-00037.1openalex-snapshot
Distribution of the ΔG210 Protoporphyrinogen Oxidase Mutation in Illinois Waterhemp (Amaranthus tuberculatus) and an Improved Molecular Method for Detection
inferredcites →https://doi.org/10.1614/wt-05-084r1.1openalex-snapshot
Herbicide-Resistant Weeds: Management Tactics and Practices
inferredcites →https://doi.org/10.1614/wt-d-12-00113.1openalex-snapshot
Palmer Amaranth ( Amaranthus palmeri ): A Review
inferredcites →https://doi.org/10.2533/chimia.2011.961openalex-snapshot
Protoporphyrinogen Oxidase Inhibitor: An Ideal Target for Herbicide Discovery
inferredcites →https://doi.org/10.5772/61512openalex-snapshot
Herbicide-Resistant Palmer amaranth (Amaranthus palmeri S. Wats.) in the United States — Mechanisms of Resistance, Impact, and Management

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Functional PPO2 mutations: co‐occurrence in one plant or the same ppo2 allele of herbicide‐resistant Amaranthus palmeri in the US mid‐south
inferred← citeshttps://doi.org/10.1002/ps.6523openalex-snapshot
Design, synthesis, and herbicidal activity of novel phenoxypyridine derivatives containing natural product coumarin
inferred← citeshttps://doi.org/10.1002/ps.6850openalex-snapshot
Can double PPO mutations exist in the same allele and are such mutants functional?
inferred← citeshttps://doi.org/10.1002/ps.70603openalex-snapshot
Design, synthesis and herbicidal evaluation of novel ester‐functionalized N ‐phenylphthalimide derivatives containing pyridine as protoporphyrinogen IX oxidase inhibitors
inferred← citeshttps://doi.org/10.1002/ps.71056openalex-snapshot
Persistence of PPO mutations and dynamics of Amaranthus palmeri resistance to PPO ‐inhibitor herbicides in a decade
inferred← citeshttps://doi.org/10.1002/ps.71187openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/ps.71306openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/ps.71345openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/ps.7216openalex-snapshot
Inhibition profile of trifludimoxazin towards PPO2 target site mutations
inferred← citeshttps://doi.org/10.1002/ps.7425openalex-snapshot
Design, synthesis and screening of herbicidal activity for new phenyl pyrazole‐based protoporphyrinogen oxidase‐inhibitors ( PPO ) overcoming resistance issues
inferred← citeshttps://doi.org/10.1002/ps.8861openalex-snapshot
Discovery of novel benzoxazinone derivatives as promising protoporphyrinogen IX oxidase inhibitors
inferred← citeshttps://doi.org/10.1007/978-3-031-08072-2_14openalex-snapshot
Applications of Gene Drive for Weeds and Pest Management Using CRISPR/Cas9 System in Plants
inferred← citeshttps://doi.org/10.1007/s00122-026-05184-yopenalex-snapshot
Gene mapping and identification of candidate genes associated with fomesafen herbicide tolerance in Mung bean (Vigna radiata L.)
inferred← citeshttps://doi.org/10.1016/b978-0-12-821035-2.00037-1openalex-snapshot
Tirexor®—design of a new resistance breaking protoporphyrinogen IX oxidase inhibitor
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2020.127380openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.csbj.2023.07.024openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.pestbp.2020.104560openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.pestbp.2022.105288openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.pestbp.2023.105449openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.pestbp.2023.105487openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.pestbp.2025.106312openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.pestbp.2025.106572openalex-snapshot
Recent advances in the discovery of novel bleaching herbicides inspired by natural products
inferred← citeshttps://doi.org/10.1016/j.pestbp.2026.107085openalex-snapshot
Target-site and metabolic mechanisms confer broad resistance to PPO-inhibiting herbicides in Amaranthus retroflexus
inferred← citeshttps://doi.org/10.1016/j.plantsci.2019.110255openalex-snapshot
Herbicide resistant weeds: A call to integrate conventional agricultural practices, molecular biology knowledge and new technologies
inferred← citeshttps://doi.org/10.1017/wet.2019.84openalex-snapshot
Comparing responses of sensitive and resistant populations of Palmer amaranth (Amaranthus palmeri) and waterhemp (Amaranthus tuberculatus var. rudis) to PPO inhibitors
inferred← citeshttps://doi.org/10.1017/wet.2020.74openalex-snapshot
Distribution and validation of genotypic and phenotypic glyphosate and PPO-inhibitor resistance in Palmer amaranth (Amaranthus palmeri) from southwestern Nebraska
inferred← citeshttps://doi.org/10.1017/wet.2020.86openalex-snapshot
Molecular confirmation of resistance to PPO inhibitors in Amaranthus tuberculatus and Amaranthus palmeri, and isolation of the G399A PPO2 substitution in A. palmeri
inferred← citeshttps://doi.org/10.1017/wet.2024.6openalex-snapshot
Oxyfluorfen-resistant rice tolerance and weed control when using oxyfluorfen
inferred← citeshttps://doi.org/10.1017/wet.2025.40openalex-snapshot
Distribution of target site PPO-inhibiting herbicide resistance mutations in waterhemp and Palmer amaranth and association of epyrifenacil efficacy with PPX2 target site variants
inferred← citeshttps://doi.org/10.1017/wsc.2019.43openalex-snapshot
Large crabgrass (Digitaria sanguinalis) and Palmer amaranth (Amaranthus palmeri) intraspecific and interspecific interference in soybean
inferred← citeshttps://doi.org/10.1017/wsc.2019.61openalex-snapshot
Multiple resistance to PPO and ALS inhibitors in redroot pigweed (Amaranthus retroflexus)
inferred← citeshttps://doi.org/10.1017/wsc.2020.4openalex-snapshot
Differences in efficacy, resistance mechanism and target protein interaction between two PPO inhibitors in Palmer amaranth ( Amaranthus palmeri )
inferred← citeshttps://doi.org/10.1017/wsc.2020.42openalex-snapshot
Arg-128-Leu target-site mutation in PPO2 evolves in wild poinsettia ( Euphorbia heterophylla ) with cross-resistance to PPO-inhibiting herbicides
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inferred← citeshttps://doi.org/10.1017/wsc.2021.14openalex-snapshot
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inferred← citeshttps://doi.org/10.1017/wsc.2022.9openalex-snapshot
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inferred← citeshttps://doi.org/10.1017/wsc.2023.15openalex-snapshot
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Common target-site resistance mutations for PPO-inhibiting herbicides in waterhemp ( Amaranthus tuberculatus ) and Palmer amaranth ( Amaranthus palmeri ) do not confer cross-resistance to trifludimoxazin
inferred← citeshttps://doi.org/10.1017/wsc.2024.79openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acs.jafc.3c00951openalex-snapshot
Carboxylic Acid Derivatives in Herbicide Development
inferred← citeshttps://doi.org/10.1021/acs.jafc.3c03108openalex-snapshot
Design, Synthesis, and Biological Activity Determination of Novel Phenylpyrazole Protoporphyrinogen Oxidase Inhibitor Herbicides Containing Five-Membered Heterocycles
inferred← citeshttps://doi.org/10.1021/acs.jafc.3c05333openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acs.jafc.3c08596openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acs.jafc.4c07526openalex-snapshot
Design, Synthesis, and Herbicidal Activity of Biaryl-Pyridazinone/Phthalimide Derivatives as Novel Protoporphyrinogen Oxidase Inhibitors
inferred← citeshttps://doi.org/10.1021/acs.jafc.5c02641openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acs.jafc.5c04293openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acs.jafc.5c05004openalex-snapshot
Dimeric Prodrug Self-Assemblies Based on Carfentrazone with High Herbicidal Activity and Low Risks to Environment
inferred← citeshttps://doi.org/10.1021/bk-2021-1390.ch002openalex-snapshot
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inferred← citeshttps://doi.org/10.1038/s41598-020-77649-zopenalex-snapshot
A holistic approach in herbicide resistance research and management: from resistance detection to sustainable weed control
inferred← citeshttps://doi.org/10.1080/07352689.2019.1665769openalex-snapshot
The Genetic Inheritance of Herbicide Resistance in Weeds
inferred← citeshttps://doi.org/10.1080/21645698.2025.2572188openalex-snapshot
Safety assessment of membrane-associated protoporphyrinogen IX oxidase from Enterobacter cloacae expressed in genetically modified crops
inferred← citeshttps://doi.org/10.1080/21655979.2023.2259526openalex-snapshot
Health effects of herbicides and its current removal strategies
inferred← citeshttps://doi.org/10.1088/1755-1315/951/1/012027openalex-snapshot
Effect of pendimethalin and sulfentrazone on characteristics of weeds in soybean cultivation
inferred← citeshttps://doi.org/10.1093/jxb/eraf220openalex-snapshot
The biological and agronomic nexus behind the resistance to protoporphyrinogen IX oxidase-inhibiting herbicides in crops
inferred← citeshttps://doi.org/10.1093/plphys/kiag140openalex-snapshot
An ABCG-type transporter endows fomesafen resistance in Amaranthus retroflexus L.
inferred← citeshttps://doi.org/10.1101/2020.08.26.265678openalex-snapshot
Potential For Applying Continuous Directed Evolution To Plant Enzymes
inferred← citeshttps://doi.org/10.1111/wre.12626openalex-snapshot
Amaranthus palmeri S. Watson reproduction system: Implications for distribution and management strategies
inferred← citeshttps://doi.org/10.1371/journal.pone.0233254openalex-snapshot
Genetic variation associated with PPO-inhibiting herbicide tolerance in sorghum
inferred← citeshttps://doi.org/10.15407/agrisp9.02.023openalex-snapshot
Effectiveness of using the mixtures of herbicides flumioxazine and fluorochloridone in sunflower crops
inferred← citeshttps://doi.org/10.29335/tals.2019.57.1openalex-snapshot
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inferred← citeshttps://doi.org/10.3389/fagro.2022.869770openalex-snapshot
Multiple Genomic Regions Govern Tolerance to Sulfentrazone in Snap Bean (Phaseolus Vulgaris L.)
inferred← citeshttps://doi.org/10.3389/fpls.2020.614618openalex-snapshot
Predominance of Metabolic Resistance in a Six-Way-Resistant Palmer Amaranth (Amaranthus palmeri) Population
inferred← citeshttps://doi.org/10.3389/fpls.2026.1904705openalex-snapshot
Novel amino acid substitutions in Protoporphyrinogen oxidase 1 endow resistance to PPO-inhibiting herbicides in Bassia scoparia
inferred← citeshttps://doi.org/10.3390/agriculture11030187openalex-snapshot
Recurrent Selection with Low Herbicide Rates and Salt Stress Decrease Sensitivity of Echinochloa colona to Imidazolinone
inferred← citeshttps://doi.org/10.3390/agriculture11080760openalex-snapshot
PPO2 Mutations in Amaranthus palmeri: Implications on Cross-Resistance
inferred← citeshttps://doi.org/10.3390/agronomy10111619openalex-snapshot
Recurrent Selection by Herbicide Sublethal Dose and Drought Stress Results in Rapid Reduction of Herbicide Sensitivity in Junglerice
inferred← citeshttps://doi.org/10.3390/agronomy13020592openalex-snapshot
Assessment of Efficacy and Mechanism of Resistance to Soil-Applied PPO Inhibitors in Amaranthus palmeri
inferred← citeshttps://doi.org/10.3390/biology12040592openalex-snapshot
Enhanced Herbicide Metabolism and Target-Site Mutations Confer Multiple Resistance to Fomesafen and Nicosulfuron in Amaranthus retroflexus L.
inferred← citeshttps://doi.org/10.3390/genes13061044openalex-snapshot
Field-Evolved ΔG210-ppo2 from Palmer Amaranth Confers Pre-emergence Tolerance to PPO-Inhibitors in Rice and Arabidopsis
inferred← citeshttps://doi.org/10.3390/life10090179openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/plants10020284openalex-snapshot
Effect of Herbicides on the Management of the Invasive Weed Solanum rostratum Dunal (Solanaceae)
inferred← citeshttps://doi.org/10.3390/plants12091886openalex-snapshot
A New V361A Mutation in Amaranthus palmeri PPX2 Associated with PPO-Inhibiting Herbicide Resistance
inferred← citeshttps://doi.org/10.3390/plants14040515openalex-snapshot
Rapid Resistance Detection of Amaranthus retroflexus to Fomesafen via Kompetitive Allele-Specific PCR (KASP)
inferred← citeshttps://doi.org/10.3390/plants8100382openalex-snapshot
Target-Site Mutations Conferring Herbicide Resistance
inferred← citeshttps://doi.org/10.64898/2026.01.15.699694openalex-snapshot
Novel Protoporphyrinogen oxidase 1 mutations endow resistance to PPO-inhibiting herbicides in Bassia scoparia
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