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Antimicrobial Peptides—Mechanisms of Action, Antimicrobial Effects and Clinical Applications

https://doi.org/10.3390/antibiotics11101417

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Antifungal peptides: To be or not to be membrane active

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Cathelicidin-mediated lipopolysaccharide signaling via intracellular TLR4 in colonic epithelial cells evokes CXCL8 production

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Benchmarks in antimicrobial peptide prediction are biased due to the selection of negative data

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Azole-Resistant Aspergillosis: Epidemiology, Molecular Mechanisms, and Treatment

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Glycosaminoglycans inhibit the antibacterial activity of LL-37 in biological fluids

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Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up‐regulated in myeloid cells by 1,25‐dihydroxyvitamin D 3

inferredcites →https://doi.org/10.1101/2021.05.06.442606openalex-snapshot

Classical macrophage polarisation is limited by human β-defensin-3 via an autocrine IL-4 dependent process

inferredcites →https://doi.org/10.1111/2049-632x.12151openalex-snapshot

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Intracellular Targeting Mechanisms by Antimicrobial Peptides

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Bacterial Wall as Target for Attack

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Cryptococcus neoformans Cells in Biofilms Are Less Susceptible than Planktonic Cells to Antimicrobial Molecules Produced by the Innate Immune System

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Antimicrobial Peptides: a New Frontier in Antifungal Therapy

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BMAP-28, an Antibiotic Peptide of Innate Immunity, Induces Cell Death through Opening of the Mitochondrial Permeability Transition Pore

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d -Amino acids in antimicrobial peptides: a potential approach to treat and combat antimicrobial resistance

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Precision Reengineering of the Oral Microbiome for Caries Management

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A Review of Antifungal Peptides : Basis to New Era of Antifungal Drugs = مضادات الفطريات الببتيدية : عصر جديد من العقاقير المضادة للفطريات

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Antiviral Activity and Increased Host Defense against Influenza Infection Elicited by the Human Cathelicidin LL-37

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PXL01 in Sodium Hyaluronate for Improvement of Hand Recovery after Flexor Tendon Repair Surgery: Randomized Controlled Trial

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Lipopolysaccharide -mediated resistance to host antimicrobial peptides and hemocyte-derived reactive-oxygen species are the major Providencia alcalifaciens virulence factors in Drosophila melanogaster

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Evidence of Antibiotic Resistance from Population-Based Studies: A Narrative Review

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Advances in Peptide Pharmaceuticals

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Antifungal Peptides as Therapeutic Agents

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Overlapping Properties of the Short Membrane-Active Peptide BP100 With (i) Polycationic TAT and (ii) α-helical Magainin Family Peptides

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Bioactive Peptides Against Fungal Biofilms

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Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields

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Association between Antimicrobial Peptide Histatin 5 Levels and Prevalence of Candida in Saliva of Patients with Down Syndrome

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Histatin-1 Attenuates LPS-Induced Inflammatory Signaling in RAW264.7 Macrophages

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Antifungal Activity of Antimicrobial Peptides and Proteins against Aspergillus fumigatus

inferredcites →https://doi.org/10.3390/jof6030124openalex-snapshot

Zinc Binding by Histatin 5 Promotes Fungicidal Membrane Disruption in C. albicans and C. glabrata

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inferred← citeshttps://doi.org/10.1021/acsbiomedchemau.5c00084openalex-snapshot

Poly-Arginine Tails and Helical Segments of Natural Antimicrobial Peptides Display Concerted Action at Membranes for Enhanced Antimicrobial Effects

inferred← citeshttps://doi.org/10.1021/acsinfecdis.3c00206openalex-snapshot

Mimicking Nonribosomal Peptides from the Marine Actinomycete Streptomyces sp. H-KF8 Leads to Antimicrobial Peptides

inferred← citeshttps://doi.org/10.1021/acsinfecdis.4c00476openalex-snapshot

Antifungal Efficacy of Ultrashort β-Peptides against Candida Species: Mechanistic Understanding and Therapeutic Implications

inferred← citeshttps://doi.org/10.1021/acsinfecdis.4c00806openalex-snapshot

Decoding the Role of Antimicrobial Peptides in the Fight against Mycobacterium tuberculosis

inferred← citeshttps://doi.org/10.1021/acsinfecdis.5c00667openalex-snapshot

Harnessing AMPs to Tackle ESKAPE Pathogens

inferred← citeshttps://doi.org/10.1021/acsmeasuresciau.5c00126openalex-snapshot

Integrating Docking, Dynamics, and Assays to Predict Antimicrobial Peptide Interactions with Mycolic Acid Membranes in Mycobacterium tuberculosis

inferred← citeshttps://doi.org/10.1021/acsmedchemlett.4c00375openalex-snapshot

Hybrids of Membrane-Translocating Antimicrobial Peptides Show Enhanced Activity through Membrane Permeabilization

inferred← citeshttps://doi.org/10.1021/acsmedchemlett.5c00140openalex-snapshot

Broad-Spectrum Antimicrobial Efficacy of Cyclic Antimicrobial Peptide Against Multidrug-Resistant Staphylococcus aureus Infections

inferred← citeshttps://doi.org/10.1021/acsomega.3c04878openalex-snapshot

Development of New Leishmanicidal Compounds via Bioconjugation of Antimicrobial Peptides and Antileishmanial Guanidines

inferred← citeshttps://doi.org/10.1021/jacs.5c14236openalex-snapshot

Bacterial Phospholipid-Inducible Helix-Transformable Antimicrobial Polypeptides

inferred← citeshttps://doi.org/10.1038/s41467-025-67532-8openalex-snapshot

Small molecule inhibitor targets OmpV to treat pandemic Vibrio cholerae infection

inferred← citeshttps://doi.org/10.1038/s41598-025-17002-4openalex-snapshot

Potential application of Healitide-GP1, a novel antibacterial peptide, in wound healing: in vitro studies

inferred← citeshttps://doi.org/10.1038/s41598-026-57481-7openalex-snapshot

A novel bioactive contact lens for corneal epithelial regeneration in a rabbit model

inferred← citeshttps://doi.org/10.1038/s41598-026-60957-1openalex-snapshot

Antimicrobial peptides as computational candidates for SARS-CoV-2 papain-like protease inhibition

inferred← citeshttps://doi.org/10.1039/d2dt04099aopenalex-snapshot

Synthesis of temporin L hydroxamate-based peptides and evaluation of their coordination properties with iron( iii )

inferred← citeshttps://doi.org/10.1039/d4md00911hopenalex-snapshot

Self-responsive biomimetic short lipopeptide-based delivery systems for enhanced antibiotic efficacy against drug-resistant infections

inferred← citeshttps://doi.org/10.1039/d4np00042kopenalex-snapshot

Human microbiota peptides: important roles in human health

inferred← citeshttps://doi.org/10.1039/d4nr02233eopenalex-snapshot

Development of a two-dimensional peptide functionalized-reduced graphene oxide biomaterial for wound care applications

inferred← citeshttps://doi.org/10.1039/d5tb01872bopenalex-snapshot

Self-assembled nanostructured antimicrobial peptides: design strategies, structures, mechanism and therapeutic applications

inferred← citeshttps://doi.org/10.1039/d6bm00486eopenalex-snapshot

Nature-inspired biomaterial innovations to counter medical device-associated infections

inferred← citeshttps://doi.org/10.1039/d6fb00050aopenalex-snapshot

Enzymatic production, fractionation, and multi-assay bioactivity profiling of dual-function antimicrobial and antioxidant peptides from Moringa oleifera leaf protein

inferred← citeshttps://doi.org/10.1039/d6ra02550aopenalex-snapshot

Synthesis and antibacterial activity study of anti-biofilm agents based on American oyster defensin analog A4

inferred← citeshttps://doi.org/10.1073/pnas.2424461123openalex-snapshot

Dermcidin has antiviral activity and protects against influenza

inferred← citeshttps://doi.org/10.1080/07391102.2025.2458328openalex-snapshot

Structure-activity relationship of peptide conjugates derived from BP100 and insights into their interactions with lipid membranes by NMR and MD simulations

inferred← citeshttps://doi.org/10.1080/13102818.2024.2367736openalex-snapshot

AMEP412 as a potent antifungal agent against rice blast fungus Magnaporthe oryzae in vivo and in vitro

inferred← citeshttps://doi.org/10.1080/14737175.2023.2244162openalex-snapshot

Viruses - a major cause of amyloid deposition in the brain

inferred← citeshttps://doi.org/10.1080/14787210.2024.2377677openalex-snapshot

Applications of β-defensins against infectious pathogenic microorganisms

inferred← citeshttps://doi.org/10.1080/17429145.2026.2651842openalex-snapshot

Elucidating the biocontrol potential of Trichoderma yunnanense TM10 for managing sheath blight disease ( Rhizoctonia solani Kühn) in rice ( Oryza sativa L.)

inferred← citeshttps://doi.org/10.1080/17512433.2026.2739560openalex-snapshot

Non-antibiotic therapeutic approaches for antimicrobial resistance: current evidence and future directions

inferred← citeshttps://doi.org/10.1093/femsmc/xtag003openalex-snapshot

Enhanced antibacterial activity of antimicrobial peptide—antibiotic combinations against multidrug-resistant bacteria

inferred← citeshttps://doi.org/10.1093/jambio/lxae290openalex-snapshot

Harnessing bacterial antimicrobial peptides: a comprehensive review on properties, mechanisms, applications, and challenges in combating antimicrobial resistance

inferred← citeshttps://doi.org/10.1093/jambio/lxag093openalex-snapshot

Peptoid-based antimicrobial strategies against polymyxin-resistant Gram-negative bacteria

inferred← citeshttps://doi.org/10.1101/2024.09.15.613163openalex-snapshot

High Throughput Meta-analysis of Antimicrobial Peptides for Characterizing Class Specific Therapeutic Candidates: An in-silico Approach

inferred← citeshttps://doi.org/10.1101/2025.01.31.635854openalex-snapshot

Structural and Functional Versatility of the Amyloidogenic Antimicrobial Peptide Citropin 1.3

inferred← citeshttps://doi.org/10.1101/2025.07.02.662646openalex-snapshot

Synergistic Antimicrobial Activity of Epinecidin-1 and Its Variants with Antibiotics Against Nosocomial Pathogens: Implications for In Vivo Wound Healing

inferred← citeshttps://doi.org/10.1128/spectrum.00265-24openalex-snapshot

Antimicrobial activity of novel symmetrical antimicrobial peptides centered on a hydrophilic motif against resistant clinical isolates: in vitro and in vivo analyses

inferred← citeshttps://doi.org/10.1128/spectrum.02908-24openalex-snapshot

A novel function of short cationic peptide FP-CATH9 without antimicrobial activity reverses resistance to minocycline in common multidrug-resistant gram-negative bacteria

inferred← citeshttps://doi.org/10.1155/sci5/9748832openalex-snapshot

Antimicrobial Peptides and Laying Hens Farming: A Review to Analyze the Improvement of the Animal Performance, Health, and Egg Quality

inferred← citeshttps://doi.org/10.11606/d.46.2024.tde-01112024-164857openalex-snapshot

New aqueous dispersions of gramicidin D and poly (diallyldimethylammonium chloride): preparation, characterization and antimicrobial activity

inferred← citeshttps://doi.org/10.1186/s13018-024-05143-7openalex-snapshot

A review on the promising antibacterial agents in bone cement–From past to current insights

inferred← citeshttps://doi.org/10.1186/s44149-025-00168-9openalex-snapshot

Functional immunopeptides: advancing prevention and therapeutic strategies against animal diseases

inferred← citeshttps://doi.org/10.12998/wjcc.v11.i8.1669openalex-snapshot

Understanding the multifaceted etiopathogenesis of foot complications in individuals with diabetes

inferred← citeshttps://doi.org/10.1371/journal.pone.0329497openalex-snapshot

In vitro study of probiotic Lactobacillus helveticus: Antibacterial effects on Porphyromonas gingivalis

inferred← citeshttps://doi.org/10.17513/msnv.21262openalex-snapshot

NON-RIBOSOMAL PEPTIDES AND THEIR APPLICATION IN MODERN MEDI-CINE

inferred← citeshttps://doi.org/10.17513/spno.32620openalex-snapshot

ANTIMICROBIAL PEPTIDES – A MODERN ALTERNATIVE TO ANTIBIOTICS

inferred← citeshttps://doi.org/10.17533/udea.hm.v14n2a02openalex-snapshot

Péptidos Bioactivos de Streptomyces: Una Revisión Actualizada de su Potencial Terapéutico

inferred← citeshttps://doi.org/10.18311/jnr/2026/55979openalex-snapshot

Antimicrobial Peptides in Microorganisms and Lower Eukaryotes: Diversity, Mechanisms, and Applications

inferred← citeshttps://doi.org/10.21203/rs.3.rs-5430498/v1openalex-snapshot

Prediction and Characterization of Antimicrobial Peptides from Sea Cucumbers (Holothuria sp.) in Papuan Waters, Indonesia

inferred← citeshttps://doi.org/10.21203/rs.3.rs-7528629/v1openalex-snapshot

Pharmacological Insights into Antimicrobial Plant Peptides and Global Trends in Encapsulation and Drug Delivery Research from 2000 to 2024

inferred← citeshttps://doi.org/10.21203/rs.3.rs-7586160/v1openalex-snapshot

Computational Insights into Papain-Like Protease Inhibition: Antimicrobial Peptides as Potential Therapeutics Against SARS-CoV-2

inferred← citeshttps://doi.org/10.2174/0109298665327474241112093601openalex-snapshot

Recombinant Production of Ib-AMP4 and Oncorhyncin II Antimicrobial Peptides and Antimicrobial Synergistic Assessment on the Treatment of Staphylococcus aureus Under In vitro Condition

inferred← citeshttps://doi.org/10.2174/0109298665417414251007054305openalex-snapshot

Customizing Proteins: Reassigning Functionality of Proteins via Incorporation of Unnatural Amino Acids

inferred← citeshttps://doi.org/10.2174/0115680266435068250902102329openalex-snapshot

Recent Advances in Antimicrobial Research

inferred← citeshttps://doi.org/10.22490/24629448.11776openalex-snapshot

Bacterias Gram negativas resistentes a carbapenémicos aisladas en un hospital colombiano: caracterización molecular y evaluación in vitro de péptidos antimicrobianos derivados del LL37

inferred← citeshttps://doi.org/10.2478/aoas-2025-0117openalex-snapshot

A comprehensive review of classification, mechanisms, application and future prospects for antimicrobial peptides

inferred← citeshttps://doi.org/10.26444/monz/167425openalex-snapshot

New antibiotics in clinical trials – prospects for antibacterial treatment development

inferred← citeshttps://doi.org/10.29235/1814-6023-2026-23-2-125-139openalex-snapshot

In vitro analysis of combined phenotypic resistance of clinical isolates of Escherichia coli and Klebsiella pneumoniae to antibiotics and humoral factors of innate immunity

inferred← citeshttps://doi.org/10.33263/briac164.105openalex-snapshot

Polystyrene Nanoparticles Attenuate Brevinin-1 E8.13-induced Cytotoxicity and Alter Nanoparticles-Peptide Interactions In Human Lung Epithelial Cells

inferred← citeshttps://doi.org/10.3389/fbioe.2025.1678136openalex-snapshot

Recent progress of polydopamine nanoparticles as advanced antimicrobial nanomaterials

inferred← citeshttps://doi.org/10.3389/fbioe.2026.1914224openalex-snapshot

Collagen targeted self-anchoring antimicrobial molecular agents

inferred← citeshttps://doi.org/10.3389/fcimb.2024.1446626openalex-snapshot

Unravelling the mechanisms causing murepavadin resistance in Pseudomonas aeruginosa: lipopolysaccharide alterations and its consequences

inferred← citeshttps://doi.org/10.3389/fimmu.2023.1194923openalex-snapshot

Mycobacterium tuberculosis cell-wall and antimicrobial peptides: a mission impossible?

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