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Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Determination of Metabolic Viability and Cell Mass Using a Tandem Resazurin/Sulforhodamine B Assay
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Fast Gradient HPLC Method to Determine Compounds Binding to Human Serum Albumin. Relationships with Octanol/Water and Immobilized Artificial Membrane Lipophilicity
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Mitochondria-Targeted Agents: Mitochondriotropics, Mitochondriotoxics, and Mitocans
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Mitochondria in Neurodegeneration
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Protective Effects of Piperine Against Corticosterone-Induced Neurotoxicity in PC12 Cells
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A review on cholinesterase inhibitors for Alzheimer’s disease
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A new and rapid colorimetric determination of acetylcholinesterase activity
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Boron trihalide-methyl sulfide complexes as convenient reagents for dealkylation of aryl ethers
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Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: Implications for mitochondria-specific therapies and probes
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Alkyl esters of hydroxycinnamic acids with improved antioxidant activity and lipophilicity protect PC12 cells against oxidative stress
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Fine-tuning the neuroprotective and blood-brain barrier permeability profile of multi-target agents designed to prevent progressive mitochondrial dysfunction
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Strategies to target bioactive molecules to subcellular compartments. Focus on natural compounds
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Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies
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In vitro screening assays to identify natural or synthetic acetylcholinesterase inhibitors: Thin layer chromatography versus microplate methods
inferredcites →https://doi.org/10.1016/j.ejps.2012.05.014openalex-snapshot
The exploration of thienothiazines as selective butyrylcholinesterase inhibitors
inferredcites →https://doi.org/10.1016/j.fct.2008.06.014openalex-snapshot
Piperine, the potential functional food for mood and cognitive disorders
inferredcites →https://doi.org/10.1016/j.fct.2009.12.009openalex-snapshot
Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer’s disease
inferredcites →https://doi.org/10.1016/j.febslet.2009.12.002openalex-snapshot
Mitochondria‐targeted antioxidant SkQR1 selectively protects MDR (Pgp 170)‐negative cells against oxidative stress
inferredcites →https://doi.org/10.1016/j.foodchem.2011.08.019openalex-snapshot
Microwave-assisted extraction of phenolics with maximal antioxidant activities in tomatoes
inferredcites →https://doi.org/10.1016/j.foodchem.2020.128110openalex-snapshot
Electrochemical behaviour of piperine. Comparison with control antioxidants
inferredcites →https://doi.org/10.1016/j.jconrel.2015.03.036openalex-snapshot
Mitochondrial biology, targets, and drug delivery
inferredcites →https://doi.org/10.1016/j.molstruc.2019.01.060openalex-snapshot
Development of piperic acid-based monoamine oxidase inhibitors: Synthesis, structural characterization and biological evaluation
inferredcites →https://doi.org/10.1016/j.neuropharm.2019.05.025openalex-snapshot
New evidence for dual binding site inhibitors of acetylcholinesterase as improved drugs for treatment of Alzheimer's disease
inferredcites →https://doi.org/10.1021/ac001388jopenalex-snapshot
High-Throughput Liquid Chromatography/Mass Spectrometry Method for the Determination of the Chromatographic Hydrophobicity Index
inferredcites →https://doi.org/10.1021/ac961242dopenalex-snapshot
Chromatographic Hydrophobicity Index by Fast-Gradient RP-HPLC: A High-Throughput Alternative to log P/log D
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Development of a PEGylated-Based Platform for Efficient Delivery of Dietary Antioxidants Across the Blood–Brain Barrier
inferredcites →https://doi.org/10.1021/acs.chemrev.7b00042openalex-snapshot
Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications
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Development of a Mitochondriotropic Antioxidant Based on Caffeic Acid: Proof of Concept on Cellular and Mitochondrial Oxidative Stress Models
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Design, Synthesis, and Pharmacological Characterization of Carbazole Based Dopamine Agonists as Potential Symptomatic and Neuroprotective Therapeutic Agents for Parkinson’s Disease
inferredcites →https://doi.org/10.1021/jf010586oopenalex-snapshot
Development and Validation of an Improved Oxygen Radical Absorbance Capacity Assay Using Fluorescein as the Fluorescent Probe
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Structure−Brain Exposure Relationships
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Oxidative Stress in Alzheimer’s Disease: Are We Connecting the Dots?
inferredcites →https://doi.org/10.1038/nprot.2008.75openalex-snapshot
Neutral red uptake assay for the estimation of cell viability/cytotoxicity
inferredcites →https://doi.org/10.1038/s41598-017-07272-yopenalex-snapshot
Development of hydroxybenzoic-based platforms as a solution to deliver dietary antioxidants to mitochondria
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Novel 2-pheynlbenzofuran derivatives as selective butyrylcholinesterase inhibitors for Alzheimer’s disease
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A novel bifunctional mitochondria-targeted anticancer agent with high selectivity for cancer cells
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Ciproxifan, a histamine H3 receptor antagonist, reversibly inhibits monoamine oxidase A and B
inferredcites →https://doi.org/10.1073/pnas.0931245100openalex-snapshot
Delivery of bioactive molecules to mitochondria in vivo
inferredcites →https://doi.org/10.1074/jbc.m210241200openalex-snapshot
Crystal Structure of Human Butyrylcholinesterase and of Its Complexes with Substrate and Products
inferredcites →https://doi.org/10.1080/105172399242573openalex-snapshot
PURIFICATION AND DETERMINATION OF THE AMINO ACID SEQUENCE OF EQUINE SERUM BUTYRYLCHOLINESTERASE
inferredcites →https://doi.org/10.1107/97809553602060000865openalex-snapshot
PHENIX: a comprehensive Python-based system for macromolecular structure solution
inferredcites →https://doi.org/10.1107/s0021889807021206openalex-snapshot
Phaser crystallographic software
inferredcites →https://doi.org/10.1107/s0907444909052925openalex-snapshot
PHENIX : a comprehensive Python-based system for macromolecular structure solution
inferredcites →https://doi.org/10.1107/s0907444910007493openalex-snapshot
Features and development of Coot
inferredcites →https://doi.org/10.1111/cns.12655openalex-snapshot
Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment
inferredcites →https://doi.org/10.1111/j.1582-4934.2010.01010.xopenalex-snapshot
Basic mechanisms of neurodegeneration: a critical update
inferredcites →https://doi.org/10.1111/j.1742-4658.2012.08672.xopenalex-snapshot
Human butyrylcholinesterase produced in insect cells: huprine‐based affinity purification and crystal structure
inferredcites →https://doi.org/10.1124/jpet.112.192138openalex-snapshot
Mitochondrial Dysfunction in Neurodegenerative Diseases
inferredcites →https://doi.org/10.1155/2011/683728openalex-snapshot
Oxidative Toxicity in Neurodegenerative Diseases: Role of Mitochondrial Dysfunction and Therapeutic Strategies
inferredcites →https://doi.org/10.1158/0008-5472.can-15-2534openalex-snapshot
Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells
inferredcites →https://doi.org/10.1248/cpb.53.832openalex-snapshot
Piperine from the Fruits of Piper longum with Inhibitory Effect on Monoamine Oxidase and Antidepressant-Like Activity
inferredcites →https://doi.org/10.1602/neurorx.2.4.541openalex-snapshot
Medicinal chemical properties of successful central nervous system drugs
inferredcites →https://doi.org/10.18632/oncotarget.11661openalex-snapshot
Piperine induces autophagy by enhancing protein phosphotase 2A activity in a rotenone-induced Parkinson's disease model
inferredcites →https://doi.org/10.2174/0929867013372643openalex-snapshot
Rapid Method for the Estimation of Octanol / Water Partition Coefficient (Log Poct) from Gradient RP-HPLC Retention and a Hydrogen Bond Acidity Term (Sigma alpha2H)
inferredcites →https://doi.org/10.2174/0929867321666141106122628openalex-snapshot
Recent Development of Multifunctional Agents as Potential Drug Candidates for the Treatment of Alzheimer’s Disease
inferredcites →https://doi.org/10.3109/10715762.2012.662593openalex-snapshot
Rational discovery and development of a mitochondria-targeted antioxidant based on cinnamic acid scaffold
inferredcites →https://doi.org/10.3109/10715762.2014.965702openalex-snapshot
New insights into the antioxidant activity of hydroxycinnamic and hydroxybenzoic systems: Spectroscopic, electrochemistry, and cellular studies
inferredcites →https://doi.org/10.3389/fchem.2018.00126openalex-snapshot
Hydroxybenzoic Acid Derivatives as Dual-Target Ligands: Mitochondriotropic Antioxidants and Cholinesterase Inhibitors
inferredcites →https://doi.org/10.3389/fnins.2016.00375openalex-snapshot
Key Targets for Multi-Target Ligands Designed to Combat Neurodegeneration
inferredcites →https://doi.org/10.3390/molecules25020276openalex-snapshot
Exploring the Multi-Target Performance of Mitochondriotropic Antioxidants against the Pivotal Alzheimer’s Disease Pathophysiological Hallmarks
inferredcites →https://doi.org/10.3892/ijmm.2015.2356openalex-snapshot
Neuroprotective effects of piperine on the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease mouse model
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Solvent-free synthesis of quinazolinone–chalcone hybrids and their evaluation as dual inhibitors of AChE and BuChE for alzheimer’s disease
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Rapid discovery and crystallography study of highly potent and selective butylcholinesterase inhibitors based on oxime-containing libraries and conformational restriction strategies
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Interactions-guided blueprint of acetylcholinesterase binding: A review on structural and molecular determinants
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Comprehensive analysis of acetylcholinesterase inhibitor and reactivator complexes: implications for drug design and antidote development
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From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects
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Straightforward access to novel mitochondriotropics derived from 2-arylethanol as potent and selective antiproliferative agents
inferred← citeshttps://doi.org/10.1016/j.molstruc.2026.145611openalex-snapshot
Structure-guided design and synthesis of selective butyrylcholinesterase inhibitors
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c01748openalex-snapshot
A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning
inferred← citeshttps://doi.org/10.1039/d4md00060aopenalex-snapshot
Carltonine-derived compounds for targeted butyrylcholinesterase inhibition
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Discovery of novel 2-(4-(benzyloxy)-5-(hydroxyl) phenyl) benzothiazole derivatives as multifunctional MAO-B inhibitors for the treatment of Parkinson’s disease
inferred← citeshttps://doi.org/10.3390/ijms241310494openalex-snapshot
Mitochondria-Targeted Delivery Strategy of Dual-Loaded Liposomes for Alzheimer’s Disease Therapy
inferred← citeshttps://doi.org/10.3390/ph15060673openalex-snapshot
Design, Synthesis, and In Vitro, In Silico and In Cellulo Evaluation of New Pyrimidine and Pyridine Amide and Carbamate Derivatives as Multi-Functional Cholinesterase Inhibitors
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Nanotechnology-Based Drug Delivery Strategies to Repair the Mitochondrial Function in Neuroinflammatory and Neurodegenerative Diseases
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