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PTEN in Lung Cancer: Dealing with the Problem, Building on New Knowledge and Turning the Game Around
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1 of the 115 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-21): 10.1007/s13277-015-4150-3 (notice 2021-12-21).
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/cam4.191openalex-snapshot
Alterations of INPP4B, PIK3CA and pAkt of the PI3K pathway are associated with squamous cell carcinoma of the lung
inferredcites →https://doi.org/10.1002/cam4.2220openalex-snapshot
MicroRNA‐4286 promotes cell proliferation, migration, and invasion via PTEN regulation of the PI3K/Akt pathway in non‐small cell lung cancer
inferredcites →https://doi.org/10.1002/cbf.3331openalex-snapshot
MicroRNA‐130b targets PTEN to induce resistance to cisplatin in lung cancer cells by activating Wnt/β‐catenin pathway
inferredcites →https://doi.org/10.1002/cncr.30794openalex-snapshot
Next‐generation sequencing and clinical outcomes of patients with lung adenocarcinoma treated with stereotactic body radiotherapy
inferredcites →https://doi.org/10.1002/ijc.20447openalex-snapshot
PTEN promoter is methylated in a proportion of invasive breast cancers
inferredcites →https://doi.org/10.1002/pros.22974openalex-snapshot
SLUG is a direct transcriptional repressor of PTEN tumor suppressor
inferredcites →https://doi.org/10.1007/s00018-010-0500-xopenalex-snapshot
Cigarette smoking reprograms apical junctional complex molecular architecture in the human airway epithelium in vivo
inferredcites →https://doi.org/10.1007/s00262-017-2098-4openalex-snapshot
Characterization of PD-L1 expression in Chinese non-small cell lung cancer patients with PTEN expression as a means for tissue quality screening
inferredcites →https://doi.org/10.1007/s11010-012-1443-3openalex-snapshot
MicroRNA-21 (miR-21) expression promotes growth, metastasis, and chemo- or radioresistance in non-small cell lung cancer cells by targeting PTEN
inferredcites →https://doi.org/10.1007/s13277-015-3416-0openalex-snapshot
Expression and clinical evidence of miR-494 and PTEN in non-small cell lung cancer
inferredcites →https://doi.org/10.1007/s13277-015-4150-3openalex-snapshot
MicroRNA-92a promotes growth, metastasis, and chemoresistance in non-small cell lung cancer cells by targeting PTEN
inferredcites →https://doi.org/10.1016/j.anndiagpath.2003.11.002openalex-snapshot
Co-downregulation of PTEN, KAI-1, and nm23-H1 tumor/metastasis suppressor proteins in non-small cell lung cancer
inferredcites →https://doi.org/10.1016/j.bbrc.2015.09.085openalex-snapshot
Loss of PTEN causes SHP2 activation, making lung cancer cells unresponsive to IFN-γ
inferredcites →https://doi.org/10.1016/j.biopha.2018.12.115openalex-snapshot
MiR-183-5p is required for non-small cell lung cancer progression by repressing PTEN
inferredcites →https://doi.org/10.1016/j.cell.2006.11.039openalex-snapshot
NEDD4-1 Is a Proto-Oncogenic Ubiquitin Ligase for PTEN
inferredcites →https://doi.org/10.1016/j.cell.2006.11.042openalex-snapshot
Essential Role for Nuclear PTEN in Maintaining Chromosomal Integrity
inferredcites →https://doi.org/10.1016/j.cell.2011.09.029openalex-snapshot
Coding-Independent Regulation of the Tumor Suppressor PTEN by Competing Endogenous mRNAs
inferredcites →https://doi.org/10.1016/j.cell.2011.09.032openalex-snapshot
In Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of Melanoma
inferredcites →https://doi.org/10.1016/j.cell.2014.03.027openalex-snapshot
Cancer-Associated PTEN Mutants Act in a Dominant-Negative Manner to Suppress PTEN Protein Function
inferredcites →https://doi.org/10.1016/j.ejphar.2018.01.036openalex-snapshot
PPARgamma agonists sensitize PTEN-deficient resistant lung cancer cells to EGFR tyrosine kinase inhibitors by inducing autophagy
inferredcites →https://doi.org/10.1016/j.gene.2018.01.024openalex-snapshot
MiR-93-5p up-regulation is involved in non-small cell lung cancer cells proliferation and migration and poor prognosis
inferredcites →https://doi.org/10.1016/j.humpath.2005.05.006openalex-snapshot
PTEN expression in non–small-cell lung cancer: evaluating its relation to tumor characteristics, allelic loss, and epigenetic alteration
inferredcites →https://doi.org/10.1016/j.immuni.2017.02.001openalex-snapshot
Loss of PTEN Is Associated with Resistance to Anti-PD-1 Checkpoint Blockade Therapy in Metastatic Uterine Leiomyosarcoma
inferredcites →https://doi.org/10.1016/j.jtho.2017.09.1951openalex-snapshot
Longitudinal Cell-Free DNA Analysis in Patients with Small Cell Lung Cancer Reveals Dynamic Insights into Treatment Efficacy and Disease Relapse
inferredcites →https://doi.org/10.1016/j.lungcan.2005.10.003openalex-snapshot
Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis
inferredcites →https://doi.org/10.1016/j.lungcan.2005.10.010openalex-snapshot
PPAR-γ agonist increase gefitinib's antitumor activity through PTEN expression
inferredcites →https://doi.org/10.1016/j.lungcan.2009.11.012openalex-snapshot
PTEN mutations and relationship to EGFR, ERBB2, KRAS, and TP53 mutations in non-small cell lung cancers
inferredcites →https://doi.org/10.1016/j.lungcan.2015.01.009openalex-snapshot
CpG hypermethylation contributes to decreased expression of PTEN during acquired resistance to gefitinib in human lung cancer cell lines
inferredcites →https://doi.org/10.1016/j.lungcan.2017.01.011openalex-snapshot
Mutations in TP53 , PIK3CA , PTEN and other genes in EGFR mutated lung cancers: Correlation with clinical outcomes
inferredcites →https://doi.org/10.1016/j.lungcan.2018.04.008openalex-snapshot
Genomic alterations of plasma cell-free DNAs in small cell lung cancer and their clinical relevance
inferredcites →https://doi.org/10.1016/j.lungcan.2019.01.013openalex-snapshot
PTEN inactivation induces epithelial-mesenchymal transition and metastasis by intranuclear translocation of β-catenin and snail/slug in non-small cell lung carcinoma cells
inferredcites →https://doi.org/10.1016/j.molmed.2019.03.003openalex-snapshot
PTEN Mutations Trigger Resistance to Immunotherapy
inferredcites →https://doi.org/10.1016/j.omtm.2017.11.006openalex-snapshot
Engineering PTEN-L for Cell-Mediated Delivery
inferredcites →https://doi.org/10.1016/j.omtn.2018.03.011openalex-snapshot
Targeting Nicotinamide N-Methyltransferase and miR-449a in EGFR-TKI-Resistant Non-Small-Cell Lung Cancer Cells
inferredcites →https://doi.org/10.1016/s1556-0864(15)30374-9openalex-snapshot
PTEN and PIK3CA Expression Is Associated with Prolonged Survival after Gefitinib Treatment in EGFR-Mutated Lung Cancer Patients
inferredcites →https://doi.org/10.1038/emboj.2008.238openalex-snapshot
PTEN regulation by Akt–EGR1–ARF–PTEN axis
inferredcites →https://doi.org/10.1038/nature11404openalex-snapshot
Comprehensive genomic characterization of squamous cell lung cancers
inferredcites →https://doi.org/10.1038/nature11674openalex-snapshot
COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis
inferredcites →https://doi.org/10.1038/nature13385openalex-snapshot
Comprehensive molecular profiling of lung adenocarcinoma
inferredcites →https://doi.org/10.1038/ng.556openalex-snapshot
Subtle variations in Pten dose determine cancer susceptibility
inferredcites →https://doi.org/10.1038/ni.3076openalex-snapshot
Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses
inferredcites →https://doi.org/10.1038/ni.3077openalex-snapshot
Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability
inferredcites →https://doi.org/10.1038/nrc3860openalex-snapshot
PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting
inferredcites →https://doi.org/10.1038/nrclinonc.2018.28openalex-snapshot
Targeting the PI3K pathway in cancer: are we making headway?
inferredcites →https://doi.org/10.1038/s41388-017-0088-9openalex-snapshot
MicroRNA-146b promotes PI3K/AKT pathway hyperactivation and thyroid cancer progression by targeting PTEN
inferredcites →https://doi.org/10.1038/s41388-019-0685-xopenalex-snapshot
Effect of PTEN inactivating germline mutations on innate immune cell function and thyroid cancer-induced macrophages in patients with PTEN hamartoma tumor syndrome
inferredcites →https://doi.org/10.1038/s41556-018-0065-8openalex-snapshot
CK1α suppresses lung tumour growth by stabilizing PTEN and inducing autophagy
inferredcites →https://doi.org/10.1038/s41580-018-0015-0openalex-snapshot
The functions and regulation of the PTEN tumour suppressor: new modes and prospects
inferredcites →https://doi.org/10.1038/sj.cdd.4401946openalex-snapshot
c-Jun promotes cellular survival by suppression of PTEN
inferredcites →https://doi.org/10.1038/sj.cgt.7701116openalex-snapshot
Urocanic acid-modified chitosan-mediated PTEN delivery via aerosol suppressed lung tumorigenesis in K-rasLA1 mice
inferredcites →https://doi.org/10.1038/srep43013openalex-snapshot
PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer
inferredcites →https://doi.org/10.1056/nejmoa1816047openalex-snapshot
Avelumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma
inferredcites →https://doi.org/10.1073/pnas.0811212106openalex-snapshot
A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN
inferredcites →https://doi.org/10.1074/jbc.m113.481523openalex-snapshot
Loss of Phosphatase and Tensin Homolog (PTEN) Induces Leptin-mediated Leptin Gene Expression
inferredcites →https://doi.org/10.1074/jbc.m610141200openalex-snapshot
Mitogen-activated Protein Kinase Kinase-4 Promotes Cell Survival by Decreasing PTEN Expression through an NFκB-dependent Pathway
inferredcites →https://doi.org/10.1080/14737159.2017.1393333openalex-snapshot
Putative predictors of efficacy for immune checkpoint inhibitors in non-small-cell lung cancer: facing the complexity of the immune system
inferredcites →https://doi.org/10.1080/15384101.2017.1388970openalex-snapshot
PTEN Physically Interacts with and Regulates E2F1-mediated Transcription in Lung Cancer
inferredcites →https://doi.org/10.1083/jcb.201604025openalex-snapshot
The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein
inferredcites →https://doi.org/10.1093/annonc/mdp060openalex-snapshot
Efficacy of everolimus (RAD001) in patients with advanced NSCLC previously treated with chemotherapy alone or with chemotherapy and EGFR inhibitors
inferredcites →https://doi.org/10.1093/annonc/mdt536openalex-snapshot
Phase II study of everolimus–erlotinib in previously treated patients with advanced non-small-cell lung cancer
inferredcites →https://doi.org/10.1093/annonc/mdv105openalex-snapshot
Phase I trial of everolimus in combination with thoracic radiotherapy in non-small-cell lung cancer
inferredcites →https://doi.org/10.1093/carcin/bgy086openalex-snapshot
Unmasking the impact of Rictor in cancer: novel insights of mTORC2 complex
inferredcites →https://doi.org/10.1093/hmg/7.3.507openalex-snapshot
Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation
inferredcites →https://doi.org/10.1097/jto.0b013e31824de0d6openalex-snapshot
Brief Report: A Phase II “Window-of-Opportunity” Frontline Study of the mTOR Inhibitor, Temsirolimus Given as a Single Agent in Patients with Advanced NSCLC, an NCCTG Study
inferredcites →https://doi.org/10.1097/jto.0b013e3182641d4fopenalex-snapshot
Loss of Phosphatase and Tensin Homolog Protein Expression Is an Independent Poor Prognostic Marker in Lung Adenocarcinoma
inferredcites →https://doi.org/10.1097/jto.0b013e318282709copenalex-snapshot
Phase II Study of Docetaxel in Combination with Everolimus for Second- or Third-Line Therapy of Advanced Non–Small-Cell Lung Cancer
inferredcites →https://doi.org/10.1126/sciadv.1500845openalex-snapshot
The PTEN pathway in T regs is a critical driver of the suppressive tumor microenvironment
inferredcites →https://doi.org/10.1126/science.1234907openalex-snapshot
A Secreted PTEN Phosphatase That Enters Cells to Alter Signaling and Survival
inferredcites →https://doi.org/10.1126/science.275.5308.1943openalex-snapshot
PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer
inferredcites →https://doi.org/10.1126/science.aau0159openalex-snapshot
Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway
inferredcites →https://doi.org/10.1126/scisignal.2003084openalex-snapshot
The Tumor Suppressor PTEN Is Exported in Exosomes and Has Phosphatase Activity in Recipient Cells
inferredcites →https://doi.org/10.1126/scisignal.2005560openalex-snapshot
A Unified Nomenclature and Amino Acid Numbering for Human PTEN
inferredcites →https://doi.org/10.1128/mcb.02061-07openalex-snapshot
Repression of PTEN Phosphatase by Snail1 Transcriptional Factor during Gamma Radiation-Induced Apoptosis
inferredcites →https://doi.org/10.1158/0008-5472.can-06-0384openalex-snapshot
Epigenetic Silencing of the PTEN Gene in Melanoma
inferredcites →https://doi.org/10.1158/0008-5472.can-07-3117openalex-snapshot
Pten Inactivation Accelerates Oncogenic K-ras –Initiated Tumorigenesis in a Mouse Model of Lung Cancer
inferredcites →https://doi.org/10.1158/0008-5472.can-08-4055openalex-snapshot
PTEN Loss Contributes to Erlotinib Resistance in EGFR-Mutant Lung Cancer by Activation of Akt and EGFR
inferredcites →https://doi.org/10.1158/0008-5472.can-10-0043openalex-snapshot
Loss of PTEN Expression by Blocking Nuclear Translocation of EGR1 in Gefitinib-Resistant Lung Cancer Cells Harboring Epidermal Growth Factor Receptor–Activating Mutations
inferredcites →https://doi.org/10.1158/0008-5472.can-13-0297openalex-snapshot
miR-205 Targets PTEN and PHLPP2 to Augment AKT Signaling and Drive Malignant Phenotypes in Non–Small Cell Lung Cancer
inferredcites →https://doi.org/10.1158/1078-0432.ccr-12-2347openalex-snapshot
Phosphoinositide 3-Kinase (PI3K) Pathway Alterations Are Associated with Histologic Subtypes and Are Predictive of Sensitivity to PI3K Inhibitors in Lung Cancer Preclinical Models
inferredcites →https://doi.org/10.1158/1078-0432.ccr-13-1638openalex-snapshot
Identification of a Subset of Human Non–Small Cell Lung Cancer Patients with High PI3Kβ and Low PTEN Expression, More Prevalent in Squamous Cell Carcinoma
inferredcites →https://doi.org/10.1158/2159-8290.cd-15-0283openalex-snapshot
Loss of PTEN Promotes Resistance to T Cell–Mediated Immunotherapy
inferredcites →https://doi.org/10.1172/jci16147openalex-snapshot
Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells
inferredcites →https://doi.org/10.1172/jci39374openalex-snapshot
The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells
inferredcites →https://doi.org/10.1177/1010428317709639openalex-snapshot
Phosphatase and tensin homolog deleted on chromosome 10 degradation induced by NEDD4 promotes acquired erlotinib resistance in non–small-cell lung cancer
inferredcites →https://doi.org/10.1186/s12885-015-1770-3openalex-snapshot
Partial PTEN deletion is linked to poor prognosis in breast cancer
inferredcites →https://doi.org/10.1186/s12935-016-0308-3openalex-snapshot
Hypoxia-induced modulation of PTEN activity and EMT phenotypes in lung cancers
inferredcites →https://doi.org/10.1186/s12935-018-0612-1openalex-snapshot
MicroRNA-524 promotes cell proliferation by down-regulating PTEN expression in osteosarcoma
inferredcites →https://doi.org/10.1186/s12943-018-0803-3openalex-snapshot
PTEN/PTENP1: ‘Regulating the regulator of RTK-dependent PI3K/Akt signalling’, new targets for cancer therapy
inferredcites →https://doi.org/10.1186/s13046-015-0169-yopenalex-snapshot
MicroRNA-29b attenuates non-small cell lung cancer metastasis by targeting matrix metalloproteinase 2 and PTEN
inferredcites →https://doi.org/10.1186/s13058-014-0430-xopenalex-snapshot
Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase
inferredcites →https://doi.org/10.1186/s40880-019-0354-zopenalex-snapshot
Identification of genetic alterations associated with primary resistance to EGFR‐TKIs in advanced non‐small‐cell lung cancer patients with EGFR sensitive mutations
inferredcites →https://doi.org/10.12659/msm.912581openalex-snapshot
Upregulation of Long Noncoding RNA GAS5 Inhibits Lung Cancer Cell Proliferation and Metastasis via miR-205/PTEN Axis
inferredcites →https://doi.org/10.1371/annotation/e0bd3a57-1ce4-4eaf-83de-034d39cac787openalex-snapshot
Correction: Stem Cell Factor SALL4 Represses the Transcriptions of PTEN and SALL1 through an Epigenetic Repressor Complex
inferredcites →https://doi.org/10.1371/journal.pone.0005577openalex-snapshot
Stem Cell Factor SALL4 Represses the Transcriptions of PTEN and SALL1 through an Epigenetic Repressor Complex
inferredcites →https://doi.org/10.1371/journal.pone.0030427openalex-snapshot
Signaling Networks Associated with AKT Activation in Non-Small Cell Lung Cancer (NSCLC): New Insights on the Role of Phosphatydil-Inositol-3 kinase
inferredcites →https://doi.org/10.1371/journal.pone.0081133openalex-snapshot
Involvement of TGFβ-Induced Phosphorylation of the PTEN C-Terminus on TGFβ-Induced Acquisition of Malignant Phenotypes in Lung Cancer Cells
inferredcites →https://doi.org/10.1371/journal.pone.0174357openalex-snapshot
LZTS2 and PTEN collaboratively regulate ß-catenin in prostatic tumorigenesis
inferredcites →https://doi.org/10.18632/oncotarget.11068openalex-snapshot
PTEN expression is a prognostic marker for patients with non-small cell lung cancer: a systematic review and meta-analysis of the literature
inferredcites →https://doi.org/10.18632/oncotarget.13046openalex-snapshot
Multiple primary lung cancer displaying different EGFR and PTEN molecular profiles
inferredcites →https://doi.org/10.18632/oncotarget.22860openalex-snapshot
EYA2 promotes lung cancer cell proliferation by downregulating the expression of PTEN
inferredcites →https://doi.org/10.21037/tcr.2016.06.03openalex-snapshot
The clinical significance of loss of FHIT and PTEN expression in 289 patients with non-small-cell lung cancer
inferredcites →https://doi.org/10.2147/lctt.s161738openalex-snapshot
Response to rapamycin analogs but not PD-1 inhibitors in PTEN-mutated metastatic non-small-cell lung cancer with high tumor mutational burden
inferredcites →https://doi.org/10.2147/ott.s159612openalex-snapshot
EGFR, KRAS, BRAF, PTEN, and PIK3CA mutation in plasma of small cell lung cancer patients
inferredcites →https://doi.org/10.2217/pgs.15.122openalex-snapshot
PTEN and PI3K/AKT in Non-Small-Cell Lung Cancer
inferredcites →https://doi.org/10.2353/ajpath.2010.091075openalex-snapshot
Oncogenic Role of the E3 Ubiquitin Ligase NEDD4-1, a PTEN Negative Regulator, in Non-Small-Cell Lung Carcinomas
inferredcites →https://doi.org/10.26355/eurrev_201902_17002openalex-snapshot
MicroRNA-374b accelerates the development of lung cancer through downregulating PTEN expression via activating PI3K/Akt pathway.
inferredcites →https://doi.org/10.3389/fonc.2015.00024openalex-snapshot
PTEN: Multiple Functions in Human Malignant Tumors
inferredcites →https://doi.org/10.3892/mmr.2018.9478openalex-snapshot
miRNA‑328 overexpression confers cisplatin resistance in non‑small cell lung cancer via targeting of PTEN
inferredcites →https://doi.org/10.3892/or.2013.2755openalex-snapshot
miR-205 promotes the growth, metastasis and chemoresistance of NSCLC cells by targeting PTEN
inferredcites →https://doi.org/10.3978/j.issn.2218-6751.2012.12.08openalex-snapshot
Adaptive resistance to targeted therapies in cancer.
inferredcites →https://doi.org/10.4132/jptm.2018.03.12openalex-snapshot
Molecular Screening of Small Biopsy Samples Using Next-Generation Sequencing in Korean Patients with Advanced Non-small Cell Lung Cancer: Korean Lung Cancer Consortium (KLCC-13-01)
inferredcites →https://doi.org/10.4132/koreanjpathol.2011.45.4.329openalex-snapshot
Loss of PTEN Expression is an Independent Poor Prognostic Factor in Non-small Cell Lung Cancer
inferredcites →https://doi.org/10.4161/cbt.10.11.13814openalex-snapshot
Reduction of Pten dose leads to neoplastic development in multiple organs of Pten shRNA mice
inferredcites →https://doi.org/10.5858/arpa.2017-0046-oaopenalex-snapshot
Next-Generation Sequencing Approach to Non–Small Cell Lung Carcinoma Yields More Actionable Alterations
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4131651openalex-extracted
Comprehensive Library of Drug Response and Pan-Omic Analysis Identified Therapeutic Candidates and Accompanying Prognostic Biomarkers for Asian Cholangiocarcinoma
inferred← citeshttps://doi.org/10.1002/1878-0261.13132openalex-snapshot
Conditional ERK3 overexpression cooperates with PTEN deletion to promote lung adenocarcinoma formation in mice
inferred← citeshttps://doi.org/10.1002/bab.2104openalex-snapshot
The interplay of ROS and the PI3K/Akt pathway in autophagy regulation
inferred← citeshttps://doi.org/10.1002/cam4.4933openalex-snapshot
Integrative metabolomics and transcriptomics analysis reveals novel therapeutic vulnerabilities in lung cancer
inferred← citeshttps://doi.org/10.1002/jcla.23328openalex-snapshot
Association of phosphatase and tension homologue deleted on chromosome ten polymorphism rs1903858, but not serum levels with the risk of non–small‐cell lung cancer: A case‐control study
inferred← citeshttps://doi.org/10.1002/jcp.31053openalex-snapshot
The regulation of PTEN: Novel insights into functions as cancer biomarkers and therapeutic targets
inferred← citeshttps://doi.org/10.1007/978-3-032-12166-0_14openalex-snapshot
Targeting Lung Cancer Metabolism: Therapeutic Opportunities and Challenges
inferred← citeshttps://doi.org/10.1007/978-981-96-2763-9_3openalex-snapshot
Association of PI3K/AKT/mTOR Pathway with Cancer and Its Therapeutic Implications
inferred← citeshttps://doi.org/10.1007/s00210-023-02603-5openalex-snapshot
Zerumbone-incorporated liquid crystalline nanoparticles inhibit proliferation and migration of non-small-cell lung cancer in vitro
inferred← citeshttps://doi.org/10.1007/s00432-021-03828-8openalex-snapshot
Drug resistance of targeted therapy for advanced non-small cell lung cancer harbored EGFR mutation: from mechanism analysis to clinical strategy
inferred← citeshttps://doi.org/10.1007/s10048-026-00895-2openalex-snapshot
Inhibition of phosphatase and tensin homolog induces chemical long-term potentiation in the dentate gyrus of hippocampus
inferred← citeshttps://doi.org/10.1007/s11696-026-05399-9openalex-snapshot
Targeting MicroRNA networks in solid cancers: mechanisms, biomarkers, delivery systems, and AI-enabled therapies
inferred← citeshttps://doi.org/10.1007/s13577-021-00526-yopenalex-snapshot
Circular RNA circ-PTEN elevates PTEN inhibiting the proliferation of non-small cell lung cancer cells
inferred← citeshttps://doi.org/10.1016/bs.acr.2021.01.006openalex-snapshot
Autophagy and PTEN in DNA damage-induced senescence
inferred← citeshttps://doi.org/10.1016/j.advms.2023.02.004openalex-snapshot
The role of selected non-coding RNAs in the biology of non-small cell lung cancer
inferred← citeshttps://doi.org/10.1016/j.bbcan.2020.188405openalex-snapshot
PTEN in osteosarcoma: Recent advances and the therapeutic potential
inferred← citeshttps://doi.org/10.1016/j.bbcan.2021.188562openalex-snapshot
The emerging roles of dual-specificity phosphatases and their specific characteristics in human cancer
inferred← citeshttps://doi.org/10.1016/j.bbrc.2019.11.016openalex-snapshot
LncRNA LINC00470 promotes the degradation of PTEN mRNA to facilitate malignant behavior in gastric cancer cells
inferred← citeshttps://doi.org/10.1016/j.bbrep.2026.102761openalex-snapshot
From epigenetics to metastasis: Multifaceted roles of lncRNAs in gastric cancer
inferred← citeshttps://doi.org/10.1016/j.biopha.2020.109983openalex-snapshot
An outlined review for the role of Nedd4-1 and Nedd4-2 in lung disorders
inferred← citeshttps://doi.org/10.1016/j.drudis.2025.104407openalex-snapshot
Targeting mutant EGFR in non-small cell lung cancer in the context of cell adaptation and resistance
inferred← citeshttps://doi.org/10.1016/j.ejphar.2020.173226openalex-snapshot
PTEN: What we know of the function and regulation of this onco-suppressor factor in bladder cancer?
inferred← citeshttps://doi.org/10.1016/j.future.2025.107905openalex-snapshot
Multi-omic and quantum machine learning integration for lung subtypes classification
inferred← citeshttps://doi.org/10.1016/j.heliyon.2023.e19044openalex-snapshot
Tumor suppressor PTEN regulation by tobacco smoke in lung squamous-cell carcinoma based on bioinformatics analysis
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.136179openalex-snapshot
RETRACTED: The cellular signaling and regulatory role of protein phosphatase in tumor diagnosis: Upstream miRNAs of PTEN
inferred← citeshttps://doi.org/10.1016/j.isci.2022.105182openalex-snapshot
Comprehensive drug response profiling and pan-omic analysis identified therapeutic candidates and prognostic biomarkers for Asian cholangiocarcinoma
inferred← citeshttps://doi.org/10.1016/j.jbc.2021.101088openalex-snapshot
The deubiquitinase USP10 restores PTEN activity and inhibits non–small cell lung cancer cell proliferation
inferred← citeshttps://doi.org/10.1016/j.jtocrr.2021.100194openalex-snapshot
The Genomics of Young Lung Cancer: Comprehensive Tissue Genomic Analysis in Patients Under 40 With Lung Cancer
inferred← citeshttps://doi.org/10.1016/j.modpat.2023.100106openalex-snapshot
PTEN Deficiency in Tubo-Ovarian High-Grade Serous Carcinoma is Associated with Poor Progression-Free Survival and is Mutually Exclusive with CCNE1 Amplification
inferred← citeshttps://doi.org/10.1016/j.omtn.2021.11.018openalex-snapshot
rAAV-delivered PTEN therapeutics for prostate cancer
inferred← citeshttps://doi.org/10.1016/j.prp.2024.155484openalex-snapshot
Role of long non-coding RNAs (lncRNAs) in gastric cancer metastasis: A comprehensive review
inferred← citeshttps://doi.org/10.1016/j.tranon.2022.101364openalex-snapshot
The PI3K/Akt/mTOR pathway in lung cancer; oncogenic alterations, therapeutic opportunities, challenges, and a glance at the application of nanoparticles
inferred← citeshttps://doi.org/10.1016/j.yexcr.2022.113115openalex-snapshot
The N6-methyladenosine:mechanisms, diagnostic value, immunotherapy prospec-ts and challenges in gastric cancer
inferred← citeshttps://doi.org/10.1017/s1460396919000876openalex-snapshot
A review of predictive, prognostic and diagnostic biomarkers for non-small-cell lung cancer: towards personalised and targeted cancer therapy
inferred← citeshttps://doi.org/10.1021/acsami.4c21740openalex-snapshot
CRISPR-dCas9-Mediated PTEN Activation via Tumor Cell Membrane-Coated Nanoplatform Enhances Sensitivity to Tyrosine Kinase Inhibitors in Nonsmall Cell Lung Cancer
inferred← citeshttps://doi.org/10.1021/acsptsci.1c00040openalex-snapshot
Identification of Novel MicroRNAs Targeting SARS-CoV-2 through the Regulation of TMPRSS2/PI3K/AKT/PTEN Alignment in Lung Cancer: An in Silico Analysis
inferred← citeshttps://doi.org/10.1038/s41419-021-03835-0openalex-snapshot
KLHL38 involvement in non-small cell lung cancer progression via activation of the Akt signaling pathway
inferred← citeshttps://doi.org/10.1038/s41419-023-05802-3openalex-snapshot
The long non-coding RNA keratin-7 antisense acts as a new tumor suppressor to inhibit tumorigenesis and enhance apoptosis in lung and breast cancers
inferred← citeshttps://doi.org/10.1038/s41420-024-02038-8openalex-snapshot
DUSP22 inhibits lung tumorigenesis by suppression of EGFR/c-Met signaling
inferred← citeshttps://doi.org/10.1038/s41420-024-02216-8openalex-snapshot
The oncogenic axis YAP/MYC/EZH2 impairs PTEN tumor suppression activity enhancing lung tumorigenicity
inferred← citeshttps://doi.org/10.1038/s41467-023-42156-yopenalex-snapshot
Oncogenic context shapes the fitness landscape of tumor suppression
inferred← citeshttps://doi.org/10.1038/s41598-021-93815-3openalex-snapshot
PTEN loss promotes oncogenic function of STMN1 via PI3K/AKT pathway in lung cancer
inferred← citeshttps://doi.org/10.1038/s41698-025-01257-1openalex-snapshot
Mitochondrial translocation of MDM2 and TFAM reprograms metabolism in treatment-refractory cancers
inferred← citeshttps://doi.org/10.1080/21655979.2021.1872191openalex-snapshot
Circular RNA circ_0001287 inhibits the proliferation, metastasis, and radiosensitivity of non-small cell lung cancer cells by sponging microRNA miR-21 and up-regulating phosphatase and tensin homolog expression
inferred← citeshttps://doi.org/10.1109/access.2023.3234294openalex-snapshot
Efficient Bioinspired Feature Selection and Machine Learning Based Framework Using Omics Data and Biological Knowledge Data Bases in Cancer Clinical Endpoint Prediction
inferred← citeshttps://doi.org/10.1111/bpa.70143openalex-snapshot
PTEN homozygous deletion is a negative prognostic factor in tumor treating fields‐treated glioblastoma, IDH wildtype patients
inferred← citeshttps://doi.org/10.1134/s199075082004006xopenalex-snapshot
The Effect of Benzo[a]Pyrene on the Expression of AhR-Regulated microRNA in Lungs of Female and Male Rats
inferred← citeshttps://doi.org/10.1136/jitc-2025-012288openalex-snapshot
Genetic drivers of tumor microenvironment and immunotherapy resistance in non-small cell lung cancer: the role of KEAP1 , SMARCA4 , and PTEN mutations
inferred← citeshttps://doi.org/10.1155/2022/3472745openalex-snapshot
β-Elemene Restrains PTEN mRNA Degradation to Restrain the Growth of Lung Cancer Cells via METTL3-Mediated N6 Methyladenosine Modification
inferred← citeshttps://doi.org/10.1155/2022/4512503openalex-snapshot
PTEN: An Emerging Potential Target for Therapeutic Intervention in Respiratory Diseases
inferred← citeshttps://doi.org/10.1158/0008-5472.can-22-3023openalex-snapshot
PTEN Loss Confers Resistance to Anti–PD-1 Therapy in Non–Small Cell Lung Cancer by Increasing Tumor Infiltration of Regulatory T Cells
inferred← citeshttps://doi.org/10.1172/jci.insight.171364openalex-snapshot
Tumor suppressors in Sox2-mediated lung cancers promote distinct cell-intrinsic and immunologic remodeling
inferred← citeshttps://doi.org/10.1177/14703203251367136openalex-snapshot
MiRNAs in cancers and renin-angiotensin-aldosterone system: Implications for chemoradiotherapy resistance
inferred← citeshttps://doi.org/10.1186/s12943-024-02120-wopenalex-snapshot
CircLIFRSA/miR-1305/PTEN axis attenuates malignant cellular processes in non-small cell lung cancer by regulating AKT phosphorylation
inferred← citeshttps://doi.org/10.1186/s12964-024-01980-5openalex-snapshot
The therapeutic potential of RNA m(6)A in lung cancer
inferred← citeshttps://doi.org/10.1186/s13045-021-01137-8openalex-snapshot
Targeting Akt in cancer for precision therapy
inferred← citeshttps://doi.org/10.1186/s13046-024-03207-4openalex-snapshot
AKT kinases as therapeutic targets
inferred← citeshttps://doi.org/10.1186/s43042-025-00733-4openalex-snapshot
Evaluation of the mutation profile detected in lung adenocarcinomas with different N status
inferred← citeshttps://doi.org/10.1186/s43556-022-00107-xopenalex-snapshot
Molecular pathways, resistance mechanisms and targeted interventions in non-small-cell lung cancer
inferred← citeshttps://doi.org/10.1200/po.22.00040openalex-snapshot
Durable Response to Combined Osimertinib and Pralsetinib Treatment for Osimertinib Resistance Due to Novel IntergenicANK3-RETFusion inEGFR-Mutated Non–Small-Cell Lung Cancer
inferred← citeshttps://doi.org/10.17305/bjbms.2022.7206openalex-snapshot
Mechanism of OTUD5 in non‐small cell lung cancer cell proliferation, invasion, and migration
inferred← citeshttps://doi.org/10.18097/pbmc20206603224openalex-snapshot
Effect of benzo(a)pyrene on the expression of AhR-regulated microRNA in female and male rat lungs
inferred← citeshttps://doi.org/10.20944/preprints202111.0052.v1openalex-snapshot
Acquired Intergenic ANK3-RET Fusion as a Pralsetinib-Responsive Mechanism of Resistance to Osimertinib in EGFR-Mutated NSCLC
inferred← citeshttps://doi.org/10.21203/rs.3.rs-5032978/v1openalex-snapshot
The oncogenic axis YAP/MYC/EZH2 impairs PTEN tumor suppression activity enhancing lung tumorigenicity
inferred← citeshttps://doi.org/10.2139/ssrn.5318621openalex-snapshot
Akr1b1 Promotes Colorectal Cancer Proliferation and Metastasis by Regulating the Ampk–Glut1–Pten Axis
inferred← citeshttps://doi.org/10.2147/ijn.s505539openalex-snapshot
Utilizing Nanoparticles to Overcome Anti-PD-1/PD-L1 Immunotherapy Resistance in Non-Small Cell Lung cancer: A Potential Strategy
inferred← citeshttps://doi.org/10.2174/1566523220666200523165159openalex-snapshot
Integrated Analysis of mRNA-seq and miRNA-seq to Identify c-MYC, YAP1 and miR-3960 as Major Players in the Anticancer Effects of Caffeic Acid Phenethyl Ester in Human Small Cell Lung Cancer Cell Line
inferred← citeshttps://doi.org/10.2217/imt-2021-0090openalex-snapshot
Efficacy of immunotherapy in KRAS -mutant non-small-cell lung cancer with comutations
inferred← citeshttps://doi.org/10.2217/pgs-2020-0021openalex-snapshot
Immunotherapy in Non-Small-Cell Lung Cancer: from Targeted Molecules to Resistance Patterns
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1127071openalex-snapshot
Mechanisms of drug resistance to immune checkpoint inhibitors in non-small cell lung cancer
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1129298openalex-snapshot
Emerging role of interaction between m6A and main ncRNAs in gastrointestinal (GI) cancers
inferred← citeshttps://doi.org/10.3389/fonc.2021.619013openalex-snapshot
Overexpression of RhoV Promotes the Progression and EGFR-TKI Resistance of Lung Adenocarcinoma
inferred← citeshttps://doi.org/10.3389/fonc.2021.619346openalex-snapshot
The Association of microRNA-34a With High Incidence and Metastasis of Lung Cancer in Gejiu and Xuanwei Yunnan
inferred← citeshttps://doi.org/10.3389/fonc.2021.663183openalex-snapshot
Targeting c-Jun in A549 Cancer Cells Exhibits Antiangiogenic Activity In Vitro and In Vivo Through Exosome/miRNA-494-3p/PTEN Signal Pathway
inferred← citeshttps://doi.org/10.3389/fonc.2025.1547083openalex-snapshot
AKT inhibitors in gynecologic oncology: past, present and future
inferred← citeshttps://doi.org/10.3389/jpps.2026.16610openalex-snapshot
The cross-talk between GSK-3β, RKIP, and PTEN as potential targets for therapeutic implications in cancer: a comprehensive insight
inferred← citeshttps://doi.org/10.3390/biom12111586openalex-snapshot
CircRNAs in Tumor Radioresistance
inferred← citeshttps://doi.org/10.3390/biomedicines11020448openalex-snapshot
Biological and Genetic Mechanisms of COPD, Its Diagnosis, Treatment, and Relationship with Lung Cancer
inferred← citeshttps://doi.org/10.3390/biomedicines8080264openalex-snapshot
PTEN, a Barrier for Proliferation and Metastasis of Gastric Cancer Cells: From Molecular Pathways to Targeting and Regulation
inferred← citeshttps://doi.org/10.3390/cancers11101525openalex-snapshot
Revising PTEN in the Era of Immunotherapy: New Perspectives for an Old Story
inferred← citeshttps://doi.org/10.3390/cancers12051125openalex-snapshot
Precision Medicine for NSCLC in the Era of Immunotherapy: New Biomarkers to Select the Most Suitable Treatment or the Most Suitable Patient
inferred← citeshttps://doi.org/10.3390/cancers13153839openalex-snapshot
Tissue Factor and Extracellular Vesicles: Activation of Coagulation and Impact on Survival in Cancer
inferred← citeshttps://doi.org/10.3390/cancers14041041openalex-snapshot
Real-World Time on Treatment with First-Line Pembrolizumab Monotherapy for Advanced NSCLC with PD-L1 Expression ≥ 50%: 3-Year Follow-Up Data
inferred← citeshttps://doi.org/10.3390/cancers15082195openalex-snapshot
Regulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer
inferred← citeshttps://doi.org/10.3390/cancers15225394openalex-snapshot
Exploring Therapeutic Avenues in Lung Cancer: The Epigenetic Perspective
inferred← citeshttps://doi.org/10.3390/cells12071085openalex-snapshot
Quadra-Stable Dynamics of p53 and PTEN in the DNA Damage Response
inferred← citeshttps://doi.org/10.3390/cells12152014openalex-snapshot
Implication of mTOR Signaling in NSCLC: Mechanisms and Therapeutic Perspectives
inferred← citeshttps://doi.org/10.3390/curroncol32070389openalex-snapshot
HIV Integration into the PTEN Gene and Its Tumor Microenvironment Implications for Lung Cancer
inferred← citeshttps://doi.org/10.3390/genes11070719openalex-snapshot
PTEN Alterations and Their Role in Cancer Management: Are We Making Headway on Precision Medicine?
inferred← citeshttps://doi.org/10.3390/ijms22168885openalex-snapshot
Molecular Mechanisms of Chemoresistance Induced by Cisplatin in NSCLC Cancer Therapy
inferred← citeshttps://doi.org/10.3390/ijms232214083openalex-snapshot
BPR0C261, An Analogous of Microtubule Disrupting Agent D-24851 Enhances the Radiosensitivity of Human Non-Small Cell Lung Cancer Cells via p53-Dependent and p53-Independent Pathways
inferred← citeshttps://doi.org/10.3390/ijms24032809openalex-snapshot
Interfering with the Ubiquitin-Mediated Regulation of Akt as a Strategy for Cancer Treatment
inferred← citeshttps://doi.org/10.3390/ijms25147817openalex-snapshot
PTEN Depletion Increases Radiosensitivity in Response to Ataxia Telangiectasia-Related-3 (ATR) Inhibition in Non-Small Cell Lung Cancer (NSCLC)
inferred← citeshttps://doi.org/10.3390/jpm11020154openalex-snapshot
Comprehensive Profiling of Genomic and Transcriptomic Differences between Risk Groups of Lung Adenocarcinoma and Lung Squamous Cell Carcinoma
inferred← citeshttps://doi.org/10.3390/medsci14020254openalex-snapshot
Loss of PTEN as an Independent Poor Prognosis Indicator in Lung Adenocarcinoma, but Not in Squamous Cell Carcinoma, Is Associated with an Immunosuppressive Tumor Microenvironment and Distinct Co-Mutational Profiles
inferred← citeshttps://doi.org/10.3390/pharmaceutics15082090openalex-snapshot
Therapeutic Implications of PTEN in Non-Small Cell Lung Cancer
inferred← citeshttps://doi.org/10.3892/mco.2021.2434openalex-snapshot
Liquid biopsy: Novel perspectives on the importance and spectrum of PIK3CA, PTEN and RET mutations in solid tumors
inferred← citeshttps://doi.org/10.3892/mmr.2020.11666openalex-snapshot
Effects and mechanism of microRNA‑218 against lung cancer
inferred← citeshttps://doi.org/10.3892/ol.2022.13564openalex-snapshot
Expression level comparison of marker genes related to early embryonic development and tumor growth
inferred← citeshttps://doi.org/10.5603/ep.104958openalex-snapshot
Long non-coding RNA MIR22HG impedes the progression of anaplastic thyroid carcinoma via targeting miR-141-3p/PTEN/AKT axis
inferred← citeshttps://doi.org/10.5606/fng.btd.2023.136openalex-snapshot
PTENopathy: A review on pathology, mechanisms, and treatment strategies
inferred← citeshttps://doi.org/10.7287/peerj.15250v0.1/reviews/1openalex-snapshot
Peer Review #1 of "Meta-analysis of commonly mutated genes in leptomeningeal carcinomatosis (v0.1)"
inferred← citeshttps://doi.org/10.7287/peerj.15250v0.1/reviews/2openalex-snapshot
Peer Review #2 of "Meta-analysis of commonly mutated genes in leptomeningeal carcinomatosis (v0.1)"
inferred← citeshttps://doi.org/10.7287/peerj.15250v0.2/reviews/1openalex-snapshot
Peer Review #1 of "Meta-analysis of commonly mutated genes in leptomeningeal carcinomatosis (v0.2)"
inferred← citeshttps://doi.org/10.7287/peerj.15250v0.2/reviews/2openalex-snapshot
Peer Review #2 of "Meta-analysis of commonly mutated genes in leptomeningeal carcinomatosis (v0.2)"
inferred← citeshttps://doi.org/10.7717/peerj.15250openalex-snapshot
Meta-analysis of commonly mutated genes in leptomeningeal carcinomatosis
Editorial review for independent work. ICSAC — the Institute for Complexity
Science and Advanced Computing — runs a structured editorial panel for researchers
publishing outside journals, and publishes on CiteStamp rails. Submission is free
and goes through ORCID: icsacinstitute.org/submit.