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Heterogeneity of Response and Immune System Activity during Treatment with Nivolumab in Hepatocellular Carcinoma: Results from a Single-Institution Retrospective Analysis

https://doi.org/10.3390/cancers13020213
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jamaoncol.2020.4564openalex-snapshot
Efficacy and Safety of Nivolumab Plus Ipilimumab in Patients With Advanced Hepatocellular Carcinoma Previously Treated With Sorafenib
inferredcites →https://doi.org/10.1002/hep.25777openalex-snapshot
Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma
inferredcites →https://doi.org/10.1002/hep.26731openalex-snapshot
Immunodominance and functional alterations of tumor-associated antigen-specific CD8+ T-cell responses in hepatocellular carcinoma
inferredcites →https://doi.org/10.1002/hep4.1132openalex-snapshot
Distinct clinical and magnetic resonance features of metastatic hepatocellular carcinoma treated with pembrolizumab: A case report of late response after pseudoprogression
inferredcites →https://doi.org/10.1007/s00262-013-1447-1openalex-snapshot
Increase in CD14+HLA-DR−/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis
inferredcites →https://doi.org/10.1007/s00262-015-1768-3openalex-snapshot
Metastatic spread in patients with non-small cell lung cancer is associated with a reduced density of tumor-infiltrating T cells
inferredcites →https://doi.org/10.1007/s00262-018-2255-4openalex-snapshot
Opposing roles of eosinophils in cancer
inferredcites →https://doi.org/10.1007/s11523-020-00757-3openalex-snapshot
Prognostic Role of Blood Eosinophil Count in Patients with Sorafenib-Treated Hepatocellular Carcinoma
inferredcites →https://doi.org/10.1016/j.cell.2017.07.025openalex-snapshot
Heterogeneous Tumor-Immune Microenvironments among Differentially Growing Metastases in an Ovarian Cancer Patient
inferredcites →https://doi.org/10.1016/j.ejca.2017.10.017openalex-snapshot
Patterns of responses in metastatic NSCLC during PD-1 or PDL-1 inhibitor therapy: Comparison of RECIST 1.1, irRECIST and iRECIST criteria
inferredcites →https://doi.org/10.1016/j.jaut.2009.08.008openalex-snapshot
Immune tolerance: What is unique about the liver
inferredcites →https://doi.org/10.1016/j.jcmgh.2019.08.004openalex-snapshot
Unique T-Cell Populations Define Immune-Inflamed Hepatocellular Carcinoma
inferredcites →https://doi.org/10.1016/j.jhep.2019.09.026openalex-snapshot
mRECIST for HCC: Performance and novel refinements
inferredcites →https://doi.org/10.1016/j.jhep.2020.08.010openalex-snapshot
Hyperprogressive disease during PD-1 blockade in patients with advanced hepatocellular carcinoma
inferredcites →https://doi.org/10.1016/j.jtho.2017.04.027openalex-snapshot
Liver Metastasis Is Associated with Poor Progression-Free Survival in Patients with Non–Small Cell Lung Cancer Treated with Nivolumab
inferredcites →https://doi.org/10.1016/s0140-6736(16)32453-9openalex-snapshot
Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial
inferredcites →https://doi.org/10.1016/s0140-6736(17)31046-2openalex-snapshot
Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial
inferredcites →https://doi.org/10.1016/s0140-6736(18)30207-1openalex-snapshot
Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial
inferredcites →https://doi.org/10.1016/s1470-2045(15)00050-9openalex-snapshot
Ramucirumab versus placebo as second-line treatment in patients with advanced hepatocellular carcinoma following first-line therapy with sorafenib (REACH): a randomised, double-blind, multicentre, phase 3 trial
inferredcites →https://doi.org/10.1016/s1470-2045(17)30074-8openalex-snapshot
iRECIST: guidelines for response criteria for use in trials testing immunotherapeutics
inferredcites →https://doi.org/10.1016/s1470-2045(18)30351-6openalex-snapshot
Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib (KEYNOTE-224): a non-randomised, open-label phase 2 trial
inferredcites →https://doi.org/10.1016/s1470-2045(18)30937-9openalex-snapshot
Ramucirumab after sorafenib in patients with advanced hepatocellular carcinoma and increased α-fetoprotein concentrations (REACH-2): a randomised, double-blind, placebo-controlled, phase 3 trial
inferredcites →https://doi.org/10.1038/bjc.2012.581openalex-snapshot
Cancer heterogeneity: implications for targeted therapeutics
inferredcites →https://doi.org/10.1038/bjc.2016.308openalex-snapshot
Patterns of response to anti-PD-1 treatment: an exploratory comparison of four radiological response criteria and associations with overall survival in metastatic melanoma patients
inferredcites →https://doi.org/10.1038/ni.2035openalex-snapshot
T cell exhaustion
inferredcites →https://doi.org/10.1038/nrgastro.2015.173openalex-snapshot
Immunological landscape and immunotherapy of hepatocellular carcinoma
inferredcites →https://doi.org/10.1038/s41422-020-0337-2openalex-snapshot
The future of cancer immunotherapy: microenvironment-targeting combinations
inferredcites →https://doi.org/10.1038/s41598-020-60437-0openalex-snapshot
Hyperprogression under Immune Checkpoint Inhibitor: a potential role for germinal immunogenetics
inferredcites →https://doi.org/10.1038/s41598-020-71340-zopenalex-snapshot
Distinct tumor immune microenvironments in primary and metastatic lesions in gastric cancer patients
inferredcites →https://doi.org/10.1038/srep13886openalex-snapshot
Non-Classical monocytes display inflammatory features: Validation in Sepsis and Systemic Lupus Erythematous
inferredcites →https://doi.org/10.1038/srep14757openalex-snapshot
Identification of a FOXP3+CD3+CD56+ population with immunosuppressive function in cancer tissues of human hepatocellular carcinoma
inferredcites →https://doi.org/10.1053/j.gastro.2008.03.020openalex-snapshot
A New Population of Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Induces CD4+CD25+Foxp3+ T Cells
inferredcites →https://doi.org/10.1053/j.gastro.2016.02.040openalex-snapshot
Tumor-Associated Neutrophils Recruit Macrophages and T-Regulatory Cells to Promote Progression of Hepatocellular Carcinoma and Resistance to Sorafenib
inferredcites →https://doi.org/10.1056/nejmoa0708857openalex-snapshot
Sorafenib in Advanced Hepatocellular Carcinoma
inferredcites →https://doi.org/10.1056/nejmoa1717002openalex-snapshot
Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma
inferredcites →https://doi.org/10.1056/nejmoa1915745openalex-snapshot
Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma
inferredcites →https://doi.org/10.1056/nejmra1713263openalex-snapshot
Hepatocellular Carcinoma
inferredcites →https://doi.org/10.1080/2162402x.2016.1214788openalex-snapshot
Activity and safety of radiotherapy with anti-PD-1 drug therapy in patients with metastatic melanoma
inferredcites →https://doi.org/10.1093/annonc/mdz003openalex-snapshot
Novel patterns of response under immunotherapy
inferredcites →https://doi.org/10.1111/cas.14706openalex-snapshot
Eosinophil prognostic scores for patients with head and neck squamous cell carcinoma treated with nivolumab
inferredcites →https://doi.org/10.1126/science.aac9407openalex-snapshot
Patrolling monocytes control tumor metastasis to the lung
inferredcites →https://doi.org/10.1136/jitc-2020-001033openalex-snapshot
Post-registration experience of nivolumab in advanced hepatocellular carcinoma: an international study
inferredcites →https://doi.org/10.1158/1078-0432.ccr-17-2386openalex-snapshot
Baseline Tumor Size Is an Independent Prognostic Factor for Overall Survival in Patients with Melanoma Treated with Pembrolizumab
inferredcites →https://doi.org/10.1158/2326-6066.cir-16-0325openalex-snapshot
Liver Metastasis and Treatment Outcome with Anti-PD-1 Monoclonal Antibody in Patients with Melanoma and NSCLC
inferredcites →https://doi.org/10.1159/000489021openalex-snapshot
Increased Expression of Programmed Death-Ligand 1 in Infiltrating Immune Cells in Hepatocellular Carcinoma Tissues after Sorafenib Treatment
inferredcites →https://doi.org/10.1159/000501275openalex-snapshot
Differential Organ-Specific Tumor Response to Immune Checkpoint Inhibitors in Hepatocellular Carcinoma
inferredcites →https://doi.org/10.1159/000502714openalex-snapshot
Impact of Baseline Characteristics on the Overall Survival of HCC Patients Treated with Sorafenib: Ten Years of Experience
inferredcites →https://doi.org/10.1186/s40425-016-0117-1openalex-snapshot
Systemic inflammation in a melanoma patient treated with immune checkpoint inhibitors—an autopsy study
inferredcites →https://doi.org/10.1186/s40425-019-0749-zopenalex-snapshot
Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response
inferredcites →https://doi.org/10.1186/s41747-019-0134-1openalex-snapshot
Imaging of tumour response to immunotherapy
inferredcites →https://doi.org/10.1200/jco.20.00808openalex-snapshot
Phase Ib Study of Lenvatinib Plus Pembrolizumab in Patients With Unresectable Hepatocellular Carcinoma
inferredcites →https://doi.org/10.18632/oncotarget.11565openalex-snapshot
Immune inflammation indicators and implication for immune modulation strategies in advanced hepatocellular carcinoma patients receiving sorafenib
inferredcites →https://doi.org/10.18632/oncotarget.4572openalex-snapshot
Characterization of tumor infiltrating lymphocytes in paired primary and metastatic renal cell carcinoma specimens
inferredcites →https://doi.org/10.2217/imt-2020-0265openalex-snapshot
Prognosticating Role of Serum Eosinophils on Immunotherapy Efficacy in Patients with Advanced Melanoma
inferredcites →https://doi.org/10.3322/caac.21492openalex-snapshot
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
inferredcites →https://doi.org/10.3389/fimmu.2018.00367openalex-snapshot
The Role of Natural Killer T Cells in Cancer—A Phenotypical and Functional Approach
inferredcites →https://doi.org/10.3390/cancers12051089openalex-snapshot
Scientific Rationale for Combined Immunotherapy with PD-1/PD-L1 Antibodies and VEGF Inhibitors in Advanced Hepatocellular Carcinoma
inferredcites →https://doi.org/10.4049/jimmunol.182.1.240openalex-snapshot
Cancer-Expanded Myeloid-Derived Suppressor Cells Induce Anergy of NK Cells through Membrane-Bound TGF-β1
inferredcites →https://doi.org/10.7326/0003-4819-87-5-642_1openalex-snapshot
Hepatocellular Carcinoma.

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4775796openalex-extracted
Monocyte-Related Markers as Predictors of Immune Checkpoint Inhibitor Efficacy and Immune-Related Adverse Events: A Systematic Review and Meta-Analysis
inferred← citeshttps://doi.org/10.1002/cpt.70336openalex-snapshot
Model‐Informed Dosing Strategies for Epcoritamab Monotherapy in Relapsed or Refractory Large B‐Cell Lymphoma
inferred← citeshttps://doi.org/10.1007/s00432-022-04512-1openalex-snapshot
Clinical outcomes with atezolizumab plus bevacizumab or lenvatinib in patients with hepatocellular carcinoma: a multicenter real-world study
inferred← citeshttps://doi.org/10.1007/s10555-025-10246-6openalex-snapshot
Monocyte-related markers as predictors of immune checkpoint inhibitor efficacy and immune-related adverse events: a systematic review and meta-analysis
inferred← citeshttps://doi.org/10.1007/s40278-021-92489-3openalex-snapshot
Nivolumab
inferred← citeshttps://doi.org/10.1055/s-0043-1776127openalex-snapshot
Unraveling the Complexities of Immune Checkpoint Inhibitors in Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.1097/rlu.0000000000005896openalex-snapshot
Prognostic Significance of Volumetric Parameters on Pretreatment FDG PET/CT in Patients With Hepatocellular Carcinoma Receiving Atezolizumab Plus Bevacizumab Therapy
inferred← citeshttps://doi.org/10.1159/000525582openalex-snapshot
Systemic Treatment of Advanced Unresectable Hepatocellular Carcinoma after First-Line Therapy: Expert Recommendations from Hong Kong, Singapore, and Taiwan
inferred← citeshttps://doi.org/10.1177/03008916211033353openalex-snapshot
Efficacy of lenvatinib plus pembrolizumab in hepatocellular carcinoma with metachronous lung metastasis: a report of two cases
inferred← citeshttps://doi.org/10.2147/jhc.s358082openalex-snapshot
Systemic Therapy for Hepatocellular Carcinoma: Current Updates and Outlook
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