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Identification of Nucleolin as a Novel AEG-1-Interacting Protein in Breast Cancer via Interactome Profiling

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1 of the 52 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-21): 10.1084/jem.20120950 (notice 2026-06-30).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/ijc.31937openalex-snapshot

Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods

inferredcites →https://doi.org/10.1002/mc.20834openalex-snapshot

Interleukin‐9 receptor gene is transcriptionally regulated by nucleolin in T‐Cell lymphoma cells

inferredcites →https://doi.org/10.1007/s00018-006-6137-0openalex-snapshot

Hepatocyte growth factor differently influences Met-E-cadherin phosphorylation and downstream signaling pathway in two models of breast cells

inferredcites →https://doi.org/10.1007/s00432-009-0733-yopenalex-snapshot

Nucleolin as cell surface receptor for tumor necrosis factor-α inducing protein: a carcinogenic factor of Helicobacter pylori

inferredcites →https://doi.org/10.1007/s10549-012-2051-3openalex-snapshot

Oncogene amplification in male breast cancer: analysis by multiplex ligation-dependent probe amplification

inferredcites →https://doi.org/10.1007/s12282-012-0398-2openalex-snapshot

Overexpression of metadherin/MTDH is associated with an aggressive phenotype and a poor prognosis in invasive breast cancer

inferredcites →https://doi.org/10.1016/b978-0-12-401676-7.00001-2openalex-snapshot

AEG-1/MTDH/LYRIC, the Beginning

inferredcites →https://doi.org/10.1016/j.bbrc.2013.08.076openalex-snapshot

Proteomic profiling of a mouse model of acute intestinal Apc deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC)

inferredcites →https://doi.org/10.1016/j.biochi.2015.03.023openalex-snapshot

The roles of nucleolin subcellular localization in cancer

inferredcites →https://doi.org/10.1016/j.ccr.2008.11.013openalex-snapshot

MTDH Activation by 8q22 Genomic Gain Promotes Chemoresistance and Metastasis of Poor-Prognosis Breast Cancer

inferredcites →https://doi.org/10.1016/j.gene.2005.04.006openalex-snapshot

Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1

inferredcites →https://doi.org/10.1016/j.pharmthera.2011.01.008openalex-snapshot

Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology

inferredcites →https://doi.org/10.1016/j.yexcr.2003.11.020openalex-snapshot

3D3/lyric: a novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus

inferredcites →https://doi.org/10.1016/s1535-6108(04)00079-0openalex-snapshot

Metadherin, a cell surface protein in breast tumors that mediates lung metastasis

inferredcites →https://doi.org/10.1021/bi101633bopenalex-snapshot

Heterogeneous Nuclear Ribonucleoprotein K and Nucleolin as Transcriptional Activators of the Vascular Endothelial Growth Factor Promoter through Interaction with Secondary DNA Structures

inferredcites →https://doi.org/10.1021/jf2021489openalex-snapshot

Osthole Suppresses Hepatocyte Growth Factor (HGF)-Induced Epithelial-Mesenchymal Transition via Repression of the c-Met/Akt/mTOR Pathway in Human Breast Cancer Cells

inferredcites →https://doi.org/10.1023/a:1006348317841openalex-snapshot

Inhibition of HGF/SF-induced breast cancer cell motility and invasion by the HGF/SF variant, NK4

inferredcites →https://doi.org/10.1038/ncomms7658openalex-snapshot

Quantitative analysis of the TNF-α-induced phosphoproteome reveals AEG-1/MTDH/LYRIC as an IKKβ substrate

inferredcites →https://doi.org/10.1038/nrc3496openalex-snapshot

Dysregulation of the basal RNA polymerase transcription apparatus in cancer

inferredcites →https://doi.org/10.1038/s41419-017-0067-7openalex-snapshot

Nucleolin and ErbB2 inhibition reduces tumorigenicity of ErbB2-positive breast cancer

inferredcites →https://doi.org/10.1038/sj.onc.1205445openalex-snapshot

Identification and cloning of human astrocyte genes displaying elevated expression after infection with HIV-1 or exposure to HIV-1 envelope glycoprotein by rapid subtraction hybridization, RaSH

inferredcites →https://doi.org/10.1038/sj.onc.1210713openalex-snapshot

Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling

inferredcites →https://doi.org/10.1073/pnas.0608386103openalex-snapshot

Astrocyte elevated gene-1 ( AEG-1 ) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc

inferredcites →https://doi.org/10.1073/pnas.0910936106openalex-snapshot

Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis

inferredcites →https://doi.org/10.1074/jbc.m104446200openalex-snapshot

Inhibition of DNA Replication and Induction of S Phase Cell Cycle Arrest by G-rich Oligonucleotides

inferredcites →https://doi.org/10.1074/jbc.m111.240077openalex-snapshot

Identification of Staphylococcal Nuclease Domain-containing 1 (SND1) as a Metadherin-interacting Protein with Metastasis-promoting Functions

inferredcites →https://doi.org/10.1074/jbc.m210656200openalex-snapshot

Hepatocyte Growth Factor Receptor Tyrosine Kinase Met Is a Substrate of the Receptor Protein-tyrosine Phosphatase DEP-1

inferredcites →https://doi.org/10.1084/jem.20011053openalex-snapshot

Nucleolin as Activator of Human Papillomavirus Type 18 Oncogene Transcription in Cervical Cancer

inferredcites →https://doi.org/10.1084/jem.20120950openalex-snapshot

RETRACTED: In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation

inferredcites →https://doi.org/10.1093/emboj/18.13.3688openalex-snapshot

A novel RNA polymerase II‐containing complex potentiates Tat‐enhanced HIV‐1 transcription

inferredcites →https://doi.org/10.1096/fasebj.13.14.1911openalex-snapshot

Molecular dissection of nucleolin's role in growth and cell proliferation: new insights

inferredcites →https://doi.org/10.1111/apm.12131openalex-snapshot

Overexpression of nucleolin and different expression sites both related to the prognosis of gastric cancer

inferredcites →https://doi.org/10.1128/mcb.00456-16openalex-snapshot

Astrocyte Elevated Gene 1 Interacts with Acetyltransferase p300 and c-Jun To Promote Tumor Aggressiveness

inferredcites →https://doi.org/10.1158/0008-5472.can-05-3029openalex-snapshot

Activation of the Nuclear Factor κB Pathway by Astrocyte Elevated Gene-1: Implications for Tumor Progression and Metastasis

inferredcites →https://doi.org/10.1158/0008-5472.can-06-4206openalex-snapshot

AS1411 Alters the Localization of a Complex Containing Protein Arginine Methyltransferase 5 and Nucleolin

inferredcites →https://doi.org/10.1158/0008-5472.can-07-6164openalex-snapshot

Molecular Basis of Nuclear Factor-κB Activation by Astrocyte Elevated Gene-1

inferredcites →https://doi.org/10.1158/0008-5472.can-10-2887openalex-snapshot

Oncogenic Synergism between ErbB1, Nucleolin, and Mutant Ras

inferredcites →https://doi.org/10.1158/0008-5472.can-13-2978openalex-snapshot

Astrocyte Elevated Gene-1 Interacts with Akt Isoform 2 to Control Glioma Growth, Survival, and Pathogenesis

inferredcites →https://doi.org/10.1158/1078-0432.ccr-07-4054openalex-snapshot

Astrocyte Elevated Gene-1 is a Novel Prognostic Marker for Breast Cancer Progression and Overall Patient Survival

inferredcites →https://doi.org/10.1172/jci36460openalex-snapshot

Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression

inferredcites →https://doi.org/10.1186/s12920-019-0514-7openalex-snapshot

GENT2: an updated gene expression database for normal and tumor tissues

inferredcites →https://doi.org/10.1242/jcs.112.6.761openalex-snapshot

Structure and functions of nucleolin

inferredcites →https://doi.org/10.1371/journal.pone.0002310openalex-snapshot

Identification of Nucleolin as New ErbB Receptors- Interacting Protein

inferredcites →https://doi.org/10.1371/journal.pone.0002518openalex-snapshot

Suppression of Tumor Growth and Angiogenesis by a Specific Antagonist of the Cell-Surface Expressed Nucleolin

inferredcites →https://doi.org/10.1371/journal.pone.0006128openalex-snapshot

Structure-Function Analysis of Nucleolin and ErbB Receptors Interactions

inferredcites →https://doi.org/10.1371/journal.pone.0015787openalex-snapshot

Surface Expressed Nucleolin Is Constantly Induced in Tumor Cells to Mediate Calcium-Dependent Ligand Internalization

inferredcites →https://doi.org/10.1371/journal.pone.0054674openalex-snapshot

Prognostic Significance of the Combined Score of Endothelial Expression of Nucleolin and CD31 in Surgically Resected Non-Small Cell Lung Cancer

inferredcites →https://doi.org/10.18632/oncotarget.11323openalex-snapshot

Nucleolin-binding by ErbB2 enhances tumorigenicity of ErbB2-positive breast cancer

inferredcites →https://doi.org/10.2967/jnumed.115.157834openalex-snapshot

Clinical Diagnosis and Management of Breast Cancer

inferredcites →https://doi.org/10.3322/caac.21660openalex-snapshot

Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

inferredcites →https://doi.org/10.3390/ijms21239276openalex-snapshot

Activity-Based Protein Profiling Reveals Potential Dasatinib Targets in Gastric Cancer

inferredcites →https://doi.org/10.3390/pharmaceutics12070689openalex-snapshot

Combinatorial Inhibition of Cell Surface Receptors Using Dual Aptamer-Functionalized Nanoconstructs for Cancer Treatment

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4652710openalex-extracted

inferred← citeshttps://doi.org/10.1002/jev2.12357openalex-snapshot

Mass‐produced gram‐negative bacterial outer membrane vesicles activate cancer antigen‐specific stem‐like CD8 + T cells which enables an effective combination immunotherapy with anti‐PD‐1

inferred← citeshttps://doi.org/10.1007/s00018-026-06352-5openalex-snapshot

Moesin is an ανβ3 integrin-interacting protein that affects endothelial cell activation and angiogenesis through balancing c-Met and VEGFR2 activation

inferred← citeshttps://doi.org/10.1007/s00430-025-00851-1openalex-snapshot

Therapeutic potential of Bacillus sonorensis PMC204 membrane vesicles against drug-resistant Mycobacterium tuberculosis

inferred← citeshttps://doi.org/10.1007/s00432-022-04361-yopenalex-snapshot

Secretome analysis reveals reduced expression of COL4A2 in hypoxic cancer-associated fibroblasts with a tumor-promoting function in gastric cancer

inferred← citeshttps://doi.org/10.1016/bs.acr.2025.06.003openalex-snapshot

AEG-1 on cancer drug resistance: From molecular insights to therapeutic challenges

inferred← citeshttps://doi.org/10.1016/j.gene.2025.149479openalex-snapshot

Investigating the multifaceted role of nucleolin in cellular function and Cancer: Structure, Regulation, and therapeutic implications

inferred← citeshttps://doi.org/10.1016/j.lfs.2023.121655openalex-snapshot

CAMSAP3 negatively regulates lung cancer cell invasion and angiogenesis through nucleolin/HIF-1α mRNA complex stabilization

inferred← citeshttps://doi.org/10.1016/j.mcpro.2025.100944openalex-snapshot

Metabolic Reprogramming Into a Glycolysis Phenotype Induced by Extracellular Vesicles Derived From Prostate Cancer Cells

inferred← citeshttps://doi.org/10.1038/s41392-022-01285-4openalex-snapshot

Ribosome biogenesis in disease: new players and therapeutic targets

inferred← citeshttps://doi.org/10.1186/s12964-024-01783-8openalex-snapshot

Activity-based protein profiling and global proteome analysis reveal MASTL as a potential therapeutic target in gastric cancer

inferred← citeshttps://doi.org/10.1186/s40543-025-00489-xopenalex-snapshot

Proteomic characterization and bioinformatic insights into MUC18 function in gastric cancer

inferred← citeshttps://doi.org/10.21203/rs.3.rs-2568517/v1openalex-snapshot

The Expression of Angiogenesis Genes is Related to Immune Microenvironment and Prognosis of Lung Adenocarcinoma

inferred← citeshttps://doi.org/10.3389/fimmu.2024.1484226openalex-snapshot

mRNA-seq-based analysis predicts: AEG-1 is a therapeutic target and immunotherapy biomarker for pan-cancer, including OSCC

inferred← citeshttps://doi.org/10.3390/cancers17081375openalex-snapshot

Astrocyte Elevated Gene-1/Metadherin (AEG-1/MTDH): A Promising Molecular Marker and Therapeutic Target for Hepatocellular Carcinoma

inferred← citeshttps://doi.org/10.58837/chula.the.2022.295openalex-snapshot

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