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CBP/p300: Critical Co-Activators for Nuclear Steroid Hormone Receptors and Emerging Therapeutic Targets in Prostate and Breast Cancers
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1 of the 200 references listed on this page is in the Retraction Watch database as retracted (export 2026-11-04): 10.1002/pros.20865 (notice 2025-02-21).
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/path.1609openalex-snapshotThe androgen receptor co‐activator CBP is up‐regulated following androgen withdrawal and is highly expressed in advanced prostate cancer
inferredcites →https://doi.org/10.1002/pros.23689openalex-snapshotInhibition of androgen receptor transactivation function by adenovirus type 12 E1A undermines prostate cancer cell survival
inferredcites →https://doi.org/10.1007/s10637-015-0235-5openalex-snapshotAZD3514, an oral selective androgen receptor down-regulator in patients with castration-resistant prostate cancer – results of two parallel first-in-human phase I studies
inferredcites →https://doi.org/10.1016/j.ccr.2010.04.027openalex-snapshotRegression of Castrate-Recurrent Prostate Cancer by a Small-Molecule Inhibitor of the Amino-Terminus Domain of the Androgen Receptor
inferredcites →https://doi.org/10.1016/j.ejmech.2018.01.087openalex-snapshotDiscovery and optimization of 1-(1 H -indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer
inferredcites →https://doi.org/10.1016/j.sbi.2008.09.004openalex-snapshotStructure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltransferase evolution and function
inferredcites →https://doi.org/10.1016/s0002-9440(10)63814-xopenalex-snapshotThe Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function
inferredcites →https://doi.org/10.1021/acs.jmedchem.7b00796openalex-snapshotGNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP)
inferredcites →https://doi.org/10.1038/42750openalex-snapshotA signature motif in transcriptional co-activators mediates binding to nuclear receptors
inferredcites →https://doi.org/10.1038/nm.4378openalex-snapshotProstate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4
inferredcites →https://doi.org/10.1038/nm.4379openalex-snapshotIntrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT–mTORC1 activation
inferredcites →https://doi.org/10.1038/nsmb924openalex-snapshotCtBP represses p300-mediated transcriptional activation by direct association with its bromodomain
inferredcites →https://doi.org/10.1038/onc.2016.382openalex-snapshotGenomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer
inferredcites →https://doi.org/10.1038/onc.2017.80openalex-snapshotSPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein
inferredcites →https://doi.org/10.1038/s41388-020-1370-9openalex-snapshotAndrogen receptor-induced integrin α6β1 and Bnip3 promote survival and resistance to PI3K inhibitors in castration-resistant prostate cancer
inferredcites →https://doi.org/10.1038/sj.leu.2401983openalex-snapshotFusion of MOZ and p300 histone acetyltransferases in acute monocytic leukemia with a t(8;22)(p11;q13) chromosome translocation
inferredcites →https://doi.org/10.1038/sj.onc.1201002openalex-snapshotInhibition of p53-mediated transactivation and cell cycle arrest by E1A through its p300/CBP-interacting regionSelfcloseTable
inferredcites →https://doi.org/10.1073/pnas.1205132109openalex-snapshotAcetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation
inferredcites →https://doi.org/10.1073/pnas.93.17.8884openalex-snapshotCREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription.
inferredcites →https://doi.org/10.1074/jbc.m000660200openalex-snapshotp300 and p300/cAMP-response Element-binding Protein-associated Factor Acetylate the Androgen Receptor at Sites Governing Hormone-dependent Transactivation
inferredcites →https://doi.org/10.1074/jbc.m111.300194openalex-snapshotSelective Roles for cAMP Response Element-binding Protein Binding Protein and p300 Protein as Coregulators for Androgen-regulated Gene Expression in Advanced Prostate Cancer Cells
inferredcites →https://doi.org/10.1074/jbc.m513405200openalex-snapshotEstrogen-occupied Estrogen Receptor Represses Cyclin G2 Gene Expression and Recruits a Repressor Complex at the Cyclin G2 Promoter
inferredcites →https://doi.org/10.1080/15384047.2017.1323586openalex-snapshotCtBP- an emerging oncogene and novel small molecule drug target: Advances in the understanding of its oncogenic action and identification of therapeutic inhibitors
inferredcites →https://doi.org/10.1101/gad.12.3.331openalex-snapshotp300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation
inferredcites →https://doi.org/10.1101/gad.8.8.869openalex-snapshotMolecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.
inferredcites →https://doi.org/10.1126/sciadv.aaw7781openalex-snapshotA novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death
inferredcites →https://doi.org/10.1128/mcb.19.12.8123openalex-snapshotBiochemical Analysis of Distinct Activation Functions in p300 That Enhance Transcription Initiation with Chromatin Templates
inferredcites →https://doi.org/10.1128/mcb.21.1.39-50.2001openalex-snapshotAnalysis of the Steroid Receptor Coactivator 1 (SRC1)-CREB Binding Protein Interaction Interface and Its Importance for the Function of SRC1
inferredcites →https://doi.org/10.1128/mcb.23.1.335-348.2003openalex-snapshotMediator and p300/CBP-Steroid Receptor Coactivator Complexes Have Distinct Roles, but Function Synergistically, during Estrogen Receptor α-Dependent Transcription with Chromatin Templates
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/advs.202518185openalex-snapshotIdentification of A p300–SP1–BRD4 Transcriptional Axis as a Key Driver of AR Hyperactivation in Polycystic Ovarian Syndrome
inferred← citeshttps://doi.org/10.1002/dvg.23518openalex-snapshotHistone acetyltransferases and histone deacetyl transferases play crucial role during oogenesis and early embryo development
inferred← citeshttps://doi.org/10.1016/j.bioorg.2022.105803openalex-snapshotDesign, synthesis and biological evaluation of (R)-5-methylpyrrolidin-2-ones as p300 bromodomain inhibitors with Anti-Tumor activities in multiple tumor lines
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.3c01789openalex-snapshotDiscovery of CBPD-409 as a Highly Potent, Selective, and Orally Efficacious CBP/p300 PROTAC Degrader for the Treatment of Advanced Prostate Cancer
inferred← citeshttps://doi.org/10.1038/s41380-025-03293-6openalex-snapshotPosttranslational regulation of CREB-binding protein expression by F-box leucine-rich repeat-containing protein 19 and ubiquitin-specific peptidase 14 in the paraventricular nucleus participates in chronic stress-induced symptomatology via the modulation of the hypothalamic‒pituitary‒adrenal axis
inferred← citeshttps://doi.org/10.1039/d2fo01438fopenalex-snapshotAnalysis of the multi-physiological and functional mechanism of wheat alkylresorcinols based on reverse molecular docking and network pharmacology
inferred← citeshttps://doi.org/10.1177/10668969251358831openalex-snapshotMicronodular Thymic Carcinoma With Lymphoid Hyperplasia: A Case Report and Next Generation Sequencing Analysis With its Benign Counterpart Multinodular Thymoma With Lymphoid Stroma
inferred← citeshttps://doi.org/10.1177/15330338261470883openalex-snapshotThe Dysregulation of Lysine Acetylation in Esophageal Squamous Cell Carcinoma: Mechanisms, Therapeutic Targets and Clinical Perspectives
inferred← citeshttps://doi.org/10.1186/s13062-024-00491-0openalex-snapshotPNSC928, a plant-derived compound, specifically disrupts CtBP2-p300 interaction and reduces inflammation in mice with acute respiratory distress syndrome
inferred← citeshttps://doi.org/10.2147/ijn.s579436openalex-snapshotNovel Strategies for Precision Diagnosis and Treatment of Prostate Cancer Based on Multifunctional Nanocarrier Systems
inferred← citeshttps://doi.org/10.3390/cancers13112799openalex-snapshotPharmacological Inhibition of CBP/p300 Blocks Estrogen Receptor Alpha (ERα) Function through Suppressing Enhancer H3K27 Acetylation in Luminal Breast Cancer
inferred← citeshttps://doi.org/10.3892/etm.2024.12770openalex-snapshotMicroRNA‑4327 regulates TGF‑β1 stimulation of matrix metalloproteinase‑13 expression via CREB‑binding protein‑mediated Runx2 acetylation in human osteoblasts
inferred← citeshttps://doi.org/10.4103/etmj.etmj-d-25-00055openalex-snapshotThe role of the ESR1 gene in breast cancer: A comprehensive review of detailed analysis of biology, mutational landscapes, pathways, and therapeutic implications
inferred← citeshttps://doi.org/10.6084/m9.figshare.26074164openalex-snapshotAdditional file 1 of PNSC928, a plant-derived compound, specifically disrupts CtBP2-p300 interaction and reduces inflammation in mice with acute respiratory distress syndrome
inferred← citeshttps://doi.org/10.6084/m9.figshare.26597315openalex-snapshotAdditional file 1 of CITED1 as a marker of favourable outcome in anti-endocrine treated, estrogen-receptor positive, lymph-node negative breast cancer
inferred← citeshttps://doi.org/10.6084/m9.figshare.26597318openalex-snapshotAdditional file 2 of CITED1 as a marker of favourable outcome in anti-endocrine treated, estrogen-receptor positive, lymph-node negative breast cancer
inferred← citeshttps://doi.org/10.7554/elife.98386openalex-snapshotVGLL2 and TEAD1 fusion proteins identified in human sarcoma drive YAP/TAZ-independent tumorigenesis by engaging EP300
inferred← citeshttps://doi.org/10.7554/elife.98386.1.sa0openalex-snapshotReviewer #2 (Public Review): VGLL2 and TEAD1 fusion proteins drive YAP/TAZ-independent transcription and tumorigenesis by engaging p300
inferred← citeshttps://doi.org/10.7554/elife.98386.1.sa1openalex-snapshotReviewer #1 (Public Review): VGLL2 and TEAD1 fusion proteins drive YAP/TAZ-independent transcription and tumorigenesis by engaging p300
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