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The PATHFINDER Study: Assessment of the Implementation of an Investigational Multi-Cancer Early Detection Test into Clinical Practice

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Screening for Colorectal Cancer
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Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA
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European Code against Cancer, 4th Edition: Cancer screening
inferredcites →https://doi.org/10.1016/j.ccell.2021.02.004openalex-snapshot
Multi-cancer early detection: A new paradigm for reducing cancer-specific and all-cause mortality
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Coronavirus disease 2019 (COVID-19) pandemic: Review of guidelines for resuming non-urgent imaging and procedures in radiology during Phase II
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P1.11-19 Trial in Progress: Cancer Screening Study With or Without Low Dose Lung CT to Validate a Multi-Cancer Early Detection Blood Test
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A brief assessment of concerns associated with genetic testing for cancer: The multidimensional impact of cancer risk assessment (MICRA) questionnaire.
inferredcites →https://doi.org/10.1038/d41573-020-00093-1openalex-snapshot
Impact of COVID-19 on oncology clinical trials
inferredcites →https://doi.org/10.1038/s41586-018-0703-0openalex-snapshot
Sensitive tumour detection and classification using plasma cell-free DNA methylomes
inferredcites →https://doi.org/10.1038/s41586-019-1272-6openalex-snapshot
Genome-wide cell-free DNA fragmentation in patients with cancer
inferredcites →https://doi.org/10.1038/s41698-018-0066-xopenalex-snapshot
Universal cancer screening: revolutionary, rational, and realizable
inferredcites →https://doi.org/10.1038/s43018-020-0043-5openalex-snapshot
Circulating tumor DNA and liquid biopsy in oncology
inferredcites →https://doi.org/10.1056/nejmoa1102873openalex-snapshot
Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening
inferredcites →https://doi.org/10.1093/annonc/mdz394.074openalex-snapshot
Simultaneous multi-cancer detection and tissue of origin (TOO) localization using targeted bisulfite sequencing of plasma cell-free DNA (cfDNA)
inferredcites →https://doi.org/10.1093/ije/dyv175openalex-snapshot
Impact of changing US cigarette smoking patterns on incident cancer: risks of 20 smoking-related cancers among the women and men of the NIH-AARP cohort
inferredcites →https://doi.org/10.1093/jnci/93.14.1054openalex-snapshot
Phases of Biomarker Development for Early Detection of Cancer
inferredcites →https://doi.org/10.1093/jnci/dju289openalex-snapshot
Effects of Screening and Systemic Adjuvant Therapy on ER-Specific US Breast Cancer Mortality
inferredcites →https://doi.org/10.1097/01.ogx.0000549540.69362.81openalex-snapshot
Screening for Cervical Cancer: US Preventive Services Task Force Recommendation Statement
inferredcites →https://doi.org/10.1126/science.aar3247openalex-snapshot
Detection and localization of surgically resectable cancers with a multi-analyte blood test
inferredcites →https://doi.org/10.1126/science.abb9601openalex-snapshot
Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention
inferredcites →https://doi.org/10.1158/1055-9965.epi-20-1134openalex-snapshot
Modeled Reductions in Late-stage Cancer with a Multi-Cancer Early Detection Test
inferredcites →https://doi.org/10.1177/0272989x18776637openalex-snapshot
Estimation of a Preference-Based Summary Score for the Patient-Reported Outcomes Measurement Information System: The PROMIS ® -Preference (PROPr) Scoring System
inferredcites →https://doi.org/10.1370/afm.942openalex-snapshot
Cumulative Incidence of False-Positive Results in Repeated, Multimodal Cancer Screening
inferredcites →https://doi.org/10.3111/13696998.2013.848208openalex-snapshot
Healthcare costs, treatment patterns, and resource utilization among pancreatic cancer patients in a managed care population
inferredcites →https://doi.org/10.3322/caac.21557openalex-snapshot
Cancer screening in the United States, 2019: A review of current American Cancer Society guidelines and current issues in cancer screening
inferredcites →https://doi.org/10.3322/caac.21590openalex-snapshot
Cancer statistics, 2020
inferredcites →https://doi.org/10.3748/wjg.v23.i28.5086openalex-snapshot
Colorectal cancer screening: An updated review of the available options
inferredcites →https://doi.org/10.5888/pcd15.170465openalex-snapshot
Patterns and Trends in Cancer Screening in the United States
inferredcites →https://doi.org/10.6004/jadpro.2020.11.2.1openalex-snapshot
The American Cancer Society’s Facts & Figures: 2020 Edition
inferredcites →https://doi.org/10.6004/jnccn.2017.0036openalex-snapshot
Colon Cancer, Version 1.2017, NCCN Clinical Practice Guidelines in Oncology
inferredcites →https://doi.org/10.6004/jnccn.2017.7065openalex-snapshot
Medical Care Costs Associated With Cancer in Integrated Delivery Systems
inferredcites →https://doi.org/10.6004/jnccn.2018.0020openalex-snapshot
Lung Cancer Screening, Version 3.2018, NCCN Clinical Practice Guidelines in Oncology
inferredcites →https://doi.org/10.6004/jnccn.2018.0061openalex-snapshot
Rectal Cancer, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology
inferredcites →https://doi.org/10.6004/jnccn.2018.0083openalex-snapshot
Breast Cancer Screening and Diagnosis, Version 3.2018, NCCN Clinical Practice Guidelines in Oncology
inferredcites →https://doi.org/10.7326/m13-2771openalex-snapshot
Screening for Lung Cancer: U.S. Preventive Services Task Force Recommendation Statement
inferredcites →https://doi.org/10.7326/m15-2886openalex-snapshot
Screening for Breast Cancer: U.S. Preventive Services Task Force Recommendation Statement

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Analytical and Clinical Validation of a Circulating Tumor DNA-Based Assay for Multi-Cancer Early Detection
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The modeling of multicancer early detection (MCED) tests’ residual risk and the challenges of MCED evaluation and implementation
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Liquid Biopsy in Early-Stage Breast Cancer
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Liquid biopsy based on circulating tumor DNA for lung cancer: A step toward prevention
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inferred← citeshttps://doi.org/10.1016/j.ajur.2022.11.002openalex-snapshot
Cell-free DNA in the management of prostate cancer: Current status and future prospective
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Challenges in promoter methylation analysis in the new era of translational oncology: a focus on liquid biopsy
inferred← citeshttps://doi.org/10.1016/j.cmpb.2026.109346openalex-snapshot
Frequency-Domain Dynamic Light Scattering (FEDSA) for in vivo screening of breast tissue abnormalities: A proof-of-concept study
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Blood-Based Biomarkers in the Diagnosis and Risk Stratification of Pancreatic Cysts
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Biomarkers for Gastric Cancer and Premalignant Gastric Conditions
inferred← citeshttps://doi.org/10.1016/j.hoc.2024.04.004openalex-snapshot
Biomarkers in Cancer Screening
inferred← citeshttps://doi.org/10.1016/j.jlb.2023.100126openalex-snapshot
Harnessing liquid biopsies: Exosomes and ctDNA as minimally invasive biomarkers for precision cancer medicine
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Kidney cancer screening: novel concepts beyond population-level screening
inferred← citeshttps://doi.org/10.1016/j.surge.2023.10.010openalex-snapshot
Risk-stratified screening for the early detection of kidney cancer
inferred← citeshttps://doi.org/10.1016/s0140-6736(23)01700-2openalex-snapshot
Blood-based tests for multicancer early detection (PATHFINDER): a prospective cohort study
inferred← citeshttps://doi.org/10.1016/s1470-2045(24)00645-4openalex-snapshot
Psychosocial impact associated with a multicancer early detection test (PATHFINDER): a prospective, multicentre, cohort study
inferred← citeshttps://doi.org/10.1017/s0963180124000744openalex-snapshot
Ethical Considerations and Implications of Multi-Cancer Early Detection Screening: Reliability, Access and Cost to Test and Treat
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Advances in Epigenomic Sequencing and Their Applications in Cancer Diagnostics
inferred← citeshttps://doi.org/10.1038/s41416-021-01498-4openalex-snapshot
Estimating the population health impact of a multi-cancer early detection genomic blood test to complement existing screening in the US and UK
inferred← citeshttps://doi.org/10.1038/s41431-026-02014-zopenalex-snapshot
Non-invasive screening in hereditary cancer: a randomized controlled trial to test cell-free DNA-based early detection in the CHARM consortium
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Multimodal cell-free DNA whole-genome TAPS is sensitive and reveals specific cancer signals
inferred← citeshttps://doi.org/10.1038/s41598-025-08986-0openalex-snapshot
Validation of an AI-enabled exome/transcriptome liquid biopsy platform for early detection, MRD, disease monitoring, and therapy selection for solid tumors
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Monitoring treatment response using an ultra-sensitive ctDNA assay in advanced esophagogastric cancer patients
inferred← citeshttps://doi.org/10.1038/s41698-023-00467-9openalex-snapshot
Incidental detection of FGFR3 fusion via liquid biopsy leading to earlier diagnosis of urothelial carcinoma
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Multiomics biomarkers were not superior to clinical variables for pan-cancer screening
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Die Rolle der Liquid Biopsy beim primären und metastasierten Mammakarzinom
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Clinical validation of a ctDNA-Based Assay for Multi-Cancer Detection: An Interim Report from a Vietnamese Longitudinal Prospective Cohort Study of 2795 Participants
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Circulating tumor DNA (ctDNA): can it be used as a pan-cancer early detection test?
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A consultation and work-up diagnosis protocol for a multicancer early detection test: a case series study
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Perspectives of private payers on multicancer early-detection tests: informing research, implementation, and policy
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Benchmarking reliability and calibration of LLMs for multi-cancer early detection test communication
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Revisiting the standard blueprint for biomarker development to address emerging cancer early detection technologies
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The National Health Service–Galleri multicancer screening trial: explanation and justification of unique and important design issues
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Tumor localization strategies of multicancer early detection tests: a quantitative assessment
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Multimodal cell-free DNA whole-genome analysis combined with TET-Assisted Pyridine Borane Sequencing is sensitive and reveals specific cancer signals
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Evaluation of the Multi-Cancer Early Detection (MCED) value of YiDiXie ™ -HS and YiDiXie ™ -SS
inferred← citeshttps://doi.org/10.1101/2025.05.23.25328255openalex-snapshot
AI enabled exome and transcriptome liquid biopsy platform spanning the continuum of care in oncology
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Comparative Analysis of Machine Learning Models for Early Prediction of Cancer
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Is this the end of colonoscopy screening for colorectal cancer? An Asia‐Pacific perspective
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Multi-Cancer Early Detection: The New Frontier in Cancer Early Detection
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Projecting the Impact of Multi-Cancer Early Detection on Late-Stage Incidence Using Multi-State Disease Modeling
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Clonal Evolution in Healthy and Premalignant Tissues: Implications for Early Cancer Interception Strategies
inferred← citeshttps://doi.org/10.1158/1940-6207.capr-24-0468openalex-snapshot
Clinical Evaluation of Cancer Signal Origin Prediction and Diagnostic Resolution following Multicancer Early Detection Testing in the PATHFINDER Study
inferred← citeshttps://doi.org/10.1172/jci154941openalex-snapshot
Circulating tumor DNA: current challenges for clinical utility
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Challenges of early detection of pancreatic cancer
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Multi-cancer early detection tests: Attributes for clinical implementation
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Implementation of a Multicancer Detection (MCD) Test in a Tertiary Referral Center in Asymptomatic Patients: An 18-Month Prospective Cohort Study
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Impact of clinical factors on accuracy of ovarian cancer detection via platelet RNA profiling
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Prospective validation study: a non-invasive circulating tumor DNA-based assay for simultaneous early detection of multiple cancers in asymptomatic adults
inferred← citeshttps://doi.org/10.1186/s12917-022-03429-8openalex-snapshot
Evaluation of plasma nucleosome concentrations in dogs with a variety of common cancers and in healthy dogs
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Artificial Intelligence in cancer epigenomics: a review on advances in pan-cancer detection and precision medicine
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Gastrointestinal cancer: molecular pathogenesis and targeted therapy
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Regulation of Laboratory-Developed Tests in Preventive Oncology: Emerging Needs and Opportunities
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Multicancer Detection Tests for Population-Wide Screening of Asymptomatic Individuals: A Systematic Review
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Optimizing Access to Liquid Biopsy in the Present and Future Cancer Landscape
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Multi-cancer early detection liquid biopsy testing: A predictive genetic test not quite ready for prime time
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Clinical validation of a next-generation sequencing-based multi-cancer early detection “liquid biopsy” blood test in over 1,000 dogs using an independent testing set: The CANcer Detection in Dogs (CANDiD) study
inferred← citeshttps://doi.org/10.14218/jerp.2023.00007openalex-snapshot
Multicancer Early Detection Tests for Cancer Diagnosis
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Advances in lung cancer screening and early detection
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Current and future applications of liquid biopsy in non-small-cell lung cancer—a narrative review
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Ultra-sensitive, tumor-informed ctDNA profiling in pembrolizumab-treated esophagogastric cancer patients predicts clinical responses
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Detecting hidden threats using longitudinal liquid biopsies
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Screening approaches for lung cancer by blood-based biomarkers: Challenges and opportunities
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Multi-cancer early detection tests for general population screening: a systematic literature review
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Cancer epigenetics in clinical practice
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Deconstructing Pancreatic Cancer Using Next Generation-Omic Technologies–From Discovery to Knowledge-Guided Platforms for Better Patient Management
inferred← citeshttps://doi.org/10.3390/biomedicines14010158openalex-snapshot
Liquid Biopsy in Early Screening of Cancers: Emerging Technologies and New Prospects
inferred← citeshttps://doi.org/10.3390/cancers13225615openalex-snapshot
Liquid Biopsies beyond Mutation Calling: Genomic and Epigenomic Features of Cell-Free DNA in Cancer
inferred← citeshttps://doi.org/10.3390/cancers14194818openalex-snapshot
Cell-Free DNA–Based Multi-Cancer Early Detection Test in an Asymptomatic Screening Population (NHS-Galleri): Design of a Pragmatic, Prospective Randomised Controlled Trial
inferred← citeshttps://doi.org/10.3390/cancers14205105openalex-snapshot
The Role of ctDNA in Gastric Cancer
inferred← citeshttps://doi.org/10.3390/cancers15102702openalex-snapshot
Liquid Biopsy in Early-Stage Lung Cancer: Current and Future Clinical Applications
inferred← citeshttps://doi.org/10.3390/cancers15102780openalex-snapshot
Biomarker Reproducibility Challenge: A Review of Non-Nucleotide Biomarker Discovery Protocols from Body Fluids in Breast Cancer Diagnosis
inferred← citeshttps://doi.org/10.3390/cancers15194774openalex-snapshot
Exploring the Potential of Non-Coding RNAs as Liquid Biopsy Biomarkers for Lung Cancer Screening: A Literature Review
inferred← citeshttps://doi.org/10.3390/cancers15225463openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/cancers16061191openalex-snapshot
Cancer Screening: Present Recommendations, the Development of Multi-Cancer Early Development Tests, and the Prospect of Universal Cancer Screening
inferred← citeshttps://doi.org/10.3390/cancers16193335openalex-snapshot
Evolution of Liquid Biopsies for Detecting Pancreatic Cancer
inferred← citeshttps://doi.org/10.3390/cancers17111867openalex-snapshot
Innovative Approaches to Early Detection of Cancer-Transforming Screening for Breast, Lung, and Hard-to-Screen Cancers
inferred← citeshttps://doi.org/10.3390/cells12060935openalex-snapshot
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Plasma Cell-Free Tumor Methylome as a Biomarker in Solid Tumors: Biology and Applications
inferred← citeshttps://doi.org/10.3390/diagnostics12051243openalex-snapshot
The Promise of Multicancer Early Detection. Comment on Pons-Belda et al. Can Circulating Tumor DNA Support a Successful Screening Test for Early Cancer Detection? The Grail Paradigm. Diagnostics 2021, 11, 2171
inferred← citeshttps://doi.org/10.3390/ijms24032996openalex-snapshot
DNA Methylation as a Diagnostic, Prognostic, and Predictive Biomarker in Head and Neck Cancer
inferred← citeshttps://doi.org/10.3390/ijms241713219openalex-snapshot
Using cfDNA and ctDNA as Oncologic Markers: A Path to Clinical Validation
inferred← citeshttps://doi.org/10.3390/jpm13111613openalex-snapshot
Primary Care Patient Interest in Multi-Cancer Early Detection for Cancer Screening
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Establishment and Performance Evaluation of a Multiplexed TET2–APOBEC-Mediated cfDNA Methylation Detection Workflow Using qPCR and dPCR Readouts
inferred← citeshttps://doi.org/10.3399/bjgp24x739113openalex-snapshot
A multi-cancer early detection (MCED) test: clinical update for GPs
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Kidney Cancer Screening and Epidemiology
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Screening and prevention of ovarian cancer
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Multicancer Detection Tests for Screening
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