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Administration of an Acidic Sphingomyelinase (ASMase) Inhibitor, Imipramine, Reduces Hypoglycemia-Induced Hippocampal Neuronal Death

https://doi.org/10.3390/cells11040667
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Hypoglycemic Episodes and Risk of Dementia in Older Patients With Type 2 Diabetes Mellitus
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Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress–induced death of motor neurons in amyotrophic lateral sclerosis
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Critical role of acidic sphingomyelinase in murine hepatic ischemia-reperfusion injury
inferredcites →https://doi.org/10.1002/jnr.23542openalex-snapshot
Changes in the metabolism of sphingolipids after subarachnoid hemorrhage
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Role of Ceramide in Stimulation of the Transcription of Cytosolic Phospholipase A2and Cyclooxygenase 2
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The Role of NADPH Oxidase and Neuronal Nitric Oxide Synthase in Zinc-Induced Poly(ADP-ribose) Polymerase Activation and Cell Death in Cortical Culture
inferredcites →https://doi.org/10.1007/bf02246453openalex-snapshot
Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2C receptor
inferredcites →https://doi.org/10.1007/s00125-017-4233-3openalex-snapshot
Cognitive deficits associated with impaired awareness of hypoglycaemia in type 1 diabetes
inferredcites →https://doi.org/10.1007/s00401-012-1014-4openalex-snapshot
Fingolimod attenuates ceramide-induced blood–brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes
inferredcites →https://doi.org/10.1007/s00702-005-0374-5openalex-snapshot
High activity of acid sphingomyelinase in major depression
inferredcites →https://doi.org/10.1007/s00726-016-2370-5openalex-snapshot
Prevention of hypoglycemia-induced hippocampal neuronal death by N-acetyl-l-cysteine (NAC)
inferredcites →https://doi.org/10.1007/s10495-010-0520-xopenalex-snapshot
Zinc induced apoptotic death of mouse dendritic cells
inferredcites →https://doi.org/10.1016/0165-0327(95)00034-kopenalex-snapshot
Therapeutic efficacy of antidepressants in agitated anxious depression — a meta-analysis of moclobemide studies
inferredcites →https://doi.org/10.1016/1074-7613(95)90142-6openalex-snapshot
FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway
inferredcites →https://doi.org/10.1016/j.bbadis.2017.08.010openalex-snapshot
Adiponectin attenuates NADPH oxidase-mediated oxidative stress and neuronal damage induced by cerebral ischemia-reperfusion injury
inferredcites →https://doi.org/10.1016/j.bbamem.2008.07.030openalex-snapshot
Ceramide-enriched membrane domains—Structure and function
inferredcites →https://doi.org/10.1016/j.bbrc.2019.09.111openalex-snapshot
Progranulin protects against cerebral ischemia-reperfusion (I/R) injury by inhibiting necroptosis and oxidative stress
inferredcites →https://doi.org/10.1016/j.biocel.2019.105622openalex-snapshot
Inflammatory role of extracellular sphingolipids in Cystic Fibrosis
inferredcites →https://doi.org/10.1016/j.brainres.2004.07.024openalex-snapshot
Upregulation of ceramide and its regulating mechanism in a rat model of chronic cerebral ischemia
inferredcites →https://doi.org/10.1016/j.diabres.2019.107843openalex-snapshot
Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition
inferredcites →https://doi.org/10.1016/j.euroneuro.2007.05.002openalex-snapshot
Neuroprotection by Imipramine against lipopolysaccharide-induced apoptosis in hippocampus-derived neural stem cells mediated by activation of BDNF and the MAPK pathway
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2007.12.017openalex-snapshot
Ceramide-induced formation of ROS and ATP depletion trigger necrosis in lymphoid cells
inferredcites →https://doi.org/10.1016/j.jdiacomp.2016.08.010openalex-snapshot
Associations between recent severe hypoglycemia, retinal vessel diameters, and cognition in adults with type 1 diabetes
inferredcites →https://doi.org/10.1016/j.jhep.2014.06.009openalex-snapshot
ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis
inferredcites →https://doi.org/10.1016/j.jns.2016.09.028openalex-snapshot
Associations between plasma ceramides and cognitive and neuropsychiatric manifestations in Parkinson's disease dementia
inferredcites →https://doi.org/10.1016/j.lfs.2005.08.013openalex-snapshot
Ceramide-induced preconditioning involves reactive oxygen species
inferredcites →https://doi.org/10.1016/j.nbd.2004.04.017openalex-snapshot
Zinc release contributes to hypoglycemia-induced neuronal death
inferredcites →https://doi.org/10.1016/j.neuropharm.2008.06.045openalex-snapshot
Inhibition of glial inflammatory activation and neurotoxicity by tricyclic antidepressants
inferredcites →https://doi.org/10.1016/j.neuroscience.2004.12.038openalex-snapshot
Neuronal expression of the NADPH oxidase NOX4, and its regulation in mouse experimental brain ischemia
inferredcites →https://doi.org/10.1016/s0006-291x(02)02593-7openalex-snapshot
Ceramide induces neuronal apoptosis through the caspase-9/caspase-3 pathway
inferredcites →https://doi.org/10.1016/s0006-8993(00)02513-0openalex-snapshot
Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration
inferredcites →https://doi.org/10.1016/s0014-5793(04)00033-xopenalex-snapshot
Interactions of acid sphingomyelinase and lipid bilayers in the presence of the tricyclic antidepressant desipramine
inferredcites →https://doi.org/10.1016/s1044-7431(02)00028-3openalex-snapshot
Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3β, and induction of the mitochondrial-dependent intrinsic caspase pathway
inferredcites →https://doi.org/10.1023/a:1007041329052openalex-snapshot
Characterization of sphingomyelinase activity released by thrombin-stimulated platelets
inferredcites →https://doi.org/10.1038/nm.2279openalex-snapshot
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
inferredcites →https://doi.org/10.1038/nm1539openalex-snapshot
Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide
inferredcites →https://doi.org/10.1038/nm1748openalex-snapshot
Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis
inferredcites →https://doi.org/10.1038/nm823openalex-snapshot
Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts
inferredcites →https://doi.org/10.1038/sj.cdd.4400666openalex-snapshot
Perturbation of membrane microdomains reduces mitogenic signaling and increases susceptibility to apoptosis after T cell receptor stimulation
inferredcites →https://doi.org/10.1038/sj.npp.1300924openalex-snapshot
Cell Proliferation is Influenced by Bulbectomy and Normalized by Imipramine Treatment in a Region-Specific Manner
inferredcites →https://doi.org/10.1038/srep15926openalex-snapshot
Ceramides And Stress Signalling Intersect With Autophagic Defects In Neurodegenerative Drosophila blue cheese (bchs) Mutants
inferredcites →https://doi.org/10.1038/srep20040openalex-snapshot
Xuefu Zhuyu decoction, a traditional Chinese medicine, provides neuroprotection in a rat model of traumatic brain injury via an anti-inflammatory pathway
inferredcites →https://doi.org/10.1042/bst0320144openalex-snapshot
Connection of lipid peroxide oxidation with the sphingomyelin pathway in the development of Alzheimer's disease
inferredcites →https://doi.org/10.1046/j.1471-4159.2000.740740.xopenalex-snapshot
Caspase‐3 Mediated Neuronal Death After Traumatic Brain Injury in Rats
inferredcites →https://doi.org/10.1055/s-2003-41810openalex-snapshot
Secretory Zn2+-dependent Sphingomyelinase Activity in the Serum of Patients with Type 2 Diabetes is Elevated
inferredcites →https://doi.org/10.1055/s-2005-870235openalex-snapshot
Ceramides, Sphinganine, Sphingosine and Acid Sphingomyelinases in the Human Umbilical Cord Blood
inferredcites →https://doi.org/10.1074/jbc.273.12.6921openalex-snapshot
Ceramide Formation Leads to Caspase-3 Activation during Hypoxic PC12 Cell Death
inferredcites →https://doi.org/10.1074/jbc.273.29.18250openalex-snapshot
The Cellular Trafficking and Zinc Dependence of Secretory and Lysosomal Sphingomyelinase, Two Products of the Acid Sphingomyelinase Gene
inferredcites →https://doi.org/10.1074/jbc.m110.125609openalex-snapshot
Regulated Secretion of Acid Sphingomyelinase
inferredcites →https://doi.org/10.1074/jbc.m110.155234openalex-snapshot
A Novel Mechanism of Lysosomal Acid Sphingomyelinase Maturation
inferredcites →https://doi.org/10.1074/jbc.m601451200openalex-snapshot
Endosomal Acidification and Activation of NADPH Oxidase Isoforms Are Upstream Events in Hyperosmolarity-induced Hepatocyte Apoptosis
inferredcites →https://doi.org/10.1084/jem.20132451openalex-snapshot
Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer’s disease
inferredcites →https://doi.org/10.1089/ars.2007.1692openalex-snapshot
Ceramide: A Novel Player in Reactive Oxygen Species-Induced Signaling?
inferredcites →https://doi.org/10.1097/01.wcb.0000119990.06999.a9openalex-snapshot
Glucosylceramide Synthase Activity and Ceramide Levels are Modulated during Cerebral Ischemia after Ischemic Preconditioning
inferredcites →https://doi.org/10.1111/1440-1681.13083openalex-snapshot
Acid sphingomyelinase mediates the noise‐induced liver disorder in mice
inferredcites →https://doi.org/10.1111/j.1600-0404.1980.tb03047.xopenalex-snapshot
Effects of severe hypoglycemia on the human brain neuropathological case reports
inferredcites →https://doi.org/10.1126/science.8456305openalex-snapshot
Programmed Cell Death Induced by Ceramide
inferredcites →https://doi.org/10.1136/bmjdrc-2017-000503openalex-snapshot
Real-world crude incidence of hypoglycemia in adults with diabetes: Results of the InHypo-DM Study, Canada
inferredcites →https://doi.org/10.1136/thoraxjnl-2015-208067openalex-snapshot
Role of acid sphingomyelinase and IL-6 as mediators of endotoxin-induced pulmonary vascular dysfunction
inferredcites →https://doi.org/10.1159/000350071openalex-snapshot
Therapy of CF-Patients with Amitriptyline and Placebo - a Randomised, Double-Blind, Placebo-Controlled Phase IIb Multicenter, Cohort-Study
inferredcites →https://doi.org/10.1159/000434722openalex-snapshot
Melatonin Reduces Hypoglycemia-Induced Neuronal Death in Rats
inferredcites →https://doi.org/10.1159/000484621openalex-snapshot
Blockade of Experimental Multiple Sclerosis by Inhibition of the Acid Sphingomyelinase/Ceramide System
inferredcites →https://doi.org/10.1161/hs1101.098367openalex-snapshot
Intravenous Administration of Human Umbilical Cord Blood Reduces Behavioral Deficits After Stroke in Rats
inferredcites →https://doi.org/10.1172/jci30077openalex-snapshot
Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase
inferredcites →https://doi.org/10.1177/1545968314550367openalex-snapshot
Developing a Clinically Relevant Model of Cognitive Training After Experimental Traumatic Brain Injury
inferredcites →https://doi.org/10.1182/blood.2019001400openalex-snapshot
Acid sphingomyelinase plays a critical role in LPS- and cytokine-induced tissue factor procoagulant activity
inferredcites →https://doi.org/10.1186/1742-2094-10-109openalex-snapshot
Early activation of nSMase2/ceramide pathway in astrocytes is involved in ischemia-associated neuronal damage via inflammation in rat hippocampi
inferredcites →https://doi.org/10.1186/s12929-016-0249-0openalex-snapshot
Electroacupuncture preconditioning reduces ROS generation with NOX4 down-regulation and ameliorates blood-brain barrier disruption after ischemic stroke
inferredcites →https://doi.org/10.1186/s12974-019-1436-1openalex-snapshot
Astrocytic ceramide as possible indicator of neuroinflammation
inferredcites →https://doi.org/10.1186/s13104-018-3162-7openalex-snapshot
Neuroprotection by chitosan nanoparticles in oxidative stress-mediated injury
inferredcites →https://doi.org/10.1194/jlr.m062828openalex-snapshot
Suppression of NLRP3 inflammasome by γ-tocotrienol ameliorates type 2 diabetes
inferredcites →https://doi.org/10.1194/jlr.ra120000627openalex-snapshot
Dynamics of sphingolipids and the serine palmitoyltransferase complex in rat oligodendrocytes during myelination
inferredcites →https://doi.org/10.1371/journal.pone.0021586openalex-snapshot
Acute Hypoglycemia Induces Retinal Cell Death in Mouse
inferredcites →https://doi.org/10.1371/journal.pone.0073094openalex-snapshot
Plasma Ceramide and Glucosylceramide Metabolism Is Altered in Sporadic Parkinson's Disease and Associated with Cognitive Impairment: A Pilot Study
inferredcites →https://doi.org/10.1385/jmn:15:2:85openalex-snapshot
Pivotal Role for Acidic Sphingomyelinase in Cerebral Ischemia-Induced Ceramide and Cytokine Production, and Neuronal Apoptosis
inferredcites →https://doi.org/10.1523/jneurosci.1236-08.2008openalex-snapshot
Zinc Triggers Microglial Activation
inferredcites →https://doi.org/10.1523/jneurosci.20-23-j0001.2000openalex-snapshot
Induction and Activation by Zinc of NADPH Oxidase in Cultured Cortical Neurons and Astrocytes
inferredcites →https://doi.org/10.1523/jneurosci.23-33-10681.2003openalex-snapshot
Hypoglycemic Neuronal Death and Cognitive Impairment Are Prevented by Poly(ADP-Ribose) Polymerase Inhibitors Administered after Hypoglycemia
inferredcites →https://doi.org/10.2337/db06-0419openalex-snapshot
Feasibility of Automating Insulin Delivery for the Treatment of Type 1 Diabetes
inferredcites →https://doi.org/10.2337/diab.33.11.1090openalex-snapshot
Hypoglycemic Brain Injury in the Rat: Correlation of Density of Brain Damage with the EEG Isoelectric Time: A Quantitative Study
inferredcites →https://doi.org/10.3233/jad-2011-111202openalex-snapshot
Increased Ceramide in Brains with Alzheimer's and Other Neurodegenerative Diseases
inferredcites →https://doi.org/10.3390/cells8050405openalex-snapshot
The Effects of Sodium Dichloroacetate on Mitochondrial Dysfunction and Neuronal Death Following Hypoglycemia-Induced Injury
inferredcites →https://doi.org/10.3390/ijms21031001openalex-snapshot
NADPH Oxidase-Mediated Activation of Neutral Sphingomyelinase Is Responsible for Diesel Particulate Extract-Induced Keratinocyte Apoptosis
inferredcites →https://doi.org/10.4049/jimmunol.174.4.2288openalex-snapshot
Poly(ADP-Ribose) Polymerase-1 Promotes Microglial Activation, Proliferation, and Matrix Metalloproteinase-9-Mediated Neuron Death
inferredcites →https://doi.org/10.4062/biomolther.2015.044openalex-snapshot
Vitamin C Stimulates Epidermal Ceramide Production by Regulating Its Metabolic Enzymes
inferredcites →https://doi.org/10.5483/bmbrep.2019.52.2.033openalex-snapshot
Acid sphingomyelinase-mediated blood-brain barrier disruption in aging
inferredcites →https://doi.org/10.7150/thno.50905openalex-snapshot
Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1038/s41598-024-55032-6openalex-snapshot
Metabolomic associations of impaired awareness of hypoglycaemia in type 1 diabetes
inferred← citeshttps://doi.org/10.3389/fneur.2024.1394499openalex-snapshot
Effect of hypoglycemic events on cognitive function in individuals with type 2 diabetes mellitus: a dose–response meta-analysis
inferred← citeshttps://doi.org/10.3390/antiox11112192openalex-snapshot
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Effects of Pyruvate Kinase M2 (PKM2) Gene Deletion on Astrocyte-Specific Glycolysis and Global Cerebral Ischemia-Induced Neuronal Death
inferred← citeshttps://doi.org/10.3390/cells14040281openalex-snapshot
Imipramine, an Acid Sphingomyelinase Inhibitor, Promotes Newborn Neuron Survival in the Hippocampus After Seizure
inferred← citeshttps://doi.org/10.3390/ijms232314749openalex-snapshot
Acid Sphingomyelinase Inhibitor, Imipramine, Reduces Hippocampal Neuronal Death after Traumatic Brain Injury
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The Presence of Periodontitis Exacerbates Non-Alcoholic Fatty Liver Disease via Sphingolipid Metabolism-Associated Insulin Resistance and Hepatic Inflammation in Mice with Metabolic Syndrome
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Pathogens That Rewrite the Rules: Ascoviruses, Elegant Manipulators of Cell Death Pathways and Architects of the Extracellular Viral Paradigm
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