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High-LET-Radiation-Induced Persistent DNA Damage Response Signaling and Gastrointestinal Cancer Development

https://doi.org/10.3390/curroncol30060416
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Outgoing claims: the papers this work cites, builds on, or argues with.

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Cancer genetics
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Mechanisms of DNA damage, repair, and mutagenesis
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DNA methylation biomarkers in colorectal cancer: Clinical applications for precision medicine
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MLH1‐silenced and non‐silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes
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Stress and stem cells
inferredcites →https://doi.org/10.1007/978-3-319-09216-4openalex-snapshot
Applications of EPR in Radiation Research
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General aspects of the cellular response to low- and high-LET radiation
inferredcites →https://doi.org/10.1007/s00411-007-0105-4openalex-snapshot
Countermeasures against space radiation induced oxidative stress in mice
inferredcites →https://doi.org/10.1007/s00411-022-00997-zopenalex-snapshot
Predominant contribution of the dose received from constituent heavy-ions in the induction of gastrointestinal tumorigenesis after simulated space radiation exposure
inferredcites →https://doi.org/10.1007/s11670-012-0083-1openalex-snapshot
Typical cell signaling response to ionizing radiation: DNA damage and extranuclear damage
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Stromal neoplasms of the rectum and anal canal
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Nucleotide Excision Repair in Eukaryotes
inferredcites →https://doi.org/10.1016/b978-0-12-420117-0.00001-3openalex-snapshot
Reactive Oxygen Species in Normal and Tumor Stem Cells
inferredcites →https://doi.org/10.1016/j.bcp.2012.07.022openalex-snapshot
Redox modulation of the DNA damage response
inferredcites →https://doi.org/10.1016/j.biochi.2018.11.003openalex-snapshot
Role of adenomatous polyposis coli (APC) gene mutations in the pathogenesis of colorectal cancer; current status and perspectives
inferredcites →https://doi.org/10.1016/j.cell.2014.04.051openalex-snapshot
Gut Microbial Metabolism Drives Transformation of Msh2-Deficient Colon Epithelial Cells
inferredcites →https://doi.org/10.1016/j.celrep.2018.03.076openalex-snapshot
Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas
inferredcites →https://doi.org/10.1016/j.celrep.2020.108434openalex-snapshot
DNA Damage Baseline Predicts Resilience to Space Radiation and Radiotherapy
inferredcites →https://doi.org/10.1016/j.celrep.2021.108840openalex-snapshot
DSB repair pathway choice is regulated by recruitment of 53BP1 through cell cycle-dependent regulation of Sp1
inferredcites →https://doi.org/10.1016/j.cels.2017.09.015openalex-snapshot
Orchestration of DNA Damage Checkpoint Dynamics across the Human Cell Cycle
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The genomics of oxidative DNA damage, repair, and resulting mutagenesis
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The Ku-dependent non-homologous end-joining but not other repair pathway is inhibited by high linear energy transfer ionizing radiation
inferredcites →https://doi.org/10.1016/j.dnarep.2015.11.015openalex-snapshot
Mouse models of DNA mismatch repair in cancer research
inferredcites →https://doi.org/10.1016/j.dnarep.2019.01.004openalex-snapshot
Distinct response of adult neural stem cells to low versus high dose ionising radiation
inferredcites →https://doi.org/10.1016/j.dnarep.2022.103289openalex-snapshot
DNA damage-induced sumoylation of Sp1 induces its interaction with RNF4 and degradation in S phase to remove 53BP1 from DSBs and permit HR
inferredcites →https://doi.org/10.1016/j.eururo.2011.05.052openalex-snapshot
Late Gastrointestinal Toxicities Following Radiation Therapy for Prostate Cancer
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Exposure to Ionizing Radiation Causes Long-Term Increase in Serum Estradiol and Activation of PI3K-Akt Signaling Pathway in Mouse Mammary Gland
inferredcites →https://doi.org/10.1016/j.ijrobp.2015.10.057openalex-snapshot
Relative Biological Effectiveness of Energetic Heavy Ions for Intestinal Tumorigenesis Shows Male Preponderance and Radiation Type and Energy Dependence in APC1638N/+ Mice
inferredcites →https://doi.org/10.1016/j.lssr.2015.04.002openalex-snapshot
Safe days in space with acceptable uncertainty from space radiation exposure
inferredcites →https://doi.org/10.1016/j.lssr.2016.02.001openalex-snapshot
Galactic cosmic ray simulation at the NASA Space Radiation Laboratory
inferredcites →https://doi.org/10.1016/j.lssr.2017.01.005openalex-snapshot
Predictions of space radiation fatality risk for exploration missions
inferredcites →https://doi.org/10.1016/j.lssr.2017.04.003openalex-snapshot
Low and high dose rate heavy ion radiation-induced intestinal and colonic tumorigenesis in APC1638N/+ mice
inferredcites →https://doi.org/10.1016/j.lssr.2020.07.001openalex-snapshot
Heavy ion space radiation triggers ongoing DNA base damage by downregulating DNA repair pathways
inferredcites →https://doi.org/10.1016/j.lssr.2021.09.001openalex-snapshot
Effects of dietary aspirin on high-LET radiation-induced prostaglandin E2 levels and gastrointestinal tumorigenesis in Apc mice
inferredcites →https://doi.org/10.1016/j.lssr.2022.09.005openalex-snapshot
Countermeasure development against space radiation-induced gastrointestinal carcinogenesis: Current and future perspectives
inferredcites →https://doi.org/10.1016/j.molcel.2006.08.014openalex-snapshot
A Mechanism of Nucleotide Misincorporation during Transcription due to Template-Strand Misalignment
inferredcites →https://doi.org/10.1016/j.molcel.2007.11.015openalex-snapshot
The DNA Damage Response: Ten Years After
inferredcites →https://doi.org/10.1016/j.molcel.2019.08.023openalex-snapshot
Life or Death after a Break: What Determines the Choice?
inferredcites →https://doi.org/10.1016/j.mrfmmm.2010.11.002openalex-snapshot
Mechanism of cluster DNA damage repair in response to high-atomic number and energy particles radiation
inferredcites →https://doi.org/10.1016/j.mrfmmm.2011.02.012openalex-snapshot
Heavy charged particle radiobiology: Using enhanced biological effectiveness and improved beam focusing to advance cancer therapy
inferredcites →https://doi.org/10.1016/j.radonc.2018.12.028openalex-snapshot
DNA damage response of clinical carbon ion versus photon radiation in human glioblastoma cells
inferredcites →https://doi.org/10.1016/j.tranon.2020.100822openalex-snapshot
Quantifying DNA damage induced by ionizing radiation and hyperthermia using single DNA molecule imaging
inferredcites →https://doi.org/10.1016/j.trecan.2018.04.007openalex-snapshot
Epigenetic Priming in Cancer Initiation
inferredcites →https://doi.org/10.1016/s0016-5085(98)70478-0openalex-snapshot
Apc1638N: A mouse model for familial adenomatous polyposis–associated desmoid tumors and cutaneous cysts
inferredcites →https://doi.org/10.1016/s0140-6736(15)61167-9openalex-snapshot
Long-term effects of radiation exposure on health
inferredcites →https://doi.org/10.1038/cr.2007.115openalex-snapshot
Mechanisms and functions of DNA mismatch repair
inferredcites →https://doi.org/10.1038/cr.2008.1openalex-snapshot
Homologous recombination in DNA repair and DNA damage tolerance
inferredcites →https://doi.org/10.1038/ncb1909openalex-snapshot
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
inferredcites →https://doi.org/10.1038/onc.2015.395openalex-snapshot
Radiation promotes colorectal cancer initiation and progression by inducing senescence-associated inflammatory responses
inferredcites →https://doi.org/10.1038/onc.2017.60openalex-snapshot
New factors in mammalian DNA repair—the chromatin connection
inferredcites →https://doi.org/10.1038/s41467-018-06308-9openalex-snapshot
Persistent repair intermediates induce senescence
inferredcites →https://doi.org/10.1038/s41588-020-0623-4openalex-snapshot
Cas9 activates the p53 pathway and selects for p53-inactivating mutations
inferredcites →https://doi.org/10.1038/s41596-022-00724-4openalex-snapshot
Designing and executing prime editing experiments in mammalian cells
inferredcites →https://doi.org/10.1038/s41598-017-02087-3openalex-snapshot
Non-Targeted Effects Models Predict Significantly Higher Mars Mission Cancer Risk than Targeted Effects Models
inferredcites →https://doi.org/10.1038/s41598-018-23202-yopenalex-snapshot
Integrated Modelling of Cell Responses after Irradiation for DNA-Targeted Effects and Non-Targeted Effects
inferredcites →https://doi.org/10.1038/sj.onc.1208439openalex-snapshot
Medium-mediated intercellular communication is involved in bystander responses of X-ray-irradiated normal human fibroblasts
inferredcites →https://doi.org/10.1038/srep14568openalex-snapshot
A generalized target theory and its applications
inferredcites →https://doi.org/10.1038/srep31853openalex-snapshot
Space radiation exposure persistently increased leptin and IGF1 in serum and activated leptin-IGF1 signaling axis in mouse intestine
inferredcites →https://doi.org/10.1039/9781839162541-00426openalex-snapshot
Chapter 31. Gamma- and Ion-beam DNA Radiation Damage: Theory and Experiment
inferredcites →https://doi.org/10.1073/pnas.0403131101openalex-snapshot
Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality
inferredcites →https://doi.org/10.1073/pnas.0800966105openalex-snapshot
Extreme resistance of bdelloid rotifers to ionizing radiation
inferredcites →https://doi.org/10.1073/pnas.1807522115openalex-snapshot
Space radiation triggers persistent stress response, increases senescent signaling, and decreases cell migration in mouse intestine
inferredcites →https://doi.org/10.1073/pnas.2119132119openalex-snapshot
Formation of clustered DNA damage in vivo upon irradiation with ionizing radiation: Visualization and analysis with atomic force microscopy
inferredcites →https://doi.org/10.1080/09553000902748591openalex-snapshot
Stress response of a p53 homologue in the radioresistant Sf9 insect cells
inferredcites →https://doi.org/10.1080/09553000902883836openalex-snapshot
Ionising radiation and cancer risks: What have we learned from epidemiology?
inferredcites →https://doi.org/10.1080/09553002.2019.1589020openalex-snapshot
The Million Person Study relevance to space exploration and Mars
inferredcites →https://doi.org/10.1080/09553002.2019.1665208openalex-snapshot
Primary and secondary bystander effect and genomic instability in cells exposed to high and low linear energy transfer radiations
inferredcites →https://doi.org/10.1080/10715762.2018.1452204openalex-snapshot
The effect of carbon irradiation is associated with greater oxidative stress in mouse intestine and colon relative to γ-rays
inferredcites →https://doi.org/10.1080/15384101.2018.1482136openalex-snapshot
Measuring cell cycle-dependent DNA damage responses and p53 regulation on a cell-by-cell basis from image analysis
inferredcites →https://doi.org/10.1080/19491034.2017.1384893openalex-snapshot
Heterochromatin and DNA damage repair: Use different histone variants and relax
inferredcites →https://doi.org/10.1089/ars.2012.5036openalex-snapshot
Oxidative DNA Damage and Nucleotide Excision Repair
inferredcites →https://doi.org/10.1091/mbc.e18-10-0668openalex-snapshot
Preserving genome integrity in human cells via DNA double-strand break repair
inferredcites →https://doi.org/10.1093/carcin/bgr236openalex-snapshot
Resveratrol protects mouse embryonic stem cells from ionizing radiation by accelerating recovery from DNA strand breakage
inferredcites →https://doi.org/10.1093/emboj/cdg203openalex-snapshot
Non‐homologous end joining as an important mutagenic process in cell cycle‐arrested cells
inferredcites →https://doi.org/10.1093/femsyr/fow071openalex-snapshot
Understanding how mismatch repair proteins participate in the repair/anti-recombination decision
inferredcites →https://doi.org/10.1093/jrr/rrv005openalex-snapshot
Low-dose energetic protons induce adaptive and bystander effects that protect human cells against DNA damage caused by a subsequent exposure to energetic iron ions
inferredcites →https://doi.org/10.1093/jrr/rry096openalex-snapshot
Clustered DNA double-strand break formation and the repair pathway following heavy-ion irradiation
inferredcites →https://doi.org/10.1093/mutage/geq022openalex-snapshot
RE: Multiple factors conferring high radioresistance in insect Sf9 cells. (Mutagenesis, 24, 259-269, 2009)
inferredcites →https://doi.org/10.1093/rpd/nci141openalex-snapshot
Implications of the space radiation environment for human exploration in deep space
inferredcites →https://doi.org/10.1097/cej.0b013e328341017aopenalex-snapshot
Curcumin prevents DNA damage and enhances the repair potential in a chronically arsenic-exposed human population in West Bengal, India
inferredcites →https://doi.org/10.1097/hp.0000000000001572openalex-snapshot
Medical Countermeasure Requirements to Meet NASA’s Space Radiation Permissible Exposure Limits for a Mars Mission Scenario
inferredcites →https://doi.org/10.1098/rsob.200253openalex-snapshot
The role of antioxidants in restoring MAPK 14 and a DNA damage marker level following autophagy suppression
inferredcites →https://doi.org/10.1101/cshperspect.a012609openalex-snapshot
Nucleotide Excision Repair in Eukaryotes
inferredcites →https://doi.org/10.1101/cshperspect.a016600openalex-snapshot
Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins
inferredcites →https://doi.org/10.1101/gad.13.10.1309openalex-snapshot
Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development
inferredcites →https://doi.org/10.1101/gad.2021311openalex-snapshot
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications
inferredcites →https://doi.org/10.1109/tns.2020.3032946openalex-snapshot
Radiation Shielding Evaluation of Spacecraft Walls Against Heavy Ions Using Microdosimetry
inferredcites →https://doi.org/10.1111/acel.13013openalex-snapshot
Senescence‐associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15
inferredcites →https://doi.org/10.1111/tpj.15567openalex-snapshot
Cell cycle checkpoint control in response to DNA damage by environmental stresses
inferredcites →https://doi.org/10.1146/annurev-biochem-062917-012415openalex-snapshot
The MRE11–RAD50–NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair
inferredcites →https://doi.org/10.1155/2018/2389523openalex-snapshot
Targeting Oxidatively Induced DNA Damage Response in Cancer: Opportunities for Novel Cancer Therapies
inferredcites →https://doi.org/10.1155/2020/4834965openalex-snapshot
The Determinant of DNA Repair Pathway Choices in Ionising Radiation‐Induced DNA Double‐Strand Breaks
inferredcites →https://doi.org/10.1158/1535-7163.mct-08-0929openalex-snapshot
Base excision repair of reactive oxygen species–initiated 7,8-dihydro-8-oxo-2′-deoxyguanosine inhibits the cytotoxicity of platinum anticancer drugs
inferredcites →https://doi.org/10.1158/1538-7445.am2019-3728openalex-snapshot
Abstract 3728: Inverse effect of 28Si and 56Fe radiation on intestinal tumorigenesis vs. carcinogenesis in APC1638N/+ mice
inferredcites →https://doi.org/10.1158/1538-7445.am2019-3736openalex-snapshot
Abstract 3736: Space radiation-induced decline in gut autophagy and expansion of both mitotic and senescent population denotes an aging phenotype with enhanced cancer risk
inferredcites →https://doi.org/10.1172/jci43169openalex-snapshot
Genes methylated by DNA methyltransferase 3b are similar in mouse intestine and human colon cancer
inferredcites →https://doi.org/10.1177/0300985814559404openalex-snapshot
Epithelial Cell Shedding and Barrier Function
inferredcites →https://doi.org/10.1186/s12885-018-4609-xopenalex-snapshot
Gene promoter and exon DNA methylation changes in colon cancer development – mRNA expression and tumor mutation alterations
inferredcites →https://doi.org/10.1186/s12943-019-0962-xopenalex-snapshot
Stem cells in homeostasis and cancer of the gut
inferredcites →https://doi.org/10.1200/jco.2020.38.15_suppl.4064openalex-snapshot
The landscape of DNA damage response (DDR) pathway in colorectal cancer (CRC).
inferredcites →https://doi.org/10.1201/9780429490606openalex-snapshot
Basic Clinical Radiobiology
inferredcites →https://doi.org/10.1269/jrr.07123openalex-snapshot
Formation of Clustered DNA Damage after High-LET Irradiation: A Review
inferredcites →https://doi.org/10.1289/ehp.8563195openalex-snapshot
Multistage Models of Carcinogenesis
inferredcites →https://doi.org/10.1371/journal.pgen.1000110openalex-snapshot
Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair
inferredcites →https://doi.org/10.1371/journal.pgen.1003250openalex-snapshot
DNA–Methylome Analysis of Mouse Intestinal Adenoma Identifies a Tumour-Specific Signature That Is Partly Conserved in Human Colon Cancer
inferredcites →https://doi.org/10.1371/journal.pone.0021540openalex-snapshot
Increased Frequency of Spontaneous Neoplastic Transformation in Progeny of Bystander Cells from Cultures Exposed to Densely Ionizing Radiation
inferredcites →https://doi.org/10.1371/journal.pone.0042224openalex-snapshot
Exposure to Heavy Ion Radiation Induces Persistent Oxidative Stress in Mouse Intestine
inferredcites →https://doi.org/10.1371/journal.pone.0059295openalex-snapshot
Heavy Ion Radiation Exposure Triggered Higher Intestinal Tumor Frequency and Greater β-Catenin Activation than γ Radiation in APCMin/+ Mice
inferredcites →https://doi.org/10.1371/journal.pone.0085158openalex-snapshot
Dramatic Increase in Oxidative Stress in Carbon-Irradiated Normal Human Skin Fibroblasts
inferredcites →https://doi.org/10.1371/journal.pone.0155725openalex-snapshot
Both Complexity and Location of DNA Damage Contribute to Cellular Senescence Induced by Ionizing Radiation
inferredcites →https://doi.org/10.1371/journal.pone.0180412openalex-snapshot
Simulated space radiation-induced mutants in the mouse kidney display widespread genomic change
inferredcites →https://doi.org/10.14338/ijpt-18-00018.1openalex-snapshot
Comparing Photon and Charged Particle Therapy Using DNA Damage Biomarkers
inferredcites →https://doi.org/10.1667/rade-21-00059.1openalex-snapshot
Comparison of All Solid Cancer Mortality and Incidence Dose-Response in the Life Span Study of Atomic Bomb Survivors, 1958–2009
inferredcites →https://doi.org/10.1667/rr009cc.1openalex-snapshot
Scaling Human Cancer Risks from Low LET to High LET when Dose-Effect Relationships are Complex
inferredcites →https://doi.org/10.1667/rr1117.1openalex-snapshot
Biophysical Models of Radiation Bystander Effects: 1. Spatial Effects in Three-Dimensional Tissues
inferredcites →https://doi.org/10.1667/rr13572.1openalex-snapshot
Role of 53BP1 in the Regulation of DNA Double-Strand Break Repair Pathway Choice
inferredcites →https://doi.org/10.1667/rr13747.1openalex-snapshot
Biological Characterization of Low-Energy Ions with High-Energy Deposition on Human Cells
inferredcites →https://doi.org/10.1667/rr13770.1openalex-snapshot
Wip1 Abrogation Decreases Intestinal Tumor Frequency in APCMin/+Mice Irrespective of Radiation Quality
inferredcites →https://doi.org/10.1667/rr13804.1openalex-snapshot
Understanding Cancer Development Processes after HZE-Particle Exposure: Roles of ROS, DNA Damage Repair and Inflammation
inferredcites →https://doi.org/10.1667/rr13904.1openalex-snapshot
The Major DNA Repair Pathway after Both Proton and Carbon-Ion Radiation is NHEJ, but the HR Pathway is More Relevant in Carbon Ions
inferredcites →https://doi.org/10.1667/rr14092.1openalex-snapshot
Co-culturing with High-Charge and Energy Particle Irradiated Cells Increases Mutagenic Joining of Enzymatically Induced DNA Double-Strand Breaks in Nonirradiated Cells
inferredcites →https://doi.org/10.1667/rr1415.1openalex-snapshot
Two- and Three-Dimensional Models for Risk Assessment of Radiation-Enhanced Colorectal Tumorigenesis
inferredcites →https://doi.org/10.1667/rr1804.1openalex-snapshot
Comparative Analysis of Cell Killing and Autosomal Mutation in Mouse Kidney Epithelium Exposed to 1 GeV/nucleon Iron IonsIn VitroorIn Situ
inferredcites →https://doi.org/10.1667/rr2155.1openalex-snapshot
CDDO-Me Protects against Space Radiation-Induced Transformation of Human Colon Epithelial Cells
inferredcites →https://doi.org/10.1667/rr3489.1openalex-snapshot
Repair of DNA Damage Induced by Accelerated Heavy Ions in Mammalian Cells Proficient and Deficient in the Non-homologous End-Joining Pathway
inferredcites →https://doi.org/10.18632/aging.100587openalex-snapshot
Therapeutic and space radiation exposure of mouse brain causes impaired DNA repair response and premature senescence by chronic oxidant production
inferredcites →https://doi.org/10.18632/aging.102043openalex-snapshot
Intestinal stem cells acquire premature senescence and senescence associated secretory phenotype concurrent with persistent DNA damage after heavy ion radiation in mice
inferredcites →https://doi.org/10.18632/oncotarget.22679openalex-snapshot
3D-structured illumination microscopy reveals clustered DNA double-strand break formation in widespread γH2AX foci after high LET heavy-ion particle radiation
inferredcites →https://doi.org/10.21037/atm-20-2920openalex-snapshot
Alterations of DNA damage repair in cancer: from mechanisms to applications
inferredcites →https://doi.org/10.2147/ott.s175112openalex-snapshot
Elevated urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine and serum uric acid are associated with progression and are prognostic factors of colorectal cancer
inferredcites →https://doi.org/10.3109/10715762.2011.645207openalex-snapshot
Mitochondrial dysfunction, a probable cause of persistent oxidative stress after exposure to ionizing radiation
inferredcites →https://doi.org/10.3109/10715762.2011.653969openalex-snapshot
Mechanisms of free radical-induced damage to DNA
inferredcites →https://doi.org/10.31661/jbpe.v0i0.713openalex-snapshot
Radiation-induced Non-targeted Effect and Carcinogenesis; Implications in Clinical Radiotherapy
inferredcites →https://doi.org/10.3389/fcell.2021.661931openalex-snapshot
The Intestinal Epithelium – Fluid Fate and Rigid Structure From Crypt Bottom to Villus Tip
inferredcites →https://doi.org/10.3389/fgene.2015.00063openalex-snapshot
Bystander communication and cell cycle decisions after DNA damage
inferredcites →https://doi.org/10.3389/fonc.2015.00218openalex-snapshot
Decreased RXRα is Associated with Increased β-Catenin/TCF4 in 56Fe-Induced Intestinal Tumors
inferredcites →https://doi.org/10.3389/fonc.2020.549777openalex-snapshot
DNA Damage Repair Gene Mutations Are Indicative of a Favorable Prognosis in Colorectal Cancer Treated With Immune Checkpoint Inhibitors
inferredcites →https://doi.org/10.3390/biom6040047openalex-snapshot
Repair of DNA Double-Strand Breaks in Heterochromatin
inferredcites →https://doi.org/10.3390/cancers11111789openalex-snapshot
Ionizing Radiation and Complex DNA Damage: From Prediction to Detection Challenges and Biological Significance
inferredcites →https://doi.org/10.3390/cancers12103022openalex-snapshot
Carbon Ion Radiobiology
inferredcites →https://doi.org/10.3390/cancers12123560openalex-snapshot
Pathogenic Germline Mutations of DNA Repair Pathway Components in Early-Onset Sporadic Colorectal Polyp and Cancer Patients
inferredcites →https://doi.org/10.3390/cancers13092125openalex-snapshot
The Role of p53 Signaling in Colorectal Cancer
inferredcites →https://doi.org/10.3390/cancers14061388openalex-snapshot
Targeting the DNA Damage Response Pathway as a Novel Therapeutic Strategy in Colorectal Cancer
inferredcites →https://doi.org/10.3390/ijms161024094openalex-snapshot
Cancer Microenvironment: What Can We Learn from the Stem Cell Niche
inferredcites →https://doi.org/10.3390/life10120341openalex-snapshot
Repair Kinetics of DNA Double Strand Breaks Induced by Simulated Space Radiation
inferredcites →https://doi.org/10.3390/molecules27113567openalex-snapshot
Targeting Mechanisms of the DNA Damage Response (DDR) and DNA Repair by Natural Compounds to Improve cAT-Triggered Tumor Cell Death
inferredcites →https://doi.org/10.3978/j.issn.2218-676x.2013.04.02openalex-snapshot
DNA double strand break repair via non-homologous end-joining.
inferredcites →https://doi.org/10.4161/cc.7.18.6679openalex-snapshot
DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells
inferredcites →https://doi.org/10.7150/jca.13387openalex-snapshot
Colorectal Carcinogenesis, Radiation Quality, and the Ubiquitin-Proteasome Pathway
inferredcites →https://doi.org/10.7554/elife.62852openalex-snapshot
DNA damage—how and why we age?
inferredcites →https://doi.org/10.7554/elife.79208openalex-snapshot
Highly efficient generation of isogenic pluripotent stem cell models using prime editing

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Assessment of Radioprotective Potential of Zingerone, Ibuprofen, and Sulfasalazine Compounds Against Gamma Radiation
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Integrating Biological and Physical Principles of Next‐Generation Radiotherapy to Fabricate Engineered Nanoplatforms for Improving Radiotherapy Efficacy
inferred← citeshttps://doi.org/10.1007/s00249-025-01765-9openalex-snapshot
From survival of irradiated mice to modern molecular insights: a seventy-year journey in radiobiology at the institute of biophysics, Czech academy of sciences
inferred← citeshttps://doi.org/10.1007/s00411-025-01174-8openalex-snapshot
Radiation shielding efficiency of rice husk ash-based low-density glasses: a comparative study
inferred← citeshttps://doi.org/10.1007/s00432-024-05757-8openalex-snapshot
A perspective on tumor radiation resistance following high-LET radiation treatment
inferred← citeshttps://doi.org/10.1007/s40778-026-00255-8openalex-snapshot
Genomic Instability and Clonal Hematopoiesis in the Deep-Space Environment: The Role of Sex-Chromosome Asymmetry and High-LET Radiation
inferred← citeshttps://doi.org/10.1016/j.apradiso.2025.111762openalex-snapshot
Resilient STR loci under gamma radiation: A preliminary study on DNA stability in buccal swabs
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2025.119224openalex-snapshot
Biomolecular signatures of γ-irradiation exposure: Differential cell death pathways and Raman spectral profiles in human epidermal keratinocytes and melanocytes
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e39533openalex-snapshot
Transcriptomic analysis of embryonic mouse hypothalamic N38 cells exposed to high-energy protons and/or simulated microgravity
inferred← citeshttps://doi.org/10.1016/j.hoc.2024.11.007openalex-snapshot
Heavy Ion Particle Therapy in Modern Day Radiation Oncology
inferred← citeshttps://doi.org/10.1016/j.jenvrad.2025.107850openalex-snapshot
The unnatural selection: Plant evolution and adaptation in the Chernobyl and Fukushima Exclusion Zones
inferred← citeshttps://doi.org/10.1016/j.lssr.2026.01.006openalex-snapshot
Dose and LET-dependence of gastric cancer risk in Apc1638N/+ mice exposed to space-relevant radiation types
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2026.08.007openalex-snapshot
Low-dose ionizing radiation and cognitive function: evidence, mechanisms, and controversies
inferred← citeshttps://doi.org/10.1016/j.prenap.2025.100441openalex-snapshot
Natural guardians as radioprotective complements in oncological therapy: A review
inferred← citeshttps://doi.org/10.1016/j.prp.2025.156115openalex-snapshot
Mechanisms of aging-related secretory phenotype regulation in osteoporosis: Network regulation, trade-offs and homeostasis
inferred← citeshttps://doi.org/10.1016/j.radmp.2025.07.002openalex-snapshot
Understanding of FLASH radiotherapy through physical to biological interpretation
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.5c00678openalex-snapshot
Anthraquinone Rhein Mitigates Heavy Ion Radiation-Induced Lung Injury by Maintaining Thioredoxin Reductase/Thioredoxin (TrxR/Trx) Redox Homeostasis
inferred← citeshttps://doi.org/10.1038/s41526-025-00544-2openalex-snapshot
The role and mechanism of ARRB1 in simulated space radiation and microgravity-induced lung carcinogenesis
inferred← citeshttps://doi.org/10.1080/09553002.2024.2430250openalex-snapshot
Trichostatin A mitigates acute and late effects of radiation in intestine by regulation of DNA damage repair and Wnt/TGFβ/Smad signaling
inferred← citeshttps://doi.org/10.1186/s40360-024-00744-8openalex-snapshot
Iron overload induced submandibular glands toxicity in gamma irradiated rats with possible mitigation by hesperidin and rutin
inferred← citeshttps://doi.org/10.1227/neuprac.0000000000000220openalex-snapshot
Neoplastic Cauda Equina Syndrome: When Do We Not Operate?
inferred← citeshttps://doi.org/10.1515/ract-2025-0042openalex-snapshot
Assessing the protective properties of Anti-inflammatory and antioxidant compounds against gamma radiation
inferred← citeshttps://doi.org/10.1667/rade-23-00205.1openalex-snapshot
How We Got Here: One Laboratory's Odyssey in the Field of Radiation-Inducible Genes
inferred← citeshttps://doi.org/10.18632/aging.206183openalex-snapshot
Senolytic agent ABT-263 mitigates low- and high-LET radiation-induced gastrointestinal cancer development in Apc1638N/+ mice
inferred← citeshttps://doi.org/10.20944/preprints202406.0689.v1openalex-snapshot
FLASH Radiotherapy versus Conventional Therapy in Cancer Treatment; Promises, Paradoxes and Problems
inferred← citeshttps://doi.org/10.3389/fcimb.2025.1715061openalex-snapshot
Opposing fates: a bipolar cellular model for FMDV replication shaped by 12C6+heavy-ion mutagenesis
inferred← citeshttps://doi.org/10.3389/fcimb.2026.1852596openalex-snapshot
The gut microbiota-enteric nervous system axis: from bidirectional programming to precision therapeutics in digestive diseases
inferred← citeshttps://doi.org/10.3389/fonc.2026.1869974openalex-snapshot
Transcriptomic differences in chromatin and cell cycle regulation in A549 cells after irradiation with carbon ions and X-rays
inferred← citeshttps://doi.org/10.3390/app16041860openalex-snapshot
Medicinal Plants in the Space Exploration Era: Opportunities and Challenges for Mitigating Spaceflight-Induced Health Hazards
inferred← citeshttps://doi.org/10.3390/cancers16193392openalex-snapshot
Effects of High-Linear-Energy-Transfer Heavy Ion Radiation on Intestinal Stem Cells: Implications for Gut Health and Tumorigenesis
inferred← citeshttps://doi.org/10.3390/cells14221767openalex-snapshot
cGAS/STING Pathway Mediates Accelerated Intestinal Cell Senescence and SASP After GCR Exposure in Mice
inferred← citeshttps://doi.org/10.3390/dna4030015openalex-snapshot
8-OxodG: A Potential Biomarker for Chronic Oxidative Stress Induced by High-LET Radiation
inferred← citeshttps://doi.org/10.3390/genes16010085openalex-snapshot
Integrative Analysis of Radiation-Induced Senescence-Associated Secretory Phenotype Factors in Kidney Cancer Progression
inferred← citeshttps://doi.org/10.3390/gidisord6020025openalex-snapshot
Enteric Nervous System Alterations in Inflammatory Bowel Disease: Perspectives and Implications
inferred← citeshttps://doi.org/10.3390/horticulturae12050614openalex-snapshot
Carbon-Ion Irradiation Modulates Early Development of Lettuce Seedlings: A Morphotype-Specific Response
inferred← citeshttps://doi.org/10.3390/ijms27010211openalex-snapshot
Elevated SASP Factors, Reduced Antioxidant Enzymes, and Increased Tumor Susceptibility in Space Radiation-Exposed ApcMin/+ Mice
inferred← citeshttps://doi.org/10.3390/ijtm4030038openalex-snapshot
FLASH Radiotherapy Versus Conventional Cancer Therapy: Promises, Paradoxes and Problems
inferred← citeshttps://doi.org/10.3390/medicina60040653openalex-snapshot
Health Effects of Ionizing Radiation on the Human Body
inferred← citeshttps://doi.org/10.4038/kjms.v7i1.175openalex-snapshot
Health Physics Implications of Space Radiation for Astronauts
inferred← citeshttps://doi.org/10.5772/intechopen.1009748openalex-snapshot
In-Depth Exploration of Radiation-Induced Cell Death Mechanisms in Tumor
inferred← citeshttps://doi.org/10.70675/c231f089z5eaaz4a1azbaa6z5efcb63c119dopenalex-snapshot
The Role of α-Tubulin Acetyltransferase (αTAT1) in Glioblastoma Cellular Responses to Radiotherapy
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