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Common Fragile Sites: Genomic Hotspots of DNA Damage and Carcinogenesis

https://doi.org/10.3390/ijms130911974

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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jama.1991.03460100092031openalex-snapshot

Diagnostic X-ray Procedures and Risk of Leukemia, Lymphoma, and Multiple Myeloma

inferredcites →https://doi.org/10.1002/(sici)1098-2264(199802)21:2<152::aid-gcc11>3.0.co;2-topenalex-snapshot

Fish mapping of YAC clones at human chromosomal band 7q31.2: Identification of YACS spanning FRA7G within the common region of LOH in breast and prostate cancer

inferredcites →https://doi.org/10.1002/(sici)1098-2264(199901)24:1<48::aid-gcc7>3.0.co;2-vopenalex-snapshot

Frequent deletions within FRA7G at 7q31.2 in invasive epithelial ovarian cancer

inferredcites →https://doi.org/10.1002/gcc.10000openalex-snapshot

Molecular characterization of FRAXB and comparative common fragile site instability in cancer cells

inferredcites →https://doi.org/10.1002/gcc.10236openalex-snapshot

Characterization of FRA6E and its potential role in autosomal recessive juvenile parkinsonism and ovarian cancer

inferredcites →https://doi.org/10.1002/gcc.10290openalex-snapshot

The role of late/slow replication of the FRA16D in common fragile site induction

inferredcites →https://doi.org/10.1002/gcc.20591openalex-snapshot

Stably transfected common fragile site sequences exhibit instability at ectopic sites

inferredcites →https://doi.org/10.1002/gcc.20710openalex-snapshot

Claspin inhibition leads to fragile site expression

inferredcites →https://doi.org/10.1002/gcc.2870050209openalex-snapshot

Viral integration and fragile sites in human papillomavirus‐lmmortalized human keratinocyte cell lines

inferredcites →https://doi.org/10.1002/ijc.22049openalex-snapshot

Identification of the human/mouse syntenic common fragile site FRA7K/Fra12C1—Relation of FRA7K and other human common fragile sites on chromosome 7 to evolutionary breakpoints

inferredcites →https://doi.org/10.1002/ijc.23659openalex-snapshot

Constitutive overexpression of CDC25A in primary human mammary epithelial cells results in both defective DNA damage response and chromosomal breaks at fragile sites

inferredcites →https://doi.org/10.1002/mc.20122openalex-snapshot

Expression of common chromosomal fragile site genes, WWOX/FRA16D and FHIT/FRA3B is downregulated by exposure to environmental carcinogens, UV, and BPDE but not by IR

inferredcites →https://doi.org/10.1006/geno.1993.1330openalex-snapshot

Determination of the Specificity of Aphidicolin-Induced Breakage of the Human 3p14.2 Fragile Site

inferredcites →https://doi.org/10.1006/geno.2000.6272openalex-snapshot

Characterization of the Human TESTIN Gene Localized in the FRA7G Region at 7q31.2

inferredcites →https://doi.org/10.1007/bf00272988openalex-snapshot

DNA polymerase ? inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes

inferredcites →https://doi.org/10.1007/s00247-002-0672-0openalex-snapshot

Ionizing radiation and cancer risk: evidence from epidemiology

inferredcites →https://doi.org/10.1007/s00412-010-0279-4openalex-snapshot

Replication dynamics at common fragile site FRA6E

inferredcites →https://doi.org/10.1007/s00439-012-1165-3openalex-snapshot

Genomic rearrangements at the FRA2H common fragile site frequently involve non-homologous recombination events across LTR and L1(LINE) repeats

inferredcites →https://doi.org/10.1016/0092-8674(95)90039-xopenalex-snapshot

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

inferredcites →https://doi.org/10.1016/0165-4608(86)90381-xopenalex-snapshot

Fragile sites: Overview, occurrence in acute nonlymphocytic leukemia and effects of caffeine on expression

inferredcites →https://doi.org/10.1016/0165-4608(89)90084-8openalex-snapshot

Preferential sites for viral integration on mammalian genome

inferredcites →https://doi.org/10.1016/0165-4608(92)90207-oopenalex-snapshot

Herpes simplex virus and human papillomavirus sites correlate with chromosomal breakpoints in human cervical carcinoma

inferredcites →https://doi.org/10.1016/j.ajhg.2010.06.006openalex-snapshot

Mechanisms of Genomic Instabilities Underlying Two Common Fragile-Site-Associated Loci, PARK2 and DMD, in Germ Cell and Cancer Cell Lines

inferredcites →https://doi.org/10.1016/j.cancergencyto.2004.01.028openalex-snapshot

Positioning of cervical carcinoma and Burkitt lymphoma translocation breakpoints with respect to the human papillomavirus integration cluster in FRA8C at 8q24.13

inferredcites →https://doi.org/10.1016/j.cancergencyto.2010.06.008openalex-snapshot

Characterization of FRA7B, a human common fragile site mapped at the 7p chromosome terminal region

inferredcites →https://doi.org/10.1016/j.canlet.2005.07.039openalex-snapshot

The molecular basis of common and rare fragile sites

inferredcites →https://doi.org/10.1016/j.dnarep.2010.03.005openalex-snapshot

Inhibition of topoisomerase I prevents chromosome breakage at common fragile sites

inferredcites →https://doi.org/10.1016/j.lungcan.2011.11.009openalex-snapshot

FATS expression is associated with cisplatin sensitivity in non small cell lung cancer

inferredcites →https://doi.org/10.1016/j.molcel.2007.06.012openalex-snapshot

An AT-Rich Sequence in Human Common Fragile Site FRA16D Causes Fork Stalling and Chromosome Breakage in S. cerevisiae

inferredcites →https://doi.org/10.1016/j.molcel.2011.05.019openalex-snapshot

Failure of Origin Activation in Response to Fork Stalling Leads to Chromosomal Instability at Fragile Sites

inferredcites →https://doi.org/10.1016/j.molcel.2011.10.013openalex-snapshot

Collisions between Replication and Transcription Complexes Cause Common Fragile Site Instability at the Longest Human Genes

inferredcites →https://doi.org/10.1016/j.mrfmmm.2006.01.020openalex-snapshot

Mechanisms of tandem repeat instability in bacteria

inferredcites →https://doi.org/10.1016/j.mrfmmm.2009.12.012openalex-snapshot

ATR preferentially interacts with common fragile site FRA3B and the binding requires its kinase activity in response to aphidicolin treatment

inferredcites →https://doi.org/10.1016/j.mrfmmm.2011.04.006openalex-snapshot

Common fragile sites in colon cancer cell lines: Role of mismatch repair, RAD51 and poly(ADP-ribose) polymerase-1

inferredcites →https://doi.org/10.1016/j.tig.2011.10.003openalex-snapshot

Common fragile sites: mechanisms of instability revisited

inferredcites →https://doi.org/10.1016/j.tig.2012.02.006openalex-snapshot

The complex basis underlying common fragile site instability in cancer

inferredcites →https://doi.org/10.1016/s0006-2952(03)00484-2openalex-snapshot

Molecular mechanisms underlying WOX1 activation during apoptotic and stress responses

inferredcites →https://doi.org/10.1016/s0092-8674(00)80201-9openalex-snapshot

Expression of Fragile Sites Triggers Intrachromosomal Mammalian Gene Amplification and Sets Boundaries to Early Amplicons

inferredcites →https://doi.org/10.1016/s0092-8674(00)81034-xopenalex-snapshot

The FHIT Gene, Spanning the Chromosome 3p14.2 Fragile Site and Renal Carcinoma–Associated t(3;8) Breakpoint, Is Abnormal in Digestive Tract Cancers

inferredcites →https://doi.org/10.1016/s0092-8674(02)01113-3openalex-snapshot

ATR Regulates Fragile Site Stability

inferredcites →https://doi.org/10.1016/s0140-6736(12)60815-0openalex-snapshot

Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study

inferredcites →https://doi.org/10.1016/s0168-9525(98)01628-xopenalex-snapshot

Fragile sites still breaking

inferredcites →https://doi.org/10.1016/s0888-7543(02)00029-0openalex-snapshot

Candidate tumor suppressor genes at FRA7G are coamplified with MET and do not suppress malignancy in a gastric cancer

inferredcites →https://doi.org/10.1016/s0888-7543(03)00007-7openalex-snapshot

Characterization of the human common fragile site FRA2G

inferredcites →https://doi.org/10.1016/s0959-8049(01)00432-4openalex-snapshot

High frequency of LOH, MSI and abnormal expression of FHIT in gastric cancer

inferredcites →https://doi.org/10.1016/s1535-6108(02)00017-xopenalex-snapshot

A role for common fragile site induction in amplification of human oncogenes

inferredcites →https://doi.org/10.1021/bi961415topenalex-snapshot

Fhit, a Putative Tumor Suppressor in Humans, Is a Dinucleoside 5‘,5‘ ‘‘-P1,P3-Triphosphate Hydrolase

inferredcites →https://doi.org/10.1038/377552a0openalex-snapshot

Radiation-induced cell cycle arrest compromised by p21 deficiency

inferredcites →https://doi.org/10.1038/nature08768openalex-snapshot

Signatures of mutation and selection in the cancer genome

inferredcites →https://doi.org/10.1038/nature09745openalex-snapshot

Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site

inferredcites →https://doi.org/10.1038/nbt0402-393openalex-snapshot

Genome-wide detection of chromosomal imbalances in tumors using BAC microarrays

inferredcites →https://doi.org/10.1038/ncb1882openalex-snapshot

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis

inferredcites →https://doi.org/10.1038/ncb1984openalex-snapshot

Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

inferredcites →https://doi.org/10.1038/ng.491openalex-snapshot

Somatic mutations of the Parkinson's disease–associated gene PARK2 in glioblastoma and other human malignancies

inferredcites →https://doi.org/10.1038/ng0695-213openalex-snapshot

Expansion and deletion of CTG repeats from human disease genes are determined by the direction of replication in E. coli

inferredcites →https://doi.org/10.1038/ng0994-66openalex-snapshot

p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis

inferredcites →https://doi.org/10.1038/nrc2231openalex-snapshot

Reflecting on 25 years with MYC

inferredcites →https://doi.org/10.1038/nrd772openalex-snapshot

Histone-deacetylase inhibitors: novel drugs for the treatment of cancer

inferredcites →https://doi.org/10.1038/nrg1689openalex-snapshot

Repeat instability: mechanisms of dynamic mutations

inferredcites →https://doi.org/10.1038/nsmb.2155openalex-snapshot

Molecular profiling of common fragile sites in human fibroblasts

inferredcites →https://doi.org/10.1038/onc.2009.502openalex-snapshot

DNA breaks at fragile sites generate oncogenic RET/PTC rearrangements in human thyroid cells

inferredcites →https://doi.org/10.1038/onc.2010.19openalex-snapshot

An HDAC1-binding domain within FATS bridges p21 turnover to radiation-induced tumorigenesis

inferredcites →https://doi.org/10.1038/onc.2012.225openalex-snapshot

RET is a potential tumor suppressor gene in colorectal cancer

inferredcites →https://doi.org/10.1038/onc.2013.494openalex-snapshot

FATS is an E2-independent ubiquitin ligase that stabilizes p53 and promotes its activation in response to DNA damage

inferredcites →https://doi.org/10.1038/sj.bjc.6601778openalex-snapshot

Frequent allelic deletion at the FHIT locus associated with p53 overexpression in squamous cell carcinoma subtype of Taiwanese non-small-cell lung cancers

inferredcites →https://doi.org/10.1038/sj.onc.1201209openalex-snapshot

New deletion in low-grade oligodendroglioma at the glioblastoma suppressor locus on chromosome 10q25-26

inferredcites →https://doi.org/10.1038/sj.onc.1201330openalex-snapshot

Frequent deletions of FHIT and FRA3B in Barrett's metaplasia and esophageal adenocarcinomas

inferredcites →https://doi.org/10.1038/sj.onc.1205573openalex-snapshot

Cloning and characterization of the common fragile site FRA6F harboring a replicative senescence gene and frequently deleted in human tumors

inferredcites →https://doi.org/10.1038/sj.onc.1206171openalex-snapshot

Characterization of the common fragile site FRA9E and its potential role in ovarian cancer

inferredcites →https://doi.org/10.1038/sj.onc.1207006openalex-snapshot

Preferential integration of human papillomavirus type 18 near the c-myc locus in cervical carcinoma

inferredcites →https://doi.org/10.1038/sj.onc.1207809openalex-snapshot

Characterization of a conserved aphidicolin-sensitive common fragile site at human 4q22 and mouse 6C1: possible association with an inherited disease and cancer

inferredcites →https://doi.org/10.1038/sj.onc.1208926openalex-snapshot

Genomic instability in radiation-induced mouse lymphoma from p53 heterozygous mice

inferredcites →https://doi.org/10.1038/sj.onc.1209057openalex-snapshot

Genomic amplification of MET with boundaries within fragile site FRA7G and upregulation of MET pathways in esophageal adenocarcinoma

inferredcites →https://doi.org/10.1038/sj.onc.1209268openalex-snapshot

Interphase chromosome folding determines spatial proximity of genes participating in carcinogenic RET/PTC rearrangements

inferredcites →https://doi.org/10.1038/sj.onc.1209466openalex-snapshot

Depletion of CHK1, but not CHK2, induces chromosomal instability and breaks at common fragile sites

inferredcites →https://doi.org/10.1038/sj.onc.1210849openalex-snapshot

Interplay between ATM and ATR in the regulation of common fragile site stability

inferredcites →https://doi.org/10.1038/sj.onc.1210989openalex-snapshot

Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions. A genome-wide study

inferredcites →https://doi.org/10.1054/bjoc.1999.1062openalex-snapshot

Loss of Fhit expression in non-small-cell lung cancer: correlation with molecular genetic abnormalities and clinicopathological features

inferredcites →https://doi.org/10.1073/pnas.0609783104openalex-snapshot

Targeted deletion of Wwox reveals a tumor suppressor function

inferredcites →https://doi.org/10.1073/pnas.0703664105openalex-snapshot

The tumor suppressor Fhit acts as a repressor of β-catenin transcriptional activity

inferredcites →https://doi.org/10.1073/pnas.0708097105openalex-snapshot

Replication stress induces tumor-like microdeletions in FHIT /FRA3B

inferredcites →https://doi.org/10.1073/pnas.1009941107openalex-snapshot

PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice

inferredcites →https://doi.org/10.1073/pnas.191345898openalex-snapshot

The tumor spectrum in FHIT- deficient mice

inferredcites →https://doi.org/10.1073/pnas.94.25.13771openalex-snapshot

Replacement of Fhit in cancer cells suppresses tumorigenicity

inferredcites →https://doi.org/10.1073/pnas.95.14.8141openalex-snapshot

Molecular characterization of a common fragile site ( FRA7H ) on human chromosome 7 by the cloning of a simian virus 40 integration site

inferredcites →https://doi.org/10.1073/pnas.96.13.7456openalex-snapshot

Cancer-specific chromosome alterations in the constitutive fragile region FRA3 B

inferredcites →https://doi.org/10.1074/jbc.m806866200openalex-snapshot

Conformational Variants of Duplex DNA Correlated with Cytosine-rich Chromosomal Fragile Sites

inferredcites →https://doi.org/10.1083/jcb.200705126openalex-snapshot

Werner syndrome helicase activity is essential in maintaining fragile site stability

inferredcites →https://doi.org/10.1091/mbc.e06-10-0957openalex-snapshot

Increased Common Fragile Site Expression, Cell Proliferation Defects, and Apoptosis following Conditional Inactivation of MouseHus1in Primary Cultured Cells

inferredcites →https://doi.org/10.1093/carcin/bgq133openalex-snapshot

The PI3K–Akt mediates oncogenic Met-induced centrosome amplification and chromosome instability

inferredcites →https://doi.org/10.1093/carcin/bgs206openalex-snapshot

Perturbed replication induced genome wide or at common fragile sites is differently managed in the absence of WRN

inferredcites →https://doi.org/10.1093/hmg/11.23.2887openalex-snapshot

Initiation of the breakage-fusion-bridge mechanism through common fragile site activation in human breast cancer cells: the model of PIP gene duplication from a break at FRA7I

inferredcites →https://doi.org/10.1093/hmg/5.2.187openalex-snapshot

FRA3B Extends Over a Broad Region and Contains a Spontaneous HPV16 Integration Site: Direct Evidence for the Coincidence of Viral Integration Sites and Fragile Sites

inferredcites →https://doi.org/10.1093/hmg/7.4.755openalex-snapshot

Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction: implications for the mechanism of fragile site induction

inferredcites →https://doi.org/10.1093/hmg/8.3.431openalex-snapshot

Allele-specific late replication and fragility of the most active common fragile site, FRA3B

inferredcites →https://doi.org/10.1093/hmg/9.11.1651openalex-snapshot

Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells

inferredcites →https://doi.org/10.1093/hmg/ddi049openalex-snapshot

SMC1 involvement in fragile site expression

inferredcites →https://doi.org/10.1093/hmg/ddi065openalex-snapshot

The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability

inferredcites →https://doi.org/10.1093/hmg/ddp470openalex-snapshot

Impaired replication dynamics at the FRA3B common fragile site

inferredcites →https://doi.org/10.1093/nar/gkp1131openalex-snapshot

DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D

inferredcites →https://doi.org/10.1095/biolreprod.109.079517openalex-snapshot

Lack of Functional Pregnancy-Associated Plasma Protein-A (PAPPA) Compromises Mouse Ovarian Steroidogenesis and Female Fertility1

inferredcites →https://doi.org/10.1126/science.1675488openalex-snapshot

Mapping of DNA Instability at the Fragile X to a Trinucleotide Repeat Sequence P(CCG) n

inferredcites →https://doi.org/10.1126/science.282.5393.1497openalex-snapshot

Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage

inferredcites →https://doi.org/10.1126/science.6239375openalex-snapshot

Constitutive Fragile Sites and Cancer

inferredcites →https://doi.org/10.1128/mcb.00115-09openalex-snapshot

Human DNA Polymerase η Is Required for Common Fragile Site Stability during Unperturbed DNA Replication

inferredcites →https://doi.org/10.1128/mcb.02084-07openalex-snapshot

Reduced Levels of DNA Polymerase δ Induce Chromosome Fragile Site Instability in Yeast

inferredcites →https://doi.org/10.1128/mcb.20.12.4420-4427.2000openalex-snapshot

Replication Delay along FRA7H, a Common Fragile Site on Human Chromosome 7, Leads to Chromosomal Instability

inferredcites →https://doi.org/10.1128/mcb.23.20.7143-7151.2003openalex-snapshot

Molecular Basis for Expression of Common and Rare Fragile Sites

inferredcites →https://doi.org/10.1128/mcb.24.15.6701-6709.2004openalex-snapshot

BRCA1 Is Required for Common-Fragile-Site Stability via Its G 2 /M Checkpoint Function

inferredcites →https://doi.org/10.1146/annurev.genet.40.051206.105231openalex-snapshot

Surviving the Breakup: The DNA Damage Checkpoint

inferredcites →https://doi.org/10.1146/annurev.genet.41.042007.165900openalex-snapshot

Chromosome Fragile Sites

inferredcites →https://doi.org/10.1155/2012/927683openalex-snapshot

The Role of Fragile Sites in Sporadic Papillary Thyroid Carcinoma

inferredcites →https://doi.org/10.1158/0008-5472.can-06-3376openalex-snapshot

Physical Association with WWOX Suppresses c-Jun Transcriptional Activity

inferredcites →https://doi.org/10.1158/0008-5472.can-07-0677openalex-snapshot

Fragile Histidine Triad–Mediated Tumor Suppression of Lung Cancer by Targeting Multiple Components of the Ras/Rho GTPase Molecular Switch

inferredcites →https://doi.org/10.1158/0008-5472.can-07-1081openalex-snapshot

Inactivation of the Wwox Gene Accelerates Forestomach Tumor Progression In vivo

inferredcites →https://doi.org/10.1158/0008-5472.can-11-3760openalex-snapshot

MET Signaling Regulates Glioblastoma Stem Cells

inferredcites →https://doi.org/10.1158/1078-0432.806.11.2openalex-snapshot

Adenoviral Transduction of TESTIN Gene into Breast and Uterine Cancer Cell Lines Promotes Apoptosis and Tumor Reduction In vivo

inferredcites →https://doi.org/10.1158/1078-0432.ccr-03-0096openalex-snapshot

The Tumor Suppressor Gene WWOX at FRA16D Is Involved in Pancreatic Carcinogenesis

inferredcites →https://doi.org/10.1158/1078-0432.ccr-03-0594openalex-snapshot

Loss of WWOX Expression in Gastric Carcinoma

inferredcites →https://doi.org/10.1158/1538-7445.am2013-5171openalex-snapshot

Abstract 5171: FATS is an E2-independent ubiquitin ligase that stabilizes p53 and promotes p53-dependent checkpoint response.

inferredcites →https://doi.org/10.1158/1541-7786.mcr-07-0324openalex-snapshot

Histone Deacetylase Inhibitors: Overview and Perspectives

inferredcites →https://doi.org/10.1159/000072844openalex-snapshot

WWOX, the common chromosomal fragile site, FRA16D, cancer gene

inferredcites →https://doi.org/10.1159/000073411openalex-snapshot

How common are common fragile sites in humans: interindividual variation in the distribution of aphidicolin-induced fragile sites

inferredcites →https://doi.org/10.1159/000112061openalex-snapshot

DMD and IL1RAPL1: two large adjacent genes localized within a common fragile site (FRAXC) have reduced expression in cultured brain tumors

inferredcites →https://doi.org/10.1159/000138885openalex-snapshot

Replication timing of two human common fragile sites: FRA1H and FRA2G

inferredcites →https://doi.org/10.1172/jci27236openalex-snapshot

Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype

inferredcites →https://doi.org/10.1182/blood-2010-12-323659openalex-snapshot

Tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma (PEL) cell lines

inferredcites →https://doi.org/10.1186/1471-2407-5-64openalex-snapshot

WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome

inferredcites →https://doi.org/10.1186/1476-4598-9-244openalex-snapshot

FATS is a transcriptional target of p53 and associated with antitumor activity

inferredcites →https://doi.org/10.1242/jcs.077313openalex-snapshot

Regulation of fragile sites expression in budding yeast by MEC1, RRM3 and hydroxyurea

inferredcites →https://doi.org/10.1530/eje.1.02289openalex-snapshot

RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture

inferredcites →https://doi.org/10.1534/genetics.112.141051openalex-snapshot

Genome Rearrangements Caused by Depletion of Essential DNA Replication Proteins inSaccharomyces cerevisiae

inferredcites →https://doi.org/10.1615/critreveukargeneexpr.v20.i3.10openalex-snapshot

Genome Instability in the Context of Chromatin Structure and Fragile Sites

inferredcites →https://doi.org/10.2174/138920210791616699openalex-snapshot

DNA Instability at Chromosomal Fragile Sites in Cancer

inferredcites →https://doi.org/10.3892/ijo.26.6.1681openalex-snapshot

WWOX mRNA expression profile in epithelial ovarian cancer supports the role of WWOX variant 1 as a tumour suppressor, although the role of variant 4 remains unclear

inferredcites →https://doi.org/10.3892/ijo_00000501openalex-snapshot

New aspects on chromosomal instability: Chromosomal break-points in Fanconi anemia patients co-localize on the molecular level with fragile sites

inferredcites →https://doi.org/10.3892/ijo_00000572openalex-snapshot

Global screening and extended nomenclature for 230 aphidicolin-inducible fragile sites, including 61 yet unreported ones

inferredcites →https://doi.org/10.4161/cc.10.23.18409openalex-snapshot

Understanding the molecular basis of common fragile sites instability: Role of the proteins involved in the recovery of stalled replication forks

inferredcites →https://doi.org/10.6061/clinics/2012(sup01)14openalex-snapshot

Molecular mechanisms of RET receptor-mediated oncogenesis in multiple endocrine neoplasia 2

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4648582openalex-extracted

inferred← citeshttps://doi.org/10.1002/bies.201900177openalex-snapshot

Repair and Reconstruction of Telomeric and Subtelomeric Regions and Genesis of New Telomeres: Implications for Chromosome Evolution

inferred← citeshttps://doi.org/10.1002/gcc.22341openalex-snapshot

Complex chromosomal rearrangements leading to MECOM overexpression are recurrent in myeloid malignancies with various 3q abnormalities

inferred← citeshttps://doi.org/10.1002/gcc.22715openalex-snapshot

Genomic instability in fragile sites—still adding the pieces

inferred← citeshttps://doi.org/10.1002/ijc.35417openalex-snapshot

Role of fragile sites FATS and FMR1 in tumor progression and their potential clinical significance

inferred← citeshttps://doi.org/10.1002/slct.202505441openalex-snapshot

The Computational Study of Toxic Heavy Metal Binding to Cancer‐Related Mutation Proteins

inferred← citeshttps://doi.org/10.1007/978-1-4939-1652-8_15openalex-snapshot

BAC-Probes Applied for Characterization of Fragile Sites (FS)

inferred← citeshttps://doi.org/10.1007/978-1-4939-9500-4_24openalex-snapshot

FISHing for Damage on Metaphase Chromosomes

inferred← citeshttps://doi.org/10.1007/978-981-10-3035-2_7openalex-snapshot

Fragile Sites

inferred← citeshttps://doi.org/10.1007/978-981-10-6955-0_21openalex-snapshot

Fragility Extraordinaire: Unsolved Mysteries of Chromosome Fragile Sites

inferred← citeshttps://doi.org/10.1007/s00018-014-1717-xopenalex-snapshot

Are common fragile sites merely structural domains or highly organized “functional” units susceptible to oncogenic stress?

inferred← citeshttps://doi.org/10.1007/s00018-014-1723-zopenalex-snapshot

Molecular characterization of common fragile sites as a strategy to discover cancer susceptibility genes

inferred← citeshttps://doi.org/10.1007/s00335-014-9537-8openalex-snapshot

A high resolution map of mammalian X chromosome fragile regions assessed by large-scale comparative genomics

inferred← citeshttps://doi.org/10.1007/s10529-013-1387-zopenalex-snapshot

Efficient targeting of FATS at a common fragile site in mice through TALEN-mediated double-hit genome modification

inferred← citeshttps://doi.org/10.1007/s10577-015-9471-yopenalex-snapshot

Canine urothelial carcinoma: genomically aberrant and comparatively relevant

inferred← citeshttps://doi.org/10.1007/s11357-015-9764-2openalex-snapshot

Cellular senescence: from growth arrest to immunogenic conversion

inferred← citeshttps://doi.org/10.1007/s11825-019-0236-4openalex-snapshot

Chromosomes in the DNA era: Perspectives in diagnostics and research

inferred← citeshttps://doi.org/10.1007/s13353-015-0282-9openalex-snapshot

Genomic instability in the PARK2 locus is associated with Parkinson’s disease

inferred← citeshttps://doi.org/10.1007/s40142-018-0154-9openalex-snapshot

Fragile Sites as Drivers of Gene and Genome Evolution

inferred← citeshttps://doi.org/10.1016/j.biopha.2017.11.100openalex-snapshot

Selective anticancer activity of the novel steroidal dihydropyridine spirooxindoles against human esophageal EC109 cells

inferred← citeshttps://doi.org/10.1016/j.ccell.2021.03.006openalex-snapshot

Oncogenic extrachromosomal DNA functions as mobile enhancers to globally amplify chromosomal transcription

inferred← citeshttps://doi.org/10.1016/j.cell.2020.08.006openalex-snapshot

Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs

inferred← citeshttps://doi.org/10.1016/j.celrep.2024.114820openalex-snapshot

Base-excision repair pathway regulates transcription-replication conflicts in pancreatic ductal adenocarcinoma

inferred← citeshttps://doi.org/10.1016/j.cytogfr.2015.03.003openalex-snapshot

Functions of Fibroblast Growth Factor Receptors in cancer defined by novel translocations and mutations

inferred← citeshttps://doi.org/10.1016/j.ejmech.2015.03.061openalex-snapshot

Coumarin sharing the benzene ring with quinoline for quenching radicals and inhibiting DNA oxidation

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2026.07.002openalex-snapshot

Low-dose ionizing radiation drives thyroid carcinogenesis via VPS53 enhanced EGFR Re-recycling

inferred← citeshttps://doi.org/10.1016/j.jbiotec.2023.05.009openalex-snapshot

Genomic features of recombinant CHO clones arising from transposon-based and randomized integration

inferred← citeshttps://doi.org/10.1016/j.semcdb.2020.11.003openalex-snapshot

Alternative paths to telomere elongation

inferred← citeshttps://doi.org/10.1021/acs.jpcb.0c06954openalex-snapshot

Single-Molecule Mechanical Unfolding of AT-Rich Chromosomal Fragile Site DNA Hairpins: Resolving the Thermodynamic and Kinetic Effects of a Single G-T Mismatch

inferred← citeshttps://doi.org/10.1021/ja311282kopenalex-snapshot

Oxidative Thymine Mutation in DNA: Water-Wire-Mediated Proton-Coupled Electron Transfer

inferred← citeshttps://doi.org/10.1038/mt.2015.197openalex-snapshot

Evaluation of TCR Gene Editing Achieved by TALENs, CRISPR/Cas9, and megaTAL Nucleases

inferred← citeshttps://doi.org/10.1038/onc.2013.494openalex-snapshot

FATS is an E2-independent ubiquitin ligase that stabilizes p53 and promotes its activation in response to DNA damage

inferred← citeshttps://doi.org/10.1038/s41388-020-01403-yopenalex-snapshot

Cell-cycle-dependent phosphorylation of RRM1 ensures efficient DNA replication and regulates cancer vulnerability to ATR inhibition

inferred← citeshttps://doi.org/10.1038/s41389-022-00417-3openalex-snapshot

Heterozygotic Brca1 mutation initiates mouse genome instability at embryonic stage

inferred← citeshttps://doi.org/10.1038/s41419-024-07164-wopenalex-snapshot

FATS inhibits the Wnt pathway and induces apoptosis through degradation of MYH9 and enhances sensitivity to paclitaxel in breast cancer

inferred← citeshttps://doi.org/10.1038/s41568-022-00518-6openalex-snapshot

Leveraging the replication stress response to optimize cancer therapy

inferred← citeshttps://doi.org/10.1038/s41698-025-00909-6openalex-snapshot

Diagnostic and prognostic potential of cell-free RNAs in cerebrospinal fluid and plasma for brain tumors

inferred← citeshttps://doi.org/10.1038/srep19649openalex-snapshot

Somatic Copy Number Alterations at Oncogenic Loci Show Diverse Correlations with Gene Expression

inferred← citeshttps://doi.org/10.1080/15384101.2017.1288322openalex-snapshot

Rescue from replication stress during mitosis

inferred← citeshttps://doi.org/10.1101/2024.03.21.586072openalex-snapshot

Hepatitis B Virus genomes associate with cellular sites of DNA damage by inducing replication stress

inferred← citeshttps://doi.org/10.1101/287839openalex-snapshot

The Origins and Consequences of Localized and Global Somatic Hypermutation

inferred← citeshttps://doi.org/10.1128/jvi.01014-25openalex-snapshot

Association of hepatitis B virus genomes with active chromatin hubs challenges host replication fidelity, leading to DNA damage

inferred← citeshttps://doi.org/10.1152/physiolgenomics.00029.2026openalex-snapshot

Multiomic characterization of DNA released after airway exposure to allergens and nanoparticles reveals selective export of repetitive and fragile site DNA

inferred← citeshttps://doi.org/10.1155/2013/851817openalex-snapshot

Polymorphisms of the Homologous Recombination GeneRAD51in Keratoconus and Fuchs Endothelial Corneal Dystrophy

inferred← citeshttps://doi.org/10.1159/000534656openalex-snapshot

Applicability of Scoring Calyculin A-Induced Premature Chromosome Condensation Objects for Dose Assessment Including for Radiotherapy Patients

inferred← citeshttps://doi.org/10.1186/s12885-015-1570-9openalex-snapshot

A functional genetic variant in fragile-site gene FATS modulates the risk of breast cancer in triparous women

inferred← citeshttps://doi.org/10.1186/s13039-016-0280-6openalex-snapshot

First molecular-cytogenetic characterization of Fanconi anemia fragile sites in primary lymphocytes of FA-D2 patients in different stages of the disease

inferred← citeshttps://doi.org/10.1186/s13045-022-01291-7openalex-snapshot

Integrated proteogenomic characterization of urothelial carcinoma of the bladder

inferred← citeshttps://doi.org/10.1371/journal.pgen.1009392openalex-snapshot

Genome-wide association study of resistance to Mycobacterium tuberculosis infection identifies a locus at 10q26.2 in three distinct populations

inferred← citeshttps://doi.org/10.1371/journal.ppat.1013142openalex-snapshot

Adeno-Associated Virus 2 (AAV2) - Induced RPA exhaustion generates cellular DNA damage and restricts viral gene expression

inferred← citeshttps://doi.org/10.1593/neo.131574openalex-snapshot

Alternative Lengthening of Telomeres: Recurrent Cytogenetic Aberrations and Chromosome Stability under Extreme Telomere Dysfunction

inferred← citeshttps://doi.org/10.17305/bjbms.2021.6404openalex-snapshot

Plasma exosome-derived fragile-site associated tumor suppressor is a powerful predictor of prognosis in patients with ovarian cancer

inferred← citeshttps://doi.org/10.17513/spno.30817openalex-snapshot

CHROMOHELKOSIS — A UNUSUAL FORM OF CHROMOSOME INSTABILITY AND SOMATIC MOSAICISM ASSOCIATED WITH CENTRAL NERVOUS SYSTEM DISEASES IN CHILDREN

inferred← citeshttps://doi.org/10.18632/genesandcancer.169openalex-snapshot

The untold stories of the speech gene, the FOXP2 cancer gene

inferred← citeshttps://doi.org/10.18632/oncotarget.17776openalex-snapshot

Inhibition of colorectal cancer genomic copy number alterations and chromosomal fragile site tumor suppressor FHIT and WWOX deletions by DNA mismatch repair

inferred← citeshttps://doi.org/10.21203/rs.3.rs-136297/v1openalex-snapshot

Annotations of Recurrent Structural Variant Events in Pan-cancer Whole Genome Data for Precision Medicine

inferred← citeshttps://doi.org/10.21203/rs.3.rs-560273/v1openalex-snapshot

Plasma Exosome-Derived Fragile-Site Associated Tumor Suppressor is a Powerful Predictor of Prognosis in Patients with Ovarian Cancer

inferred← citeshttps://doi.org/10.22541/au.165816370.02613398/v1openalex-snapshot

Genomic Features of Transposase and Randomly Derived Recombinant CHO Clones

inferred← citeshttps://doi.org/10.3389/fcell.2022.931387openalex-snapshot

Quaking but not parkin is the major tumor suppressor in 6q deleted region in glioblastoma

inferred← citeshttps://doi.org/10.3389/fonc.2018.00606openalex-snapshot

Insights Into SND1 Oncogene Promoter Regulation

inferred← citeshttps://doi.org/10.3390/biom11081249openalex-snapshot

Transcription-Replication Collisions—A Series of Unfortunate Events

inferred← citeshttps://doi.org/10.3390/genes8110292openalex-snapshot

Exceptional Chromosomal Evolution and Cryptic Speciation of Blind Mole Rats Nannospalax leucodon (Spalacinae, Rodentia) from South-Eastern Europe

inferred← citeshttps://doi.org/10.3390/ijms20040826openalex-snapshot

From Human Cytogenetics to Human Chromosomics

inferred← citeshttps://doi.org/10.3390/ijms21218328openalex-snapshot

The Cytogenomic “Theory of Everything”: Chromohelkosis May Underlie Chromosomal Instability and Mosaicism in Disease and Aging

inferred← citeshttps://doi.org/10.3390/ijms242316903openalex-snapshot

Cellular Responses to Widespread DNA Replication Stress

inferred← citeshttps://doi.org/10.3390/ijms25116061openalex-snapshot

Effect of Hydroxyurea on Morphology, Proliferation, and Protein Expression on Taenia crassiceps WFU Strain

inferred← citeshttps://doi.org/10.3390/ijms251910496openalex-snapshot

Novel Oncogenic Value of C10orf90 in Colon Cancer Identified as a Clinical Diagnostic and Prognostic Marker

inferred← citeshttps://doi.org/10.3390/jcm10040856openalex-snapshot

Implications of Endogenous Retroelements in the Etiopathogenesis of Systemic Lupus Erythematosus

inferred← citeshttps://doi.org/10.3390/v14010086openalex-snapshot

Non-Random Pattern of Integration for Epstein-Barr Virus with Preference for Gene-Poor Genomic Chromosomal Regions into the Genome of Burkitt Lymphoma Cell Lines

inferred← citeshttps://doi.org/10.3390/v17040494openalex-snapshot

Small Genomes, Big Disruptions: Parvoviruses and the DNA Damage Response

inferred← citeshttps://doi.org/10.4103/njcp.njcp_46_24openalex-snapshot

Potential of AKNA as a Predictive Biomarker for Ovarian Cancer and Its Relationship to Tumor Grading

inferred← citeshttps://doi.org/10.4269/ajtmh.16-0427openalex-snapshot

What is a Hotspot Anyway?

inferred← citeshttps://doi.org/10.5772/61249openalex-snapshot

Mechanisms of Oncogene Activation

inferred← citeshttps://doi.org/10.6084/m9.figshare.20000999openalex-snapshot

Additional file 10 of Integrated proteogenomic characterization of urothelial carcinoma of the bladder

inferred← citeshttps://doi.org/10.6084/m9.figshare.20001002openalex-snapshot

Additional file 11 of Integrated proteogenomic characterization of urothelial carcinoma of the bladder

inferred← citeshttps://doi.org/10.6084/m9.figshare.20001005openalex-snapshot

Additional file 12 of Integrated proteogenomic characterization of urothelial carcinoma of the bladder

inferred← citeshttps://doi.org/10.6084/m9.figshare.20001008openalex-snapshot

Additional file 13 of Integrated proteogenomic characterization of urothelial carcinoma of the bladder

inferred← citeshttps://doi.org/10.6084/m9.figshare.20001011openalex-snapshot

Additional file 14 of Integrated proteogenomic characterization of urothelial carcinoma of the bladder

inferred← citeshttps://doi.org/10.6084/m9.figshare.20001014openalex-snapshot

Additional file 15 of Integrated proteogenomic characterization of urothelial carcinoma of the bladder

inferred← citeshttps://doi.org/10.6084/m9.figshare.20001017openalex-snapshot

Additional file 16 of Integrated proteogenomic characterization of urothelial carcinoma of the bladder

inferred← citeshttps://doi.org/10.6084/m9.figshare.20001020openalex-snapshot

Additional file 17 of Integrated proteogenomic characterization of urothelial carcinoma of the bladder

inferred← citeshttps://doi.org/10.6084/m9.figshare.20001023openalex-snapshot

Additional file 18 of Integrated proteogenomic characterization of urothelial carcinoma of the bladder

inferred← citeshttps://doi.org/10.6084/m9.figshare.20001026openalex-snapshot

Additional file 19 of Integrated proteogenomic characterization of urothelial carcinoma of the bladder

inferred← citeshttps://doi.org/10.6084/m9.figshare.20001029openalex-snapshot

Additional file 1 of Integrated proteogenomic characterization of urothelial carcinoma of the bladder

inferred← citeshttps://doi.org/10.6084/m9.figshare.20001032openalex-snapshot

Additional file 20 of Integrated proteogenomic characterization of urothelial carcinoma of the bladder

inferred← citeshttps://doi.org/10.6084/m9.figshare.20001035openalex-snapshot

Additional file 2 of Integrated proteogenomic characterization of urothelial carcinoma of the bladder

inferred← citeshttps://doi.org/10.6084/m9.figshare.20001038openalex-snapshot

Additional file 3 of Integrated proteogenomic characterization of urothelial carcinoma of the bladder

inferred← citeshttps://doi.org/10.6084/m9.figshare.20001041openalex-snapshot

Additional file 4 of Integrated proteogenomic characterization of urothelial carcinoma of the bladder

inferred← citeshttps://doi.org/10.6084/m9.figshare.20001047openalex-snapshot

Additional file 5 of Integrated proteogenomic characterization of urothelial carcinoma of the bladder

inferred← citeshttps://doi.org/10.6084/m9.figshare.20001050openalex-snapshot

Additional file 6 of Integrated proteogenomic characterization of urothelial carcinoma of the bladder

inferred← citeshttps://doi.org/10.6084/m9.figshare.20001053openalex-snapshot

Additional file 7 of Integrated proteogenomic characterization of urothelial carcinoma of the bladder

inferred← citeshttps://doi.org/10.6084/m9.figshare.20001056openalex-snapshot

Additional file 8 of Integrated proteogenomic characterization of urothelial carcinoma of the bladder

inferred← citeshttps://doi.org/10.6084/m9.figshare.20001059openalex-snapshot

Additional file 9 of Integrated proteogenomic characterization of urothelial carcinoma of the bladder

inferred← citeshttps://doi.org/10.70675/eb51eb1ezc51dz4737zaf38z954d1a68dbeaopenalex-snapshot

Mutations de la voie ATR-CHK1, réponse au stress réplicatif et cancer

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