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Downregulation of α-Melanocyte-Stimulating Hormone-Induced Activation of the Pax3-MITF-Tyrosinase Axis by Sorghum Ethanolic Extract in B16F10 Melanoma Cells

https://doi.org/10.3390/ijms19061640

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Pax‐3, a novel murine DNA binding protein expressed during early neurogenesis.

inferredcites →https://doi.org/10.1002/mnfr.201100651openalex-snapshot

2′‐Hydroxyflavanone induces apoptosis through E gr‐1 involving expression of B ax, p21, and NAG ‐1 in colon cancer cells

inferredcites →https://doi.org/10.1006/abio.1999.4090openalex-snapshot

A Standardized Protocol for Assessing Regulators of Pigmentation

inferredcites →https://doi.org/10.1007/978-1-59259-726-0_112openalex-snapshot

Waardenburg Syndrome

inferredcites →https://doi.org/10.1007/bf02980069openalex-snapshot

(−)-Epigallocatechin-3-gallate and hinokitiol reduce melanin synthesisvia decreased MITF production

inferredcites →https://doi.org/10.1007/s00018-014-1791-0openalex-snapshot

MITF in melanoma: mechanisms behind its expression and activity

inferredcites →https://doi.org/10.1007/s004390000328openalex-snapshot

Transcription factor hierarchy in Waardenburg syndrome: regulation of MITF expression by SOX10 and PAX3

inferredcites →https://doi.org/10.1016/0014-5793(96)00109-3openalex-snapshot

Tyrosinase and related proteins in mammalian pigmentation

inferredcites →https://doi.org/10.1016/0092-8674(93)90429-topenalex-snapshot

Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein

inferredcites →https://doi.org/10.1016/j.drudis.2016.09.016openalex-snapshot

Downregulation of melanogenesis: drug discovery and therapeutic options

inferredcites →https://doi.org/10.1016/j.jcs.2006.06.007openalex-snapshot

Sorghum and millet phenols and antioxidants

inferredcites →https://doi.org/10.1016/j.jdermsci.2018.03.014openalex-snapshot

Agerarin inhibits α-MSH–induced TYR gene transcription via STAT3 suppression independent of CREB-MITF pathway

inferredcites →https://doi.org/10.1016/j.molcel.2008.11.002openalex-snapshot

Inhibition of PAX3 by TGF-β Modulates Melanocyte Viability

inferredcites →https://doi.org/10.1016/j.phytochem.2004.04.001openalex-snapshot

Sorghum phytochemicals and their potential impact on human health

inferredcites →https://doi.org/10.1016/s0006-2952(98)00340-2openalex-snapshot

Inhibitors of mammalian melanocyte tyrosinase: in vitro comparisons of alkyl esters of gentisic acid with other putative inhibitors

inferredcites →https://doi.org/10.1016/s0076-6879(04)78005-2openalex-snapshot

Quinone Chemistry and Melanogenesis

inferredcites →https://doi.org/10.1021/jf304882kopenalex-snapshot

Sorghum, a Healthy and Gluten-free Food for Celiac Patients As Demonstrated by Genome, Biochemical, and Immunochemical Analyses

inferredcites →https://doi.org/10.1021/jf403669kopenalex-snapshot

Antioxidant and Tyrosinase Inhibitory Activities of Flavonoids fromTrifolium nigrescensSubsp.petrisavi

inferredcites →https://doi.org/10.1023/a:1023620501702openalex-snapshot

Inhibitory Effects of Some Flavonoids on the Activity of Mushroom Tyrosinase

inferredcites →https://doi.org/10.1034/j.1600-0749.2000.130203.xopenalex-snapshot

Cyclic AMP a Key Messenger in the Regulation of Skin Pigmentation

inferredcites →https://doi.org/10.1034/j.1600-0749.2000.130503.xopenalex-snapshot

The Tyrosinase Gene and Oculocutaneous Albinism Type 1 (OCA1): A Model for Understanding the Molecular Biology of Melanin Formation

inferredcites →https://doi.org/10.1038/355635a0openalex-snapshot

Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene

inferredcites →https://doi.org/10.1038/modpathol.3801019openalex-snapshot

PAX3 expression in primary melanomas and nevi

inferredcites →https://doi.org/10.1038/sj.onc.1206766openalex-snapshot

Paired-Box genes are frequently expressed in cancer and often required for cancer cell survival

inferredcites →https://doi.org/10.1039/c6fo00757kopenalex-snapshot

Phytochemical concentrations and biological activities of Sorghum bicolor alcoholic extracts

inferredcites →https://doi.org/10.1046/j.1523-1747.2001.01290.xopenalex-snapshot

The Paracrine Role of Stem Cell Factor/c-kit Signaling in the Activation of Human Melanocytes in Ultraviolet-B-Induced Pigmentation

inferredcites →https://doi.org/10.1046/j.1523-1747.2002.19615.xopenalex-snapshot

Modulation of Microphthalmia-associated Transcription Factor Gene Expression Alters Skin Pigmentation

inferredcites →https://doi.org/10.1046/j.1524-4725.1999.08236.xopenalex-snapshot

Treatment of Melasma Using Kojic Acid in a Gel Containing Hydroquinone and Glycolic Acid

inferredcites →https://doi.org/10.1080/87559129.2015.1022832openalex-snapshot

Sorghum: An Underutilized Cereal Whole Grain with the Potential to Assist in the Prevention of Chronic Disease

inferredcites →https://doi.org/10.1083/jcb.142.3.827openalex-snapshot

Microphthalmia Gene Product as a Signal Transducer in cAMP-Induced Differentiation of Melanocytes

inferredcites →https://doi.org/10.1093/hmg/9.13.1907openalex-snapshot

Interaction among SOX10, PAX3 and MITF, three genes altered in Waardenburg syndrome

inferredcites →https://doi.org/10.1093/nar/18.24.7293openalex-snapshot

Conserved cysteine to serine mutation in tyrosinase is responsible for the classical albino mutation in laboratory mice

inferredcites →https://doi.org/10.1111/j.1600-0625.2007.00675.xopenalex-snapshot

Regulation of melanogenesis – controversies and new concepts

inferredcites →https://doi.org/10.1111/j.1600-0625.2009.01053.xopenalex-snapshot

“Transcription physiology” of pigment formation in melanocytes: central role of MITF

inferredcites →https://doi.org/10.1111/j.1600-0749.1997.tb00488.xopenalex-snapshot

The Role of Endothelin‐1 in Epidermal Hyperpigmentation and Signaling Mechanisms of Mitogenesis and Melanogenesis

inferredcites →https://doi.org/10.1111/j.1600-0749.1998.tb00494.xopenalex-snapshot

The Inhibitory Effect of Glabridin from Licorice Extracts on Melanogenesis and Inflammation

inferredcites →https://doi.org/10.1111/j.1600-0749.1998.tb00731.xopenalex-snapshot

Effect of Arbutin on Melanogenic Proteins in Human Melanocytes

inferredcites →https://doi.org/10.1111/j.1600-0749.2006.00348.xopenalex-snapshot

Activation of the Mitf promoter by lipid‐stimulated activation of p38‐stress signalling to CREB

inferredcites →https://doi.org/10.1111/j.1755-148x.2011.00898.xopenalex-snapshot

L‐tyrosine and L‐dihydroxyphenylalanine as hormone‐like regulators of melanocyte functions

inferredcites →https://doi.org/10.1128/mcb.14.12.8058openalex-snapshot

Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene.

inferredcites →https://doi.org/10.1128/mcb.14.12.8058-8070.1994openalex-snapshot

Microphthalmia-Associated Transcription Factor as a Regulator for Melanocyte-Specific Transcription of the Human Tyrosinase Gene

inferredcites →https://doi.org/10.1128/mcb.15.3.1833openalex-snapshot

Microphthalmia-Associated Transcription Factor as a Regulator for Melanocyte-Specific Transcription of the Human Tyrosinase Gene

inferredcites →https://doi.org/10.1158/1541-7786.mcr-09-0454openalex-snapshot

Transcription Factor Egr-1 Is Essential for Maximal Matrix Metalloproteinase-9 Transcription by Tumor Necrosis Factor α

inferredcites →https://doi.org/10.1371/journal.pone.0009977openalex-snapshot

PAX3 Expression in Normal Skin Melanocytes and Melanocytic Lesions (Naevi and Melanomas)

inferredcites →https://doi.org/10.3390/ijms160818384openalex-snapshot

Hesperidin, A Popular Antioxidant Inhibits Melanogenesis via Erk1/2 Mediated MITF Degradation

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Transcriptome and Metabolome Provide Insight into the Formation Mechanism of Skin Pigmentation Diversity in Chinese Soft-Shelled Turtle (Pelodiscus Sinensis)

inferred← citeshttps://doi.org/10.1002/jsfa.10933openalex-snapshot

A mechanistic review: potential chronic disease‐preventive properties of sorghum

inferred← citeshttps://doi.org/10.1007/s11101-025-10079-9openalex-snapshot

Green decontaminants for the remediation of chemical, biological, radiological and nuclear contaminants

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Integrative transcriptomics and metabolomics analysis provide insight into the formation of skin pigmentation diversity in Chinese soft-shelled turtle (Pelodiscus sinensis)

inferred← citeshttps://doi.org/10.1016/j.cbpb.2022.110720openalex-snapshot

Molecular characterization of Pax7 and its role in melanin synthesis in Crassostrea gigas

inferred← citeshttps://doi.org/10.1016/j.jafr.2026.103357openalex-snapshot

Novel tyrosinase inhibitory peptides from Kaempferia parviflora protein hydrolysate with melanin suppression and mechanistic insights from B16F10 cells and zebrafish models

inferred← citeshttps://doi.org/10.1016/j.jddst.2025.107937openalex-snapshot

Caffeic acid–functionalized silver nanoparticles for skin therapy: Antioxidant, antibacterial, and anti-melanogenic properties

inferred← citeshttps://doi.org/10.1016/j.jid.2019.04.029openalex-snapshot

The Long Noncoding RNA UCA1 Negatively Regulates Melanogenesis in Melanocytes

inferred← citeshttps://doi.org/10.1038/s41419-023-06223-yopenalex-snapshot

Transglutaminase Type 2-MITF axis regulates phenotype switching in skin cutaneous melanoma

inferred← citeshttps://doi.org/10.1111/exd.14752openalex-snapshot

Depigmenting topical therapy based on a synergistic combination of compounds targeting the key pathways involved in melasma pathophysiology

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Licorice zinc suppresses melanogenesis via inhibiting the activation of P38MAPK and JNK signaling pathway in Balb/c mice skin

inferred← citeshttps://doi.org/10.2298/vsp180613128mopenalex-snapshot

Association of PAX3 and TMTC2 gene polymorphism with the face morphology change after excision of skin tumors

inferred← citeshttps://doi.org/10.3390/cosmetics8030070openalex-snapshot

The Ethanol Extract of Musa sapientum Linn. Peel Inhibits Melanogenesis through AKT Signaling Pathway

inferred← citeshttps://doi.org/10.3390/ijms19123700openalex-snapshot

Pax3 Gene Regulated Melanin Synthesis by Tyrosinase Pathway in Pteria penguin

inferred← citeshttps://doi.org/10.3390/ijms21249631openalex-snapshot

Suppression of Pax3–MITF-M Axis Protects from UVB-Induced Skin Pigmentation by Tetrahydroquinoline Carboxamide

inferred← citeshttps://doi.org/10.3390/ijms241914662openalex-snapshot

Anhydrous Alum Inhibits α-MSH-Induced Melanogenesis by Down-Regulating MITF via Dual Modulation of CREB and ERK

inferred← citeshttps://doi.org/10.3390/life11020162openalex-snapshot

Effect of 7-Methylsulfinylheptyl Isothiocyanate on the Inhibition of Melanogenesis in B16-F1 Cells

inferred← citeshttps://doi.org/10.3390/md24030107openalex-snapshot

Microalgal Exosome-like Nanovesicles from Nannochloropsis oculata Attenuate Melanogenesis Through Tyrosinase Inhibition in B16-F10 Melanoma Cells

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Brown Macroalgae Sargassum cristaefolium Extract Inhibits Melanin Production and Cellular Oxygen Stress in B16F10 Melanoma Cells

inferred← citeshttps://doi.org/10.3892/etm.2020.8687openalex-snapshot

Natural skin‑whitening compounds for the treatment of melanogenesis (Review)

inferred← citeshttps://doi.org/10.4103/2221-1691.273092openalex-snapshot

Antioxidant and anti-melanogenic activities of ultrasonic extract from Stichopus japonicus

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Exploring the Potential of Red Fruit Oil to Modulate Melanogenesis by Evaluating MITF Gene Expression in α-MSH-Induced B16F10 Melanoma Cells

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