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Synthesis, Bioapplications, and Toxicity Evaluation of Chitosan-Based Nanoparticles

https://doi.org/10.3390/ijms20225776

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Chitosan cross-linked docetaxel loaded EGF receptor targeted nanoparticles for lung cancer cells

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Anticancer properties of chitosan on human melanoma are cell line dependent

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Evaluation of different factors affecting antimicrobial properties of chitosan

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Chitosan/TiO 2 composite membrane improves proliferation and survival of L929 fibroblast cells: Application in wound dressing and skin regeneration

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Comparative studies of tripolyphosphate and glutaraldehyde cross-linked chitosan-botanical pesticide nanoparticles and their agricultural applications

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Chitosan as biomaterial in drug delivery and tissue engineering

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Trans-resveratrol loaded chitosan nanoparticles modified with biotin and avidin to target hepatic carcinoma

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Antibacterial Activity of Ti3C2T x MXene

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Effect of Chitosan on Epithelial Cell Tight Junctions

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The Effect of Chemical Modification and Nanoparticle Formulation on Stability and Biodistribution of siRNA in Mice

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Parameters influencing the size of chitosan-TPP nano- and microparticles

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Chitosan encapsulation modulates the effect of capsaicin on the tight junctions of MDCK cells

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Two-dimensional transition metal carbides and nitrides (MXenes) for biomedical applications

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Humic-based bionanocomposites containing stable paramagnetic gold nanoparticles for prospective use in pharmaceuticals

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Chitosan-TPP nanoparticles stabilized by poloxamer for controlling the release and enhancing the bioavailability of doxazosin mesylate: in vitro, and in vivo evaluation

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Functional biomimetic nanoparticles for drug delivery and theranostic applications in cancer treatment

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Acceleration of wound healing in healing‐impaired db/db mice with a photocrosslinkable chitosan hydrogel containing fibroblast growth factor‐2

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Chitosan and Chitosan Derivatives for Biological Applications: Chemistry and Functionalization

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Antifungal Activity of Chitosan Nanoparticles and Correlation with Their Physical Properties

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Anticancer Activity of Chitosan, Chitosan Derivatives, and Their Mechanism of Action

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Specific Targeting of Brain Tumors with an Optical/Magnetic Resonance Imaging Nanoprobe across the Blood-Brain Barrier

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Chitosan: a New Versatile Bio-polymer for Various Applications

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Biomedical Applications of Chitosan: An Overview

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Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good Response Randomized Controlled Trial

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Drug Delivery Approaches in Addressing Clinical Pharmacology-Related Issues: Opportunities and Challenges

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Review: doxorubicin delivery systems based on chitosan for cancer therapy

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Review: doxorubicin delivery systems based on chitosan for cancer therapy

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Growth-inhibitory effect of hexa-N-acetylchitohexaose and chitohexaose against Meth-A solid tumor.

inferredcites →https://doi.org/10.1590/s0104-14282009000300013openalex-snapshot

A review of the antimicrobial activity of chitosan

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A New Horizon in Modifications of Chitosan: Syntheses and Applications

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Preparation and characterization of 6-mercaptopurine-coated magnetite nanoparticles as a drug delivery system

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A facile doxorubicin-dichloroacetate conjugate nanomedicine with high drug loading for safe drug delivery

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Toxicity evaluation of biodegradable chitosan nanoparticles using a zebrafish embryo model

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Endocytosis and exocytosis of nanoparticles in mammalian cells

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Preparation and in vitro and in vivo characterization of cyclosporin A-loaded, PEGylated chitosan-modified, lipid-based nanoparticles

inferredcites →https://doi.org/10.2147/nano.2006.1.2.181openalex-snapshot

Chitosan and lactic acid-grafted chitosan nanoparticles as carriers for prolonged drug delivery

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Chitosan Amphiphilic Derivatives. Chemistry and Applications

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Nanotechnology Derived Nanotools in Biomedical Perspectives: An Update

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Chitosan in Biomedical Engineering: A Critical Review

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Functional Characterization of Chitin and Chitosan

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Chitosan and its Modifications as Biologically Active Compounds in Different Applications

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Chitosan as Promising Materials for Biomedical Application: Review

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Omeprazole and Dry Mouth

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Effects of the Molecular Weight and the Degree of Deacetylation of Chitosan Oligosaccharides on Antitumor Activity

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Molecular Mechanisms of Chitosan Interactions with Fungi and Plants

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Stability of Chitosan—A Challenge for Pharmaceutical and Biomedical Applications

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Multifaceted Applications of Chitosan in Cancer Drug Delivery and Therapy

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Mesoporous Silica Nanoparticles for Drug Delivery: Current Insights

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An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery

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Variation in Chitosan and Salicylic Acid Efficacy Towards Soil-borne and Air-borne Fungi and Their Suppressive Effect of Tomato Wilt Severity

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Influence of the Chemical Structure and Physicochemical Properties of Chitin- and Chitosan-Based Materials on Their Biomedical Activity

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Innovative synthesis approaches and health implications of organic-inorganic Nanohybrids for food industry applications

inferred← citeshttps://doi.org/10.1016/j.foodhyd.2020.106394openalex-snapshot

Multifunctional coating composed of Eryngium campestre L. essential oil encapsulated in nano-chitosan to prolong the shelf-life of fresh cherry fruits

inferred← citeshttps://doi.org/10.1016/j.foodres.2024.114068openalex-snapshot

Dietary gallic acid as an antioxidant: A review of its food industry applications, health benefits, bioavailability, nano-delivery systems, and drug interactions

inferred← citeshttps://doi.org/10.1016/j.fuel.2024.132774openalex-snapshot

Co-immobilization of magnesium precursor and Candida rugosa lipase on alumina via covalent bonding for biodiesel production

inferred← citeshttps://doi.org/10.1016/j.heliyon.2022.e11893openalex-snapshot

Chitosan nanoparticles (ChNPs): A versatile growth promoter in modern agricultural production

inferred← citeshttps://doi.org/10.1016/j.heliyon.2023.e20724openalex-snapshot

Nature to Nurture: Chitosan nanopowder a natural carbohydrate polymer choice of egg parasitoid, Trichogramma Japonicum Ashmead

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2018.12.193openalex-snapshot

Antibacterial activity of quaternized chitosan modified nanofiber membrane

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2021.02.005openalex-snapshot

Zebrafish as a potential biomaterial testing platform for bone tissue engineering application: A special note on chitosan based bioactive materials

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2021.03.098openalex-snapshot

Chitosan, xanthan and locust bean gum matrices crosslinked with β-cyclodextrin as green sorbents of aromatic compounds

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2021.05.012openalex-snapshot

Does polysaccharide quaternization improve biological activity?

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2021.06.108openalex-snapshot

Magnetic chitosan nanocomposites for simultaneous hyperthermia and drug delivery applications: A review

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2022.01.047openalex-snapshot

Angiogenic potential and wound healing efficacy of chitosan derived hydrogels at varied concentrations of APTES in chick and mouse models

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2022.01.162openalex-snapshot

Recent advances of chitosan-based nanoparticles for biomedical and biotechnological applications

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2022.10.178openalex-snapshot

A low-molecular-weight chitosan fluorometric-based assay for evaluating antiangiogenic drugs

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2023.126706openalex-snapshot

Co-administration of amoxicillin-loaded chitosan nanoparticles and inulin: A novel strategy for mitigating antibiotic resistance and preserving microbiota balance in Helicobacter pylori treatment

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2023.127454openalex-snapshot

Grafting of sinapic acid onto glucosamine nanoparticle as a potential therapeutic drug with enhanced anti-inflammatory activities in osteoarthritis treatment

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2023.128655openalex-snapshot

Immobilization of l-asparaginase on chitosan nanoparticles for the purpose of long-term application

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.129522openalex-snapshot

A review of chitosan nanoparticles: Nature's gift for transforming agriculture through smart and effective delivery mechanisms

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.131334openalex-snapshot

Role of chitosan in intestinal integrity: TLR4 and IFNAR signaling in the induction of E-cadherin and CD103 in mice

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.132386openalex-snapshot

Recent advances in chitosan-based nanocomposites for adsorption and removal of heavy metal ions

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.133499openalex-snapshot

Synthesis of novel chitosan-Schiff bases nanoparticles for high efficiency Helicobacter pylori inhibition

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.135362openalex-snapshot

Potential mitochondrial ROS-mediated damage induced by chitosan nanoparticles bee venom-loaded on cancer cell lines

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.138195openalex-snapshot

A review of carbohydrate polymer-synthesized nanoparticles in cancer immunotherapy: Past, present and future perspectives

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.138256openalex-snapshot

Chitosan-BODIPY fluorescent composite materials for photodynamical antibacterial and therapy

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.141433openalex-snapshot

A review-chitosan nanoparticles towards enhancing nutrient use efficiency in crops

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.142832openalex-snapshot

Chitosan, derivatives, and its nanoparticles: Preparation, physicochemical properties, biological activities, and biomedical applications – A comprehensive review

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.143050openalex-snapshot

N-(3-trimethoxysilylpropyl)ethylenediamine-crosslinked sodium alginate hydrogel: applications in angiogenesis and wound healing across avian and murine models

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.149499openalex-snapshot

Advances in chitosan based nanoformulations to enhance crop productivity and resilience

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2026.150563openalex-snapshot

Engineering chitosan-functionalized liposomes for targeted drug delivery and biomedical applications

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2026.152484openalex-snapshot

Chitosan-shielded stem cell exosomes as a tight-junction-modulating bio-shuttle for enhanced transdermal delivery and skin rejuvenation

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2026.152961openalex-snapshot

Nanoparticle-based delivery of corn silk extract for the treatment of CCl₄-induced hepatotoxicity

inferred← citeshttps://doi.org/10.1016/j.ijpharm.2024.124897openalex-snapshot

Codelivery of metformin and methotrexate with optimized chitosan nanoparticles for synergistic triple-negative breast cancer therapy in vivo

inferred← citeshttps://doi.org/10.1016/j.inoche.2026.116373openalex-snapshot

An overview of chitosan-coated magnetic nanocatalysts in hydrogenation nitroarenes

inferred← citeshttps://doi.org/10.1016/j.intimp.2022.109300openalex-snapshot

Immune checkpoint blockade in melanoma: Advantages, shortcomings and emerging roles of the nanoparticles

inferred← citeshttps://doi.org/10.1016/j.jconrel.2021.12.012openalex-snapshot

Chitosan: A versatile bio-platform for breast cancer theranostics

inferred← citeshttps://doi.org/10.1016/j.jconrel.2023.10.022openalex-snapshot

Emerging applications of anti-angiogenic nanomaterials in oncotherapy

inferred← citeshttps://doi.org/10.1016/j.jconrel.2025.01.017openalex-snapshot

The (re)emergence of aerosol delivery: Treatment of pulmonary diseases and its clinical challenges

inferred← citeshttps://doi.org/10.1016/j.jddst.2023.105274openalex-snapshot

Envisioning the prospect of nanocarriers as an effective management tool against NeuroAIDS

inferred← citeshttps://doi.org/10.1016/j.jddst.2024.105661openalex-snapshot

Revolutionizing cancer treatment: The role of chitosan nanoparticles in therapeutic advancements

inferred← citeshttps://doi.org/10.1016/j.jddst.2024.105948openalex-snapshot

Application of nanotechnology to improve the antileishmanial efficacy of amphotericin B

inferred← citeshttps://doi.org/10.1016/j.jddst.2024.106287openalex-snapshot

Advances in gene therapy: Polysaccharide nanoparticles as pioneers in safe and effective gene delivery

inferred← citeshttps://doi.org/10.1016/j.jddst.2024.106430openalex-snapshot

Development of a doxepin-loaded chitosan nanogel as an innovative nano platform for oral mucositis treatment

inferred← citeshttps://doi.org/10.1016/j.jfoodeng.2022.111132openalex-snapshot

A Kinetic Model of Acrylamide Formation inside of the Heat Boundary Layer

inferred← citeshttps://doi.org/10.1016/j.jhazmat.2021.126934openalex-snapshot

A concise detection strategy of Staphylococcus aureus using N-Succinyl-Chitosan-dopped bacteria-imprinted composite film and AIE fluorescence sensor

inferred← citeshttps://doi.org/10.1016/j.jhin.2025.04.033openalex-snapshot

Exploring the bactericidal efficacy of a new potassium monopersulphate-based disinfectant

inferred← citeshttps://doi.org/10.1016/j.jics.2025.102201openalex-snapshot

Green synthesis of chitosan–piperine gold nanoparticles with synergistic antibacterial activity for wound-healing applications

inferred← citeshttps://doi.org/10.1016/j.jiec.2024.11.027openalex-snapshot

Environmental toxicity and biodegradation of chitosan derivatives: A comprehensive review

inferred← citeshttps://doi.org/10.1016/j.jobcr.2025.10.004openalex-snapshot

A novel approach utilizing Β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin- loaded chitosan microspheres for periodontal regeneration in two-wall intra bony defects

inferred← citeshttps://doi.org/10.1016/j.lfs.2020.118847openalex-snapshot

RETRACTED: Codelivery of STAT3 and PD-L1 siRNA by hyaluronate-TAT trimethyl/thiolated chitosan nanoparticles suppresses cancer progression in tumor-bearing mice

inferred← citeshttps://doi.org/10.1016/j.lfs.2022.121313openalex-snapshot

Apocynin and its chitosan nanoparticles attenuated cisplatin-induced multiorgan failure: Synthesis, characterization, and biological evaluation

inferred← citeshttps://doi.org/10.1016/j.mtchem.2025.102676openalex-snapshot

A chitosan-based deep tumor-penetrating nano-photothermal agent for enhanced chemo-photothermal combination therapy

inferred← citeshttps://doi.org/10.1016/j.mtcomm.2025.112805openalex-snapshot

Enhancing the antimicrobial and anticancer capabilities of new salicyl-imine-chitosan hydrogels using ionic liquid brushes: Influence of anion metathesis

inferred← citeshttps://doi.org/10.1016/j.nanoso.2025.101565openalex-snapshot

Therapeutic potential of chitosan-encapsulated phytochemicals: A review on antimicrobial strategies against nosocomial infections

inferred← citeshttps://doi.org/10.1016/j.neuarg.2025.05.003openalex-snapshot

Recent advancements in nanoparticle drug delivery systems to cure neurological disorders via the nasal route

inferred← citeshttps://doi.org/10.1016/j.nexres.2025.100910openalex-snapshot

Recent progress and challenges in exosomes for advanced therapeutics applications: A comprehensive review

inferred← citeshttps://doi.org/10.1016/j.nxmate.2025.101559openalex-snapshot

Chitosan, conducting polymer, and metal oxide nanocomposites: Mechanistic insights and sustainable approaches for water treatment

inferred← citeshttps://doi.org/10.1016/j.nxnano.2026.100553openalex-snapshot

Chitosan nanoconjugates loaded with Sophora flavescens phytochemicals for enhanced antimicrobial and antibiofilm activity against nosocomial pathogens

inferred← citeshttps://doi.org/10.1016/j.plana.2026.100306openalex-snapshot

Enhanced delivery of essential oil biofungicides using chitosan nanoparticles: A review

inferred← citeshttps://doi.org/10.1016/j.pmatsci.2022.100999openalex-snapshot

From renewable biomass to nanomaterials: Does biomass origin matter?

inferred← citeshttps://doi.org/10.1016/j.polymer.2025.128382openalex-snapshot

Bioactive hybrid hydrogels reinforced with biomimetic nanocomposites and dual-biomolecular cross-linking for enhanced antibacterial and photothermal therapeutic effects

inferred← citeshttps://doi.org/10.1016/j.prenap.2025.100438openalex-snapshot

Synthesis of chitosan nanoparticles from cuttlebone of Sepia pharaonis (Ehrenberg, 1831) and its antimicrobial effects against oral pathogens

inferred← citeshttps://doi.org/10.1016/j.procbio.2021.11.025openalex-snapshot

Numerous nanoparticles as drug delivery system to control secondary immune response and promote spinal cord injury regeneration

inferred← citeshttps://doi.org/10.1016/j.procbio.2023.04.008openalex-snapshot

Laboratory to industrial scale synthesis of chitosan-based nanomaterials: A review

inferred← citeshttps://doi.org/10.1016/j.reactfunctpolym.2023.105567openalex-snapshot

Binding selectivity of N-alkylaminated modified chitosan nanoparticles produce a synergistic antibacterial effect against gram-negative strains

inferred← citeshttps://doi.org/10.1016/j.rineng.2025.104076openalex-snapshot

Eco-friendly synthesis of chitosan NPs from Fioria vitifolia (L.) L: Potential to antibacterial, antioxidant, cytotoxicity properties of HepG2 cells and their evaluation of safety on Zebrafish embryo

inferred← citeshttps://doi.org/10.1016/j.scitotenv.2024.171862openalex-snapshot

Agriculture and environmental management through nanotechnology: Eco-friendly nanomaterial synthesis for soil-plant systems, food safety, and sustainability

inferred← citeshttps://doi.org/10.1016/j.susmat.2025.e01524openalex-snapshot

Chitosan-based bionanocomposites for elimination of hazardous environmental contaminants and food packaging: A comprehensive review

inferred← citeshttps://doi.org/10.1016/j.talanta.2024.127330openalex-snapshot

Dual-mode colorimetric-fluorescence biosensor for endotoxin detection based on CS@Fe,Cu/CDs-MnO2 nanomaterials

inferred← citeshttps://doi.org/10.1016/j.theriogenology.2024.08.016openalex-snapshot

Hydroxyapatite nanoparticle improves ovine oocyte developmental capacity by alleviating oxidative stress in response to vitrification stimuli

inferred← citeshttps://doi.org/10.1016/j.toxrep.2023.06.012openalex-snapshot

Chitosan nanoparticle toxicity: A comprehensive literature review of in vivo and in vitro assessments for medical applications

inferred← citeshttps://doi.org/10.1021/acsami.3c11756openalex-snapshot

Chitosan-Alginate Polymeric Nanocomposites as a Potential Oral Vaccine Carrier Against Influenza Virus Infection

inferred← citeshttps://doi.org/10.1021/acsami.4c18094openalex-snapshot

Formulation of Ethyl Cellulose Nanoparticles Encapsulated with Osthole Provides Long-Lasting Plant Protection against a Major Pest Mite

inferred← citeshttps://doi.org/10.1021/acsbiomaterials.3c01090openalex-snapshot

Design and Fabrication of Environmentally Responsive Nanoparticles for the Diagnosis and Treatment of Atherosclerosis

inferred← citeshttps://doi.org/10.1021/acsbiomaterials.9b01820openalex-snapshot

Glycogen Synthase Kinase 3β Inhibitor Delivered by Chitosan Nanocapsules Promotes Safe, Fast, and Efficient Activation of Wnt Signaling In Vivo

inferred← citeshttps://doi.org/10.1021/acsnano.4c08072openalex-snapshot

A Multicomponent Microneedle Patch for the Delivery of Meloxicam for Veterinary Applications

inferred← citeshttps://doi.org/10.1038/s41598-023-40653-0openalex-snapshot

Ceftazidime-assisted synthesis of ultrasmall chitosan nanoparticles for biofilm penetration and eradication of Pseudomonas aeruginosa

inferred← citeshttps://doi.org/10.1038/s41598-025-17781-wopenalex-snapshot

Batch experimental studies on Acid Blue 25 dye removal by synthesized chitosan containing sodium alginate and halloysite nanotubes

inferred← citeshttps://doi.org/10.1038/s41598-025-25252-5openalex-snapshot

Exploring the role of chitosan and curcumin-loaded chitosan nanoparticles against chronic toxoplasma infection in experimental mice

inferred← citeshttps://doi.org/10.1038/s41698-025-00869-xopenalex-snapshot

Design of self-assembled micelles based on natural dual-targeting strategies and evaluation of their anti-liver cancer effects as drug delivery systems

inferred← citeshttps://doi.org/10.1039/d0bm01254hopenalex-snapshot

Poly-γ-glutamic acid derived nanopolyplexes for up-regulation of gamma-glutamyl transpeptidase to augment tumor active targeting and enhance synergistic antitumor therapy by regulating intracellular redox homeostasis

inferred← citeshttps://doi.org/10.1039/d0nh00696copenalex-snapshot

Chitin and chitosan on the nanoscale

inferred← citeshttps://doi.org/10.1039/d2ra02717hopenalex-snapshot

Vanillin-crosslinked chitosan/ZnO nanocomposites as a drug delivery system for 5-fluorouracil: study on the release behavior via mesoporous ZrO 2 –Co 3 O 4 nanoparticles modified sensor and antitumor activity

inferred← citeshttps://doi.org/10.1039/d3fb00098bopenalex-snapshot

A chitosan-based biopolymer as an encapsulating nanomaterial for enhancing the antifungal and aflatoxin B 1 inhibitory efficacy of Zanthoxylum alatum (Roxb) essential oil and elucidation of the mode of action

inferred← citeshttps://doi.org/10.1039/d4ra00371copenalex-snapshot

Biological activity of lyophilized chitosan scaffolds with inclusion of chitosan and zinc oxide nanoparticles

inferred← citeshttps://doi.org/10.1039/d4ra00410hopenalex-snapshot

Nanogel-based composites for bacterial antibiofilm activity: advances, challenges, and prospects

inferred← citeshttps://doi.org/10.1039/d5ra09767copenalex-snapshot

Smart microdevices for biomedical drug delivery: endogenous stimuli as the key to safer therapeutics

inferred← citeshttps://doi.org/10.1051/epjconf/202534304010openalex-snapshot

A Review: Chitosan nanoparticles and its biological application

inferred← citeshttps://doi.org/10.1063/5.0223937openalex-snapshot

Designing polysaccharide materials for tissue repair and regeneration

inferred← citeshttps://doi.org/10.1063/5.0228274openalex-snapshot

Phyto-nanotechnology for the treatment of diabetes

inferred← citeshttps://doi.org/10.1080/02652048.2025.2507638openalex-snapshot

The pH-controlled release properties of chitosan–gold nanoparticles encapsulated nobiletin to induce apoptosis through PI3K/AKT/mTOR signalling pathway on gastric cancer cell lines

showing the first 200 of 358

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