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ACAT1/SOAT1 Blockade Suppresses LPS-Mediated Neuroinflammation by Modulating the Fate of Toll-like Receptor 4 in Microglia

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/glia.20467openalex-snapshot

Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

inferredcites →https://doi.org/10.1007/s00018-020-03656-yopenalex-snapshot

TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling

inferredcites →https://doi.org/10.1016/j.atherosclerosis.2006.05.048openalex-snapshot

A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels

inferredcites →https://doi.org/10.1016/j.bbamem.2015.03.014openalex-snapshot

Role of lipid microdomains in TLR-mediated signalling

inferredcites →https://doi.org/10.1016/j.cellimm.2012.06.001openalex-snapshot

N9 microglial cells polarized by LPS and IL4 show differential responses to secondary environmental stimuli

inferredcites →https://doi.org/10.1016/j.celrep.2017.12.066openalex-snapshot

Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models

inferredcites →https://doi.org/10.1016/j.jsbmb.2014.09.008openalex-snapshot

Acyl-CoA:cholesterol acyltransferases (ACATs/SOATs): Enzymes with multiple sterols as substrates and as activators

inferredcites →https://doi.org/10.1016/j.micinf.2008.11.001openalex-snapshot

Chlamydia pneumoniae induces macrophage-derived foam cell formation by up-regulating acyl-coenzyme A: cholesterol acyltransferase 1

inferredcites →https://doi.org/10.1016/j.nbd.2009.10.006openalex-snapshot

Inflammation, microglia, and alzheimer's disease

inferredcites →https://doi.org/10.1016/j.neurobiolaging.2015.04.002openalex-snapshot

Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage

inferredcites →https://doi.org/10.1016/j.neuron.2004.08.043openalex-snapshot

The ACAT Inhibitor CP-113,818 Markedly Reduces Amyloid Pathology in a Mouse Model of Alzheimer's Disease

inferredcites →https://doi.org/10.1016/j.neuron.2015.11.013openalex-snapshot

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

inferredcites →https://doi.org/10.1016/j.neuron.2019.12.007openalex-snapshot

TREM2 Regulates Microglial Cholesterol Metabolism Upon Chronic Phagocytic Challenge

inferredcites →https://doi.org/10.1016/j.npep.2019.101938openalex-snapshot

Apelin-13 regulates LPS-induced N9 microglia polarization involving STAT3 signaling pathway

inferredcites →https://doi.org/10.1016/j.stem.2018.12.013openalex-snapshot

Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

inferredcites →https://doi.org/10.1016/s0021-9258(19)36846-2openalex-snapshot

Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells.

inferredcites →https://doi.org/10.1016/s0197-4580(00)00124-xopenalex-snapshot

Inflammation and Alzheimer's disease

inferredcites →https://doi.org/10.1016/s1474-4422(15)70016-5openalex-snapshot

Neuroinflammation in Alzheimer's disease

inferredcites →https://doi.org/10.1023/a:1020568013953openalex-snapshot

Intracerebral Production of Tumor Necrosis Factor-α, a Local Neuroprotective Agent, in Alzheimer Disease and Vascular Dementia

inferredcites →https://doi.org/10.1038/cddis.2014.535openalex-snapshot

TLR4-mediated inflammation promotes foam cell formation of vascular smooth muscle cell by upregulating ACAT1 expression

inferredcites →https://doi.org/10.1038/mt.2013.118openalex-snapshot

Acat1 Knockdown Gene Therapy Decreases Amyloid-β in a Mouse Model of Alzheimer's Disease

inferredcites →https://doi.org/10.1038/nature17412openalex-snapshot

Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism

inferredcites →https://doi.org/10.1038/ncb1001-905openalex-snapshot

Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid β-peptide

inferredcites →https://doi.org/10.1038/nrn3012openalex-snapshot

Linking lipids to Alzheimer's disease: cholesterol and beyond

inferredcites →https://doi.org/10.1038/s41580-019-0190-7openalex-snapshot

Mechanisms and regulation of cholesterol homeostasis

inferredcites →https://doi.org/10.1038/s41598-019-42286-8openalex-snapshot

Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice

inferredcites →https://doi.org/10.1038/sj.emboj.7600991openalex-snapshot

Endocytic pathways regulate Toll‐like receptor 4 signaling and link innate and adaptive immunity

inferredcites →https://doi.org/10.1042/bj20050428openalex-snapshot

Investigating the allosterism of acyl-CoA:cholesterol acyltransferase (ACAT) by using various sterols: in vitro and intact cell studies

inferredcites →https://doi.org/10.1073/pnas.0807450105openalex-snapshot

Transport of LDL-derived cholesterol from the NPC1 compartment to the ER involves the trans-Golgi network and the SNARE protein complex

inferredcites →https://doi.org/10.1073/pnas.0913828107openalex-snapshot

ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD

inferredcites →https://doi.org/10.1073/pnas.2201646119openalex-snapshot

Acat1/Soat1 knockout extends the mutant Npc1 mouse lifespan and ameliorates functional deficiencies in multiple organelles of mutant cells

inferredcites →https://doi.org/10.1073/pnas.95.22.13018openalex-snapshot

Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis

inferredcites →https://doi.org/10.1074/jbc.273.41.26747openalex-snapshot

Identification of a Form of Acyl-CoA:Cholesterol Acyltransferase Specific to Liver and Intestine in Nonhuman Primates

inferredcites →https://doi.org/10.1074/jbc.273.41.26765openalex-snapshot

Characterization of Two Human Genes Encoding Acyl Coenzyme A:Cholesterol Acyltransferase-related Enzymes

inferredcites →https://doi.org/10.1074/jbc.m111.274142openalex-snapshot

Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease

inferredcites →https://doi.org/10.1074/jbc.m116.713818openalex-snapshot

Myeloid Acyl-CoA:Cholesterol Acyltransferase 1 Deficiency Reduces Lesion Macrophage Content and Suppresses Atherosclerosis Progression

inferredcites →https://doi.org/10.1074/jbc.m207873200openalex-snapshot

Lipopolysaccharide Rapidly Traffics to and from the Golgi Apparatus with the Toll-like Receptor 4-MD-2-CD14 Complex in a Process That Is Distinct from the Initiation of Signal Transduction

inferredcites →https://doi.org/10.1074/jbc.ra119.010564openalex-snapshot

Myeloid Acat1/Soat1 KO attenuates pro-inflammatory responses in macrophages and protects against atherosclerosis in a model of advanced lesions

inferredcites →https://doi.org/10.1111/j.1600-065x.2012.01098.xopenalex-snapshot

Regulation of NF‐κB by ubiquitination and degradation of the IκBs

inferredcites →https://doi.org/10.1111/tra.12451openalex-snapshot

Vps35‐dependent recycling of Trem2 regulates microglial function

inferredcites →https://doi.org/10.1152/ajpendo.00174.2017openalex-snapshot

Myeloid-specificAcat1ablation attenuates inflammatory responses in macrophages, improves insulin sensitivity, and suppresses diet-induced obesity

inferredcites →https://doi.org/10.1152/ajpendo.90926.2008openalex-snapshot

Acyl-coenzyme A:cholesterol acyltransferases

inferredcites →https://doi.org/10.1161/01.atv.0000120374.59826.1bopenalex-snapshot

Brain Cholesterol: Long Secret Life Behind a Barrier

inferredcites →https://doi.org/10.1186/1476-511x-12-68openalex-snapshot

Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer’s disease

inferredcites →https://doi.org/10.1194/jlr.m800484-jlr200openalex-snapshot

TNF-alpha stimulates the ACAT1 expression in differentiating monocytes to promote the CE-laden cell formation

inferredcites →https://doi.org/10.1194/jlr.m900288-jlr200openalex-snapshot

Cholesterol loading in macrophages stimulates formation of ER-derived vesicles with elevated ACAT1 activity

inferredcites →https://doi.org/10.1194/jlr.r075630openalex-snapshot

Cellular cholesterol homeostasis and Alzheimer's disease

inferredcites →https://doi.org/10.1194/jlr.r400004-jlr200openalex-snapshot

Thematic review series: Brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal

inferredcites →https://doi.org/10.1242/jcs.01270openalex-snapshot

Lateral diffusion of Toll-like receptors reveals that they are transiently confined within lipid rafts on the plasma membrane

inferredcites →https://doi.org/10.1523/jneurosci.2567-14.2014openalex-snapshot

Inhibiting ACAT1/SOAT1 in Microglia Stimulates Autophagy-Mediated Lysosomal Proteolysis and Increases Aβ1–42 Clearance

inferredcites →https://doi.org/10.3389/fnins.2020.602508openalex-snapshot

TLR4 Targeting as a Promising Therapeutic Strategy for Alzheimer Disease Treatment

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4760648openalex-extracted

Cholesterol Metabolism-Mediated Immune Regulation and Cancer Immunotherapy

inferred← citeshttps://doi.org/10.1002/alz.70879openalex-snapshot

Inhibition of Acyl‐CoenzymeA: Cholesterol Acyltransferase 1 promotes shedding of soluble triggering receptor on myeloid cells 2 (TREM2) and low‐density lipoprotein receptor 1 (LRP1)‐dependent phagocytosis of amyloid beta protein in microglia

inferred← citeshttps://doi.org/10.1007/s11010-025-05246-7openalex-snapshot

Macrophage polarization-related gene SOAT1 is involved in inflammatory response and functional recovery after spinal cord injury

inferred← citeshttps://doi.org/10.1021/acs.analchem.6c04131openalex-snapshot

A Pseudo-Targeted Method for Global Profiling of Cholesteryl Esters by Liquid Chromatography-Zeno High-Resolution Multiple Reaction Monitoring Mass Spectrometry

inferred← citeshttps://doi.org/10.1038/s44324-024-00046-xopenalex-snapshot

Myeloid ACAT1/SOAT1: a novel regulator of dyslipidemia and retinal neovascularization

inferred← citeshttps://doi.org/10.1101/2023.05.02.539100openalex-snapshot

Stealth liposomes encapsulating a potent ACAT1/SOAT1 inhibitor F12511: pharmacokinetic, biodistribution and toxicity studies in wild-type mice, and efficacy studies in triple transgenic Alzheimer Disease mice

inferred← citeshttps://doi.org/10.1101/2024.10.24.620063openalex-snapshot

Inhibiting the cholesterol storage enzyme ACAT1/SOAT1 in aging Apolipoprotein E4 mice alter their brains inflammatory profiles

inferred← citeshttps://doi.org/10.1101/2025.06.12.659424openalex-snapshot

Inhibition of Acyl-CoA: Cholesterol Acyltransferase 1 Promotes Shedding of Soluble TREM2 and LRP1-Dependent Phagocytosis of Amyloid β Protein in Microglia

inferred← citeshttps://doi.org/10.1111/jgh.70611openalex-snapshot

Macrophage ACAT1 Aggravates Alcohol‐Associated Liver Disease by Inducing Mitochondrial Damage and NLRP3 Activation

inferred← citeshttps://doi.org/10.1186/s12944-025-02633-3openalex-snapshot

Lipid droplet accumulation in microglia and their potential roles

inferred← citeshttps://doi.org/10.12677/acrvm.2023.112002openalex-snapshot

Study on the Relationship between the Increased Serum TLR4 Level and TLR4 Gene Mutation and Clinic in Patients with Coronary Heart Disease

inferred← citeshttps://doi.org/10.3390/biom14101301openalex-snapshot

Inhibiting the Cholesterol Storage Enzyme ACAT1/SOAT1 in Myelin Debris-Treated Microglial Cell Lines Activates the Gene Expression of Cholesterol Efflux Transporter ABCA1

inferred← citeshttps://doi.org/10.3390/biom16060838openalex-snapshot

A Subset of Caveolin-1 Interacts with a Fraction of Acyl-CoA:Cholesterol Acyltransferase 1 (ACAT1/SOAT1) at an Endoplasmic Reticulum Subdomain to Attenuate Cholesteryl Ester Biosynthesis

inferred← citeshttps://doi.org/10.3390/ijms24065525openalex-snapshot

Acute ACAT1/SOAT1 Blockade Increases MAM Cholesterol and Strengthens ER-Mitochondria Connectivity

inferred← citeshttps://doi.org/10.3390/ijms241311013openalex-snapshot

Stealth Liposomes Encapsulating a Potent ACAT1/SOAT1 Inhibitor F12511: Pharmacokinetic, Biodistribution, and Toxicity Studies in Wild-Type Mice and Efficacy Studies in Triple Transgenic Alzheimer’s Disease Mice

inferred← citeshttps://doi.org/10.3390/ijms241713223openalex-snapshot

Uncovering the Lipid Web: Discovering the Multifaceted Roles of Lipids in Human Diseases and Therapeutic Opportunities

inferred← citeshttps://doi.org/10.3390/ijms25179151openalex-snapshot

Characterization of Stealth Liposome-Based Nanoparticles Encapsulating the ACAT1/SOAT1 Inhibitor F26: Efficacy and Toxicity Studies In Vitro and in Wild-Type Mice

inferred← citeshttps://doi.org/10.3390/ijms252413690openalex-snapshot

Inhibiting the Cholesterol Storage Enzyme ACAT1/SOAT1 in Aging Apolipoprotein E4 Mice Alters Their Brains’ Inflammatory Profiles

inferred← citeshttps://doi.org/10.3390/molecules29204821openalex-snapshot

Protective Role of Eicosapentaenoic and Docosahexaenoic and Their N-Ethanolamide Derivatives in Olfactory Glial Cells Affected by Lipopolysaccharide-Induced Neuroinflammation

inferred← citeshttps://doi.org/10.4103/nrr.nrr-d-24-01574openalex-snapshot

The roles of microglia and astrocytes in inflammasomes and neurological disorders

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