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Preclinical Characterization of the Distribution, Catabolism, and Elimination of a Polatuzumab Vedotin-Piiq (POLIVY®) Antibody–Drug Conjugate in Sprague Dawley Rats

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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/jcph.116openalex-snapshot
CYP3A-Mediated Drug-Drug Interaction Potential and Excretion of Brentuximab Vedotin, an Antibody−Drug Conjugate, in Patients With CD30-Positive Hematologic Malignancies
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Current ADC Linker Chemistry
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Peripheral neuropathy with microtubule inhibitor containing antibody drug conjugates: Challenges and perspectives in translatability from nonclinical toxicology studies to the clinic
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Antibody–drug conjugates for cancer therapy
inferredcites →https://doi.org/10.1021/bc200212aopenalex-snapshot
Impact of Drug Conjugation on Pharmacokinetics and Tissue Distribution of Anti-STEAP1 Antibody–Drug Conjugates in Rats
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Development of potent monoclonal antibody auristatin conjugates for cancer therapy
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Production, characterization, andin vivohalf-life extension of polymeric IgA molecules in mice
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Evaluation and use of an anti‐cynomolgus monkey CD79b surrogate antibody–drug conjugate to enable clinical development of polatuzumab vedotin
inferredcites →https://doi.org/10.1158/0008-5472.can-08-2250openalex-snapshot
Antibody-Drug Conjugates for the Treatment of Non–Hodgkin's Lymphoma: Target and Linker-Drug Selection
inferredcites →https://doi.org/10.1182/blood-2009-02-205500openalex-snapshot
Therapeutic potential of an anti-CD79b antibody–drug conjugate, anti–CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma
inferredcites →https://doi.org/10.1208/s12248-012-9386-xopenalex-snapshot
ADME of Antibody–Maytansinoid Conjugates
inferredcites →https://doi.org/10.1517/14712598.2011.604630openalex-snapshot
Gemtuzumab ozogamicin in non-acute promyelocytic acute myeloid leukemia
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The return of gemtuzumab ozogamicin: a humanized anti-CD33 monoclonal antibody–drug conjugate for the treatment of newly diagnosed acute myeloid leukemia
inferredcites →https://doi.org/10.2174/138920012802138598openalex-snapshot
Catabolic Fate and Pharmacokinetic Characterization of Trastuzumab Emtansine (T-DM1): an Emphasis on Preclinical and Clinical Catabolism
inferredcites →https://doi.org/10.2967/jnumed.118.207753openalex-snapshot
Dual-Isotope Cryoimaging Quantitative Autoradiography: Investigating Antibody–Drug Conjugate Distribution and Payload Delivery Through Imaging
inferredcites →https://doi.org/10.2967/jnumed.118.213389openalex-snapshot
“Standing by” for Bystander Effects: Dual-Isotope Imaging of Antibody–Drug Conjugate and Payload Distribution
inferredcites →https://doi.org/10.3390/ijms17040561openalex-snapshot
Linkers Having a Crucial Role in Antibody–Drug Conjugates
inferredcites →https://doi.org/10.3390/ph13030040openalex-snapshot
2019 FDA TIDES (Peptides and Oligonucleotides) Harvest
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IL-12: monoclonal antibodies specific for the 40-kDa subunit block receptor binding and biologic activity on activated human lymphoblasts
inferredcites →https://doi.org/10.4161/mabs.3.1.13799openalex-snapshot
Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Linker Design for the Antibody Drug Conjugates: A Comprehensive Review
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Development of Antibody-Drug Conjugates
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Considerations for Antibody-Drug Conjugate Design: Stability and Formulation
inferred← citeshttps://doi.org/10.1007/s10928-025-09978-3openalex-snapshot
A translational physiologically-based pharmacokinetic model for MMAE-based antibody-drug conjugates
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Development of a Physiologically-Based Pharmacokinetic Model for Whole-Body Disposition of MMAE Containing Antibody-Drug Conjugate in Mice
inferred← citeshttps://doi.org/10.1016/j.addr.2024.115193openalex-snapshot
Clinical pharmacology strategies to accelerate the development of polatuzumab vedotin and summary of key findings
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Emerging trends and therapeutic applications of monoclonal antibodies
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Antibody-Drug Conjugates: A promising breakthrough in cancer therapy
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Central nervous system relapse after combination therapy including polatuzumab vedotin in patients with diffuse large B-cell lymphoma
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inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c01861openalex-snapshot
Small Molecule-Drug Conjugates: An Emerging Drug Design Strategy for Targeted Therapeutics
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On Demand Bioorthogonal Switching of an Antibody-Conjugated SPECT Probe to a Cytotoxic Payload: from Imaging to Therapy
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inferred← citeshttps://doi.org/10.1080/00498254.2024.2345849openalex-snapshot
Monomethyl auristatin E (MMAE), a payload for multiple antibody drug conjugates (ADCs), demonstrates differential red blood cell partitioning across human and animal species
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inferred← citeshttps://doi.org/10.1158/1535-7163.mct-22-0440openalex-snapshot
Payload-Binding Fab Fragments Increase the Therapeutic Index of MMAE Antibody–Drug Conjugates
inferred← citeshttps://doi.org/10.1186/s11671-025-04303-wopenalex-snapshot
Emerging trends in synthesis, characterization, and mechanism of action of antibody-drug and antibody-nanoparticle conjugates
inferred← citeshttps://doi.org/10.21037/tbcr-21-22openalex-snapshot
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Impact of body image, social support, and psychological well-being on gender identity
inferred← citeshttps://doi.org/10.3389/fphar.2024.1405023openalex-snapshot
A real-world pharmacovigilance study of polatuzumab vedotin based on the FDA adverse event reporting system (FAERS)
inferred← citeshttps://doi.org/10.3390/biology10080758openalex-snapshot
Purification and In Vitro Evaluation of an Anti-HER2 Affibody-Monomethyl Auristatin E Conjugate in HER2-Positive Cancer Cells
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Introduction of Carbonyl Groups into Antibodies
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