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Endolichenic Fungi: A Promising Medicinal Microbial Resource to Discover Bioactive Natural Molecules—An Update

https://doi.org/10.3390/jof10020099

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/cbdv.201800371openalex-snapshot

Active Metabolites from Endolichenic Fungus Talaromyces sp.

inferredcites →https://doi.org/10.1002/jccs.201800220openalex-snapshot

New phomalone derivatives from the endolichenic fungus Cochliobolus kusanoi in Ny‐Alesund Arctic

inferredcites →https://doi.org/10.1002/jccs.202000274openalex-snapshot

A new alkanol from the endolichenic fungus Daldinia childiae

inferredcites →https://doi.org/10.1002/ps.4717openalex-snapshot

Nematicidal activity of grammicin produced by Xylaria grammica KCTC 13121BP against Meloidogyne incognita

inferredcites →https://doi.org/10.1007/978-1-4757-4439-2openalex-snapshot

Advances in Microbial Toxin Research and Its Biotechnological Exploitation

inferredcites →https://doi.org/10.1007/978-3-319-13374-4openalex-snapshot

Lichen Secondary Metabolites

inferredcites →https://doi.org/10.1007/978-3-642-85243-5openalex-snapshot

Identification of Lichen Substances

inferredcites →https://doi.org/10.1007/s10600-018-2435-7openalex-snapshot

Phytotoxic Secondary Metabolites from the Endolichenic Fungus Myxotrichum sp.

inferredcites →https://doi.org/10.1007/s11101-010-9201-1openalex-snapshot

Bioactive lichen metabolites: alpine habitats as an untapped source

inferredcites →https://doi.org/10.1007/s11101-016-9473-1openalex-snapshot

Endolichenic fungi: a new source of rich bioactive secondary metabolites on the horizon

inferredcites →https://doi.org/10.1007/s11274-014-1695-zopenalex-snapshot

Biodiversity and physiological characteristics of Antarctic and Arctic lichens-associated bacteria

inferredcites →https://doi.org/10.1007/s12088-021-00994-8openalex-snapshot

Cytotoxic Bioxanthracene and Macrocyclic Polyester from Endolichenic Fungus Talaromyces pinophilus: In-Vitro and In-Silico Analysis

inferredcites →https://doi.org/10.1007/s13205-020-02213-5openalex-snapshot

Biodiscovery of antibacterial constituents from the endolichenic fungi isolated from Parmotrema rampoddense

inferredcites →https://doi.org/10.1007/s13659-021-00299-9openalex-snapshot

Structurally Diverse Sesquiterpenoids with Anti-neuroinflammatory Activity from the Endolichenic Fungus Cryptomarasmius aucubae

inferredcites →https://doi.org/10.1016/b978-0-444-63602-7.00011-4openalex-snapshot

Endolichenic Fungi

inferredcites →https://doi.org/10.1016/j.bmcl.2016.03.115openalex-snapshot

Diketopiperazines from Costa Rican endolichenic fungus Colpoma sp. CR1465A

inferredcites →https://doi.org/10.1016/j.fgb.2005.03.006openalex-snapshot

Breeding systems in the lichen-forming fungal genus Cladonia

inferredcites →https://doi.org/10.1016/j.heliyon.2023.e19185openalex-snapshot

A fatty acid-rich fraction of an endolichenic fungus Phoma sp. suppresses immune checkpoint markers via AhR/ARNT and ESR1

inferredcites →https://doi.org/10.1016/j.phytochem.2012.03.002openalex-snapshot

Guanacastane-type diterpenoids from Coprinus radians

inferredcites →https://doi.org/10.1016/j.phytochem.2018.10.031openalex-snapshot

Funiculosone, a substituted dihydroxanthene-1,9-dione with two of its analogues produced by an endolichenic fungus Talaromyces funiculosus and their antimicrobial activity

inferredcites →https://doi.org/10.1016/j.phytochem.2019.112191openalex-snapshot

Polyketides from the endolichenic fungus Eupenicillium javanicum and their anti-inflammatory activities

inferredcites →https://doi.org/10.1016/j.phytol.2015.02.008openalex-snapshot

α-Pyrone derivatives from the endolichenic fungus Nectria sp.

inferredcites →https://doi.org/10.1016/j.sajb.2019.12.008openalex-snapshot

Endolichenic fungi: A hidden source of bioactive metabolites

inferredcites →https://doi.org/10.1016/j.steroids.2015.08.004openalex-snapshot

Nodulisporisteroids C–L, new 4-methyl-progesteroid derivatives from Nodulisporium sp.

inferredcites →https://doi.org/10.1016/j.tetlet.2017.03.052openalex-snapshot

Secondary metabolites of the lichen-associated fungus Apiospora montagnei

inferredcites →https://doi.org/10.1016/j.tetlet.2020.151732openalex-snapshot

(±)-Ulodione A, a pair of unprecedented cyclopentanones from Ulospora bilgramii

inferredcites →https://doi.org/10.1017/s1473550403001216openalex-snapshot

The potential of the lichen symbiosis to cope with extreme conditions of outer space – I. Influence of UV radiation and space vacuum on the vitality of lichen symbiosis and germination capacity

inferredcites →https://doi.org/10.1021/acs.jafc.1c01148openalex-snapshot

Alkylated Salicylaldehydes and Prenylated Indole Alkaloids from the Endolichenic Fungus Aspergillus chevalieri and Their Bioactivities

inferredcites →https://doi.org/10.1021/acs.jafc.2c08710openalex-snapshot

Ethylidene-Tethered Chromene–Pyrone Hybrids as Potential Plant-Growth Regulators from an Endolichenic Phaeosphaeria Species

inferredcites →https://doi.org/10.1021/acs.jnatprod.0c00024openalex-snapshot

Talarolactone A, an Isocoumarin Derivative Fused with Dihydrothiophene with Selective Antimigratory Activity from the Endolichenic Fungus Talaromyces sp.

inferredcites →https://doi.org/10.1021/acs.jnatprod.0c00108openalex-snapshot

Cytotoxic Heptaketides from the Endolichenic Fungus Ulospora bilgramii

inferredcites →https://doi.org/10.1021/acs.jnatprod.0c01305openalex-snapshot

3-Hydroxy-4-methyldecanoic Acid-Containing Cyclotetradepsipeptides from an Endolichenic Beauveria sp.

inferredcites →https://doi.org/10.1021/acs.jnatprod.1c01108openalex-snapshot

Molecular Networking-Based Screening Led to the Discovery of a Cyclic Heptadepsipeptide from an Endolichenic Xylaria sp.

inferredcites →https://doi.org/10.1021/acs.jnatprod.2c00881openalex-snapshot

Eremoxylarins D–J, Antibacterial Eremophilane Sesquiterpenes Discovered from an Endolichenic Strain of Xylaria hypoxylon

inferredcites →https://doi.org/10.1021/acs.jnatprod.2c00991openalex-snapshot

A Modular Strategy for the Synthesis of Dothideopyrones E and F, Secondary Metabolites from an Endolichenic Fungus

inferredcites →https://doi.org/10.1021/acs.jnatprod.3c00468openalex-snapshot

Discovery of Naphthol Tetramers from Endolichenic Fungus Daldinia childiae 047219 Based on MS/MS Molecular Networking

inferredcites →https://doi.org/10.1021/acs.jnatprod.5b00986openalex-snapshot

Oxaspirol B with p97 Inhibitory Activity and Other Oxaspirols from Lecythophora sp. FL1375 and FL1031, Endolichenic Fungi Inhabiting Parmotrema tinctorum and Cladonia evansii

inferredcites →https://doi.org/10.1021/acs.jnatprod.5b00998openalex-snapshot

Heptaketides from an Endolichenic Fungus Biatriospora sp. and Their Antifungal Activity

inferredcites →https://doi.org/10.1021/acs.jnatprod.6b00197openalex-snapshot

p-Terphenyl Derivatives from the Endolichenic Fungus Floricola striata

inferredcites →https://doi.org/10.1021/acs.jnatprod.7b01022openalex-snapshot

Bioactive α-Pyrone Derivatives from the Endolichenic Fungus Dothideomycetes sp. EL003334

inferredcites →https://doi.org/10.1021/acs.jnatprod.8b00362openalex-snapshot

Cytotoxic p -Terphenyls from the Endolichenic Fungus Floricola striata

inferredcites →https://doi.org/10.1021/acs.jnatprod.8b01066openalex-snapshot

Asperunguisins A–F, Cytotoxic Asperane Sesterterpenoids from the Endolichenic Fungus Aspergillus unguis

inferredcites →https://doi.org/10.1021/acs.orglett.1c02730openalex-snapshot

Xylarins A–D, Two Pairs of Diastereoisomeric Isoindoline Alkaloids from the Endolichenic Fungus Xylaria sp.

inferredcites →https://doi.org/10.1021/acs.orglett.3c02583openalex-snapshot

Daldipyrenones A–C: Caged [6,6,6,6,6] Polyketides Derived from an Endolichenic Fungus Daldinia pyrenaica 047188

inferredcites →https://doi.org/10.1021/acs.orglett.9b00385openalex-snapshot

Isocoumarindole A, a Chlorinated Isocoumarin and Indole Alkaloid Hybrid Metabolite from an Endolichenic Fungus Aspergillus sp.

inferredcites →https://doi.org/10.1021/acsomega.3c00876openalex-snapshot

Phthalides Isolated from the Endolichenic Arthrinium sp. EL000127 Exhibits Antiangiogenic Activity

inferredcites →https://doi.org/10.1021/np070466wopenalex-snapshot

Heptaketides from Corynespora sp. Inhabiting the Cavern Beard Lichen, Usnea cavernosa: First Report of Metabolites of an Endolichenic Fungus

inferredcites →https://doi.org/10.1021/np100909yopenalex-snapshot

Isolation and Structural Elucidation of Proline-Containing Cyclopentapeptides from an Endolichenic Xylaria sp.

inferredcites →https://doi.org/10.1021/np500912topenalex-snapshot

Nodulisporiviridins A–H, Bioactive Viridins from Nodulisporium sp.

inferredcites →https://doi.org/10.1038/s41429-018-0058-7openalex-snapshot

Anti-inflammatory phomalichenones from an endolichenic fungus Phoma sp.

inferredcites →https://doi.org/10.1038/s41598-023-28773-zopenalex-snapshot

1′-O-methyl-averantin isolated from the endolichenic fungus Jackrogersella sp. EL001672 suppresses colorectal cancer stemness via sonic Hedgehog and Notch signaling

inferredcites →https://doi.org/10.1038/srep19350openalex-snapshot

Allelopathic Polyketides from an Endolichenic Fungus Myxotrichum SP. by Using OSMAC Strategy

inferredcites →https://doi.org/10.1038/srep33687openalex-snapshot

Quinone derivatives isolated from the endolichenic fungus Phialocephala fortinii are Mdr1 modulators that combat azole resistance in Candida albicans

inferredcites →https://doi.org/10.1039/a815653yopenalex-snapshot

The biosynthesis of steroids and triterpenoids

inferredcites →https://doi.org/10.1039/b100399mopenalex-snapshot

The biosynthesis of shikimate metabolites

inferredcites →https://doi.org/10.1039/b202267mopenalex-snapshot

Pigments of fungi (Macromycetes)

inferredcites →https://doi.org/10.1039/c0np00031kopenalex-snapshot

Structure, bioactivities, biosynthetic relationships and chemical synthesis of the spirodioxynaphthalenes

inferredcites →https://doi.org/10.1039/c3np70064jopenalex-snapshot

UV-protectant metabolites from lichens and their symbiotic partners

inferredcites →https://doi.org/10.1039/c8ra10329aopenalex-snapshot

Secondary metabolites from the endolichenic fungus Ophiosphaerella korrae

inferredcites →https://doi.org/10.1039/c9ra07917copenalex-snapshot

New spirobisnaphthalenes from an endolichenic fungus strain CGMCC 3.15192 and their anticancer effects through the P53–P21 pathway

inferredcites →https://doi.org/10.1039/d0ra02485fopenalex-snapshot

Sarcosenones A–C, highly oxygenated pimarane diterpenoids from an endolichenic fungus Sarcosomataceae sp.

inferredcites →https://doi.org/10.1039/d1ra03754dopenalex-snapshot

New phenol and chromone derivatives from the endolichenic fungus Daldinia species and their antiviral activities

inferredcites →https://doi.org/10.1055/a-0855-4051openalex-snapshot

Four New Cytotoxic Arborinane-Type Triterpenes from the Endolichenic Fungus Myrothecium inundatum

inferredcites →https://doi.org/10.1055/a-0957-3567openalex-snapshot

Cytotoxic Secondary Metabolites from the Endolichenic Fungus Hypoxylon fuscum

inferredcites →https://doi.org/10.1080/09168451.2019.1585746openalex-snapshot

Norlichexanthone produced by cultured endolichenic fungus induced from Pertusaria laeviganda and its antioxidant activity

inferredcites →https://doi.org/10.1080/10286020.2015.1040776openalex-snapshot

Nodulisporipyrones A–D, new bioactive α-pyrone derivatives fromNodulisporiumsp.

inferredcites →https://doi.org/10.1080/10286020.2015.1049162openalex-snapshot

Pericoterpenoid A, a new bioactive cadinane-type sesquiterpene from Periconia sp.

inferredcites →https://doi.org/10.1080/10286020.2017.1283311openalex-snapshot

Two new α-pyrone derivatives from an endolichenic fungus Tolypocladium sp.

inferredcites →https://doi.org/10.1080/14786419.2018.1544982openalex-snapshot

Antimicrobial secondary metabolites of an endolichenic Aspergillus niger isolated from lichen thallus of Parmotrema ravum

inferredcites →https://doi.org/10.1080/14786419.2019.1610758openalex-snapshot

Spororrminone A and 2-epi-spororrminone A, two new chromones from an endolichenic fungus Sporormiella irregularis

inferredcites →https://doi.org/10.1080/14786419.2021.2025366openalex-snapshot

Perylenequinone derivatives from the endolichenic fungus Phialocephala fortinii

inferredcites →https://doi.org/10.1080/14786419.2023.2209820openalex-snapshot

Three new isocoumarin analogues from an endolichenic fungus Aspergillus flavus CPCC 400810

inferredcites →https://doi.org/10.1111/ele.13930openalex-snapshot

Chemical properties of key metabolites determine the global distribution of lichens

inferredcites →https://doi.org/10.1126/science.aaf8287openalex-snapshot

Basidiomycete yeasts in the cortex of ascomycete macrolichens

inferredcites →https://doi.org/10.1155/2017/6961928openalex-snapshot

Polyketide-Terpene Hybrid Metabolites from an Endolichenic Fungus Pestalotiopsis sp.

inferredcites →https://doi.org/10.14233/ajchem.2021.23229openalex-snapshot

Identification of Novel Bioactive Compounds, Neurosporalol 1 and 2 from an Endolichenic Fungus, Neurospora ugadawe Inhabited in the Lichen Host, Graphis tsunodae Zahlbr. from Mangrove Ecosystem in Puttalam Lagoon, Sri Lanka

inferredcites →https://doi.org/10.1890/05-1459openalex-snapshot

DIVERSITY AND HOST RANGE OF FOLIAR FUNGAL ENDOPHYTES: ARE TROPICAL LEAVES BIODIVERSITY HOTSPOTS?

inferredcites →https://doi.org/10.25384/sage.c.5070071openalex-snapshot

A Novel Cytotoxic Compound From the Endolichenic Fungus, Xylaria psidii Inhabiting the Lichen, Amandinea medusulina

inferredcites →https://doi.org/10.3109/13880209.2011.633089openalex-snapshot

Biopharmaceutical potential of lichens

inferredcites →https://doi.org/10.3389/fphar.2022.986946openalex-snapshot

An acetonic extract and secondary metabolites from the endolichenic fungus Nemania sp. EL006872 exhibit immune checkpoint inhibitory activity in lung cancer cell

inferredcites →https://doi.org/10.3390/cancers15020489openalex-snapshot

Libertellenone T, a Novel Compound Isolated from Endolichenic Fungus, Induces G2/M Phase Arrest, Apoptosis, and Autophagy by Activating the ROS/JNK Pathway in Colorectal Cancer Cells

inferredcites →https://doi.org/10.3390/jof7040291openalex-snapshot

Lichens—A Potential Source for Nanoparticles Fabrication: A Review on Nanoparticles Biosynthesis and Their Prospective Applications

inferredcites →https://doi.org/10.3390/jof8101012openalex-snapshot

Access to Anti-Biofilm Compounds from Endolichenic Fungi Using a Bioguided Networking Screening

inferredcites →https://doi.org/10.3390/molecules21060764openalex-snapshot

A New Xanthone Glycoside from the Endolichenic Fungus Sporormiella irregularis

inferredcites →https://doi.org/10.3390/molecules23092393openalex-snapshot

Actinofuranones D-I from a Lichen-Associated Actinomycetes, Streptomyces gramineus, and Their Anti-Inflammatory Effects

inferredcites →https://doi.org/10.3390/molecules26154675openalex-snapshot

Nematicidal Activity of Grammicin Biosynthesis Pathway Intermediates in Xylaria grammica KCTC 13121BP against Meloidogyne incognita

inferredcites →https://doi.org/10.4038/jnsfsr.v43i3.7950openalex-snapshot

Two new bioactive polyketides from Curvularia trifolii, an endolichenic fungus isolated from Usnea sp., in Sri Lanka

inferredcites →https://doi.org/10.4038/jnsfsr.v48i2.10095openalex-snapshot

A secondary metabolite with in vitro radical scavenging activity from endolichenic fungus Daldinia eschscholzii found in lichen, Parmotrema sp. in Sri Lanka

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.3897/mycokeys.120.153906zenodo-depositor-declared

Additions of New Endolichenic Fungi to Herpotrichiellaceae (Chaetothyriales, Ascomycota) from northern Thailand

inferred← citeshttps://doi.org/10.1002/advs.77770openalex-snapshot

Beyond Conventional: A Review of Phytochemical‐Hydrogel Systems Enhanced by AI and 3D Printing for Chronic Wound Management

inferred← citeshttps://doi.org/10.1002/slct.202504515openalex-snapshot

A Comprehensive Review on Lichen‐Derived Bioactive Compounds: Integrating Synthesis, Applications, and Nanotechnology

inferred← citeshttps://doi.org/10.1007/978-3-032-01506-8_4openalex-snapshot

Diversity of Endophytic Fungi of Saxicolous Lichens

inferred← citeshttps://doi.org/10.1016/b978-0-443-49146-7.00008-xopenalex-snapshot

Bioactive lichen substances and their application

inferred← citeshttps://doi.org/10.1016/j.bcab.2026.103934openalex-snapshot

The cytotoxic potential of water-methanol-extracted secondary metabolites from lichens as an important source for treating human cancer cell lines

inferred← citeshttps://doi.org/10.1016/j.bioorg.2025.108843openalex-snapshot

Novel oxabicyclo[2.2.1]heptane-3-one derivatives with NO inhibitory and cytotoxic activities, and xanthone derivatives from the endolichenic fungus Exophiala sp.

inferred← citeshttps://doi.org/10.1016/j.fitote.2024.106318openalex-snapshot

New diketopiperazine dimers and 4-hydroxyphenylacetates from an endolichenic fungus Aspergillus sp.

inferred← citeshttps://doi.org/10.1016/j.jbiotec.2025.03.019openalex-snapshot

Genome mining of an endophytic natural yeast isolate Rhodotorula sp. Y090 and production of the potent antioxidant ergothioneine

inferred← citeshttps://doi.org/10.1016/j.medmic.2026.100172openalex-snapshot

Comparative bioactive compound profiling of endophytic fungi and their respective host plants for sustainable drug discovery

inferred← citeshttps://doi.org/10.1016/j.phytochem.2026.114803openalex-snapshot

Xylaricins A–I: Dearomatic xanthone derivatives from endolichenic fungus Xylaria sp. LCSS1a

inferred← citeshttps://doi.org/10.1016/j.scowo.2025.100070openalex-snapshot

Molecular docking and bioactive compounds from endophytic Aspergillus flavus: A pathway to new therapeutics

inferred← citeshttps://doi.org/10.1038/s41598-026-56022-6openalex-snapshot

Molecular phylogeny and ecological diversity of endolichenic fungi inhabiting Acarospora schleicheri (Ach.) A. Massal, isolated from a Chilean Andean zone

inferred← citeshttps://doi.org/10.1080/1040841x.2025.2556931openalex-snapshot

Recent biotechnological advances in bioprospecting secondary metabolites from endolichenic fungi for drug discovery applications

inferred← citeshttps://doi.org/10.1186/s40793-026-00886-8openalex-snapshot

Functional redundancy and stability support the resilience of the Evernia prunastri holobiont under urbanization

inferred← citeshttps://doi.org/10.26599/nr.2025.94908007openalex-snapshot

Natural products-integrated drug delivery systems as innovative therapeutic strategies for inflammatory bowel disease management

inferred← citeshttps://doi.org/10.3390/metabo16010077openalex-snapshot

Genomic-Driven Identification of Conserved Biosynthetic Gene Clusters in Cladosporium limoniforme: The Case of the DHN-Melanin Pathway

inferred← citeshttps://doi.org/10.3390/molecules29174117openalex-snapshot

In Vitro Antiproliferative Activity of Echinulin Derivatives from Endolichenic Fungus Aspergillus sp. against Colorectal Cancer

inferred← citeshttps://doi.org/10.3390/molecules30030470openalex-snapshot

Biopesticide Compounds from an Endolichenic Fungus Xylaria sp. Isolated from the Lichen Hypogymnia tubulosa

inferred← citeshttps://doi.org/10.4062/biomolther.2025.062openalex-snapshot

An Endolichenic Fungi-Derived Fatty Acid, cis-10-Nonadecenoic acid, Suppresses Colorectal Cancer Stemness

inferred← citeshttps://doi.org/10.5423/ppj.nt.06.2024.0087openalex-snapshot

Investigation of Antimicrobial Compounds Produced by Endolichenic Fungi in Different Culture Media

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