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Antifungal Drug Development: Targeting the Fungal Sphingolipid Pathway

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/978-1-61779-086-7_9openalex-snapshot

Biochemical Systems Analysis of Signaling Pathways to Understand Fungal Pathogenicity

inferredcites →https://doi.org/10.1016/0006-2952(78)90507-5openalex-snapshot

Mode of action of 5-fluorocytosine

inferredcites →https://doi.org/10.1016/j.bbamem.2006.08.017openalex-snapshot

Inhibitors of sphingolipid metabolism enzymes

inferredcites →https://doi.org/10.1016/j.bbamem.2017.08.017openalex-snapshot

Changes in glucosylceramide structure affect virulence and membrane biophysical properties of Cryptococcus neoformans

inferredcites →https://doi.org/10.1016/j.celrep.2018.01.035openalex-snapshot

The Role of Ceramide Synthases in the Pathogenicity of Cryptococcus neoformans

inferredcites →https://doi.org/10.1016/j.ejmech.2020.112082openalex-snapshot

New azole antifungals with a fused triazinone scaffold

inferredcites →https://doi.org/10.1016/j.ijantimicag.2009.09.011openalex-snapshot

The echinocandins: three useful choices or three too many?

inferredcites →https://doi.org/10.1016/j.jmb.2007.04.086openalex-snapshot

The Structure of Serine Palmitoyltransferase; Gateway to Sphingolipid Biosynthesis

inferredcites →https://doi.org/10.1016/j.jtbi.2003.08.010openalex-snapshot

Integration of kinetic information on yeast sphingolipid metabolism in dynamical pathway models

inferredcites →https://doi.org/10.1016/j.micinf.2004.03.004openalex-snapshot

A monoclonal antibody to glucosylceramide inhibits the growth of Fonsecaea pedrosoi and enhances the antifungal action of mouse macrophages

inferredcites →https://doi.org/10.1016/s0014-5793(04)00156-5openalex-snapshot

Glucosylceramides in Colletotrichum gloeosporioides are involved in the differentiation of conidia into mycelial cells

inferredcites →https://doi.org/10.1016/s0076-6879(00)11094-8openalex-snapshot

[35] Isolation and characterization of novel inhibitors of sphingolipid synthesis: Australifungin, viridiofungins, rustmicin, and khafrefungin

inferredcites →https://doi.org/10.1017/s0031182017000506openalex-snapshot

The antifungal Aureobasidin A and an analogue are active against the protozoan parasiteToxoplasma gondiibut do not inhibit sphingolipid biosynthesis

inferredcites →https://doi.org/10.1021/acs.bioconjchem.8b00136openalex-snapshot

Molecular Umbrellas Modulate the Selective Toxicity of Polyene Macrolide Antifungals

inferredcites →https://doi.org/10.1021/acs.jmedchem.9b01004openalex-snapshot

SAR Studies on Aromatic Acylhydrazone-Based Inhibitors of Fungal Sphingolipid Synthesis as Next-Generation Antifungal Agents

inferredcites →https://doi.org/10.1021/acs.joc.6b00952openalex-snapshot

Simplifungin and Valsafungins, Antifungal Antibiotics of Fungal Origin

inferredcites →https://doi.org/10.1021/acsinfecdis.0c00068openalex-snapshot

Discovery of Amphamide, a Drug Candidate for the Second Generation of Polyene Antibiotics

inferredcites →https://doi.org/10.1021/acsmedchemlett.5b00029openalex-snapshot

Generation of Broad-Spectrum Antifungal Drug Candidates from the Natural Product Compound Aureobasidin A

inferredcites →https://doi.org/10.1021/ja00744a036openalex-snapshot

Structure of lipoxamycin, a novel antifungal antibiotic

inferredcites →https://doi.org/10.1021/ja4059876openalex-snapshot

The Chemical Basis of Serine Palmitoyltransferase Inhibition by Myriocin

inferredcites →https://doi.org/10.1038/ja.2007.13openalex-snapshot

Pleofungins, Novel Inositol Phosphorylceramide Synthase Inhibitors, from Phoma sp. SANK 13899

inferredcites →https://doi.org/10.1038/msb.2008.17openalex-snapshot

Mathematical modeling of pathogenicity of Cryptococcus neoformans

inferredcites →https://doi.org/10.1038/nature03232openalex-snapshot

Simulation and validation of modelled sphingolipid metabolism in Saccharomyces cerevisiae

inferredcites →https://doi.org/10.1038/nrd.2017.46openalex-snapshot

The antifungal pipeline: a reality check

inferredcites →https://doi.org/10.1038/s41467-018-05613-7openalex-snapshot

A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

inferredcites →https://doi.org/10.1038/s41598-019-44544-1openalex-snapshot

The identification of small molecule inhibitors of the plant inositol phosphorylceramide synthase which demonstrate herbicidal activity

inferredcites →https://doi.org/10.1039/c9sc01375jopenalex-snapshot

A natural solution to photoprotection and isolation of the potent polyene antibiotic, marinomycin A

inferredcites →https://doi.org/10.1074/jbc.273.24.14942openalex-snapshot

Rustmicin, a Potent Antifungal Agent, Inhibits Sphingolipid Synthesis at Inositol Phosphoceramide Synthase

inferredcites →https://doi.org/10.1074/jbc.275.11.7597openalex-snapshot

Tsc3p Is an 80-Amino Acid Protein Associated with Serine Palmitoyltransferase and Required for Optimal Enzyme Activity

inferredcites →https://doi.org/10.1074/jbc.m311165200openalex-snapshot

Defensins from Insects and Plants Interact with Fungal Glucosylceramides

inferredcites →https://doi.org/10.1074/jbc.r600010200openalex-snapshot

When Do Lasses (Longevity Assurance Genes) Become CerS (Ceramide Synthases)?

inferredcites →https://doi.org/10.1080/14786419.2018.1470627openalex-snapshot

Sphingofungins G and H: new five-membered lactones fromAspergillus penicilliodesSpeg.

inferredcites →https://doi.org/10.1091/mbc.e05-06-0533openalex-snapshot

Distinct Ceramide Synthases Regulate Polarized Growth in the Filamentous Fungus Aspergillus nidulans

inferredcites →https://doi.org/10.1093/cid/ciu639openalex-snapshot

Update on Epidemiology of and Preventive Strategies for Invasive Fungal Infections in Cancer Patients

inferredcites →https://doi.org/10.1099/mic.0.033985-0openalex-snapshot

Candida albicans sphingolipid C9-methyltransferase is involved in hyphal elongation

inferredcites →https://doi.org/10.1099/mic.0.2008/018788-0openalex-snapshot

Disruption of the sphingolipid Δ8-desaturase gene causes a delay in morphological changes in Candida albicans

inferredcites →https://doi.org/10.1101/gad.856001openalex-snapshot

Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis ofC. neoformans

inferredcites →https://doi.org/10.1111/j.1365-2958.2011.07961.xopenalex-snapshot

Distinct roles of two ceramide synthases, CaLag1p and CaLac1p, in the morphogenesis of Candida albicans

inferredcites →https://doi.org/10.1111/j.1462-5822.2011.01735.xopenalex-snapshot

Methylation of glycosylated sphingolipid modulates membrane lipid topography and pathogenicity of Cryptococcus neoformans

inferredcites →https://doi.org/10.1128/aac.00156-18openalex-snapshot

Acylhydrazones as Antifungal Agents Targeting the Synthesis of Fungal Sphingolipids

inferredcites →https://doi.org/10.1128/aac.00448-08openalex-snapshot

In Vitro Activity of the Antifungal Plant Defensin RsAFP2 against Candida Isolates and Its In Vivo Efficacy in Prophylactic Murine Models of Candidiasis

inferredcites →https://doi.org/10.1128/aac.00633-08openalex-snapshot

Inhibition of Inositol Phosphorylceramide Synthase by the Cyclic Peptide Aureobasidin A

inferredcites →https://doi.org/10.1128/aac.00946-20openalex-snapshot

Preclinical Evaluation of Acylhydrazone SB-AF-1002 as a Novel Broad-Spectrum Antifungal Agent

inferredcites →https://doi.org/10.1128/aac.01975-18openalex-snapshot

In Vitro Activity of a Novel Antifungal Compound, MYC-053, against Clinically Significant Antifungal-Resistant Strains of Candida glabrata , Candida auris , Cryptococcus neoformans , and Pneumocystis spp

inferredcites →https://doi.org/10.1128/aac.39.12.2765openalex-snapshot

The AUR1 gene in Saccharomyces cerevisiae encodes dominant resistance to the antifungal agent aureobasidin A (LY295337)

inferredcites →https://doi.org/10.1128/aac.44.2.368-377.2000openalex-snapshot

Discovery of Novel Antifungal (1,3)-β- d -Glucan Synthase Inhibitors

inferredcites →https://doi.org/10.1128/ec.00318-06openalex-snapshot

Vesicular Polysaccharide Export in Cryptococcus neoformans Is a Eukaryotic Solution to the Problem of Fungal Trans-Cell Wall Transport

inferredcites →https://doi.org/10.1128/iai.68.12.7049-7060.2000openalex-snapshot

Human Antibodies against a Purified Glucosylceramide from Cryptococcus neoformans Inhibit Cell Budding and Fungal Growth

inferredcites →https://doi.org/10.1128/jb.181.4.1134-1140.1999openalex-snapshot

Analysis of Phosphorylated Sphingolipid Long-Chain Bases Reveals Potential Roles in Heat Stress and Growth Control in Saccharomyces

inferredcites →https://doi.org/10.1128/mbio.00647-15openalex-snapshot

Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids

inferredcites →https://doi.org/10.1155/2018/5378284openalex-snapshot

The Many Facets of Sphingolipids in the Specific Phases of Acute Inflammatory Response

inferredcites →https://doi.org/10.1159/000221854openalex-snapshot

Mode of Action of 5-Fluorocytosine and Mechanisms of Resistance

inferredcites →https://doi.org/10.1172/jci136068openalex-snapshot

FTY720 reactivates cryptococcal granulomas in mice through S1P receptor 3 on macrophages

inferredcites →https://doi.org/10.1172/jci27890openalex-snapshot

Glucosylceramide synthase is an essential regulator of pathogenicity of Cryptococcus neoformans

inferredcites →https://doi.org/10.1186/1471-2180-10-47openalex-snapshot

Effect of anti-glycosphingolipid monoclonal antibodies in pathogenic fungal growth and differentiation. Characterization of monoclonal antibody MEST-3 directed to Manp α1→3Manp α1→2IPC

inferredcites →https://doi.org/10.1194/jlr.d052001openalex-snapshot

A rapid ceramide synthase activity using NBD-sphinganine and solid phase extraction

inferredcites →https://doi.org/10.1194/jlr.m078600openalex-snapshot

Analysis of sphingolipids, sterols, and phospholipids in human pathogenic Cryptococcus strains

inferredcites →https://doi.org/10.1194/jlr.m088195openalex-snapshot

Tsc3 regulates SPT amino acid choice in Saccharomyces cerevisiae by promoting alanine in the sphingolipid pathway

inferredcites →https://doi.org/10.1371/journal.pone.0098149openalex-snapshot

Characterization of Scedosporium apiospermum Glucosylceramides and Their Involvement in Fungal Development and Macrophage Functions

inferredcites →https://doi.org/10.1371/journal.ppat.1005188openalex-snapshot

Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans

inferredcites →https://doi.org/10.3109/13693786.2010.535031openalex-snapshot

Disruption of sphingolipid biosynthetic geneIPT1reducesCandida albicansadhesion and prevents activation of human gingival epithelial cell innate immune defense

inferredcites →https://doi.org/10.3390/jof4020050openalex-snapshot

Lipid Biosynthesis as an Antifungal Target

inferredcites →https://doi.org/10.3390/jof4030079openalex-snapshot

Present and Future Therapy of Cryptococcus Infections

inferredcites →https://doi.org/10.7164/antibiotics.25.109openalex-snapshot

MYRIOCIN, A NEW ANTIFUNGAL ANTIBIOTIC FROM MYRIOCOCCUM ALBOMYCES

inferredcites →https://doi.org/10.7164/antibiotics.44.919openalex-snapshot

Aureobasidins, new antifungal antibiotics. Taxonomy, fermentation, isolation, and properties.

inferredcites →https://doi.org/10.7164/antibiotics.45.861openalex-snapshot

Sphingofungins A,B,C, and d; a new family of antifungal agents. I. Fermentation, isolation, and biological activity.

inferredcites →https://doi.org/10.7164/antibiotics.47.208openalex-snapshot

Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite.

inferredcites →https://doi.org/10.7164/antibiotics.47.376openalex-snapshot

Inhibition of serine palmitoyl-transferase activity by lipoxamycin.

inferredcites →https://doi.org/10.7164/antibiotics.50.339openalex-snapshot

Viridiofungins, Novel Inhibitors of Sphingolipid Synthesis.

inferredcites →https://doi.org/10.7164/antibiotics.51.837openalex-snapshot

Inhibition of Fungal Sphingolipid Biosynthesis by Rustmicin, Galbonolide B and Their New 21-Hydroxy Analogs.

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.3897/imafungus.17.177891zenodo-depositor-declared

Evolutionary diversity of sphingolipid metabolism proteins in fungi

inferred← citeshttps://doi.org/10.1002/ps.70420openalex-snapshot

Camphoryl thiosemicarbazide derivatives: promising multitarget fungicide candidates against Colletotrichum fructicola

inferred← citeshttps://doi.org/10.1007/s10658-023-02643-wopenalex-snapshot

Quantitative proteomics provides an insight into germination‐related proteins in the plant pathogenic fungi Phomopsis vexans

inferred← citeshttps://doi.org/10.1007/s13346-021-00901-0openalex-snapshot

New perspectives on the topical management of recurrent candidiasis

inferred← citeshttps://doi.org/10.1016/j.bbamem.2024.184350openalex-snapshot

Ergosterol promotes aggregation of natamycin in the yeast plasma membrane

inferred← citeshttps://doi.org/10.1016/j.bmc.2025.118406openalex-snapshot

Design, synthesis and SAR studies of N′-(Ethynylsalicylidene)arenecarbohydrazides as next-generation broad-spectrum antifungal agents

inferred← citeshttps://doi.org/10.1016/j.fbr.2023.100342openalex-snapshot

Insights into the role of sphingolipids in antifungal drug resistance

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.146139openalex-snapshot

Releases of inhibition mechanisms and binding of antifungal compounds against validated proteins for drug design post-WHO priority list: A review

inferred← citeshttps://doi.org/10.1016/j.jep.2024.118473openalex-snapshot

Antifungal bioactivity of Sarcococca hookeriana var. digyna Franch. against fluconazole-resistant Candida albicans in vitro and in vivo

inferred← citeshttps://doi.org/10.1016/j.jpha.2026.101549openalex-snapshot

Therapeutic potential of traditional Chinese medicine-derived formulations and extracts in Candida infections: Current trends and future directions

inferred← citeshttps://doi.org/10.1016/j.micpath.2025.108068openalex-snapshot

The hidden threat: Unveiling the rise of antifungal drug resistance

inferred← citeshttps://doi.org/10.1016/j.micres.2023.127347openalex-snapshot

The sphinganine C4-hydroxylase FgSur2 regulates sensitivity to azole antifungal agents and virulence of Fusarium graminearum

inferred← citeshttps://doi.org/10.1016/j.micres.2023.127517openalex-snapshot

Update on fungal lipid biosynthesis inhibitors as antifungal agents

inferred← citeshttps://doi.org/10.1016/j.str.2025.05.016openalex-snapshot

Targeting ceramide synthases for the development of new antifungals

inferred← citeshttps://doi.org/10.1038/s41385-022-00570-3openalex-snapshot

Vaccine protection by Cryptococcus neoformans Δsgl1 is mediated by γδ T cells via TLR2 signaling

inferred← citeshttps://doi.org/10.1038/s44259-025-00093-4openalex-snapshot

Targeting fungal lipid synthesis for antifungal drug development and potentiation of contemporary antifungals

inferred← citeshttps://doi.org/10.1073/pnas.2415524122openalex-snapshot

The antimicrobial activity of ETD151 defensin is dictated by the presence of glycosphingolipids in the targeted organisms

inferred← citeshttps://doi.org/10.1080/14656566.2023.2178898openalex-snapshot

An update on the use of sphingosine 1-phosphate receptor modulators for the treatment of relapsing multiple sclerosis

inferred← citeshttps://doi.org/10.1093/glycob/cwac036openalex-snapshot

Characterization of a gene cluster involved in Aspergillus fumigatus zwitterionic glycosphingolipid synthesis

inferred← citeshttps://doi.org/10.1101/2023.12.05.570146openalex-snapshot

Ergosterol mediates aggregation of natamycin in the yeast plasma membrane

inferred← citeshttps://doi.org/10.1111/apm.13389openalex-snapshot

Antifungal drug resistance in Candida: a special emphasis on amphotericin B

inferred← citeshttps://doi.org/10.1128/spectrum.00508-21openalex-snapshot

Aneuploidy Underlies Tolerance and Cross-Tolerance to Drugs in Candida parapsilosis

inferred← citeshttps://doi.org/10.11606/d.17.2022.tde-20062022-161952openalex-snapshot

Identificação de metabólitos secundários presentes em vesículas extracelulares de Candida albicans durante estresse oxidativo

inferred← citeshttps://doi.org/10.1186/s12866-025-04230-xopenalex-snapshot

In vitro and in vivo antifungal activity of Minocycline albumin nanoparticles in combination with fluconazole against azole-resistant Candida spp

inferred← citeshttps://doi.org/10.21203/rs.3.rs-6810020/v1openalex-snapshot

Novel Antifungal Compound Z247611722 Exhibits Antifungal Activity by Inhibiting Serine Palmitoyltransferase

inferred← citeshttps://doi.org/10.2174/1381612829666230807120704openalex-snapshot

N-unsubstituted Imidazoles: Design, Synthesis, and Antimicrobial Evaluation

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Comprehensive genome-scale metabolic model of the human pathogen Cryptococcus neoformans: A platform for understanding pathogen metabolism and identifying new drug targets

inferred← citeshttps://doi.org/10.3389/fcimb.2021.739027openalex-snapshot

Cryptococcus neoformans Δsgl1 Vaccination Requires Either CD4+ or CD8+ T Cells for Complete Host Protection

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Identification of in vivo induced antigens of the malacosporean parasite Tetracapsuloides bryosalmonae (Cnidaria) using in vivo induced antigen technology

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Three Models of Vaccination Strategies Against Cryptococcosis in Immunocompromised Hosts Using Heat-Killed Cryptococcus neoformans Δsgl1

inferred← citeshttps://doi.org/10.3389/fmicb.2023.1128160openalex-snapshot

Chromosome 1 trisomy confers resistance to aureobasidin A in Candida albicans

inferred← citeshttps://doi.org/10.3389/fphar.2025.1516991openalex-snapshot

Sphingosine 1-phosphate receptor 1 modulators exert neuroprotective effects in central nervous system disorders

inferred← citeshttps://doi.org/10.3390/antibiotics12121716openalex-snapshot

Lipid-Centric Approaches in Combating Infectious Diseases: Antibacterials, Antifungals and Antivirals with Lipid-Associated Mechanisms of Action

inferred← citeshttps://doi.org/10.3390/cells10051105openalex-snapshot

The Anti-Infectious Role of Sphingosine in Microbial Diseases

inferred← citeshttps://doi.org/10.3390/jof10090597openalex-snapshot

Antifungal Activity of Disalt of Epipyrone A from Epicoccum nigrum Likely via Disrupted Fatty Acid Elongation and Sphingolipid Biosynthesis

inferred← citeshttps://doi.org/10.3390/jof7060439openalex-snapshot

In Silico Predicted Antifungal Peptides: In Vitro and In Vivo Anti-Candida Activity

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Access to Anti-Biofilm Compounds from Endolichenic Fungi Using a Bioguided Networking Screening

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Deciphering the Role of PIG1 and DHN-Melanin in Scedosporium apiospermum Conidia

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Oceanapiside, a Marine Natural Product, Targets the Sphingolipid Pathway of Fluconazole-Resistant Candida glabrata

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Metabolic Features of a Novel Trichoderma asperellum YNQJ1002 with Potent Antagonistic Activity against Fusarium graminearum

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Genetic Characterization of the Acidic and Neutral Glycosphingolipid Biosynthetic Pathways in Neurospora crassa

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Functional and Biochemical Characterization of Spermidine Synthase CauSpe3 from Candidozyma auris

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Discovery of tRNA-dependent ergosterol aminoacylation in fungi

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Deciphering the mechanisms of action of promising defensins to design a new generation of antimicrobials

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