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Resveratrol, Epigallocatechin Gallate and Curcumin for Cancer Therapy: Challenges from Their Pro-Apoptotic Properties
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2 of the 167 references listed on this page are in the Retraction Watch database as retracted (export 2026-10-28): 10.1186/s12885-018-5130-y (notice 2024-04-15), 10.26355/eurrev_201904_17591 (notice 2020-07-01).
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/cncr.24699openalex-snapshotFlavonoids activated caspases for apoptosis in human glioblastoma T98G and U87MG cells but not in human normal astrocytes
inferredcites →https://doi.org/10.1002/jbt.22616openalex-snapshotCurcumin induced apoptosis is mediated through oxidative stress in mutated p53 and wild type p53 colon adenocarcinoma cell lines
inferredcites →https://doi.org/10.1002/jcp.24372openalex-snapshotEpigallocatechin gallate inhibits growth and epithelial‐to‐mesenchymal transition in human thyroid carcinoma cell lines
inferredcites →https://doi.org/10.1002/jcp.26631openalex-snapshot(−)‐ Epigallocatechin‐3‐gallate induces GRP78 accumulation in the ER and shifts mesothelioma constitutive UPR into proapoptotic ER stress
inferredcites →https://doi.org/10.1002/mc.22582openalex-snapshotResveratrol inhibits IL‐6‐induced ovarian cancer cell migration through epigenetic up‐regulation of autophagy
inferredcites →https://doi.org/10.1002/mnfr.201200560openalex-snapshotIn vitro mechanism for downregulation of ER ‐α expression by epigallocatechin gallate in ER +/ PR + human breast cancer cells
inferredcites →https://doi.org/10.1002/pros.22943openalex-snapshotRandomized clinical trial of brewed green and black tea in men with prostate cancer prior to prostatectomy
inferredcites →https://doi.org/10.1002/tox.23450openalex-snapshotCurcumin suppresses cell proliferation and triggers apoptosis in vemurafenib‐resistant melanoma cells by downregulating the EGFR signaling pathway
inferredcites →https://doi.org/10.1016/j.bbrc.2007.01.003openalex-snapshotA component of green tea, (−)-epigallocatechin-3-gallate, promotes apoptosis in T24 human bladder cancer cells via modulation of the PI3K/Akt pathway and Bcl-2 family proteins
inferredcites →https://doi.org/10.1016/j.foodchem.2020.128140openalex-snapshotCurcumin extracts from Curcuma Longa – Improvement of concentration, purity, and stability in food-approved and water-soluble surfactant-free microemulsions
inferredcites →https://doi.org/10.1016/j.radonc.2013.10.014openalex-snapshotA phase I study of concurrent chemotherapy and thoracic radiotherapy with oral epigallocatechin-3-gallate protection in patients with locally advanced stage III non-small-cell lung cancer
inferredcites →https://doi.org/10.1016/j.redox.2013.12.022openalex-snapshotNew insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate
inferredcites →https://doi.org/10.1038/aps.2014.132openalex-snapshotResveratrol induces apoptosis of human chronic myelogenous leukemia cells in vitro through p38 and JNK-regulated H2AX phosphorylation
inferredcites →https://doi.org/10.1038/s12276-020-00510-wopenalex-snapshotMETTL3 promotes adriamycin resistance in MCF-7 breast cancer cells by accelerating pri-microRNA-221-3p maturation in a m6A-dependent manner
inferredcites →https://doi.org/10.1038/srep20502openalex-snapshotCisplatin resistance in gastric cancer cells is associated with HER2 upregulation-induced epithelial-mesenchymal transition
inferredcites →https://doi.org/10.1074/jbc.m309114200openalex-snapshotA Constituent of Green Tea, Epigallocatechin-3-gallate, Activates Endothelial Nitric Oxide Synthase by a Phosphatidylinositol-3-OH-kinase-, cAMP-dependent Protein Kinase-, and Akt-dependent Pathway and Leads to Endothelial-dependent Vasorelaxation
inferredcites →https://doi.org/10.1080/09553002.2021.1876948openalex-snapshotAntioxidant activity of curcumin protects against the radiation-induced micronuclei formation in cultured human peripheral blood lymphocytes exposed to various doses of γ-Radiation
inferredcites →https://doi.org/10.1093/carcin/bgh220openalex-snapshotResveratrol induces FasL-related apoptosis through Cdc42 activation of ASK1/JNK-dependent signaling pathway in human leukemia HL-60 cells
inferredcites →https://doi.org/10.1093/carcin/bgi167openalex-snapshotCurcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through reactive oxygen species-mediated upregulation of death receptor 5 (DR5)
inferredcites →https://doi.org/10.1096/fj.10-178871openalex-snapshotResveratrol, through NF‐Y/p53/Sin3/HDAC1 complex phosphorylation, inhibits estrogen receptor α gene expression via p38 MAPK /CK2 signaling in human breast cancer cells
inferredcites →https://doi.org/10.1111/cas.14770openalex-snapshotCurcumin analog B14 has high bioavailability and enhances the effect of anti‐breast cancer cells in vitro and in vivo
inferredcites →https://doi.org/10.1111/jfbc.13758openalex-snapshotEpigallocatechin‐3‐gallate induces autophagy‐related apoptosis associated with LC3B II and Beclin expression of bladder cancer cells
inferredcites →https://doi.org/10.1111/jfbc.13888openalex-snapshotCurcumin induced G2/M cycle arrest in SK‐N‐SH neuroblastoma cells through the ROS‐mediated p53 signaling pathway
inferredcites →https://doi.org/10.1139/cjpp-2020-0588openalex-snapshotEpigallocatechin-3-gallate inhibits proliferation and triggers apoptosis in colon cancer via the hedgehog/phosphoinositide 3-kinase pathways
inferredcites →https://doi.org/10.1155/2019/3480569openalex-snapshotInduction of Endoplasmic Reticulum Stress Pathway by Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Activation of PERK/p-eIF2α/ATF4 and IRE1α
inferredcites →https://doi.org/10.1158/1940-6207.capr-08-0167openalex-snapshotTea Polyphenols Decrease Serum Levels of Prostate-Specific Antigen, Hepatocyte Growth Factor, and Vascular Endothelial Growth Factor in Prostate Cancer Patients and Inhibit Production of Hepatocyte Growth Factor and Vascular Endothelial Growth Factor In vitro
inferredcites →https://doi.org/10.1177/0300060518822213openalex-snapshotCurcumin regulates the miR-21/PTEN/Akt pathway and acts in synergy with PD98059 to induce apoptosis of human gastric cancer MGC-803 cells
inferredcites →https://doi.org/10.1182/blood-2006-02-003988openalex-snapshotResveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-κB–regulated antiapoptotic and cell survival gene products in human multiple myeloma cells
inferredcites →https://doi.org/10.1186/ar2850openalex-snapshotSynergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1β-induced NF-κB-mediated inflammation and apoptosis
inferredcites →https://doi.org/10.1186/s11671-019-3042-7openalex-snapshotOral Administration of Resveratrol-Loaded Solid Lipid Nanoparticle Improves Insulin Resistance Through Targeting Expression of SNARE Proteins in Adipose and Muscle Tissue in Rats with Type 2 Diabetes
inferredcites →https://doi.org/10.1186/s12885-018-5130-yopenalex-snapshotRETRACTED ARTICLE: Curcumin inhibits proliferation, migration, invasion and promotes apoptosis of retinoblastoma cell lines through modulation of miR-99a and JAK/STAT pathway
inferredcites →https://doi.org/10.12659/msm.902711openalex-snapshotCurcumin Inhibits Gastric Carcinoma Cell Growth and Induces Apoptosis by Suppressing the Wnt/β-Catenin Signaling Pathway
inferredcites →https://doi.org/10.12659/msm.924558openalex-snapshotThe Role of Epigallocatechin-3-Gallate in Autophagy and Endoplasmic Reticulum Stress (ERS)-Induced Apoptosis of Human Diseases
inferredcites →https://doi.org/10.3389/fnut.2021.720439openalex-snapshotEpigallocatechin Gallate (EGCG) Promotes the Immune Function of Ileum in High Fat Diet Fed Mice by Regulating Gut Microbiome Profiling and Immunoglobulin Production
inferredcites →https://doi.org/10.3390/cancers14092142openalex-snapshotResveratrol Contrasts IL-6 Pro-Growth Effects and Promotes Autophagy-Mediated Cancer Cell Dormancy in 3D Ovarian Cancer: Role of miR-1305 and of Its Target ARH-I
inferredcites →https://doi.org/10.3390/ijms21020438openalex-snapshotCurcumin-Mediated Apoptotic Cell Death in Papillary Thyroid Cancer and Cancer Stem-Like Cells through Targeting of the JAK/STAT3 Signaling Pathway
inferredcites →https://doi.org/10.3390/molecules25143146openalex-snapshotPotential Therapeutic Targets of Epigallocatechin Gallate (EGCG), the Most Abundant Catechin in Green Tea, and Its Role in the Therapy of Various Types of Cancer
inferredcites →https://doi.org/10.3892/ijmm.2014.1988openalex-snapshotEpigallocatechin-3-gallate induces the apoptosis of hepatocellular carcinoma LM6 cells but not non-cancerous liver cells
inferredcites →https://doi.org/10.3892/ijo.2013.2107openalex-snapshotCurcumin suppresses proliferation and induces apoptosis of human hepatocellular carcinoma cells via the wnt signaling pathway
inferredcites →https://doi.org/10.3892/ol.2016.5519openalex-snapshotResveratrol promotes regression of renal carcinoma cells via a renin-angiotensin system suppression-dependent mechanism
inferredcites →https://doi.org/10.4103/jcrt.jcrt_348_18openalex-snapshotCombinatorial effect of curcumin and tumor necrosis factor-α-related apoptosis-inducing ligand (TRAIL) in induction of apoptosis via inhibition of nuclear factor kappa activity and enhancement of caspase-3 activity in chronic myeloid cells: An In-vitro study
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/ardp.202300422openalex-snapshotMolecular insights into the anti‐inflammatory activity of fermented pineapple juice using multimodal computational studies
inferred← citeshttps://doi.org/10.1002/fft2.70135openalex-snapshotNatural Products Targeting the EGFR/HER2 Axis in Tumorigenesis: Interpretation of Molecular Mechanisms and Recent Insights Into Synergistic Strategies for Cancer Therapy
inferred← citeshttps://doi.org/10.1002/fft2.70214openalex-snapshotNatural Dietary Compounds Targeting NF‐κB Signaling in Cancer: Implications for Nutrition‐Based Prevention and Therapy
inferred← citeshttps://doi.org/10.1007/s10904-025-03901-6openalex-snapshotGalangin-Loaded Chitosan Nanoparticles Inhibit Lung Cancer Cell Proliferation Via Cell Cycle Arrest and Cyclin-Dependent Kinase Modulation
inferred← citeshttps://doi.org/10.1007/s11101-025-10123-8openalex-snapshotEssential oils and plant-derived bioactive compounds: a comprehensive review of their therapeutic potential, mechanisms of action, and advances in extraction technologies
inferred← citeshttps://doi.org/10.1007/s12032-026-03238-1openalex-snapshotFarnesol induces apoptosis, LC3B/SQSTM1 mediated regulation of autophagy and downregulates anaerobic Glycolysis through suppression of LDH and PKM in A549 lung adenocarcinoma cells
inferred← citeshttps://doi.org/10.1016/j.ejmcr.2024.100243openalex-snapshotEpigallocatechin-gallate ameliorates polystyrene microplastics-induced oxido-inflammation and mitochondria-mediated apoptosis in testicular cells via modulation of Nrf2/HO-1, /mTOR/Atg-7, and Cx-43/NOX-1 levels
inferred← citeshttps://doi.org/10.1016/j.inoche.2025.115596openalex-snapshotMitochondrial targeting and ROS modulation study by Trans-resveratrol loaded chitosan-coated green synthesized CeO₂ nanoparticles against Triple-negative breast cancer cell lines
inferred← citeshttps://doi.org/10.1016/j.nwnano.2026.100187openalex-snapshotQuality by design-optimized EGCG-loaded cubosomal hydrogel for controlled dermal delivery: In vitro characterization and biological evaluation against melanoma
inferred← citeshttps://doi.org/10.1515/jcim-2024-0338openalex-snapshotUnlocking the potential: integrating phytoconstituents and nanotechnology in skin cancer therapy – A comprehensive review
inferred← citeshttps://doi.org/10.3389/fphar.2024.1475102openalex-snapshotProteomic study of medicinal mushroom extracts reveals antitumor mechanisms in an advanced colon cancer animal model via ribosomal biogenesis, translation, and metabolic pathways
inferred← citeshttps://doi.org/10.3390/cancers15184520openalex-snapshotTime-Tested Strategies in Modern Context: A Bibliometric Study of Chemotherapy’s Continued Importance in Colorectal Cancer Treatment
inferred← citeshttps://doi.org/10.3390/fermentation9090838openalex-snapshotWinemaking: “With One Stone, Two Birds”? A Holistic Review of the Bio-Functional Compounds, Applications and Health Benefits of Wine and Wineries’ By-Products
inferred← citeshttps://doi.org/10.3390/ijms25010232openalex-snapshotThe Combination of Bioavailable Concentrations of Curcumin and Resveratrol Shapes Immune Responses While Retaining the Ability to Reduce Cancer Cell Survival
inferred← citeshttps://doi.org/10.3390/medicina59081376openalex-snapshotExploring the Apoptotic-Induced Biochemical Mechanism of Traditional Thai Herb (Kerra™) Extract in HCT116 Cells Using a Label-Free Proteomics Approach
inferred← citeshttps://doi.org/10.3390/ph19010012openalex-snapshotA Review of Traditional Chinese Medicine Formulations and Natural Active Ingredients with Therapeutic Potential for Male Infertility Targeting Oxidative Stress
inferred← citeshttps://doi.org/10.34172/ps.2023.27openalex-snapshotHarnessing Nanotechnology for Optimized Herbal Cancer Treatment: A Comprehensive Review of Nanoscale Drug Delivery Systems
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