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The Application of Statins in the Regeneration of Bone Defects. Systematic Review and Meta-Analysis
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/jbm.a.35499openalex-snapshot
Controlled release of simvastatin‐loaded thermo‐sensitive PLGA‐PEG‐PLGA hydrogel for bone tissue regeneration: in vitro and in vivo characteristics
inferredcites →https://doi.org/10.1002/jbmr.1558openalex-snapshot
Therapeutic effect of local administration of low-dose simvastatin-conjugated gelatin hydrogel for fracture healing
inferredcites →https://doi.org/10.1002/jor.20391openalex-snapshot
Locally delivered lovastatin nanoparticles enhance fracture healing in rats
inferredcites →https://doi.org/10.1002/jor.21421openalex-snapshot
Highly efficient release of lovastatin from poly(lactic‐co‐glycolic acid) nanoparticles enhances bone repair in rats
inferredcites →https://doi.org/10.1002/jor.22502openalex-snapshot
Percutaneous lovastatin accelerates bone healing but is associated with periosseous soft tissue inflammation in a canine tibial osteotomy model
inferredcites →https://doi.org/10.1002/term.1547openalex-snapshot
Local injection of lovastatin in biodegradable polyurethane scaffolds enhances bone regeneration in a critical-sized segmental defect in rat femora
inferredcites →https://doi.org/10.1007/s00784-018-2354-9openalex-snapshot
The effect of statins on periodontal treatment—a systematic review with meta-analyses and meta-regression
inferredcites →https://doi.org/10.1016/j.biomaterials.2013.08.060openalex-snapshot
Calvarial defect healing by recruitment of autogenous osteogenic stem cells using locally applied simvastatin
inferredcites →https://doi.org/10.1016/j.bone.2018.09.003openalex-snapshot
The sole and combined effect of simvastatin and platelet rich fibrin as a filling material in induced bone defect in tibia of albino rats
inferredcites →https://doi.org/10.1016/j.ijom.2017.12.009openalex-snapshot
The ability of topical and systemic statins to increase osteogenesis around dental implants: a systematic review of histomorphometric outcomes in animal studies
inferredcites →https://doi.org/10.1016/j.jcms.2010.03.009openalex-snapshot
The influence of local administration of simvastatin in calvarial bone healing in rats
inferredcites →https://doi.org/10.1016/j.jcms.2014.11.011openalex-snapshot
Effects of local application of simvastatin on bone regeneration in femoral bone defects in rabbit
inferredcites →https://doi.org/10.1016/j.phrs.2014.03.002openalex-snapshot
The pharmacology of statins
inferredcites →https://doi.org/10.1080/00016357.2017.1381345openalex-snapshot
Maxillary sinus lift using osteoinductive simvastatin combined with β-TCP versus β-TCP – a comparative pilot study to evaluate simvastatin enhanced and accelerated bone formation
inferredcites →https://doi.org/10.1093/nsr/nwu028openalex-snapshot
Novel applications of statins for bone regeneration
inferredcites →https://doi.org/10.1097/id.0000000000000655openalex-snapshot
Ridge Preservation After Maxillary Third Molar Extraction Using 30% Porosity PLGA/HA/β-TCP Scaffolds With and Without Simvastatin
inferredcites →https://doi.org/10.1097/scs.0000000000002728openalex-snapshot
Comparison of the Effect of Platelet-Rich Plasma and Simvastatin on Healing of Critical-Size Calvarial Bone Defects
inferredcites →https://doi.org/10.1097/scs.0000000000003120openalex-snapshot
The Effect of Local Rosuvastatin on Mandibular Fracture Healing
inferredcites →https://doi.org/10.1111/j.1582-4934.2001.tb00172.xopenalex-snapshot
Statins: mechanism of action and effects
inferredcites →https://doi.org/10.1111/j.1600-0501.2010.02135.xopenalex-snapshot
Bone healing of critical-sized nasal defects in rabbits by statins in two different carriers
inferredcites →https://doi.org/10.1111/jicd.12304openalex-snapshot
Efficacy of statin delivery as an adjunct to scaling and root planing in the treatment of chronic periodontitis: A meta‐analysis
inferredcites →https://doi.org/10.1136/bmj.b2535openalex-snapshot
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
inferredcites →https://doi.org/10.1157/13078782openalex-snapshot
Tratamiento anabólico en la osteoporosis
inferredcites →https://doi.org/10.1159/000368408openalex-snapshot
The Effect of Riding as an Alternative Treatment for Children with Cerebral Palsy: A Systematic Review and Meta-Analysis
inferredcites →https://doi.org/10.11607/jomi.te60openalex-snapshot
Topical Application of Slow-Release Simvastatin as a Bone Substitute in Bone Defects in the Rat Tibia: A Pilot Study
inferredcites →https://doi.org/10.1177/0885328214550897openalex-snapshot
Evaluation of bone repair of critical size defects treated with simvastatin-loaded poly(lactic- co -glycolic acid) microspheres in rat calvaria
inferredcites →https://doi.org/10.1186/1471-2288-14-43openalex-snapshot
SYRCLE’s risk of bias tool for animal studies
inferredcites →https://doi.org/10.1186/ar399openalex-snapshot
Statins as modulators of bone formation
inferredcites →https://doi.org/10.1371/journal.pbio.1000412openalex-snapshot
Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research
inferredcites →https://doi.org/10.1371/journal.pmed.1000097openalex-snapshot
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
inferredcites →https://doi.org/10.2174/0929867321666140601202933openalex-snapshot
Statins as Bioactive Molecules to Support Bone Regeneration
inferredcites →https://doi.org/10.3109/10717544.2016.1160458openalex-snapshot
Localized rosuvastatin via implantable bioerodible sponge and its potential role in augmenting bone healing and regeneration
inferredcites →https://doi.org/10.4103/0976-500x.72351openalex-snapshot
Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4760648openalex-extracted
Cholesterol Metabolism-Mediated Immune Regulation and Cancer Immunotherapy
inferred← citeshttps://doi.org/10.1002/chem.202101405openalex-snapshot
Hybrid Self‐Assembled Gel Beads for Tuneable pH‐Controlled Rosuvastatin Delivery
inferred← citeshttps://doi.org/10.1002/jbmb.70027openalex-snapshot
In Vitro and In Vivo Evaluation of Polycaprolactone/Carboxymethyl Chitosan Composite 3D Scaffolds Loaded With Cerivastatin and 45S5 Bioglass Nanoparticles for Bone Tissue Engineering in Rat Calvarial Defects
inferred← citeshttps://doi.org/10.1007/s40883-024-00377-7openalex-snapshot
A Comprehensive Exploration of Polymeric 3D Sponges for Regeneration of Bone
inferred← citeshttps://doi.org/10.1007/s43440-025-00716-7openalex-snapshot
Molecular mechanisms underlying the effects of statins on bone metabolism: an evolving paradigm of statins delivery modalities for bone regeneration
inferred← citeshttps://doi.org/10.1016/j.addr.2020.10.011openalex-snapshot
Synergistic use of biomaterials and licensed therapeutics to manipulate bone remodelling and promote non-union fracture repair
inferred← citeshttps://doi.org/10.1016/j.bioactmat.2021.10.034openalex-snapshot
Potential bioactive coating system for high-performance absorbable magnesium bone implants
inferred← citeshttps://doi.org/10.1016/j.drudis.2022.02.020openalex-snapshot
Effects on bone regeneration of single-dose treatment with osteogenic small molecules
inferred← citeshttps://doi.org/10.1016/j.jddst.2022.103941openalex-snapshot
The effect of simvastatin-loaded methoxy poly(ethylene glycol)-polylactic acid nanoparticles on osteoblasts
inferred← citeshttps://doi.org/10.1016/j.mtbio.2026.103275openalex-snapshot
Enhanced hemostasis and bone regeneration achieved by thrombin–simvastatin-polydopamine loaded spray-dried β-TCP/ gelatin/ soy protein isolate biocomposites in critical rat calvarial defects
inferred← citeshttps://doi.org/10.1021/acsbiomaterials.1c00462openalex-snapshot
Simvastatin-Incorporated Drug Delivery Systems for Bone Regeneration
inferred← citeshttps://doi.org/10.1111/prd.70034openalex-snapshot
Factors affecting the efficacy of nonsurgical therapy of peri‐implantitis
inferred← citeshttps://doi.org/10.1155/2022/4951455openalex-snapshot
Effect of an “Autogenous Leukocyte Platelet‐Rich Fibrin Tooth Graft” Combination around Immediately Placed Implants in Periodontally Compromised Sites: A Randomized Clinical Trial
inferred← citeshttps://doi.org/10.1177/08853282251369228openalex-snapshot
Investigation of calvarial bone regeneration in a rat model using three-dimensional polycaprolactone/carboxymethyl chitosan nano composite scaffolds containing hydroxyapatite nanoparticles along with the icariin and atorvastatin synthesized by the freeze-casting method
inferred← citeshttps://doi.org/10.22146/majkedgiind.53419openalex-snapshot
Effect of advanced-platelet rich-fibrin combined with rosuvastatin application after open flap debridement of infrabony pocket
inferred← citeshttps://doi.org/10.3390/biomimetics7040143openalex-snapshot
Effect of Diclofenac and Simvastatin on Bone Defect Healing—An In Vivo Animal Study
inferred← citeshttps://doi.org/10.3390/ijms26020851openalex-snapshot
Lovastatin and Resveratrol Synergistically Improve Wound Healing and Inhibit Bacterial Growth
inferred← citeshttps://doi.org/10.3390/molecules25173891openalex-snapshot
An Atomic-Level Perspective of HMG-CoA-Reductase: The Target Enzyme to Treat Hypercholesterolemia
inferred← citeshttps://doi.org/10.3390/pharmaceutics12111018openalex-snapshot
Preclinical and Clinical Applications of Biomaterials in the Enhancement of Wound Healing in Oral Surgery: An Overview of the Available Reviews
inferred← citeshttps://doi.org/10.5114/aic.2023.133700openalex-snapshot
Effect of statins on bone turnover markers in postmenopausal women: a pilot study
inferred← citeshttps://doi.org/10.51273/esc24.25132015openalex-snapshot
Diagnostic Accuracy of Transvaginal Sonography in Adenomyosis Taking Histo- pathology as Gold Standard in Infertile Women
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