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Heat Shock Proteins as Immunomodulants
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2 of the 119 references listed on this page are in the Retraction Watch database as retracted (export 2026-10-28): 10.1172/jci28423 (notice 2018-05-07), 10.1196/annals.1391.019 (notice 2009-06-24).
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/art.11174openalex-snapshotThe spontaneous remission of juvenile idiopathic arthritis is characterized by CD30+ T cells directed to human heat‐shock protein 60 capable of producing the regulatory cytokine interleukin‐10
inferredcites →https://doi.org/10.1002/jcp.22956openalex-snapshotParaptosis accompanied by autophagy and apoptosis was induced by celastrol, a natural compound with influence on proteasome, ER stress and Hsp90
inferredcites →https://doi.org/10.1002/prot.25600openalex-snapshotStructural and biochemical characterization of Plasmodium falciparum Hsp70‐x reveals functional versatility of its C‐terminal EEVN motif
inferredcites →https://doi.org/10.1007/s10571-011-9789-8openalex-snapshotThe Molecular Anatomy of Human Hsp60 and its Similarity with that of Bacterial Orthologs and Acetylcholine Receptor Reveal a Potential Pathogenetic Role of Anti-Chaperonin Immunity in Myasthenia Gravis
inferredcites →https://doi.org/10.1007/s12192-010-0236-4openalex-snapshotExtracellular heat shock proteins, cellular export vesicles, and the Stress Observation System: A form of communication during injury, infection, and cell damage
inferredcites →https://doi.org/10.1007/s12192-013-0460-9openalex-snapshotElevated blood Hsp60, its structural similarities and cross-reactivity with thyroid molecules, and its presence on the plasma membrane of oncocytes point to the chaperonin as an immunopathogenic factor in Hashimoto's thyroiditis
inferredcites →https://doi.org/10.1016/j.lfs.2009.11.004openalex-snapshotHuman Hsp10 and Early Pregnancy Factor (EPF) and their relationship and involvement in cancer and immunity: Current knowledge and perspectives
inferredcites →https://doi.org/10.1074/jbc.m307858200openalex-snapshotHelicobacter pylori Heat Shock Protein 60 Mediates Interleukin-6 Production by Macrophages via a Toll-like Receptor (TLR)-2-, TLR-4-, and Myeloid Differentiation Factor 88-independent Mechanism
inferredcites →https://doi.org/10.1074/jbc.m411379200openalex-snapshotMycobacterium Tuberculosis Heat Shock Proteins Use Diverse Toll-like Receptor Pathways to Activate Pro-inflammatory Signals
inferredcites →https://doi.org/10.1074/jbc.m603622200openalex-snapshotMAPK-activated Protein Kinase-2 (MK2)-mediated Formation and Phosphorylation-regulated Dissociation of the Signal Complex Consisting of p38, MK2, Akt, and Hsp27
inferredcites →https://doi.org/10.1074/jbc.m803310200openalex-snapshotCalcium Signaling in Dendritic Cells by Human or Mycobacterial Hsp70 Is Caused by Contamination and Is Not Required for Hsp70-mediated Enhancement of Cross-presentation
inferredcites →https://doi.org/10.1093/intimm/dxq475openalex-snapshotExtracellular heat shock protein 90 plays a role in translocating chaperoned antigen from endosome to proteasome for generating antigenic peptide to be cross-presented by dendritic cells
inferredcites →https://doi.org/10.1093/molehr/gat045openalex-snapshotDifferential vasodilation of human placental and myometrial arteries related to myofilament Ca2+-desensitization and the expression of Hsp20 but not MYPT1
inferredcites →https://doi.org/10.1111/j.1574-6968.2006.00140.xopenalex-snapshotAdhesion characteristics of Listeria adhesion protein (LAP)-expressing Escherichia coli to Caco-2 cells and of recombinant LAP to eukaryotic receptor Hsp60 as examined in a surface plasmon resonance sensor
inferredcites →https://doi.org/10.1111/j.1744-313x.2008.00819.xopenalex-snapshotA comparative analysis of the products of GROEL‐1 gene fromChlamydia trachomatisserovar D and the HSP60 var1 transcript fromHomo sapienssuggests a possible autoimmune response
inferredcites →https://doi.org/10.1128/iai.01379-09openalex-snapshotComparison of the Moonlighting Actions of the Two Highly Homologous Chaperonin 60 Proteins of Mycobacterium tuberculosis
inferredcites →https://doi.org/10.1128/jvi.02320-06openalex-snapshotInhibition of Human Immunodeficiency Virus Type 1 Infection of Human CD4 + T Cells by Microbial HSP70 and the Peptide Epitope 407-426
inferredcites →https://doi.org/10.1186/1476-9255-11-19openalex-snapshotHeat shock protein 70 down-regulates the production of toll-like receptor-induced pro-inflammatory cytokines by a heat shock factor-1/constitutive heat shock element-binding factor-dependent mechanism
inferredcites →https://doi.org/10.1189/jlb.1209779openalex-snapshotMolecular chaperones and protein-folding catalysts as intercellular signaling regulators in immunity and inflammation
inferredcites →https://doi.org/10.1371/journal.pone.0097657openalex-snapshotHuman Hsp60 with Its Mitochondrial Import Signal Occurs in Solution as Heptamers and Tetradecamers Remarkably Stable over a Wide Range of Concentrations
inferredcites →https://doi.org/10.3389/fimmu.2015.00162openalex-snapshotHeat Shock Protein 70 (Hsp70) Peptide Activated Natural Killer (NK) Cells for the Treatment of Patients with Non-Small Cell Lung Cancer (NSCLC) after Radiochemotherapy (RCTx) – From Preclinical Studies to a Clinical Phase II Trial
inferredcites →https://doi.org/10.4049/jimmunol.149.10.3321openalex-snapshotAntibodies and reactive T cells against the malaria heat-shock protein Pf72/Hsp70-1 and derived peptides in individuals continuously exposed to Plasmodium falciparum
inferredcites →https://doi.org/10.4049/jimmunol.157.1.369openalex-snapshotHeat shock protein 65 induces CD62e, CD106, and CD54 on cultured human endothelial cells and increases their adhesiveness for monocytes and granulocytes
inferredcites →https://doi.org/10.4049/jimmunol.164.1.13openalex-snapshotCutting Edge: Heat Shock Protein (HSP) 60 Activates the Innate Immune Response: CD14 Is an Essential Receptor for HSP60 Activation of Mononuclear Cells
inferredcites →https://doi.org/10.4049/jimmunol.174.6.3306openalex-snapshotIdentification of Stimulating and Inhibitory Epitopes within the Heat Shock Protein 70 Molecule That Modulate Cytokine Production and Maturation of Dendritic Cells
inferredcites →https://doi.org/10.4049/jimmunol.180.6.4299openalex-snapshotHsp70 Translocates into the Plasma Membrane after Stress and Is Released into the Extracellular Environment in a Membrane-Associated Form that Activates Macrophages
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4688073openalex-extractedThe Integration Analyses of Transcriptomes and Metabolomes Revealed the Effect of Dietary Tannin on the Ammonia Stress Responses of Litopenaeus Vannamei
inferred← citeshttps://doi.org/10.1002/advs.202512952openalex-snapshotStress‐Programmed Immune Niches Fuel TNFR2+ Treg Activation and Drive Neoadjuvant Chemotherapy Resistance in Breast Cancer
inferred← citeshttps://doi.org/10.1002/cac2.12429openalex-snapshotSingle‐cell atlas reveals a distinct immune profile fostered by T cell‐B cell crosstalk in triple negative breast cancer
inferred← citeshttps://doi.org/10.1002/eji.202551963openalex-snapshotFever‐Induced Heat Shock Protein‐70 Regulates Macrophage IL‐1β and IL‐10 Secretion During Mycobacterium tuberculosis Infection
inferred← citeshttps://doi.org/10.1002/etc.5798openalex-snapshotEnvironmentally Relevant Concentrations of the Insecticide Fipronil Modulated Molecular Response in Chironomus riparius
inferred← citeshttps://doi.org/10.1002/iid3.735openalex-snapshotHeat shock protein 40 of Streptococcus pneumoniae induces immune response of human dendritic cells via TLR4‐dependent p38 MAPK and JNK signaling pathways
inferred← citeshttps://doi.org/10.1002/jat.4585openalex-snapshotReactive metabolite of trovafloxacin activates inflammasomes: Implications for trovafloxacin‐induced liver injury
inferred← citeshttps://doi.org/10.1002/jum.70148openalex-snapshotLower Plasma Antioxidant Defense and Heat Shock Proteins Mark Intra‐Amniotic Sludge Ultrasound Finding
inferred← citeshttps://doi.org/10.1002/path.5349openalex-snapshotMolecular mechanisms in chaperonopathies: clues to understanding the histopathological abnormalities and developing novel therapies
inferred← citeshttps://doi.org/10.1002/path.5833openalex-snapshotElucidating the role of the kinase activity of endothelial cell focal adhesion kinase in angiocrine signalling and tumour growth
inferred← citeshttps://doi.org/10.1002/prca.202300115openalex-snapshotMass Spectrometric and Artificial Intelligence‐Based Identification of the Secretome of Plasmodium falciparum Merozoites to Provide Novel Candidates for Vaccine Development Pipeline
inferred← citeshttps://doi.org/10.1007/7515_2020_22openalex-snapshotHuntingtin Yeast Two-Hybrid Protein K (HYPK): An Intrinsically Unstructured Heat Shock Inducible Protein with Diverse Cellular and Molecular Functions
inferred← citeshttps://doi.org/10.1007/s00056-022-00391-wopenalex-snapshotImpact of phosphorylation of heat shock protein 27 on the expression profile of periodontal ligament fibroblasts during mechanical strain
inferred← citeshttps://doi.org/10.1007/s00436-025-08599-6openalex-snapshotPreliminary investigation of heat shock protein 90 gene diversity in Echinococcus granulosus sensu lato: a potential nuclear marker for species identification
inferred← citeshttps://doi.org/10.1007/s10930-025-10285-6openalex-snapshotUnveiling the Immunostimulatory Potential of the HSPA1A Mini-Chaperones Compared to the HSPA1A and HSP27 Chaperones: In Silico and In Vitro Insights for Vaccine Development
inferred← citeshttps://doi.org/10.1007/s12011-024-04199-0openalex-snapshotRutin Nanoparticles Alleviate Cadmium-Induced Oxidative and Immune Damage in Broilers’ Bursa of Fabricius via Modulating Hsp70/TLR4/NF-κB Signaling Pathway
inferred← citeshttps://doi.org/10.1007/s12011-025-04603-3openalex-snapshotUnveiling the Toxic Mechanism of Arsenic on the Spleen of Cyprinus carpio and the Antagonistic Role of Zinc via the P38 MAPK/Nrf2/HO- 1 Pathway
inferred← citeshttps://doi.org/10.1007/s12192-021-01223-3openalex-snapshotDiversity in heat shock protein families: functional implications in virus infection with a comprehensive insight of their role in the HIV-1 life cycle
inferred← citeshttps://doi.org/10.1016/j.bjorl.2022.04.001openalex-snapshotThe effect of early radiofrequency turbinate reduction, intranasal steroid, and antihistamine H-1 on persistent allergic rhinitis: a randomized clinical trial
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inferred← citeshttps://doi.org/10.1016/j.cej.2025.162926openalex-snapshotInsight into cyclodextrin hybrid framework formation mechanism to develop a universal vehicle for improving mitochondrial homeostasis
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2019.110127openalex-snapshotArsenic (III) or/and copper (II) exposure induce immunotoxicity through trigger oxidative stress, inflammation and immune imbalance in the bursa of chicken
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2021.112748openalex-snapshotTranscriptome analysis reveals the mechanism of alkalinity exposure on spleen oxidative stress, inflammation and immune function of Luciobarbus capito
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2021.112978openalex-snapshotExposure to acetochlor impairs swim bladder formation, induces heat shock protein expression, and promotes locomotor activity in zebrafish (Danio rerio) larvae
inferred← citeshttps://doi.org/10.1016/j.etap.2024.104456openalex-snapshotModulating responses of indicator genes in cellular homeostasis, immune defense and apoptotic process in the Macrophthalmus japonicus exposed to di(2-ethylhexyl) phthalate as a plastic additive
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inferred← citeshttps://doi.org/10.1016/j.fsi.2020.10.020openalex-snapshotTranscriptome analysis reveals temperature-dependent early immune response in flounder (Paralichthys olivaceus) after Hirame novirhabdovirus (HIRRV) infection
inferred← citeshttps://doi.org/10.1016/j.fsi.2022.08.014openalex-snapshotNew insights into the regulation mechanism of Litopenaeus vannamei hepatopancreas after lipopolysaccharide challenge using transcriptome analyses
inferred← citeshttps://doi.org/10.1016/j.fsi.2022.08.022openalex-snapshotA different transcriptional landscape sheds light on Russian sturgeon (Acipenser gueldenstaedtii) mechanisms to cope with bacterial infection and chronic heat stress
inferred← citeshttps://doi.org/10.1016/j.fsi.2023.109173openalex-snapshotTranscriptomic analysis of the antioxidant responses and immunomodulatory effects of dietary melatonin in red swamp crayfish (Procambarus clarkii)
inferred← citeshttps://doi.org/10.1016/j.fsi.2023.109323openalex-snapshotMolecular evolution of the heat shock protein family and the role of HSP30 in immune response and wound healing in lampreys (Lethenteron reissneri)
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.136082openalex-snapshotFractionation, characterization, and assessment of nutritional and immunostimulatory protein-rich polysaccharide-protein complexes isolated from Lentinula edodes mushroom
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inferred← citeshttps://doi.org/10.1016/j.psj.2021.101459openalex-snapshotResveratrol sustains intestinal barrier integrity, improves antioxidant capacity, and alleviates inflammation in the jejunum of ducks exposed to acute heat stress
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inferred← citeshttps://doi.org/10.1016/j.redox.2020.101581openalex-snapshotChemical modification of pro-inflammatory proteins by peroxynitrite increases activation of TLR4 and NF-κB: Implications for the health effects of air pollution and oxidative stress
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inferred← citeshttps://doi.org/10.1016/j.vas.2026.100667openalex-snapshotDietary heat-killed Limosilactobacillus ingluviei C37 postbiotic improves growth performance and modulates stress-related gene expression in heat-stressed broiler chickens
inferred← citeshttps://doi.org/10.1017/s0007485326101229openalex-snapshotMolecular cloning and expression under cold stress of two heat shock proteins from Dastarcus helophoroides (Fairmaire) (Coleoptera: Bothrideridae)
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inferred← citeshttps://doi.org/10.1074/jbc.ra119.009145openalex-snapshotHeat shock protein 70 is a positive regulator of airway inflammation and goblet cell hyperplasia in a mouse model of allergic airway inflammation
inferred← citeshttps://doi.org/10.1080/08820139.2022.2083973openalex-snapshotThe Effects of Cannabinoid Agonist, Heat Shock Protein 90 and Nitric Oxide Synthase Inhibitors on Increasing IL-13 and IL-31 Levels in Chronic Pruritus
inferred← citeshttps://doi.org/10.1080/10495398.2022.2155175openalex-snapshotHSP27–HSP40–HSP70–HSP90 pathway participated in molecular mechanism of selenium alleviating lead-caused oxidative damage and proteotoxicity in chicken Bursa of Fabricius
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inferred← citeshttps://doi.org/10.1111/apm.70071openalex-snapshotHSP22 Alleviates Lung Ischemia–Reperfusion Injury Following Pulmonary Embolism by Suppressing Inflammation, Oxidative Stress, and Apoptosis Through HIF‐1α/NOX4 Pathway
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