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Facile Synthesis of a Series of Non-Symmetric Thioethers Including a Benzothiazole Moiety and Their Use as Efficient In Vitro anti-Trypanosoma cruzi Agents

https://doi.org/10.3390/molecules24173077
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/j.actatropica.2009.11.003openalex-snapshot
Chagas disease: A Latin American health problem becoming a world health problem
inferredcites →https://doi.org/10.1016/j.actatropica.2011.12.009openalex-snapshot
In vitro and in vivo trypanocidal activity of some benzimidazole derivatives against two strains of Trypanosoma cruzi
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Technological innovation strategies for the specific treatment of Chagas disease based on Benznidazole
inferredcites →https://doi.org/10.1016/j.bioorg.2018.09.015openalex-snapshot
1,2,4-Triazole-based benzothiazole/benzoxazole derivatives: Design, synthesis, p38α MAP kinase inhibition, anti-inflammatory activity and molecular docking studies
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In vitro activity of steroidal dendrimers on Trypanosoma cruzi epimastigote form with PAMAM dendrons modified by “click” chemistry
inferredcites →https://doi.org/10.1016/j.bmc.2006.08.035openalex-snapshot
Synthesis of three classes of rhodacyanine dyes and evaluation of their in vitro and in vivo antimalarial activity
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Novel 3-nitro-1H-1,2,4-triazole-based piperazines and 2-amino-1,3-benzothiazoles as antichagasic agents
inferredcites →https://doi.org/10.1016/j.bmc.2015.02.059openalex-snapshot
Synthesis of nitro(benzo)thiazole acetamides and in vitro antiprotozoal effect against amitochondriate parasites Giardia intestinalis and Trichomonas vaginalis
inferredcites →https://doi.org/10.1016/j.ejmech.2012.05.028openalex-snapshot
Benzothiazoles: Search for anticancer agents
inferredcites →https://doi.org/10.1016/j.ejmech.2013.06.026openalex-snapshot
Design, synthesis and anticonvulsant evaluation of N-(benzo[d]thiazol-2-ylcarbamoyl)-2-methyl-4-oxoquinazoline-3(4H)-carbothioamide derivatives: A hybrid pharmacophore approach
inferredcites →https://doi.org/10.1016/j.tet.2012.11.045openalex-snapshot
Acidic-functionalized ionic liquid as an efficient, green, and metal-free catalyst for benzylation of sulfur, nitrogen, and carbon nucleophiles to benzylic alcohols
inferredcites →https://doi.org/10.1017/s0031182004006031openalex-snapshot
Activity of benzothiazoles and chemical derivatives on Plasmodium falciparum
inferredcites →https://doi.org/10.1021/acs.jafc.7b04130openalex-snapshot
Green Synthesis of Potential Antifungal Agents: 2-Benzyl Substituted Thiobenzoazoles
inferredcites →https://doi.org/10.1021/acs.joc.6b00113openalex-snapshot
One-Pot Synthesis and Evaluation of Antileishmanial Activities of Functionalized S-Alkyl/Aryl Benzothiazole-2-carbothioate Scaffold
inferredcites →https://doi.org/10.1021/jm00308a018openalex-snapshot
Antimalarials. III. Benzothiazole amino alcohols
inferredcites →https://doi.org/10.1021/jo200535eopenalex-snapshot
Synthesis of 2-Thio-Substituted Benzothiazoles via a Domino Condensation/S-Arylation/Heterocyclization Process
inferredcites →https://doi.org/10.1039/c2md20136dopenalex-snapshot
Synthesis of cyanine dyes and investigation of their in vitro antiprotozoal activities
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Chagas’ Disease
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Over Six Thousand Trypanosoma cruzi Strains Classified into Discrete Typing Units (DTUs): Attempt at an Inventory
inferredcites →https://doi.org/10.2174/157340612800493593openalex-snapshot
Structure-Activity Relationships of 2-Benzylsulfanylbenzothiazoles: Synthesis and Selective Antimycobacterial Properties
inferredcites →https://doi.org/10.3390/molecules18011053openalex-snapshot
Antiprotozoal Activity of Quinonemethide Triterpenes from Maytenus ilicifolia (Celastraceae)
inferredcites →https://doi.org/10.3390/molecules22020220openalex-snapshot
Trypanocidal Activity of Quinoxaline 1,4 Di-N-oxide Derivatives as Trypanothione Reductase Inhibitors
inferredcites →https://doi.org/10.5012/jkcs.2012.56.2.251openalex-snapshot
Synthesis and Antidiabetic Evaluation of Benzothiazole Derivatives

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Chagas Disease: History, Pathophysiology and Therapeutic Treatment
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Phenylbenzothiazole derivatives: effects against a Trypanosoma cruzi infection and toxicological profiles
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Synthesis and biological evaluation in vitro and in silico of N-propionyl-N′-benzeneacylhydrazone derivatives as cruzain inhibitors of Trypanosoma cruzi
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Thiazoles
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Potential of sulfur-selenium isosteric replacement as a strategy for the development of new anti-chagasic drugs
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Biological evaluation of guanidines, bisguanidines, and their derivatives as anti-Trypanosoma cruzi agents
inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.115002openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.117203openalex-snapshot
Synthesis strategies and anti-parasitic evaluation of novel compounds for chagas disease: Advancing drug discovery through structure-activity relationships
inferred← citeshttps://doi.org/10.1016/j.jorganchem.2020.121295openalex-snapshot
Synthesis and characterization of non-symmetric Pd(II)–POCOP pincer compounds including a meta-(2-aminobenzothiazole) fragment
inferred← citeshttps://doi.org/10.1016/j.molstruc.2020.128520openalex-snapshot
Synthesis, characterization and preliminary in vitro trypanocidal activity of N-arylfluorinated hydroxylated-Schiff bases
inferred← citeshttps://doi.org/10.1016/j.rechem.2025.102134openalex-snapshot
Green synthesis and in vitro anticancer evaluation of 1,2-disubstituted benzimidazole derivatives
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.3c01051openalex-snapshot
Bis-6-amidino-benzothiazole Derivative that Cures Experimental Stage 1 African Trypanosomiasis with a Single Dose
inferred← citeshttps://doi.org/10.1039/d1ob00823dopenalex-snapshot
Ag–Cu copromoted direct C2–H bond thiolation of azoles with Bunte salts as sulfur sources
inferred← citeshttps://doi.org/10.1039/d5ra03993bopenalex-snapshot
Synthetic strategies towards benzothiazole-based compounds of therapeutic potency: experimental, investigational and approved drugs
inferred← citeshttps://doi.org/10.1080/13543776.2023.2176219openalex-snapshot
Are patents important indicators of innovation for Chagas disease treatment?
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Synthesis, antiproliferative and antitrypanosomal activities, and DNA binding of novel 6-amidino-2-arylbenzothiazoles
inferred← citeshttps://doi.org/10.1134/s1070363223020081openalex-snapshot
First Synthesis of N-Organyl-S-silylorganyl Derivatives of 2-Mercaptobenzothiazole
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Synthesis of Acetylenic [Chloro(iodo)methyl]silanes and 2-Sulfanylbenzothiazoles Based Thereon
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First Synthesis of N-Organyl-S-silylorganyl Derivatives of 2-Mercaptobenzothiazole
inferred← citeshttps://doi.org/10.3390/chemistry6050069openalex-snapshot
Easy Synthesis and In Vitro Evaluation of Halogenated Chalcones against Trypanosoma cruzi
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Modern Approaches to the Synthesis and Transformations of Practically Valuable Benzothiazole Derivatives
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Synthesis, Characterization, and Preliminary In Vitro Cytotoxic Evaluation of a Series of 2-Substituted Benzo [d] [1,3] Azoles
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