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Semi-Synthetic Ingenol Derivative from Euphorbia tirucalli Inhibits Protein Kinase C Isotypes and Promotes Autophagy and S-Phase Arrest on Glioma Cell Lines
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/ejoc.201200733openalex-snapshot
Diterpenes from European Euphorbia Species Serving as Prototypes for Natural‐Product‐Based Drug Discovery
inferredcites →https://doi.org/10.1002/ijc.24402openalex-snapshot
The induction of autophagy by γ‐radiation contributes to the radioresistance of glioma stem cells
inferredcites →https://doi.org/10.1002/pca.2711openalex-snapshot
Quantitative Analysis of Ingenol in Euphorbia species via Validated Isotope Dilution Ultra‐high Performance Liquid Chromatography Tandem Mass Spectrometry
inferredcites →https://doi.org/10.1007/bf01411552openalex-snapshot
The role of protein kinase C (PKC) in the evolution and proliferation of malignant gliomas, and the application of PKC inhibition as a novel approach to anti-glioma therapy
inferredcites →https://doi.org/10.1007/s10637-018-0620-yopenalex-snapshot
Euphol, a tetracyclic triterpene, from Euphorbia tirucalli induces autophagy and sensitizes temozolomide cytotoxicity on glioblastoma cells
inferredcites →https://doi.org/10.1007/s10637-019-00728-0openalex-snapshot
Modified ingenol semi-synthetic derivatives from Euphorbia tirucalli induce cytotoxicity on a large panel of human cancer cell lines
inferredcites →https://doi.org/10.1016/0065-2571(84)90007-4openalex-snapshot
Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors
inferredcites →https://doi.org/10.1016/j.bbagen.2014.12.022openalex-snapshot
Tamoxifen in combination with temozolomide induce a synergistic inhibition of PKC-pan in GBM cell lines
inferredcites →https://doi.org/10.1016/j.ejphar.2012.10.019openalex-snapshot
The role of PKC/ERK1/2 signaling in the anti-inflammatory effect of tetracyclic triterpene euphol on TPA-induced skin inflammation in mice
inferredcites →https://doi.org/10.1016/j.fct.2005.08.011openalex-snapshot
Genotoxicity evaluation of kaurenoic acid, a bioactive diterpenoid present in Copaiba oil
inferredcites →https://doi.org/10.1016/j.neuroscience.2015.06.051openalex-snapshot
The antinociceptive effects of the tetracyclic triterpene euphol in inflammatory and neuropathic pain models: The potential role of PKCε
inferredcites →https://doi.org/10.1016/j.phrs.2016.01.021openalex-snapshot
Medicinal plants in Brazil: Pharmacological studies, drug discovery, challenges and perspectives
inferredcites →https://doi.org/10.1016/s0021-9258(17)37580-4openalex-snapshot
PKCu is a novel, atypical member of the protein kinase C family.
inferredcites →https://doi.org/10.1016/s1074-5521(01)00048-5openalex-snapshot
Ingenol esters induce apoptosis in Jurkat cells through an AP-1 and NF-κB independent pathway
inferredcites →https://doi.org/10.1016/s1470-2045(17)30194-8openalex-snapshot
European Association for Neuro-Oncology (EANO) guideline on the diagnosis and treatment of adult astrocytic and oligodendroglial gliomas
inferredcites →https://doi.org/10.1017/s0317167100001049openalex-snapshot
High Dose Tamoxifen and Radiotherapy in Patients with Glioblastoma Multiforme: A Phase IB Study
inferredcites →https://doi.org/10.1038/nrd3871openalex-snapshot
Protein kinase C, an elusive therapeutic target?
inferredcites →https://doi.org/10.1038/sj.bjc.6605381openalex-snapshot
Activity of the multikinase inhibitor dasatinib against ovarian cancer cells
inferredcites →https://doi.org/10.1038/sj.cdd.4401359openalex-snapshot
Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells
inferredcites →https://doi.org/10.1055/s-2005-873196openalex-snapshot
New Macrocyclic Lathyrane Diterpenes, fromEuphorbia lagascae,as Inhibitors of Multidrug Resistance of Tumour Cells
inferredcites →https://doi.org/10.1056/nejmoa043330openalex-snapshot
Radiotherapy Plus Concomitant and Adjuvant Temozolomide for Glioblastoma
inferredcites →https://doi.org/10.1056/nejmoa1111170openalex-snapshot
Ingenol Mebutate Gel for Actinic Keratosis
inferredcites →https://doi.org/10.1073/pnas.91.18.8572openalex-snapshot
Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain.
inferredcites →https://doi.org/10.1089/088922204323087741openalex-snapshot
Expression of Latent HAART-Persistent HIV Type 1 Induced by Novel Cellular Activating Agents
inferredcites →https://doi.org/10.1093/neuonc/not151openalex-snapshot
CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2006-2010
inferredcites →https://doi.org/10.1093/neuonc/now166openalex-snapshot
Cancers of the brain and CNS: global patterns and trends in incidence
inferredcites →https://doi.org/10.1093/neuonc/nox158openalex-snapshot
CBTRUS Statistical Report: Primary brain and other central nervous system tumors diagnosed in the United States in 2010–2014
inferredcites →https://doi.org/10.1111/j.1365-2184.2007.00506.xopenalex-snapshot
Involvement of PKC‐ι in glioma proliferation
inferredcites →https://doi.org/10.1111/j.1750-3639.2011.00544.xopenalex-snapshot
Autophagy in Brain Tumors: A New Target for Therapeutic Intervention
inferredcites →https://doi.org/10.1146/annurev-pathol-121808-102109openalex-snapshot
The Pathobiology of Glioma Tumors
inferredcites →https://doi.org/10.1158/0008-5472.can-03-3403openalex-snapshot
Characterization of the Interaction of Ingenol 3-Angelate with Protein Kinase C
inferredcites →https://doi.org/10.1158/1078-0432.ccr-05-1671openalex-snapshot
Synergistic Antitumor Activity of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Gefitinib and IFN-α in Head and Neck Cancer Cells In vitro and In vivo
inferredcites →https://doi.org/10.1158/1535-7163.1651.3.12openalex-snapshot
Ingenol 3-angelate induces dual modes of cell death and differentially regulates tumor necrosis factor–related apoptosis-inducing ligand–induced apoptosis in melanoma cells
inferredcites →https://doi.org/10.1158/1535-7163.mct-07-2060openalex-snapshot
Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells
inferredcites →https://doi.org/10.1159/000443404openalex-snapshot
Natural Products as a Vital Source for the Discovery of Cancer Chemotherapeutic and Chemopreventive Agents
inferredcites →https://doi.org/10.1182/blood-2004-10-4117openalex-snapshot
PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC
inferredcites →https://doi.org/10.1200/jco.2009.26.7252openalex-snapshot
Integrated Molecular Genetic Profiling of Pediatric High-Grade Gliomas Reveals Key Differences With the Adult Disease
inferredcites →https://doi.org/10.12659/msm.906049openalex-snapshot
Ingenol-3-Angelate Suppresses Growth of Melanoma Cells and Skin Tumor Development by Downregulation of NF-κB-Cox2 Signaling
inferredcites →https://doi.org/10.1371/journal.pone.0097257openalex-snapshot
Dual Role of Novel Ingenol Derivatives from Euphorbia tirucalli in HIV Replication: Inhibition of De Novo Infection and Activation of Viral LTR
inferredcites →https://doi.org/10.1590/1414-431x20121423openalex-snapshot
Kaurene diterpene induces apoptosis in U87 human malignant glioblastoma cells by suppression of anti-apoptotic signals and activation of cysteine proteases
inferredcites →https://doi.org/10.1593/tlo.12400openalex-snapshot
In Vitro and In Vivo Analysis of RTK Inhibitor Efficacy and Identification of Its Novel Targets in Glioblastomas
inferredcites →https://doi.org/10.1615/critrevoncog.2016017008openalex-snapshot
Targeting Autophagy in Glioblastoma
inferredcites →https://doi.org/10.1634/theoncologist.7-1-17openalex-snapshot
Targeting Protein Kinase C: New Therapeutic Opportunities Against High-Grade Malignant Gliomas?
inferredcites →https://doi.org/10.21037/tcr.2017.03.32openalex-snapshot
Molecular characterization of short-term primary cultures and comparison with corresponding tumor tissue of Brazilian glioblastoma patients
inferredcites →https://doi.org/10.2147/ccid.s28905openalex-snapshot
New developments in the treatment of actinic keratosis: focus on ingenol mebutate gel
inferredcites →https://doi.org/10.3390/ijms19113466openalex-snapshot
The Roles of Autophagy in Cancer
inferredcites →https://doi.org/10.3390/toxins2010174openalex-snapshot
The Protein Kinase C Agonist PEP005 (Ingenol 3-Angelate) in the Treatment of Human Cancer: A Balance between Efficacy and Toxicity
inferredcites →https://doi.org/10.3892/etm.2018.6244openalex-snapshot
In�vitro screening of cytotoxic activity of euphol from Euphorbia�tirucalli on a large panel of human cancer‑derived cell lines
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1016/j.phytochem.2020.112504zenodo-depositor-declared
Bioactive diterpenoid metabolism and cytotoxic activities of genetically transformed Euphorbia lathyris roots
inferred← citeshttps://doi.org/10.1007/s00210-024-03350-xopenalex-snapshot
Properties and medical applications of the Euphorbiaceae family and their bioproducts: a patent review
inferred← citeshttps://doi.org/10.1016/j.bbcan.2024.189168openalex-snapshot
Dual perspective on autophagy in glioma: Detangling the dichotomous mechanisms of signaling pathways for therapeutic insights
inferred← citeshttps://doi.org/10.1016/j.biopha.2026.119721openalex-snapshot
Euphol targets key oncogenic processes and promotes chemoprevention in organoid and In Vivo models of colorectal cancers
inferred← citeshttps://doi.org/10.1039/d2np00047dopenalex-snapshot
Euphorbia diterpenoids: isolation, structure, bioactivity, biosynthesis, and synthesis (2013–2021)
inferred← citeshttps://doi.org/10.1111/pbi.14525openalex-snapshot
Comparative bioactivity analysis of latex and water extract of Euphorbia gaillardotii: chemical profile, antioxidant capacity, effects on water quality, in vitro antimicrobial‐cytotoxic activities, and in silico molecular docking studies
inferred← citeshttps://doi.org/10.1177/1934578x221105691openalex-snapshot
The Role of Ingenane Diterpenes in Cancer Therapy: From Bioactive Secondary Compounds to Small Molecules
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2202481/v1openalex-snapshot
In vitro Cytogenetic Effects of the Euphorbia grisophylla Aerial Parts Aqueous Extract in Human Peripheral Lymphocytes
inferred← citeshttps://doi.org/10.2147/ijn.s257459openalex-snapshot
Transferrin Receptor-Targeted PEG-PLA Polymeric Micelles for Chemotherapy Against Glioblastoma Multiforme
inferred← citeshttps://doi.org/10.3389/fphar.2026.1760169openalex-snapshot
GPR55 and PINK1 as emerging therapeutic targets in Glioma: insights into their modulation by phytochemicals and plant extracts
inferred← citeshttps://doi.org/10.3390/molecules25030650openalex-snapshot
Antitumoral Properties of Natural Products
inferred← citeshttps://doi.org/10.3892/etm.2021.10142openalex-snapshot
Autophagy-related signaling pathways are involved in cancer (Review)
inferred← citeshttps://doi.org/10.54033/cadpedv22n13-250openalex-snapshot
In vitro citotoxicity of Euphorbia genus: a revision study
inferred← citeshttps://doi.org/10.54033/cadpedv22n7-212openalex-snapshot
Methodological proposal for qualitative research in semiology
inferred← citeshttps://doi.org/10.55905/cuadv15n11-065openalex-snapshot
Os efeitos farmacológicos e tóxicos da planta medicinal Euphorbia tirucalli: uma revisão sistemática
inferred← citeshttps://doi.org/10.56238/sevened2024.004-012openalex-snapshot
Environmental impact of pollutants and the potential contribution to phytoremediation
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