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Hybrides of Alkaloid Lappaconitine with Pyrimidine Motif on the Anthranilic Acid Moiety: Design, Synthesis, and Investigation of Antinociceptive Potency

https://doi.org/10.3390/molecules25235578

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Efficient Consecutive Four‐Component Synthesis of 5‐Acylpyrid‐2‐ones Initiated by Copper‐Free Alkynylation

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Lappaconitine, a C18-diterpenoid alkaloid, exhibits antihypersensitivity in chronic pain through stimulation of spinal dynorphin A expression

inferredcites →https://doi.org/10.1007/s10593-019-02404-wopenalex-snapshot

Synthesis of hybrid molecules containing pyrimidine and diterpene alkaloid lappaconitine fragments

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5-Substituted 2-benzylidene-1-tetralone analogues as A 1 and/or A 2A antagonists for the potential treatment of neurological conditions

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Novel LCK/FMS inhibitors based on phenoxypyrimidine scaffold as potential treatment for inflammatory disorders

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Comparative metabolism of Lappaconitine in rat and human liver microsomes and in vivo of rat using ultra high-performance liquid chromatography–quadrupole/time-of-flight mass spectrometry

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Effect of lappaconitine on neuropathic pain mediated by P2X3 receptor in rat dorsal root ganglion

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Different Effects on [3H]Noradrenaline Uptake of the Aconitum Alkaloids Aconitine, 3-Acetylaconitine, Lappaconitine, and N-Desacetyllappaconitine in Rat Hippocampus

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SYNTHETIC ANALGESICS. II. DITHIENYLBUTENYL- AND DITHIENYLBUTYLAMINES

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Study of Analgesic and Anti-inflammatory Effects of Lappaconitine Gelata

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Separation and characterization of the metabolic products of lappaconitine in rat urine by high-performance liquid chromatography

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Study of alkaloids of the Siberian and Altai flora. 10. Synthesis of N(20)-deethyllappaconitine derivatives

inferredcites →https://doi.org/10.1038/s41401-018-0067-xopenalex-snapshot

Inhibitory effects of lappaconitine on the neuronal isoforms of voltage-gated sodium channels

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Carbonylation of organic halides in the presence of terminal acetylenes; novel acetylenic ketone synthesis

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Multicomponent syntheses of functional chromophores

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Palladium-Catalyzed Molybdenum Hexacarbonyl-Mediated Gas-Free Carbonylative Reactions

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General Synthesis and Catalytic Applications of Di(1-adamantyl)alkylphosphines and their Phosphonium Salts

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The Cambridge Structural Database

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inferredcites →https://doi.org/10.1134/s0012500807100059openalex-snapshot

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Pharmacological Studies on Lappaconitine: Possible Interaction with Endogenous Noradrenergic and Serotonergic Pathways to Induce Antinociception.

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Consecutive multi-component syntheses of heterocycles via palladium-copper catalyzed generation of alkynones

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Pharmacokinetic Study of Lappaconitine Hydrobromide Transfersomes in Rats by LC-MS

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Analgesic effects of lappaconitine in leukemia bone pain in a mouse model

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.phytochem.2021.112866zenodo-depositor-declared

Diterpenoid alkaloids from the whole herb of Delphinium grandiflorum L

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An Efficient Access to 3,5‐Disubstituted Isoxazoles with Anthranilate Ester Moiety: Alkaloid Lappaconitine – Aryl Conjugates with an Isoxazole Linker

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Synthetic Transformations of Lappaconitine

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Phytosterol-mediated glycerosomes combined with peppermint oil enhance transdermal delivery of lappaconitine by modulating the lipid composition of the stratum corneum

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Microbial alkaloids and their pharmaceutical and agricultural application

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Design and structural optimization of lappaconitine derivatives as Nav1.7 inhibitors with improved analgesic efficacy and reduced lethality in mice

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A straightforward trifluoromethylation at the C6 position of morphinane alkaloids, their modification and evaluation of inhibition of the SARS-CoV-2 main protease

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Iron( iii )-catalyzed synthesis of indole–xanthydrol hybrid through oxidative cycloisomerization/hydroxylation reaction

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Therapeutic Potentials of Aconite-like Alkaloids: Bioinformatics and Experimental Approaches

inferred← citeshttps://doi.org/10.3390/ijms25158255openalex-snapshot

Advancements in Non-Addictive Analgesic Diterpenoid Alkaloid Lappaconitine: A Review

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Synthesis, Pharmacological Evaluation, and Molecular Modeling of Lappaconitine–1,5-Benzodiazepine Hybrids

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