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Acorus tatarinowii Schott: A Review of Its Botany, Traditional Uses, Phytochemistry, and Pharmacology

https://doi.org/10.3390/molecules28114525

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Outgoing claims: the papers this work cites, builds on, or argues with.

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A rapid HPLC‐ESI‐MS/MS method for determination of β ‐asarone, a potential anti‐epileptic agent, in plasma after oral administration of Acorus calamus extract to rats

inferredcites →https://doi.org/10.1002/bmc.3371openalex-snapshot

Qualitative and quantitative analysis of the major constituents in Acorus tatarinowii Schott by HPLC/ESI‐QTOF‐MS/MS

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A Novel Tropoloisoquinoline Alkaloid, Neotatarine, from Acorus calamus L.

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α‐Asarone, β‐asarone, and γ‐asarone: Current status of toxicological evaluation

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Bioactive Nitrogenous Compounds from Acorus tatarinowii

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Anticonvulsant and Sedative Effects of Eudesmin isolated from Acorus tatarinowii on mice and rats

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Anxiolytic-like effects of α-asarone in a mouse model of chronic pain

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Pro-neurogenic effect of β-asarone on RSC96 Schwann cells in vitro

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Effects of Kaixin Jieyu Decoction (开心解郁汤) on behavior, monoamine neurotransmitter levels, and serotonin receptor subtype expression in the brain of a rat depression model

inferredcites →https://doi.org/10.1016/j.biopha.2020.110679openalex-snapshot

Botany, traditional uses, phytochemistry, analytical methods, processing, pharmacology and pharmacokinetics of Bupleuri Radix: A systematic review

inferredcites →https://doi.org/10.1016/j.bmcl.2015.08.001openalex-snapshot

A novel sesquiterpene and three new phenolic compounds from the rhizomes of Acorus tatarinowii Schott

inferredcites →https://doi.org/10.1016/j.bmcl.2017.08.015openalex-snapshot

New lignans attenuating cognitive deterioration of Aβ transgenic flies discovered in Acorus tatarinowii

inferredcites →https://doi.org/10.1016/j.carbpol.2015.07.018openalex-snapshot

Characterization of polysaccharides with antioxidant and immunological activities from Rhizoma Acori Tatarinowii

inferredcites →https://doi.org/10.1016/j.carbpol.2017.10.061openalex-snapshot

Synthesis of hyaluronan-amikacin conjugate and its bactericidal activity against intracellular bacteria in vitro and in vivo

inferredcites →https://doi.org/10.1016/j.ejphar.2010.03.013openalex-snapshot

Beta-asarone protection against beta-amyloid-induced neurotoxicity in PC12 cells via JNK signaling and modulation of Bcl-2 family proteins

inferredcites →https://doi.org/10.1016/j.ejphar.2015.03.077openalex-snapshot

Anxiolytic-like effects of ursolic acid in mice

inferredcites →https://doi.org/10.1016/j.fct.2018.04.025openalex-snapshot

Formation and fate of DNA adducts of alpha- and beta-asarone in rat hepatocytes

inferredcites →https://doi.org/10.1016/j.fitote.2015.11.010openalex-snapshot

Lignans from the roots of Acorus tatarinowii Schott ameliorate β amyloid-induced toxicity in transgenic Caenorhabditis elegans

inferredcites →https://doi.org/10.1016/j.intimp.2016.03.001openalex-snapshot

Tatarinan O, a lignin-like compound from the roots of Acorus tatarinowii Schott inhibits osteoclast differentiation through suppressing the expression of c-Fos and NFATc1

inferredcites →https://doi.org/10.1016/j.jep.2009.07.018openalex-snapshot

Herbal formula SYJN protect PC12 cells from neurotoxicity induced by corticosterone

inferredcites →https://doi.org/10.1016/j.jep.2014.06.035openalex-snapshot

GC–MS method for determination and pharmacokinetic study of four phenylpropanoids in rat plasma after oral administration of the essential oil of Acorus tatarinowii Schott rhizomes

inferredcites →https://doi.org/10.1016/j.jep.2014.10.026openalex-snapshot

The effects of Acorus tatarinowii Schott on 5-HT concentrations, TPH2 and 5-HT1B expression in the dorsal raphe of exercised rats

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Optimizing the compatibility of paired-herb in an ancient Chinese herbal decoction Kai-Xin-San in activating neurofilament expression in cultured PC12 cells

inferredcites →https://doi.org/10.1016/j.jep.2019.111967openalex-snapshot

Bioactivities of serotonin transporter mediate antidepressant effects of Acorus tatarinowii Schott

inferredcites →https://doi.org/10.1016/j.jep.2020.112830openalex-snapshot

Potential effect of herbal antidepressants on cognitive deficit: Pharmacological activity and possible molecular mechanism

inferredcites →https://doi.org/10.1016/j.jep.2020.113119openalex-snapshot

Bioguided isolation, identification and activity evaluation of antifungal compounds from Acorus tatarinowii Schott

inferredcites →https://doi.org/10.1016/j.jep.2021.114598openalex-snapshot

Qisheng Wan formula ameliorates cognitive impairment of Alzheimer's disease rat via inflammation inhibition and intestinal microbiota regulation

inferredcites →https://doi.org/10.1016/j.jep.2021.114759openalex-snapshot

A comprehensive review of ethnopharmacology, phytochemistry, pharmacology, and pharmacokinetics of Schisandra chinensis (Turcz.) Baill. and Schisandra sphenanthera Rehd. et Wils.

inferredcites →https://doi.org/10.1016/j.neucli.2017.03.002openalex-snapshot

Neuromuscular fatigue during exercise: Methodological considerations, etiology and potential role in chronic fatigue

inferredcites →https://doi.org/10.1016/j.neulet.2019.134308openalex-snapshot

Asarones from Acori Tatarinowii Rhizoma stimulate expression and secretion of neurotrophic factors in cultured astrocytes

inferredcites →https://doi.org/10.1016/j.neuron.2014.12.021openalex-snapshot

Coexistence of Two Forms of LTP in ACC Provides a Synaptic Mechanism for the Interactions between Anxiety and Chronic Pain

inferredcites →https://doi.org/10.1016/j.neuropharm.2012.09.001openalex-snapshot

Alpha-asarone from Acorus gramineus alleviates epilepsy by modulating A-Type GABA receptors

inferredcites →https://doi.org/10.1016/j.phrs.2020.105376openalex-snapshot

Natural volatile oils derived from herbal medicines: A promising therapy way for treating depressive disorder

inferredcites →https://doi.org/10.1016/j.phymed.2013.09.020openalex-snapshot

An overview on traditional uses and pharmacological profile of Acorus calamus Linn. (Sweet flag) and other Acorus species

inferredcites →https://doi.org/10.1016/j.phymed.2017.04.003openalex-snapshot

Pharmacology and toxicology of α- and β-Asarone: A review of preclinical evidence

inferredcites →https://doi.org/10.1016/j.psyneuen.2013.04.011openalex-snapshot

Estrogen receptor GPR30 exerts anxiolytic effects by maintaining the balance between GABAergic and glutamatergic transmission in the basolateral amygdala of ovariectomized mice after stress

inferredcites →https://doi.org/10.1016/j.seizure.2018.08.002openalex-snapshot

Pathophysiology of convulsive status epilepticus

inferredcites →https://doi.org/10.1016/s0140-6736(06)69043-0openalex-snapshot

Incidence, cause, and short-term outcome of convulsive status epilepticus in childhood: prospective population-based study

inferredcites →https://doi.org/10.1016/s0140-6736(16)30590-6openalex-snapshot

The burden of mental, neurological, and substance use disorders in China and India: a systematic analysis of community representative epidemiological studies

inferredcites →https://doi.org/10.1016/s1474-4422(18)30499-xopenalex-snapshot

Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

inferredcites →https://doi.org/10.1016/s1474-4422(21)00023-5openalex-snapshot

Epilepsy in China: major progress in the past two decades

inferredcites →https://doi.org/10.1021/acs.chemrev.0c00199openalex-snapshot

Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond

inferredcites →https://doi.org/10.1021/acs.jnatprod.5b00328openalex-snapshot

(±)-Acortatarinowins A–F, Norlignan, Neolignan, and Lignan Enantiomers from Acorus tatarinowii

inferredcites →https://doi.org/10.1021/acs.jnatprod.7b00457openalex-snapshot

Bioactive Asarone-Derived Phenylpropanoids from the Rhizome of Acorus tatarinowii Schott

inferredcites →https://doi.org/10.1021/acsomega.1c06922openalex-snapshot

Revealing the Antiepileptic Effect of α‑Asaronol on Pentylenetetrazole-Induced Seizure Rats Using NMR-Based Metabolomics

inferredcites →https://doi.org/10.1021/jo1022712openalex-snapshot

Glucokinase-Activating Sesquinlignans from the Rhizomes of Acorus tatarinowii Schott

inferredcites →https://doi.org/10.1021/np300095copenalex-snapshot

Bioactive Sesquiterpenoids from the Rhizomes of Acorus calamus

inferredcites →https://doi.org/10.1021/np900793eopenalex-snapshot

Compounds from Acorus tatarinowii: Determination of Absolute Configuration by Quantum Computations and cAMP Regulation Activity

inferredcites →https://doi.org/10.1021/ol100451popenalex-snapshot

Acortatarins A and B, Two Novel Antioxidative Spiroalkaloids with a Naturally Unusual Morpholine Motif from Acorus tatarinowii

inferredcites →https://doi.org/10.1038/aps.2012.35openalex-snapshot

β-Asarone protects PC12 cells against OGD/R-induced injury via attenuating Beclin-1-dependent autophagy

inferredcites →https://doi.org/10.1038/ncomms8660openalex-snapshot

Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety

inferredcites →https://doi.org/10.1038/s41598-019-56149-9openalex-snapshot

Jatrorrhizine Balances the Gut Microbiota and Reverses Learning and Memory Deficits in APP/PS1 transgenic mice

inferredcites →https://doi.org/10.1038/srep22909openalex-snapshot

Antioxidant Lignans and Neolignans from Acorus tatarinowii

inferredcites →https://doi.org/10.1042/bsr20210006openalex-snapshot

Exploring the biosynthetic pathway of lignin in Acorus tatarinowii Schott using de novo leaf and rhizome transcriptome analysis

inferredcites →https://doi.org/10.1053/j.semdp.2019.04.010openalex-snapshot

Emerging and reemerging fungal infections

inferredcites →https://doi.org/10.1055/s-0029-1186217openalex-snapshot

Chemical Constituents from the Rhizome ofAcorus calamusL.

inferredcites →https://doi.org/10.1055/s-0035-1545694openalex-snapshot

Metabolite Profiling of Tissues of Acorus calamus and Acorus tatarinowii Rhizomes by Using LMD, UHPLC-QTOF MS, and GC-MS

inferredcites →https://doi.org/10.1055/s-0035-1568248openalex-snapshot

Cytotoxic Lignans and Sesquiterpenoids from the Rhizomes of Acorus tatarinowii

inferredcites →https://doi.org/10.1073/pnas.1216150110openalex-snapshot

Serotonin spillover onto the axon initial segment of motoneurons induces central fatigue by inhibiting action potential initiation

inferredcites →https://doi.org/10.1080/10286020.2010.490522openalex-snapshot

Alkaloids and sesquiterpenoids fromAcorus tatarinowii

inferredcites →https://doi.org/10.1089/rej.2018.2155openalex-snapshot

Cellular Senescence as the Key Intermediate in Tau-Mediated Neurodegeneration

inferredcites →https://doi.org/10.1111/j.0013-9580.2005.461007.xopenalex-snapshot

Study of Antiepileptic Effect of Extracts from Acorus tatarinowii Schott

inferredcites →https://doi.org/10.1124/pr.108.00505openalex-snapshot

International Union of Pharmacology. LXX. Subtypes of γ-Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Composition, Pharmacology, and Function. Update

inferredcites →https://doi.org/10.1128/cmr.00029-06openalex-snapshot

Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem

inferredcites →https://doi.org/10.1155/2013/731385openalex-snapshot

Kai-Xin-San, a Chinese Herbal Decoction Containing Ginseng Radix et Rhizoma, Polygalae Radix, Acori Tatarinowii Rhizoma, and Poria, Stimulates the Expression and Secretion of Neurotrophic Factors in Cultured Astrocytes

inferredcites →https://doi.org/10.1155/2017/8516518openalex-snapshot

Neuroprotective Effects and Mechanism of β‐Asarone against Aβ1–42‐Induced Injury in Astrocytes

inferredcites →https://doi.org/10.1155/2020/4845028openalex-snapshot

The Essential Oil from Acori Tatarinowii Rhizome (the Dried Rhizome of Acorus tatarinowii Schott) Prevents Hydrogen Peroxide‐Induced Cell Injury in PC12 Cells: A Signaling Triggered by CREB/PGC‐1α Activation

inferredcites →https://doi.org/10.1155/2021/7158444openalex-snapshot

The Combination of β ‐Asarone and Icariin Inhibits Amyloid‐ β and Reverses Cognitive Deficits by Promoting Mitophagy in Models of Alzheimer’s Disease

inferredcites →https://doi.org/10.1186/1472-6882-13-236openalex-snapshot

Beta-asarone, a major component of Acorus tatarinowii Schott, attenuates focal cerebral ischemia induced by middle cerebral artery occlusion in rats

inferredcites →https://doi.org/10.1186/s12906-020-03168-zopenalex-snapshot

Acorus tatarinowii Schott extract reduces cerebral edema caused by ischemia–reperfusion injury in rats: involvement in regulation of astrocytic NKCC1/AQP4 and JNK/iNOS-mediated signaling

inferredcites →https://doi.org/10.1186/s13020-016-0113-xopenalex-snapshot

Authentication of Acori Tatarinowii Rhizoma (Shi Chang Pu) and its adulterants by morphological distinction, chemical composition and ITS sequencing

inferredcites →https://doi.org/10.12047/j.cjap.5947.2020.066openalex-snapshot

[Effects of acorus tatarinowii Schott and alpha asarone on free radicals and nNOS/NO in hippocampus of rats with fatigue movement].

inferredcites →https://doi.org/10.1248/bpb.28.2327openalex-snapshot

Protective Effect of Acorus calamus LINN on Free Radical Scavengers and Lipid Peroxidation in Discrete Regions of Brain against Noise Stress Exposed Rat

inferredcites →https://doi.org/10.1248/bpb.b12-00376openalex-snapshot

Anticonvulsant Activity of Acute and Chronic Treatment with a-Asarone from Acorus gramineus in Seizure Models

inferredcites →https://doi.org/10.1248/yakushi.130.737openalex-snapshot

Beta-Asarone Attenuates Neuronal Apoptosis Induced by Beta Amyloid in Rat Hippocampus

inferredcites →https://doi.org/10.1271/bbb.120247openalex-snapshot

Cognitive Enhancing Effects of Alpha Asarone in Amnesic Mice by Influencing Cholinergic and Antioxidant Defense Mechanisms

inferredcites →https://doi.org/10.1371/journal.pone.0105471openalex-snapshot

Cost of Disorders of the Brain in Spain

inferredcites →https://doi.org/10.1371/journal.pone.0163337openalex-snapshot

Asarone from Acori Tatarinowii Rhizoma Potentiates the Nerve Growth Factor-Induced Neuronal Differentiation in Cultured PC12 Cells: A Signaling Mediated by Protein Kinase A

inferredcites →https://doi.org/10.1371/journal.pone.0167401openalex-snapshot

β-Asarone Rescues Pb-Induced Impairments of Spatial Memory and Synaptogenesis in Rats

inferredcites →https://doi.org/10.1371/journal.pone.0179077openalex-snapshot

Asarone from Acori Tatarinowii Rhizome prevents oxidative stress-induced cell injury in cultured astrocytes: A signaling triggered by Akt activation

inferredcites →https://doi.org/10.1517/14656566.2010.493875openalex-snapshot

Antifungals to treatCandida albicans

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[Preparation and quality evaluation of volatile oil from Acori Tatarinowii Rhizoma self-nanoemulsion].

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[Study on preparation of volatile oil from Acorus tatarinowii self-nanoemulsion dropping pills and its protective effect on acute myocardial ischemia injury].

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[Research on network pharmacology of Acori Tatarinowii Rhizoma combined with Curcumae Radix in treating epilepsy].

inferredcites →https://doi.org/10.2174/1568026618666180528121707openalex-snapshot

Emerging Virulence, Drug Resistance and Future Anti-fungal Drugs for Candida Pathogens

inferredcites →https://doi.org/10.2174/1570159x13666150716165726openalex-snapshot

Alzheimer's disease: Targeting the Cholinergic System

inferredcites →https://doi.org/10.31083/ph.2011.0618openalex-snapshot

Beta-asarone attenuates beta-amyloid-induced apoptosis through the inhibition of the activation of apoptosis signal-regulating kinase 1 in SH-SY5Y cells

inferredcites →https://doi.org/10.3109/13880209.2012.751616openalex-snapshot

Antidepressant-like effects of essential oil and asarone, a major essential oil component from the rhizome ofAcorus tatarinowii

inferredcites →https://doi.org/10.3181/0812-rm-354openalex-snapshot

Preventive Action of Kai Xin San Aqueous Extract on Depressive-Like Symptoms and Cognition Deficit Induced by Chronic Mild Stress

inferredcites →https://doi.org/10.3389/fphar.2019.01529openalex-snapshot

β-Asarone Inhibits Amyloid-β by Promoting Autophagy in a Cell Model of Alzheimer's Disease

inferredcites →https://doi.org/10.3389/fpls.2020.00965openalex-snapshot

From Folk Taxonomy to Species Confirmation of Acorus (Acoraceae): Evidences Based on Phylogenetic and Metabolomic Analyses

inferredcites →https://doi.org/10.3390/antiox11020281openalex-snapshot

Molecular Mechanisms and Therapeutic Potential of α- and β-Asarone in the Treatment of Neurological Disorders

inferredcites →https://doi.org/10.3390/molecules19055634openalex-snapshot

β-Asarone Reverses Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior and Promotes Hippocampal Neurogenesis in Rats

inferredcites →https://doi.org/10.3390/molecules22040529openalex-snapshot

New Acorane-Type Sesquiterpene from Acorus calamus L.

inferredcites →https://doi.org/10.3797/scipharm.1204-21openalex-snapshot

Comparative Study of the Cytotoxicity and Genotoxicity of Alpha- and Beta-Asarone

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Therapeutic Potential of Active Components from Acorus gramineus and Acorus tatarinowii in Neurological Disorders and Their Application in Korean Medicine

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Effect of β-asarone in normal and β-amyloid-induced Alzheimeric rats

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The volatile oil of Acorus tatarinowii Schott ameliorates Alzheimer's disease through improving insulin resistance via activating the PI3K/AKT pathway

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Improvement in Testosterone Production by Acorus gramineus for the Alleviation of Andropause Symptoms

inferred← citeshttps://doi.org/10.2139/ssrn.4953488openalex-snapshot

Elucidation of the Anti-Epileptic Effect of Acorus Tatarinowii Schott Based on Brain Metabolomics and Gut Microbiota Analysis

inferred← citeshttps://doi.org/10.3389/fphar.2023.1268000openalex-snapshot

Polygala tenuifolia and Acorus tatarinowii in the treatment of Alzheimer’s disease: a systematic review and meta-analysis

inferred← citeshttps://doi.org/10.3389/fphar.2024.1377876openalex-snapshot

Safety assessment of Acori Tatarinowii Rhizoma: acute and subacute oral toxicity

inferred← citeshttps://doi.org/10.3389/fphar.2025.1540092openalex-snapshot

The volatile oil of Acorus tatarinowii schott significantly attenuates neuroinflammatory damage in a rat model of tourette syndrome by inhibiting the p38 MAPK/NLRP3/STAT3 signaling pathway

inferred← citeshttps://doi.org/10.3389/fphar.2025.1552801openalex-snapshot

Volatile oil of Acori tatarinowii rhizoma: potential candidate drugs for mitigating dementia

inferred← citeshttps://doi.org/10.3389/fphar.2026.1811032openalex-snapshot

AI-driven network pharmacology and multi-omics validation identify KCNH2 as a prognostic biomarker and candidate therapeutic vulnerability of Acorus tatarinowii in glioblastoma

inferred← citeshttps://doi.org/10.3389/fphar.2026.1875920openalex-snapshot

Adjunctive Acorus tatarinowii essential-oil ear-canal packing for idiopathic sudden sensorineural hearing loss: study protocol for a single-center, randomized, double-blind, placebo-controlled clinical trial

inferred← citeshttps://doi.org/10.3389/fpls.2026.1761957openalex-snapshot

Catalytic mechanism and transcriptional regulation of AtsTPS2 involved in germacrene A biosynthesis in Acorus tatarinowii

inferred← citeshttps://doi.org/10.3390/antiox13020178openalex-snapshot

Management of the Brain: Essential Oils as Promising Neuroinflammation Modulator in Neurodegenerative Diseases

inferred← citeshttps://doi.org/10.3390/biology14050488openalex-snapshot

Antiepileptic Effects of Acorus tatarinowii Schott in a Rat Model of Epilepsy: Regulation of Metabolic Axes and Gut Microbiota

inferred← citeshttps://doi.org/10.3390/horticulturae11121454openalex-snapshot

Advances and Perspectives in Comprehensive Assessment of Medicinal–Ornamental Multifunctional Plants

inferred← citeshttps://doi.org/10.3390/metabo15030175openalex-snapshot

Metabolomics-Based Study on the Anticonvulsant Mechanism of Acorus tatarinowii: GABA Transaminase Inhibition Alleviates PTZ-Induced Epilepsy in Rats

inferred← citeshttps://doi.org/10.3390/molecules31091446openalex-snapshot

Shichangpu–Xiyangshen Herb Extract Alleviates Cognitive Dysfunction in Type 1 Diabetes Through Metabolism of Arachidonic Acid Cyclooxygenase and Lipoxygenase

inferred← citeshttps://doi.org/10.3390/nu16111589openalex-snapshot

New Value of Acorus tatarinowii/gramineus Leaves as a Dietary Source for Dementia Prevention

inferred← citeshttps://doi.org/10.5021/ad.25.122openalex-snapshot

The Potential Role of β-Asarone in Calcium Imbalance and Mitochondrial Dysfunction in Melanoma Cells

inferred← citeshttps://doi.org/10.56028/aetr.10.1.347.2024openalex-snapshot

Inhibitory Effect of Acorus tatarinowii Nasal in Situ Gel on Acetylcholinesterase

inferred← citeshttps://doi.org/10.56028/aetr.7.1.647.2023openalex-snapshot

Network Pharmacology Study on the Neurotoxic Mechanism of Acorus tatarinowii

inferred← citeshttps://doi.org/10.9734/jocamr/2024/v25i7543openalex-snapshot

Pharmacological Review of Plants and Natural Products with Antiepileptic Effects

Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.