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In Vitro Models of Bacterial Biofilms: Innovative Tools to Improve Understanding and Treatment of Infections

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In vitro and ex vivo systems at the forefront of infection modeling and drug discovery
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Projection Microstereolithographic Microbial Bioprinting for Engineered Biofilms
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Modulation of the mechanical properties of bacterial biofilms in response to environmental challenges
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Enzymatic Detachment of Staphylococcus epidermidis Biofilms
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Stratified Growth in Pseudomonas aeruginosa Biofilms
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Pseudomonas aeruginosa Displays Multiple Phenotypes during Development as a Biofilm
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Depolymerization of β-1,6-N-Acetyl- d -Glucosamine Disrupts the Integrity of Diverse Bacterial Biofilms
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Chronic wounds and the medical biofilm paradigm
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Environmental Acidification Drives S. pyogenes Pilus Expression and Microcolony Formation on Epithelial Cells in a FCT-Dependent Manner
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Bacterial Colony from Two-Dimensional Division to Three-Dimensional Development
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Chitinases Are Negative Regulators of Francisella novicida Biofilms
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Biofilms
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Influence of calcium ions on the mechanical properties of a model biofilm of mucoid Pseudomonas aeruginosa
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Recent advances in mechanical characterisation of biofilm and their significance for material modelling
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The Antimicrobial Peptide lin-SB056-1 and Its Dendrimeric Derivative Prevent Pseudomonas aeruginosa Biofilm Formation in Physiologically Relevant Models of Chronic Infections
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Inhibitory Effects of Lipopeptides and Glycolipids on C. albicans–Staphylococcus spp. Dual-Species Biofilms
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Bacterial Biofilm and its Role in the Pathogenesis of Disease
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Current Status of In Vitro Models and Assays for Susceptibility Testing for Wound Biofilm Infections
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Medical-Grade Silicone Coated with Rhamnolipid R89 Is Effective against Staphylococcus spp. Biofilms
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From in vitro to in vivo Models of Bacterial Biofilm-Related Infections
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Diverse Effects of Natural and Synthetic Surfactants on the Inhibition of Staphylococcus aureus Biofilm
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Alginate: From Food Industry to Biomedical Applications and Management of Metabolic Disorders
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Counter-Acting Candida albicans-Staphylococcus aureus Mixed Biofilm on Titanium Implants Using Microbial Biosurfactants
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Bacterial autoaggregation

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Nanoconjugated bacteriocin–zinc: a promising strategy to suppress biofilm genes in Pseudomonas aeruginosa
inferred← citeshttps://doi.org/10.1016/j.micpath.2024.107155openalex-snapshot
Biofilm battleground: Unveiling the hidden challenges, current approaches and future perspectives in combating biofilm associated bacterial infections
inferred← citeshttps://doi.org/10.1016/j.microb.2025.100436openalex-snapshot
A comprehensive review on biofilm-associated infections: Mechanisms, diagnostic challenges, and innovative therapeutic strategies
inferred← citeshttps://doi.org/10.1016/j.nexres.2026.102428openalex-snapshot
Targeted gene expression analysis of Streptococcus mutans interaction with oral epithelial cells in a co-culture model
inferred← citeshttps://doi.org/10.1016/j.rineng.2024.102490openalex-snapshot
Physical parametric study of bacterial biofilm disruption and removal by jet impingement: A CFD investigation
inferred← citeshttps://doi.org/10.1016/j.watcyc.2026.08.002openalex-snapshot
Tools and Techniques for Studying Biofilms in Industrial Water Systems: A Critical Review
inferred← citeshttps://doi.org/10.1021/acsanm.4c02925openalex-snapshot
Dopamine-Chelated Metal–Organic Framework Nanostructure-Based Coatings as a Photodynamic Therapy Amplifier
inferred← citeshttps://doi.org/10.1021/acsnanomed.5c00060openalex-snapshot
Engineered Nanoparticles for Combating Drug-Resistant Bacteria and Bacterial Biofilms
inferred← citeshttps://doi.org/10.1038/s41522-025-00869-6openalex-snapshot
Beyond the matrix: rethinking antibiotic tolerance in CF biofilms using 3D models
inferred← citeshttps://doi.org/10.1038/s41579-024-01086-2openalex-snapshot
Towards improved biofilm models
inferred← citeshttps://doi.org/10.1038/s41598-025-27034-5openalex-snapshot
High-throughput bacterial aggregation analysis in droplets
inferred← citeshttps://doi.org/10.1038/s44259-025-00113-3openalex-snapshot
Effect of host microenvironment and bacterial lifestyles on antimicrobial sensitivity and implications for susceptibility testing
inferred← citeshttps://doi.org/10.1039/9781837677047-00001openalex-snapshot
Biofilm: A Life for Microorganisms with Basic Biofilm Principles
inferred← citeshttps://doi.org/10.1039/d4an00393dopenalex-snapshot
Combined electrical-electrochemical phenotypic profiling of antibiotic susceptibility of in vitro biofilm models
inferred← citeshttps://doi.org/10.1039/d4bm00936copenalex-snapshot
Smart self-defensive coatings with bacteria-triggered antimicrobial response for medical devices
inferred← citeshttps://doi.org/10.1039/d5pm00094gopenalex-snapshot
Biofilms: structure, resistance mechanism, emerging control strategies, and applications
inferred← citeshttps://doi.org/10.1080/17460913.2026.2740962openalex-snapshot
Impedance-based biosensor as a promising tool for rapidly detecting the formation of multidrug-resistant Pseudomonas aeruginosa biofilms
inferred← citeshttps://doi.org/10.1088/1402-4896/ada4e7openalex-snapshot
Dielectric barrier discharge air plasma as a comprehensive disinfection approach to E. coli and S. aureus biofilm management
inferred← citeshttps://doi.org/10.1093/jac/dkag091openalex-snapshot
Experimental biofilm models for pharmacokinetic and pharmacodynamic investigations: bridging in vitro , ex vivo and in vivo systems
inferred← citeshttps://doi.org/10.1111/1751-7915.14360openalex-snapshot
Three dimensional printed biofilms: Fabrication, design and future biomedical and environmental applications
inferred← citeshttps://doi.org/10.1128/spectrum.02868-25openalex-snapshot
Exploring the anti-biofilm effect of darobactin B and colistin in static and dynamic environments
inferred← citeshttps://doi.org/10.1134/s000368382402011xopenalex-snapshot
Advantages and Limitations of the Biofilm Study Methods
inferred← citeshttps://doi.org/10.1515/med-2026-1544openalex-snapshot
Translating microbial knowledge into clinical biofilm therapies
inferred← citeshttps://doi.org/10.2139/ssrn.5345481openalex-snapshot
A Semi-Solid in Vitro Biofilm Model for Screening Antimicrobials Against Physiologically Relevant Bacterial Biofilms
inferred← citeshttps://doi.org/10.3389/fcimb.2026.1826282openalex-snapshot
Biofilm-associated antibiotic tolerance in the era of multidrug resistance: quorum-sensing mechanisms and emerging therapeutic strategies
inferred← citeshttps://doi.org/10.3389/fimmu.2026.1898257openalex-snapshot
The 3D landscape of infection: spatial organization and in vitro models
inferred← citeshttps://doi.org/10.3389/fmicb.2026.1827386openalex-snapshot
Stigmurin derivatives as potent-biofilm eradicating agents against the major human opportunistic pathogen Pseudomonas aeruginosa
inferred← citeshttps://doi.org/10.3390/antibiotics13070623openalex-snapshot
Medical Device-Associated Infections Caused by Biofilm-Forming Microbial Pathogens and Controlling Strategies
inferred← citeshttps://doi.org/10.3390/antibiotics14020118openalex-snapshot
Antimicrobial and Antibiofilm Activity of Auranofin and Its Two Derivatives Bearing Naproxen and Acetylcysteine as Ligands Against Staphylococci
inferred← citeshttps://doi.org/10.3390/antibiotics15020155openalex-snapshot
Bacteriophage-Based Control of Methicillin-Resistant Staphylococcus aureus: Anti-Biofilm Activity, Surface-Active Formulation Compatibility, and Genomic Context
inferred← citeshttps://doi.org/10.3390/ijms242417242openalex-snapshot
Culture Shock: An Investigation into the Tolerance of Pathogenic Biofilms to Antiseptics in Environments Resembling the Chronic Wound Milieu
inferred← citeshttps://doi.org/10.3390/ijms26189193openalex-snapshot
Catheter-Associated Urinary Tract Infections: Understanding the Interplay Between Bacterial Biofilm and Antimicrobial Resistance
inferred← citeshttps://doi.org/10.3390/jfb17050216openalex-snapshot
Biogenic Selenium Nanoparticles Functionalized with Natural Polymers or Phytochemicals for Targeted Disruption of Candida spp. Biofilms on Denture Materials: A Systematic Review
inferred← citeshttps://doi.org/10.3390/jfb17050237openalex-snapshot
Bioinformatic Resistome Profiling of Metal Tolerance Mechanisms in Endodontic Infections: Implications for Antimicrobial Nanoparticle-Based Biomaterials
inferred← citeshttps://doi.org/10.3390/micro6030072openalex-snapshot
A Comprehensive Review of Antimicrobial Nanoformulations: Engineered to Combat Biofilm-Associated Infections
inferred← citeshttps://doi.org/10.3390/microorganisms14040910openalex-snapshot
Biosurfactants as Antibiofilm Agents for Medical Devices: Mechanisms, Evidence and Integration into Infection Prevention and Control
inferred← citeshttps://doi.org/10.36233/0372-9311-761openalex-snapshot
Method for forming a static biofilm on various surfaces to evaluate the effectiveness of disinfectants
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