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Hesperidin Improves Memory Function by Enhancing Neurogenesis in a Mouse Model of Alzheimer’s Disease

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1 of the 42 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-28): 10.1007/s11064-015-1525-1 (notice 2024-08-23).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/hipo.10103openalex-snapshot
Neurogenesis may relate to some but not all types of hippocampal‐dependent learning
inferredcites →https://doi.org/10.1002/ptr.1074openalex-snapshot
Chemistry and pharmacology of the citrus bioflavonoid hesperidin
inferredcites →https://doi.org/10.1007/bf00308809openalex-snapshot
Neuropathological stageing of Alzheimer-related changes
inferredcites →https://doi.org/10.1007/bf02968255openalex-snapshot
Antioxidant and neuroprotective effects of hesperidin and its aglycone hesperetin
inferredcites →https://doi.org/10.1007/s11064-015-1525-1openalex-snapshot
RETRACTED ARTICLE: Neuroprotective Effect of Hesperidin on Aluminium Chloride Induced Alzheimer’s Disease in Wistar Rats
inferredcites →https://doi.org/10.1007/s11064-015-1689-8openalex-snapshot
Erratum to: Neuroprotective Effect of Hesperidin on Aluminium Chloride Induced Alzheimer’s Disease in Wistar Rats
inferredcites →https://doi.org/10.1007/s13105-019-00678-4openalex-snapshot
Hesperetin is a potent bioactivator that activates SIRT1-AMPK signaling pathway in HepG2 cells
inferredcites →https://doi.org/10.1007/s13311-019-00792-7openalex-snapshot
Picrorhiza kurroa Prevents Memory Deficits by Inhibiting NLRP3 Inflammasome Activation and BACE1 Expression in 5xFAD Mice
inferredcites →https://doi.org/10.1016/bs.pmbts.2020.09.002openalex-snapshot
Adult hippocampal neurogenesis in Alzheimer's disease
inferredcites →https://doi.org/10.1016/j.bbi.2021.09.002openalex-snapshot
Transplantation of gut microbiota derived from Alzheimer’s disease mouse model impairs memory function and neurogenesis in C57BL/6 mice
inferredcites →https://doi.org/10.1016/j.bcp.2011.11.009openalex-snapshot
Cyclic AMP response element-binding protein (CREB) phosphorylation: A mechanistic marker in the development of memory enhancing Alzheimer's disease therapeutics
inferredcites →https://doi.org/10.1016/j.bcp.2020.114083openalex-snapshot
Neuroprotective effects of hesperidin against methotrexate-induced changes in neurogenesis and oxidative stress in the adult rat
inferredcites →https://doi.org/10.1016/j.expneurol.2004.11.016openalex-snapshot
Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats
inferredcites →https://doi.org/10.1016/j.intimp.2020.106479openalex-snapshot
Pharmacological approaches to mitigate neuroinflammation in Alzheimer’s disease
inferredcites →https://doi.org/10.1016/j.jad.2019.09.013openalex-snapshot
Metformin ameliorates stress-induced depression-like behaviors via enhancing the expression of BDNF by activating AMPK/CREB-mediated histone acetylation
inferredcites →https://doi.org/10.1016/j.neuron.2011.05.001openalex-snapshot
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
inferredcites →https://doi.org/10.1016/j.neuropharm.2019.03.026openalex-snapshot
Mechanisms underpinning AMP-activated protein kinase-related effects on behavior and hippocampal neurogenesis in an animal model of depression
inferredcites →https://doi.org/10.1016/j.stem.2018.03.015openalex-snapshot
Human Hippocampal Neurogenesis Persists throughout Aging
inferredcites →https://doi.org/10.1016/s0006-8993(99)01220-2openalex-snapshot
Impaired phosphorylation of cyclic AMP response element binding protein in the hippocampus of dementia of the Alzheimer type
inferredcites →https://doi.org/10.1038/mp.2009.67openalex-snapshot
Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis
inferredcites →https://doi.org/10.1038/s41418-019-0409-3openalex-snapshot
Impaired adult neurogenesis is an early event in Alzheimer’s disease neurodegeneration, mediated by intracellular Aβ oligomers
inferredcites →https://doi.org/10.1038/s41467-019-14026-zopenalex-snapshot
Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life
inferredcites →https://doi.org/10.1038/s41591-019-0375-9openalex-snapshot
Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease
inferredcites →https://doi.org/10.1038/s41598-017-09599-yopenalex-snapshot
Homophilic binding of the neural cell adhesion molecule CHL1 regulates development of ventral midbrain dopaminergic pathways
inferredcites →https://doi.org/10.1038/s41598-021-01977-xopenalex-snapshot
Andrographolide promotes hippocampal neurogenesis and spatial memory in the APPswe/PS1ΔE9 mouse model of Alzheimer’s disease
inferredcites →https://doi.org/10.1073/pnas.0901402106openalex-snapshot
Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease
inferredcites →https://doi.org/10.1074/jbc.m112.391961openalex-snapshot
Role of Mismatch Repair Enzymes in GAA·TTC Triplet-repeat Expansion in Friedreich Ataxia Induced Pluripotent Stem Cells
inferredcites →https://doi.org/10.1126/science.abm7468openalex-snapshot
Adult neurogenesis in neurological diseases
inferredcites →https://doi.org/10.1155/2013/102741openalex-snapshot
Neuroprotective Effects of Hesperidin, a Plant Flavanone, on Rotenone-Induced Oxidative Stress and Apoptosis in a Cellular Model for Parkinson’s Disease
inferredcites →https://doi.org/10.1186/1750-1326-6-85openalex-snapshot
Adult hippocampal neurogenesis and its role in Alzheimer's disease
inferredcites →https://doi.org/10.1186/s13024-017-0207-7openalex-snapshot
Depletion of adult neurogenesis exacerbates cognitive deficits in Alzheimer’s disease by compromising hippocampal inhibition
inferredcites →https://doi.org/10.1210/jc.2010-2879openalex-snapshot
Citrus Polyphenol Hesperidin Stimulates Production of Nitric Oxide in Endothelial Cells while Improving Endothelial Function and Reducing Inflammatory Markers in Patients with Metabolic Syndrome
inferredcites →https://doi.org/10.1371/journal.pone.0051798openalex-snapshot
Restriction of Neural Precursor Ability to Respond to Nurr1 by Early Regional Specification
inferredcites →https://doi.org/10.1523/jneurosci.21-12-04125.2001openalex-snapshot
Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease.
inferredcites →https://doi.org/10.3389/fcell.2020.00671openalex-snapshot
Insight on Transcriptional Regulation of the Energy Sensing AMPK and Biosynthetic mTOR Pathway Genes
inferredcites →https://doi.org/10.3389/fnagi.2019.00062openalex-snapshot
Valproic Acid Stimulates Hippocampal Neurogenesis via Activating the Wnt/β-Catenin Signaling Pathway in the APP/PS1/Nestin-GFP Triple Transgenic Mouse Model of Alzheimer’s Disease
inferredcites →https://doi.org/10.3389/fnins.2012.00081openalex-snapshot
All in the Family: How the APPs Regulate Neurogenesis
inferredcites →https://doi.org/10.3390/ijms18020268openalex-snapshot
Integral Characterization of Defective BDNF/TrkB Signalling in Neurological and Psychiatric Disorders Leads the Way to New Therapies
inferredcites →https://doi.org/10.3390/ijms21124492openalex-snapshot
Trans-Cinnamaldehyde Alleviates Amyloid-Beta Pathogenesis via the SIRT1-PGC1α-PPARγ Pathway in 5XFAD Transgenic Mice
inferredcites →https://doi.org/10.3390/nu11040936openalex-snapshot
Hesperidin Alleviates Methotrexate-Induced Memory Deficits via Hippocampal Neurogenesis in Adult Rats
inferredcites →https://doi.org/10.4103/1673-5374.205084openalex-snapshot
Neurotrophic factors in Alzheimer's and Parkinson's diseases: implications for pathogenesis and therapy
inferredcites →https://doi.org/10.4268/cjcmm20161728openalex-snapshot
Protection mechanisms of hesperidin on mouse with insulin resistance

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4610828openalex-extracted
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inferred← citeshttps://doi.org/10.1002/ame2.70244openalex-snapshot
Multipathway modulation of neuroinflammation and oxidative stress by hesperidin in a rat single prolonged stress model of post‐traumatic stress disorder
inferred← citeshttps://doi.org/10.1007/978-3-031-42422-9_1openalex-snapshot
Neurotrophic Natural Products
inferred← citeshttps://doi.org/10.1007/978-981-99-6038-5_11openalex-snapshot
Flavonoid-Based Derivatives for Modulating Various Targets of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1007/s00441-023-03821-2openalex-snapshot
Beyond animal models: revolutionizing neurodegenerative disease modeling using 3D in vitro organoids, microfluidic chips, and bioprinting
inferred← citeshttps://doi.org/10.1007/s10495-024-02032-6openalex-snapshot
Targeted editing of CCL5 with CRISPR-Cas9 nanoparticles enhances breast cancer immunotherapy
inferred← citeshttps://doi.org/10.1007/s10565-024-09958-2openalex-snapshot
Targeting CDK1 and copper homeostasis in breast cancer via a nanopolymer drug delivery system
inferred← citeshttps://doi.org/10.1007/s11011-024-01479-5openalex-snapshot
Exploring role of citrus fruits in comorbid neurodegenerative disorders associated with psoriasis
inferred← citeshttps://doi.org/10.1007/s11064-026-04833-4openalex-snapshot
A Combination of Artemisinin, N-acetylcysteine, Resveratrol, and Hesperidin Ameliorates Hippocampal Damage and Pathological Features in an Experimental Model of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1007/s11481-025-10170-0openalex-snapshot
A Comparative Study of Nanoconjugates of a Synthetic and a Natural Drug Against T2DM-Induced Cognitive Dysfunction
inferred← citeshttps://doi.org/10.1007/s11655-024-4113-xopenalex-snapshot
Hesperidin Suppressed Colorectal Cancer through Inhibition of Glycolysis
inferred← citeshttps://doi.org/10.1007/s13205-026-05078-2openalex-snapshot
Traditional Chinese medicine for Alzheimer’s disease: pathological mechanisms and multi-target interventions
inferred← citeshttps://doi.org/10.1007/s40473-024-00284-9openalex-snapshot
The Impact of Hesperidin on Cognitive Deficit and Neurobehavioural Disorders: A Systematic Review and Meta-Analysis of Preclinical Individual Studies
inferred← citeshttps://doi.org/10.1007/s41105-025-00581-0openalex-snapshot
Correlation study of 5-HT in brain with cognitive function and anxious-like behavior in APP/PS1 transgene mice
inferred← citeshttps://doi.org/10.1016/j.bbrc.2025.151974openalex-snapshot
An updated and comprehensive review of the health benefits and pharmacological activities of hesperidin
inferred← citeshttps://doi.org/10.1016/j.bioorg.2026.110300openalex-snapshot
Regulation of different kinases for Alzheimer's disease therapy: progresses and perspectives
inferred← citeshttps://doi.org/10.1016/j.biopha.2025.118362openalex-snapshot
Eriocitrin and its derivatives against Alzheimer’s disease: Cumulative accounts of in vitro and in vivo studies
inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.117144openalex-snapshot
Efficacy and molecular mechanisms of hesperidin in mitigating Alzheimer's disease: A systematic review
inferred← citeshttps://doi.org/10.1016/j.fitote.2023.105792openalex-snapshot
Metabolite profiling, enzyme inhibitory activity and antioxidant potential of different extracts from Glycyrrhiza foetida Desf. (Fabaceae, Galegeae, Glycyrrhizinae)
inferred← citeshttps://doi.org/10.1016/j.foodw.2026.100039openalex-snapshot
The application of high-voltage pulsed electric field, ultrasound, and fermentation in the processing, resource utilization, and product development of tropical fruits: A review
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2023.10.408openalex-snapshot
Hesperidin ameliorates Amyloid-β toxicity and enhances oxidative stress resistance and lifespan of Caenorhabditis elegans through acr-16 mediated activation of the autophagy pathway
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e38937openalex-snapshot
Hesperidin:a citrus plant component, plays a role in the central nervous system
inferred← citeshttps://doi.org/10.1016/j.jep.2024.118503openalex-snapshot
Phytochemistry, pharmacological properties and pharmacokinetics of Citri Reticulatae Pericarpium: A systematic review
inferred← citeshttps://doi.org/10.1016/j.jep.2026.122084openalex-snapshot
Ditan Decoction alleviates glutamate excitotoxicity in an Aβ-induced Alzheimer's disease-like model through the regulation of ERBB2/PI3K/AKT signaling pathway
inferred← citeshttps://doi.org/10.1016/j.jfca.2025.107553openalex-snapshot
Comparison of ultrasound-assisted extraction and modified QuEChERS technique for extraction of hesperidin from lemon peel (Citrus limon L.) as determined by HPLC
inferred← citeshttps://doi.org/10.1016/j.jpha.2024.101146openalex-snapshot
Mitochondrial quality control disorder in neurodegenerative disorders: Potential and advantages of traditional Chinese medicines
inferred← citeshttps://doi.org/10.1016/j.jpha.2025.101519openalex-snapshot
ERBB2 mutations promote recurrence and metastasis in non-muscle-invasive bladder cancer via HIF-1 phosphorylation: Insights from whole exome sequencing
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Novel 3D bioprinting approach for spinal cord injury repair using neural stem cells and TGF-β1 monoclonal antibody
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2025.09.028openalex-snapshot
Decoding the neuroprotective potential of hesperidin: Insights into Alzheimer’s disease
inferred← citeshttps://doi.org/10.1016/j.phyplu.2025.100874openalex-snapshot
Role of hesperidin in modulating antioxidant enzymes in the brain of rats exposed to Nickel Chloride
inferred← citeshttps://doi.org/10.1016/j.prmcm.2025.100718openalex-snapshot
Traditional wisdom to modern science: Hesperetin and naringenin as emerging traditional Chinese medicine-based treatments for Alzheimer’s disease
inferred← citeshttps://doi.org/10.1016/j.tifs.2025.105390openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.tjnut.2026.101697openalex-snapshot
Hesperidin as an Emerging Nutraceutical in Modern Health and Preventive Medicine: A Narrative Review
inferred← citeshttps://doi.org/10.1017/s0007114523002301openalex-snapshot
Tomato and lemon extracts synergistically improve cognitive function by increasing brain-derived neurotrophic factor levels in aged mice
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inferred← citeshttps://doi.org/10.1021/acsomega.4c05527openalex-snapshot
Newer Therapeutic Approaches in Treating Alzheimer’s Disease: A Comprehensive Review
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The impact of flavonoids and BDNF on neurogenic process in various physiological/pathological conditions including ischemic insults: a narrative review
inferred← citeshttps://doi.org/10.1080/1028415x.2024.2397136openalex-snapshot
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inferred← citeshttps://doi.org/10.1080/10942912.2023.2236327openalex-snapshot
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inferred← citeshttps://doi.org/10.1080/14786419.2024.2345760openalex-snapshot
Protective effect of flavonoids on oxidative stress injury in Alzheimer’s disease
inferred← citeshttps://doi.org/10.1111/cns.14509openalex-snapshot
Survivin enhances hippocampal neurogenesis and cognitive function in Alzheimer's disease mouse model
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Oligodendrocyte‐derived exosomes‐containing SIRT2 ameliorates depressive‐like behaviors and restores hippocampal neurogenesis and synaptic plasticity via the AKT / GSK ‐3β pathway in depressed mice
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Hesperidin ameliorates H2O2-induced bovine mammary epithelial cell oxidative stress via the Nrf2 signaling pathway
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inferred← citeshttps://doi.org/10.31083/jin23090openalex-snapshot
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inferred← citeshttps://doi.org/10.33483/jfpau.1629547openalex-snapshot
HESPERİDİN VE NÖRODEJENERATİF HASTALIKLAR: ALZHEİMER VE PARKİNSON’A YÖNELİK NÖROPROTEKTİF ETKİLER
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Harnessing hesperidin for brain metabolism: epigenetic signatures, cellular homeostasis, synaptic function, and neuroprotection in age-related diseases and neurodegenerative diseases
inferred← citeshttps://doi.org/10.3389/fphar.2023.1213252openalex-snapshot
Glucosyl hesperidin exhibits more potent anxiolytic activity than hesperidin accompanied by the attenuation of noradrenaline induction in a zebrafish model
inferred← citeshttps://doi.org/10.3389/fphar.2026.1863841openalex-snapshot
Neurogenesis and neuroplasticity activities of natural products: therapeutic potential in Alzheimer’s disease
inferred← citeshttps://doi.org/10.3390/cells12020252openalex-snapshot
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inferred← citeshttps://doi.org/10.6084/m9.figshare.26697437openalex-snapshot
Additional file 1 of Hesperidin ameliorates H2O2-induced bovine mammary epithelial cell oxidative stress via the Nrf2 signaling pathway
inferred← citeshttps://doi.org/10.6084/m9.figshare.26697440openalex-snapshot
Additional file 2 of Hesperidin ameliorates H2O2-induced bovine mammary epithelial cell oxidative stress via the Nrf2 signaling pathway
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